{"title":"全身NAD内稳态的早期方面","authors":"Charles Brenner","doi":"10.1016/j.cmet.2025.06.003","DOIUrl":null,"url":null,"abstract":"Nicotinic acid riboside (NAR), one of two nucleoside precursors of nicotinamide adenine dinucleotide (NAD) coenzymes, is revealed to function in systemic NAD homeostasis. By knocking out <em>Nmnat1</em> in liver, investigators discovered a liver-to-kidney NAR transit pathway and learned that kidney can be a donor in addition to a receiver of NAD precursors.","PeriodicalId":9840,"journal":{"name":"Cell metabolism","volume":"46 1","pages":""},"PeriodicalIF":27.7000,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"The NARly side of whole-body NAD homeostasis\",\"authors\":\"Charles Brenner\",\"doi\":\"10.1016/j.cmet.2025.06.003\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Nicotinic acid riboside (NAR), one of two nucleoside precursors of nicotinamide adenine dinucleotide (NAD) coenzymes, is revealed to function in systemic NAD homeostasis. By knocking out <em>Nmnat1</em> in liver, investigators discovered a liver-to-kidney NAR transit pathway and learned that kidney can be a donor in addition to a receiver of NAD precursors.\",\"PeriodicalId\":9840,\"journal\":{\"name\":\"Cell metabolism\",\"volume\":\"46 1\",\"pages\":\"\"},\"PeriodicalIF\":27.7000,\"publicationDate\":\"2025-07-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Cell metabolism\",\"FirstCategoryId\":\"99\",\"ListUrlMain\":\"https://doi.org/10.1016/j.cmet.2025.06.003\",\"RegionNum\":1,\"RegionCategory\":\"生物学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CELL BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Cell metabolism","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1016/j.cmet.2025.06.003","RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CELL BIOLOGY","Score":null,"Total":0}
Nicotinic acid riboside (NAR), one of two nucleoside precursors of nicotinamide adenine dinucleotide (NAD) coenzymes, is revealed to function in systemic NAD homeostasis. By knocking out Nmnat1 in liver, investigators discovered a liver-to-kidney NAR transit pathway and learned that kidney can be a donor in addition to a receiver of NAD precursors.
期刊介绍:
Cell Metabolism is a top research journal established in 2005 that focuses on publishing original and impactful papers in the field of metabolic research.It covers a wide range of topics including diabetes, obesity, cardiovascular biology, aging and stress responses, circadian biology, and many others.
Cell Metabolism aims to contribute to the advancement of metabolic research by providing a platform for the publication and dissemination of high-quality research and thought-provoking articles.