Cell metabolismPub Date : 2026-08-27DOI: 10.1016/j.cmet.2026.07.020
Max C. Petersen,Gordon I. Smith,Sarah S. Farabi,Hector H. Palacios,Mahalakshmi Shankaran,Marc K. Hellerstein,Bruce W. Patterson,Samuel Klein
{"title":"Effect of diet macronutrient content on the cardiometabolic response to weight loss: A randomized clinical trial","authors":"Max C. Petersen,Gordon I. Smith,Sarah S. Farabi,Hector H. Palacios,Mahalakshmi Shankaran,Marc K. Hellerstein,Bruce W. Patterson,Samuel Klein","doi":"10.1016/j.cmet.2026.07.020","DOIUrl":"https://doi.org/10.1016/j.cmet.2026.07.020","url":null,"abstract":"The influence of diet macronutrient content on the cardiometabolic effects of weight loss in people with metabolically unhealthy obesity (prediabetes and hepatic steatosis) has important clinical implications. We evaluated the cardiometabolic effects of moderate (∼10%) weight loss induced by three popular diets with markedly different macronutrient composition (very-low-carbohydrate ketogenic, Mediterranean, and very-low-fat plant-forward). Weight loss increased muscle insulin sensitivity by ∼50% in all groups but caused a two-to-three-fold greater increase in hepatic insulin sensitivity in the very-low-carbohydrate group than the other groups (p < 0.001). Intrahepatic triglyceride content, hepatic de novo lipogenesis, glycated hemoglobin, and 24-h serial plasma glucose and insulin decreased most in the very-low-carbohydrate group. There were no differences among groups in LDL-cholesterol, apolipoprotein B, or 24-h plasma triglyceride concentrations. These results demonstrate that a very-low-carbohydrate diet has greater cardiometabolic benefits, particularly in hepatic metabolic function, than matched 10% weight loss induced by a Mediterranean or very-low-fat diet in people with metabolically unhealthy obesity.","PeriodicalId":9840,"journal":{"name":"Cell metabolism","volume":"16 1","pages":""},"PeriodicalIF":29.0,"publicationDate":"2026-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148821555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Cell metabolismPub Date : 2026-08-26DOI: 10.1016/j.cmet.2026.08.002
Rie Matsuzaki,W. Michael Caudle,Timothy R. Sampson
{"title":"The microbiota at the interface of environmental toxicants and the brain","authors":"Rie Matsuzaki,W. Michael Caudle,Timothy R. Sampson","doi":"10.1016/j.cmet.2026.08.002","DOIUrl":"https://doi.org/10.1016/j.cmet.2026.08.002","url":null,"abstract":"Throughout life, humans are exposed to a diverse array of xenobiotics originating from diet, pharmaceuticals, and environmental contaminants. Positioned at the interface between the host and the external environment, the gut microbiota is uniquely situated to both sense and modify the effects of these exposures prior to systemic circulation and delivery to their host targets. Growing evidence indicates that the microbiota play critical roles in shaping xenobiotic fate through both direct metabolic transformation and modulation of host detoxification pathways, barrier integrity, and immune signaling. In this review, we summarize the impacts of disease-relevant environmental neurotoxicants on both the brain and microbial composition. We further integrate emerging mechanistic insights illustrating how microbiota-dependent processes can influence host toxicant responses and detoxification capacity, ultimately modifying exposure outcomes. Collectively, these findings position the gut microbiota as central mediators between environmental exposures and neurological health, providing a framework to better understand potential risk-modifying relationships.","PeriodicalId":9840,"journal":{"name":"Cell metabolism","volume":"11 1","pages":""},"PeriodicalIF":29.0,"publicationDate":"2026-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148821631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Cell metabolismPub Date : 2026-08-19DOI: 10.1016/j.cmet.2026.08.012
Alexander S. Banks,Ja Young Kim-Muller,Teresa L. Mastracci,Natalie M. Kofler,Li Qiang,Rebecca A. Haeusler,Michael J. Jurczak,Dina Laznik,Garrett Heinrich,Varman T. Samuel,Gerald I. Shulman,Virginia E. Papaioannou,Domenico Accili
{"title":"Dissociation of the Glucose and Lipid Regulatory Functions of FoxO1 by Targeted Knockin of Acetylation-Defective Alleles in Mice","authors":"Alexander S. Banks,Ja Young Kim-Muller,Teresa L. Mastracci,Natalie M. Kofler,Li Qiang,Rebecca A. Haeusler,Michael J. Jurczak,Dina Laznik,Garrett Heinrich,Varman T. Samuel,Gerald I. Shulman,Virginia E. Papaioannou,Domenico Accili","doi":"10.1016/j.cmet.2026.08.012","DOIUrl":"https://doi.org/10.1016/j.cmet.2026.08.012","url":null,"abstract":"","PeriodicalId":9840,"journal":{"name":"Cell metabolism","volume":"35 1","pages":""},"PeriodicalIF":29.0,"publicationDate":"2026-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148768885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Cell metabolismPub Date : 2026-08-17DOI: 10.1016/j.cmet.2026.08.005
Sora Q. Kim, Sangho Yu, Christopher D. Morrison
{"title":"Protein restriction and the hallmarks of aging: A coordinated physiological adaptive response?","authors":"Sora Q. Kim, Sangho Yu, Christopher D. Morrison","doi":"10.1016/j.cmet.2026.08.005","DOIUrl":"https://doi.org/10.1016/j.cmet.2026.08.005","url":null,"abstract":"","PeriodicalId":9840,"journal":{"name":"Cell metabolism","volume":"6 1","pages":""},"PeriodicalIF":29.0,"publicationDate":"2026-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148755351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Cell metabolismPub Date : 2026-08-12DOI: 10.1016/j.cmet.2026.07.023
Elisabetta Mereu, Diego Balboa, Johannes Liebig, Aitor Gonzalez-Herrero, Anna Martinez Casals, Mariya Mardamshina, Fanny Mollandin, Felix Schicktanz, Alexander Sudy, Luca Tosti, Maarten van Agen, Valerie Vandenbempt, Dana Avrahami, Frederic Ballllosera Navarro, Edgar Bernardo, Frida Björklund, Robert Lorenz Chua, Marten Engelse, Javier García-Hurtado, Nathalie Groen, Maaike Hanegraaf, Pablo Iañez, Katharina Jechow, Björn Konukiewitz, Christian Lawerenz, Nadja Lewandowski-Hoppe, Domenica Marchese, Mauro J. Muraro, Silvia Pellegrini, Valeria Sordi, Ulrike Taron, Foo Wei Ten, Timo Trefzer, Sven Twardziok, Johannes Wirth, Françoise Carlotti, Eelco de Koning, Jorge Ferrer, Benjamin Glaser, Holger Heyn, Emma Lundberg, Lorenzo Piemonti, Katja Steiger, Alexander van Oudenaarden, Wilko Weichert, Christian Conrad, Roland Eils
{"title":"A single-cell multi-omic atlas of the human pancreas reveals potential for cellular plasticity across development, health, and disease","authors":"Elisabetta Mereu, Diego Balboa, Johannes Liebig, Aitor Gonzalez-Herrero, Anna Martinez Casals, Mariya Mardamshina, Fanny Mollandin, Felix Schicktanz, Alexander Sudy, Luca Tosti, Maarten van Agen, Valerie Vandenbempt, Dana Avrahami, Frederic Ballllosera Navarro, Edgar Bernardo, Frida Björklund, Robert Lorenz Chua, Marten Engelse, Javier García-Hurtado, Nathalie Groen, Maaike Hanegraaf, Pablo Iañez, Katharina Jechow, Björn Konukiewitz, Christian Lawerenz, Nadja Lewandowski-Hoppe, Domenica Marchese, Mauro J. Muraro, Silvia Pellegrini, Valeria Sordi, Ulrike Taron, Foo Wei Ten, Timo Trefzer, Sven Twardziok, Johannes Wirth, Françoise Carlotti, Eelco de Koning, Jorge Ferrer, Benjamin Glaser, Holger Heyn, Emma Lundberg, Lorenzo Piemonti, Katja Steiger, Alexander van Oudenaarden, Wilko Weichert, Christian Conrad, Roland Eils","doi":"10.1016/j.cmet.2026.07.023","DOIUrl":"https://doi.org/10.1016/j.cmet.2026.07.023","url":null,"abstract":"","PeriodicalId":9840,"journal":{"name":"Cell metabolism","volume":"166 1","pages":""},"PeriodicalIF":29.0,"publicationDate":"2026-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148715633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Cell metabolismPub Date : 2026-08-04DOI: 10.1016/j.cmet.2026.05.013
Stefano Pluchino,Evridiki Asimakidou
{"title":"Microglia go beyond surveillance to fuel neuronal protein synthesis on demand","authors":"Stefano Pluchino,Evridiki Asimakidou","doi":"10.1016/j.cmet.2026.05.013","DOIUrl":"https://doi.org/10.1016/j.cmet.2026.05.013","url":null,"abstract":"In this issue of Cell Metabolism, Adler et al.11.Adler, D. ∙ Martín-Ávila, A. ∙ Cheng, E. ...Activity-dependent protein synthesis in neurons requires microglia-metabolic couplingCell Metab. 2026; 38:1650-1667.e10Full TextFull Text (PDF)Scopus (0)Google Scholar demonstrate that microglia coordinate multicellular metabolic interactions within the neurovascular niche. They identify microglia-derived cysteine-rich angiogenic inducer 61 (CYR61) as a mediator promoting cerebral glucose uptake and neuronal protein synthesis, thereby highlighting a role for microglia in supporting neuronal adaptation on demand.","PeriodicalId":9840,"journal":{"name":"Cell metabolism","volume":"39 1","pages":""},"PeriodicalIF":29.0,"publicationDate":"2026-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148665607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Cell metabolismPub Date : 2026-08-04DOI: 10.1016/j.cmet.2026.06.013
Amanda Garrido,Nathan L. Price,Rafael de Cabo
{"title":"Methionine tuning for health without frailty","authors":"Amanda Garrido,Nathan L. Price,Rafael de Cabo","doi":"10.1016/j.cmet.2026.06.013","DOIUrl":"https://doi.org/10.1016/j.cmet.2026.06.013","url":null,"abstract":"Dietary protein quality, not merely quantity, shapes metabolic health and aging trajectories. Fanti et al. show that moderate methionine supplementation to a low-protein, Mediterranean-inspired diet activates a GH-GLP-1-FGF21 axis that reduces adiposity and frailty without caloric restriction; their findings provide a mechanism for why traditional plant-rich diets may promote longevity while sometimes compromising physical robustness.","PeriodicalId":9840,"journal":{"name":"Cell metabolism","volume":"26 1","pages":""},"PeriodicalIF":29.0,"publicationDate":"2026-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148665659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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