Foam cell-derived exosomes: Messengers between atherosclerosis and microglia

IF 30.9 1区生物学 Q1 CELL BIOLOGY

Cell metabolism Pub Date : 2025-08-05 DOI:10.1016/j.cmet.2025.07.005

Yan Yue, Shiping Li, Dezhi Mu

引用次数: 0

Abstract

Atherosclerosis (AS) is an independent risk factor for vascular cognitive impairment (VCI). Zhang et al.¹ revealed that foam cell-derived exosomes transmit redox imbalance and metabolic defects to microglia via the miR-101-3p-Nrf2-Slc2a1 axis, causing microglial dysfunction and exacerbating VCI, uncovering a peripheral-brain link and potential therapeutic targets for AS-induced VCI.

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泡沫细胞衍生外泌体：动脉粥样硬化和小胶质细胞之间的信使

动脉粥样硬化（AS）是血管性认知障碍（VCI）的独立危险因素。Zhang等人1发现泡沫细胞衍生的外泌体通过mir -101- p3 - nrf2 - slc2a1轴将氧化还原失衡和代谢缺陷传递给小胶质细胞，导致小胶质细胞功能障碍并加剧VCI，揭示了as诱导的VCI的外周-脑联系和潜在的治疗靶点。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cell metabolism 生物-内分泌学与代谢

CiteScore

48.60

自引率

1.40%

发文量

173

审稿时长

2.5 months

期刊介绍： Cell Metabolism is a top research journal established in 2005 that focuses on publishing original and impactful papers in the field of metabolic research.It covers a wide range of topics including diabetes, obesity, cardiovascular biology, aging and stress responses, circadian biology, and many others. Cell Metabolism aims to contribute to the advancement of metabolic research by providing a platform for the publication and dissemination of high-quality research and thought-provoking articles.