{"title":"在体内和体外通过Nrf2/HO-1信号通路参与对缺血性损伤的心脏保护作用","authors":"Xiaojing Ma, Guodong Yang, Changxin Liu, Wenfu Ma, Qiuyuan Ding, Xiaojuan Li, Feng Zhou, Jessore Jurat, Xiaoli Gao, Kelsang Norbu, Xingyun Chai","doi":"10.1002/cbdv.202502483","DOIUrl":null,"url":null,"abstract":"<p><p>As part of a systematic study, this research aims to investigate the protective effects of subfraction I<sub>3</sub> from Syringa pinnatifolia against oxidative damage following acute myocardial infarction (AMI) in mice and its underlying mechanisms. The I<sub>3</sub> was chemically characterized by using IT-TOF-ESI-MS. The anti-AMI effects of fraction C and subfractions I<sub>2</sub> and I<sub>3</sub> were evaluated by using H&E staining, immunofluorescence, and Western blotting. The results showed that I<sub>3</sub> improves the impaired cardiac function, bringing it to a level comparable to that of C in vivo and/or in vitro, whereas I<sub>2</sub> did not exhibit this effect, suggesting the lignan rather than terpenoid fraction contributes the anti-AMI effect of S. pinnatifolia, and the mechanism of action may be related to the promotion of the Nrf2/HO-1 signaling pathway activation.</p>","PeriodicalId":9878,"journal":{"name":"Chemistry & Biodiversity","volume":" ","pages":"e02483"},"PeriodicalIF":2.5000,"publicationDate":"2025-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Syringa pinnatifolia Lignans Contribute to the Cardioprotective Effect Against Ischemic Injury through the Nrf2/HO-1 Signaling Pathway in Vitro and in Vivo.\",\"authors\":\"Xiaojing Ma, Guodong Yang, Changxin Liu, Wenfu Ma, Qiuyuan Ding, Xiaojuan Li, Feng Zhou, Jessore Jurat, Xiaoli Gao, Kelsang Norbu, Xingyun Chai\",\"doi\":\"10.1002/cbdv.202502483\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>As part of a systematic study, this research aims to investigate the protective effects of subfraction I<sub>3</sub> from Syringa pinnatifolia against oxidative damage following acute myocardial infarction (AMI) in mice and its underlying mechanisms. The I<sub>3</sub> was chemically characterized by using IT-TOF-ESI-MS. The anti-AMI effects of fraction C and subfractions I<sub>2</sub> and I<sub>3</sub> were evaluated by using H&E staining, immunofluorescence, and Western blotting. The results showed that I<sub>3</sub> improves the impaired cardiac function, bringing it to a level comparable to that of C in vivo and/or in vitro, whereas I<sub>2</sub> did not exhibit this effect, suggesting the lignan rather than terpenoid fraction contributes the anti-AMI effect of S. pinnatifolia, and the mechanism of action may be related to the promotion of the Nrf2/HO-1 signaling pathway activation.</p>\",\"PeriodicalId\":9878,\"journal\":{\"name\":\"Chemistry & Biodiversity\",\"volume\":\" \",\"pages\":\"e02483\"},\"PeriodicalIF\":2.5000,\"publicationDate\":\"2025-10-13\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Chemistry & Biodiversity\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://doi.org/10.1002/cbdv.202502483\",\"RegionNum\":3,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"BIOCHEMISTRY & MOLECULAR BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Chemistry & Biodiversity","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.1002/cbdv.202502483","RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
Syringa pinnatifolia Lignans Contribute to the Cardioprotective Effect Against Ischemic Injury through the Nrf2/HO-1 Signaling Pathway in Vitro and in Vivo.
As part of a systematic study, this research aims to investigate the protective effects of subfraction I3 from Syringa pinnatifolia against oxidative damage following acute myocardial infarction (AMI) in mice and its underlying mechanisms. The I3 was chemically characterized by using IT-TOF-ESI-MS. The anti-AMI effects of fraction C and subfractions I2 and I3 were evaluated by using H&E staining, immunofluorescence, and Western blotting. The results showed that I3 improves the impaired cardiac function, bringing it to a level comparable to that of C in vivo and/or in vitro, whereas I2 did not exhibit this effect, suggesting the lignan rather than terpenoid fraction contributes the anti-AMI effect of S. pinnatifolia, and the mechanism of action may be related to the promotion of the Nrf2/HO-1 signaling pathway activation.
期刊介绍：
Chemistry & Biodiversity serves as a high-quality publishing forum covering a wide range of biorelevant topics for a truly international audience. This journal publishes both field-specific and interdisciplinary contributions on all aspects of biologically relevant chemistry research in the form of full-length original papers, short communications, invited reviews, and commentaries. It covers all research fields straddling the border between the chemical and biological sciences, with the ultimate goal of broadening our understanding of how nature works at a molecular level.
Since 2017, Chemistry & Biodiversity is published in an online-only format.
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