The NARly side of whole-body NAD homeostasis

IF 27.7 1区生物学 Q1 CELL BIOLOGY

Cell metabolism Pub Date : 2025-07-01 DOI:10.1016/j.cmet.2025.06.003

Charles Brenner

引用次数: 0

Abstract

Nicotinic acid riboside (NAR), one of two nucleoside precursors of nicotinamide adenine dinucleotide (NAD) coenzymes, is revealed to function in systemic NAD homeostasis. By knocking out Nmnat1 in liver, investigators discovered a liver-to-kidney NAR transit pathway and learned that kidney can be a donor in addition to a receiver of NAD precursors.

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全身NAD内稳态的早期方面

烟酸核糖体（NAR）是烟酰胺腺嘌呤二核苷酸（NAD）辅酶的两种核苷前体之一，被发现在全身NAD稳态中起作用。通过敲除肝脏中的Nmnat1，研究人员发现了肝脏到肾脏的NAR转运途径，并了解到肾脏除了是NAD前体的受体外，还可以是供体。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cell metabolism 生物-内分泌学与代谢

CiteScore

48.60

自引率

1.40%

发文量

173

审稿时长

2.5 months

期刊介绍： Cell Metabolism is a top research journal established in 2005 that focuses on publishing original and impactful papers in the field of metabolic research.It covers a wide range of topics including diabetes, obesity, cardiovascular biology, aging and stress responses, circadian biology, and many others. Cell Metabolism aims to contribute to the advancement of metabolic research by providing a platform for the publication and dissemination of high-quality research and thought-provoking articles.