发布求助
文献互助 智能选刊 最新文献

Cell metabolism最新文献

筛选
英文 中文
When lactate speaks: Rewiring astrocyte-neuron metabolism in Alzheimer’s disease 乳酸说话时：阿尔茨海默病中星形细胞-神经元代谢的重新布线
IF 29 1区 生物学
Cell metabolism Pub Date : 2026-08-04 DOI: 10.1016/j.cmet.2026.05.007
Jessica Furtado,Marc Schneeberger
{"title":"When lactate speaks: Rewiring astrocyte-neuron metabolism in Alzheimer’s disease","authors":"Jessica Furtado,Marc Schneeberger","doi":"10.1016/j.cmet.2026.05.007","DOIUrl":"https://doi.org/10.1016/j.cmet.2026.05.007","url":null,"abstract":"Metabolic dysfunction is a defining but poorly understood feature of Alzheimer’s disease. Du et al. show that a brain-penetrant GLP-1 receptor agonist rewires astrocyte-neuron metabolic coupling through lactate-driven histone lactylation, linking astrocytic glycolysis to neuronal lipid homeostasis and positioning metabolite signaling as a therapeutic axis in neurodegeneration.","PeriodicalId":9840,"journal":{"name":"Cell metabolism","volume":"37 1","pages":""},"PeriodicalIF":29.0,"publicationDate":"2026-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148665748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Weight-loss-independent actions of GLP-1 medicines GLP-1药物的非减肥作用
IF 29 1区 生物学
Cell metabolism Pub Date : 2026-08-04 DOI: 10.1016/j.cmet.2026.07.006
Maria J. Gonzalez-Rellan,Daniel J. Drucker
{"title":"Weight-loss-independent actions of GLP-1 medicines","authors":"Maria J. Gonzalez-Rellan,Daniel J. Drucker","doi":"10.1016/j.cmet.2026.07.006","DOIUrl":"https://doi.org/10.1016/j.cmet.2026.07.006","url":null,"abstract":"The unprecedented broad efficacy of GLP-1 medicines reflects mechanisms beyond weight loss. GLP-1R agonism recruits neural and immune circuits, inter-organ communication, and engages local GLP-1Rs to improve cardiovascular, renal, hepatic, musculoskeletal, and organismal health. Defining dose-response relationships for weight-loss-independent mechanisms will facilitate optimization of the therapeutic potential of GLP-1 medicines.","PeriodicalId":9840,"journal":{"name":"Cell metabolism","volume":"4 2 1","pages":""},"PeriodicalIF":29.0,"publicationDate":"2026-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148665775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Decoding neural signals to build metabolic therapies 解码神经信号来建立代谢疗法
IF 29 1区 生物学
Cell metabolism Pub Date : 2026-08-04 DOI: 10.1016/j.cmet.2026.06.010
Tune H. Pers,Amber L. Alhadeff,Martin G. Myers Jr.,Alice E. Adriaenssens,Henning Fenselau,Sarah A. Stanley,Virginie Mansuy-Aubert,Ana I. Domingos,Alejandro Caicedo,Beste Mutlu
{"title":"Decoding neural signals to build metabolic therapies","authors":"Tune H. Pers,Amber L. Alhadeff,Martin G. Myers Jr.,Alice E. Adriaenssens,Henning Fenselau,Sarah A. Stanley,Virginie Mansuy-Aubert,Ana I. Domingos,Alejandro Caicedo,Beste Mutlu","doi":"10.1016/j.cmet.2026.06.010","DOIUrl":"https://doi.org/10.1016/j.cmet.2026.06.010","url":null,"abstract":"Ongoing research points to neural circuits as the major targets for the incretin-mimetic drugs that are transforming obesity treatment. In this Voices piece, we asked researchers to discuss their work on how central and peripheral pathways influence energy balance and metabolism, and what next steps are needed to therapeutically target these pathways.","PeriodicalId":9840,"journal":{"name":"Cell metabolism","volume":"23 1","pages":""},"PeriodicalIF":29.0,"publicationDate":"2026-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148665662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Hormone Cell Atlas decodes the human endocrine system, one cell at a time 激素细胞图谱解码人类内分泌系统，一次一个细胞
IF 29 1区 生物学
Cell metabolism Pub Date : 2026-08-04 DOI: 10.1016/j.cmet.2026.06.019
Dominique Langin,André C. Carpentier
{"title":"The Hormone Cell Atlas decodes the human endocrine system, one cell at a time","authors":"Dominique Langin,André C. Carpentier","doi":"10.1016/j.cmet.2026.06.019","DOIUrl":"https://doi.org/10.1016/j.cmet.2026.06.019","url":null,"abstract":"Farooqi, Teichmann, and collaborators developed the Hormone Cell Atlas, a 14-million-cell dataset mapping hormone production and sensitivity across 47 human tissues. Their findings expand knowledge on sites of production and receiver cells, opening new avenues in endocrinology and metabolism.","PeriodicalId":9840,"journal":{"name":"Cell metabolism","volume":"15 1","pages":""},"PeriodicalIF":29.0,"publicationDate":"2026-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148665747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A mitochondrial antioxidant axis fuels iron addiction in colorectal cancer 线粒体抗氧化轴促进结直肠癌的铁依赖
IF 29 1区 生物学
Cell metabolism Pub Date : 2026-08-04 DOI: 10.1016/j.cmet.2026.06.011
Le Jin Sun,Gina M. DeNicola
{"title":"A mitochondrial antioxidant axis fuels iron addiction in colorectal cancer","authors":"Le Jin Sun,Gina M. DeNicola","doi":"10.1016/j.cmet.2026.06.011","DOIUrl":"https://doi.org/10.1016/j.cmet.2026.06.011","url":null,"abstract":"Colorectal cancer (CRC) cells accumulate iron to fuel proliferation yet paradoxically resist its toxicity. Jain et al. reveal that heme stabilizes succinate dehydrogenase subunit C, sustaining complex II-dependent coenzyme Q reduction and its redistribution to the plasma membrane, enabling CRC cells to buffer oxidative stress and iron-induced cell death.","PeriodicalId":9840,"journal":{"name":"Cell metabolism","volume":"55 1","pages":""},"PeriodicalIF":29.0,"publicationDate":"2026-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148665780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pulsatile FXR activation for liver diseases 脉冲FXR激活治疗肝病
IF 29 1区 生物学
Cell metabolism Pub Date : 2026-08-04 DOI: 10.1016/j.cmet.2026.07.005
Pingxin Sun,Ke Feng,Wenlin Li
{"title":"Pulsatile FXR activation for liver diseases","authors":"Pingxin Sun,Ke Feng,Wenlin Li","doi":"10.1016/j.cmet.2026.07.005","DOIUrl":"https://doi.org/10.1016/j.cmet.2026.07.005","url":null,"abstract":"Sustained receptor activation is often prioritized in drug development. Zang and colleagues challenge this paradigm with linafexor, a rapidly cleared farnesoid X receptor agonist that produces pulsatile activation, preserves receptor responsiveness, reduces broad transcriptional disruption, and improves efficacy and safety, highlighting temporal alignment as a design principle for metabolic therapeutics.","PeriodicalId":9840,"journal":{"name":"Cell metabolism","volume":"295 1","pages":""},"PeriodicalIF":29.0,"publicationDate":"2026-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148665781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
High-Mobility Group Box 1 Is Essential for Mitochondrial Quality Control 高迁移率组盒1对线粒体质量控制至关重要
IF 29 1区 生物学
Cell metabolism Pub Date : 2026-07-18 DOI: 10.1016/j.cmet.2026.07.009
Daolin Tang, Rui Kang, Kristen M. Livesey, Guido Kroemer, Timothy R. Billiar, Bennett Van Houten, Herbert J. Zeh III, Michael T. Lotze
{"title":"High-Mobility Group Box 1 Is Essential for Mitochondrial Quality Control","authors":"Daolin Tang, Rui Kang, Kristen M. Livesey, Guido Kroemer, Timothy R. Billiar, Bennett Van Houten, Herbert J. Zeh III, Michael T. Lotze","doi":"10.1016/j.cmet.2026.07.009","DOIUrl":"https://doi.org/10.1016/j.cmet.2026.07.009","url":null,"abstract":"","PeriodicalId":9840,"journal":{"name":"Cell metabolism","volume":"241 1","pages":""},"PeriodicalIF":29.0,"publicationDate":"2026-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148538988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
FGF21 synergizes with leptin to counteract obesity-related metabolic comorbidities by reversing hepatic leptin resistance FGF21与瘦素协同作用，通过逆转肝脏瘦素抵抗来对抗肥胖相关的代谢合并症
IF 29 1区 生物学
Cell metabolism Pub Date : 2026-07-16 DOI: 10.1016/j.cmet.2026.06.021
Qing Shen, Hailan Zou, Leigang Jin, Jiaxin Liu, Shixiang Wang, Na Li, Runhong Zhou, Ming Yue, Baile Wang, Ranyao Yang, Erfei Song, Yifen Lin, Songyan Liao, Zhiwei Chen, Yang Xiao, Yun-Shen Chan, Hung-Fat Tse, Aimin Xu
{"title":"FGF21 synergizes with leptin to counteract obesity-related metabolic comorbidities by reversing hepatic leptin resistance","authors":"Qing Shen, Hailan Zou, Leigang Jin, Jiaxin Liu, Shixiang Wang, Na Li, Runhong Zhou, Ming Yue, Baile Wang, Ranyao Yang, Erfei Song, Yifen Lin, Songyan Liao, Zhiwei Chen, Yang Xiao, Yun-Shen Chan, Hung-Fat Tse, Aimin Xu","doi":"10.1016/j.cmet.2026.06.021","DOIUrl":"https://doi.org/10.1016/j.cmet.2026.06.021","url":null,"abstract":"","PeriodicalId":9840,"journal":{"name":"Cell metabolism","volume":"43 1","pages":""},"PeriodicalIF":29.0,"publicationDate":"2026-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148461663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Oxidative stress-induced astrocytic collagen biosynthesis drives glial barrier formation and neuronal death in ischemic stroke 氧化应激诱导的星形胶质细胞胶原生物合成驱动缺血性卒中的胶质屏障形成和神经元死亡
IF 29 1区 生物学
Cell metabolism Pub Date : 2026-04-27 DOI: 10.1016/j.cmet.2026.04.001
Jae-Hun Lee, In-Young Hwang, Hyun Jun Jang, Hyeon-Gu Yeo, Jiwoon Lim, Jinyoung Won, Benedict Reve Delmo, Myungju Kim, Eunji Lee, Woojin Won, Elijah Hwejin Lee, Ki Jung Kim, Tai Young Kim, Jiwoong Jung, Kyung Seob Lim, Chang-Yeop Jeon, Junghyung Park, Minji Kim, Jisun Min, Hyerin Jang, C. Justin Lee
{"title":"Oxidative stress-induced astrocytic collagen biosynthesis drives glial barrier formation and neuronal death in ischemic stroke","authors":"Jae-Hun Lee, In-Young Hwang, Hyun Jun Jang, Hyeon-Gu Yeo, Jiwoon Lim, Jinyoung Won, Benedict Reve Delmo, Myungju Kim, Eunji Lee, Woojin Won, Elijah Hwejin Lee, Ki Jung Kim, Tai Young Kim, Jiwoong Jung, Kyung Seob Lim, Chang-Yeop Jeon, Junghyung Park, Minji Kim, Jisun Min, Hyerin Jang, C. Justin Lee","doi":"10.1016/j.cmet.2026.04.001","DOIUrl":"https://doi.org/10.1016/j.cmet.2026.04.001","url":null,"abstract":"Astrocytes regulate brain metabolism and homeostasis, but how oxidative stress reshapes astrocytic metabolism to drive neuronal damage remains unclear. Here, we demonstrate that oxidative stress turns on astrocytic type I collagen (COL1) production via a redox-glycosylation coupling mechanism. Hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>) suppresses miR-29 and enhances fucosyltransferase 8 (FUT8)-mediated core fucosylation, integrating post-transcriptional and glycosylation-dependent regulation of COL1. Astrocyte-derived COL1 activates integrin signaling and promotes neuronal death. In a photothrombotic stroke model, an H<sub>2</sub>O<sub>2</sub> surge induces astrogliosis, glycosylation remodeling, and COL1 expression, leading to glial barrier formation, neuronal loss, and neurological deficits. These pathological cascades are mitigated by astrocyte-specific silencing of COL1 or FUT8 or by KDS12025, a peroxidase enhancer that reduces H<sub>2</sub>O<sub>2</sub> burden. Notably, KDS12025 exerts potent neuroprotection in a non-human primate stroke model. Together, our findings identify an unprecedented astrocytic metabolic pathway linking oxidative stress to glycosylation-driven COL1 production, highlighting the H<sub>2</sub>O<sub>2</sub> surge, astrocytic COL1, and FUT8 as promising therapeutic targets for recovery after stroke.","PeriodicalId":9840,"journal":{"name":"Cell metabolism","volume":"35 1","pages":""},"PeriodicalIF":29.0,"publicationDate":"2026-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147751599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
DGAT-driven futile lipid cycling has a pronounced, yet concealed, thermogenic function dgat驱动的无用脂质循环具有明显但隐蔽的产热功能
IF 29 1区 生物学
Cell metabolism Pub Date : 2026-04-22 DOI: 10.1016/j.cmet.2026.04.007
Anand Kumar Sharma, Radhika Khandelwal, Jelena Zurkovic, Fen Long, Tongtong Wang, Revati S. Dewal, Chunyan Wu, Adhideb Ghosh, Klug Manuel, Alaa Othman, Chandramohan Chitraju, Robert V. Farese Jr., Tobias C. Walther, Miroslav Balaz, Christoph Thiele, Christian Wolfrum
{"title":"DGAT-driven futile lipid cycling has a pronounced, yet concealed, thermogenic function","authors":"Anand Kumar Sharma, Radhika Khandelwal, Jelena Zurkovic, Fen Long, Tongtong Wang, Revati S. Dewal, Chunyan Wu, Adhideb Ghosh, Klug Manuel, Alaa Othman, Chandramohan Chitraju, Robert V. Farese Jr., Tobias C. Walther, Miroslav Balaz, Christoph Thiele, Christian Wolfrum","doi":"10.1016/j.cmet.2026.04.007","DOIUrl":"https://doi.org/10.1016/j.cmet.2026.04.007","url":null,"abstract":"","PeriodicalId":9840,"journal":{"name":"Cell metabolism","volume":"1 1","pages":""},"PeriodicalIF":29.0,"publicationDate":"2026-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147752614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
首页 上一页 下一页 尾页
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整，为了账户安全，请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们：info@booksci.cn Book学术提供免费学术资源搜索服务，方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号：604180095
Book学术官方微信
小红书