Cell metabolism最新文献_第5页

Feeling the pressure: PIEZO2-positive sensory neurons regulate adipose function 感受压力：piezo2阳性感觉神经元调节脂肪功能

IF 29 1区生物学

Cell metabolism Pub Date : 2025-04-01 DOI: 10.1016/j.cmet.2025.03.007

Henrique Camara, Brian I. Park, Yu-Hua Tseng

引用次数: 0

Can we talk? The cryptic communications of hepatic stellate cells in lipid metabolism 我们能谈谈吗？肝星状细胞在脂质代谢中的隐性通讯

IF 29 1区生物学

Cell metabolism Pub Date : 2025-04-01 DOI: 10.1016/j.cmet.2025.03.008

Scott L. Friedman

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Embracing the unknown: Proteomic insights into the human microbiome 拥抱未知：人类微生物组的蛋白质组学见解

IF 29 1区生物学

Cell metabolism Pub Date : 2025-04-01 DOI: 10.1016/j.cmet.2025.02.003

Shuqin Zeng, Alexandre Almeida, Dezhi Mu, Shaopu Wang

引用次数: 0

Ceramide-induced FGF13 impairs systemic metabolic health 神经酰胺诱导的FGF13损害全身代谢健康

IF 29 1区生物学

Cell metabolism Pub Date : 2025-03-31 DOI: 10.1016/j.cmet.2025.03.002

Jamal Naderi, Amanda Kelsey Johnson, Himani Thakkar, Bhawna Chandravanshi, Alec Ksiazek, Ajay Anand, Vinnyfred Vincent, Aaron Tran, Anish Kalimireddy, Pratibha Singh, Ayushi Sood, Aasthika Das, Chad Lamar Talbot, Isabella A. Distefano, J. Alan Maschek, James Cox, Ying Li, Scott A. Summers, Donald J. Atkinson, Tursun Turapov, Bhagirath Chaurasia

{"title":"Ceramide-induced FGF13 impairs systemic metabolic health","authors":"Jamal Naderi, Amanda Kelsey Johnson, Himani Thakkar, Bhawna Chandravanshi, Alec Ksiazek, Ajay Anand, Vinnyfred Vincent, Aaron Tran, Anish Kalimireddy, Pratibha Singh, Ayushi Sood, Aasthika Das, Chad Lamar Talbot, Isabella A. Distefano, J. Alan Maschek, James Cox, Ying Li, Scott A. Summers, Donald J. Atkinson, Tursun Turapov, Bhagirath Chaurasia","doi":"10.1016/j.cmet.2025.03.002","DOIUrl":"https://doi.org/10.1016/j.cmet.2025.03.002","url":null,"abstract":"Ceramide accumulation impairs adipocytes’ ability to efficiently store and utilize nutrients, leading to energy and glucose homeostasis deterioration. Using a comparative transcriptomic screen, we identified the non-canonical, non-secreted fibroblast growth factor FGF13 as a ceramide-regulated factor that impairs adipocyte function. Obesity robustly induces FGF13 expression in adipose tissue in mice and humans and is positively associated with glycemic indices of type 2 diabetes. Pharmacological or genetic inhibition of ceramide biosynthesis reduces FGF13 expression. Using mice with loss and gain of function of FGF13, we demonstrate that FGF13 is both necessary and sufficient to impair energy and glucose homeostasis independent of ceramides. Mechanistically, FGF13 exerts these effects by inhibiting mitochondrial content and function, metabolic elasticity, and caveolae formation, which cumulatively impairs glucose utilization and thermogenesis. These studies suggest the therapeutic potential of targeting FGF13 to prevent and treat metabolic diseases.","PeriodicalId":9840,"journal":{"name":"Cell metabolism","volume":"53 1","pages":""},"PeriodicalIF":29.0,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143736964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gang of 3: How the Krebs cycle-linked metabolites itaconate, succinate, and fumarate regulate macrophages and inflammation 3组：克雷布斯循环相关代谢产物衣康酸酯、琥珀酸酯和富马酸酯如何调节巨噬细胞和炎症

IF 29 1区生物学

Cell metabolism Pub Date : 2025-03-31 DOI: 10.1016/j.cmet.2025.03.004

Eva M. Pålsson-McDermott, Luke A.J. O’Neill

引用次数: 0

Intermittent fasting boosts sexual behavior by limiting the central availability of tryptophan and serotonin 间歇性禁食通过限制色氨酸和血清素的中枢可用性来促进性行为

IF 29 1区生物学

Cell metabolism Pub Date : 2025-03-28 DOI: 10.1016/j.cmet.2025.03.001

Kan Xie, Chengfeng Wang, Enzo Scifo, Brandon Pearson, Devon Ryan, Kristin Henzel, Astrid Markert, Kristina Schaaf, Xue Mi, Xin Tian, Jiajia Jia, Meiqin Wang, Stefan Bonn, Manuel Schölling, Christoph Möhl, Daniele Bano, Yu Zhou, Dan Ehninger

{"title":"Intermittent fasting boosts sexual behavior by limiting the central availability of tryptophan and serotonin","authors":"Kan Xie, Chengfeng Wang, Enzo Scifo, Brandon Pearson, Devon Ryan, Kristin Henzel, Astrid Markert, Kristina Schaaf, Xue Mi, Xin Tian, Jiajia Jia, Meiqin Wang, Stefan Bonn, Manuel Schölling, Christoph Möhl, Daniele Bano, Yu Zhou, Dan Ehninger","doi":"10.1016/j.cmet.2025.03.001","DOIUrl":"https://doi.org/10.1016/j.cmet.2025.03.001","url":null,"abstract":"Aging affects reproductive capabilities in males through physiological and behavioral alterations, including endocrine changes and decreased libido. In this study, we investigated the influence of intermittent fasting (IF) on these aging-related declines, using male C57BL/6J mice. Our findings revealed that IF significantly preserved reproductive success in aged mice, not by improving traditional reproductive metrics such as sperm quality or endocrine functions but by enhancing mating behavior. This behavioral improvement was attributed to IF’s ability to counter age-dependent increases in serotonergic inhibition, primarily through the decreased supply of the serotonin precursor tryptophan from the periphery to the brain. Our research underscores the potential of dietary interventions like IF in mitigating age-associated declines in male reproductive health and suggests a novel approach to managing conditions related to reduced sexual desire, highlighting the complex interplay between diet, metabolism, and reproductive behavior.","PeriodicalId":9840,"journal":{"name":"Cell metabolism","volume":"59 1","pages":""},"PeriodicalIF":29.0,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143723811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Discovery of a potent allosteric activator of DGKQ that ameliorates obesity-induced insulin resistance via the sn-1,2-DAG-PKCε signaling axis 发现一种有效的DGKQ变构激活剂，可通过sn-1,2- dag - pkcε信号轴改善肥胖诱导的胰岛素抵抗

IF 29 1区生物学

Cell metabolism Pub Date : 2025-03-26 DOI: 10.1016/j.cmet.2025.03.010

Zu-Guo Zheng, Yin-Yue Xu, Wen-Ping Liu, Yang Zhang, Chong Zhang, Han-Ling Liu, Xiao-Yu Zhang, Run-Zhou Liu, Yi-Ping Zhang, Meng-Ying Shi, Hua Yang, Ping Li

引用次数: 0

Remote limb ischemic conditioning alleviates steatohepatitis via extracellular vesicle-mediated muscle-liver crosstalk 远端肢体缺血调节通过细胞外囊泡介导的肌肝串扰减轻脂肪性肝炎

IF 29 1区生物学

Cell metabolism Pub Date : 2025-03-20 DOI: 10.1016/j.cmet.2025.02.009

Yichao Zhao, Ling Gao, Jianqing Chen, Jingze Wei, Guanqiao Lin, Kewei Hu, Wubin Zhao, Weijun Wei, Wei Huang, Lingchen Gao, Ancai Yuan, Kun Qian, Alex F. Chen, Jun Pu

{"title":"Remote limb ischemic conditioning alleviates steatohepatitis via extracellular vesicle-mediated muscle-liver crosstalk","authors":"Yichao Zhao, Ling Gao, Jianqing Chen, Jingze Wei, Guanqiao Lin, Kewei Hu, Wubin Zhao, Weijun Wei, Wei Huang, Lingchen Gao, Ancai Yuan, Kun Qian, Alex F. Chen, Jun Pu","doi":"10.1016/j.cmet.2025.02.009","DOIUrl":"https://doi.org/10.1016/j.cmet.2025.02.009","url":null,"abstract":"Metabolic dysfunction-associated steatohepatitis (MASH) is an advanced form of liver disease with adverse outcomes. Manipulating interorgan communication is considered a promising strategy for managing metabolic disease, including steatohepatitis. Here, we report that remote limb ischemic conditioning (RIC), a clinically validated therapy for distant organ protection by transient muscle ischemia, significantly alleviated steatohepatitis in different mouse models. The beneficial effect of limb ischemic conditioning was mediated by muscle-to-liver transfer of small extracellular vesicles (sEVs) and their cargo microRNAs, leading to elevation of miR-181d-5p in the liver. Hepatic miR-181d-5p overexpression faithfully mirrored the molecular and histological benefits of limb ischemic conditioning by suppressing nuclear receptor 4A3 (NR4A3). Furthermore, circulating EVs from human volunteers undergoing limb ischemic conditioning improved steatohepatitis and transcriptomic perturbations in primary human hepatocytes and animal models. Our data underscore the translational potential of limb ischemic conditioning for steatohepatitis management and extend our understanding of muscle-liver crosstalk.","PeriodicalId":9840,"journal":{"name":"Cell metabolism","volume":"56 1","pages":""},"PeriodicalIF":29.0,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143660408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pyruvate metabolism enzyme DLAT promotes tumorigenesis by suppressing leucine catabolism 丙酮酸代谢酶DLAT通过抑制亮氨酸分解代谢促进肿瘤发生

IF 29 1区生物学

Cell metabolism Pub Date : 2025-03-19 DOI: 10.1016/j.cmet.2025.02.008

Ning Wang, Sijia Lu, Ziyi Cao, Huimin Li, Junting Xu, Qian Zhou, Hanrui Yin, Qiqi Qian, Xianjing Zhang, Mijia Tao, Quanxin Jiang, Peihui Zhou, Liaoyuan Zheng, Liu Han, Hongtao Li, Limin Yin, Yunqing Gu, Xuefeng Dou, Haipeng Sun, Wei Wang, Junli Liu

{"title":"Pyruvate metabolism enzyme DLAT promotes tumorigenesis by suppressing leucine catabolism","authors":"Ning Wang, Sijia Lu, Ziyi Cao, Huimin Li, Junting Xu, Qian Zhou, Hanrui Yin, Qiqi Qian, Xianjing Zhang, Mijia Tao, Quanxin Jiang, Peihui Zhou, Liaoyuan Zheng, Liu Han, Hongtao Li, Limin Yin, Yunqing Gu, Xuefeng Dou, Haipeng Sun, Wei Wang, Junli Liu","doi":"10.1016/j.cmet.2025.02.008","DOIUrl":"https://doi.org/10.1016/j.cmet.2025.02.008","url":null,"abstract":"Pyruvate and branched-chain amino acid (BCAA) metabolism are pivotal pathways in tumor progression, yet the intricate interplay between them and its implications for tumor progression remain elusive. Our research reveals that dihydrolipoamide S-acetyltransferase (DLAT), a pyruvate metabolism enzyme, promotes leucine accumulation and sustains mammalian target of rapamycin (mTOR) complex activation in hepatocellular carcinoma (HCC). Mechanistically, DLAT directly acetylates the K109 residue of AU RNA-binding methylglutaconyl-coenzyme A (CoA) hydratase (AUH), a critical enzyme in leucine catabolism, inhibiting its activity and leading to leucine accumulation. Notably, DLAT upregulation correlates with poor prognosis in patients with HCC. Therefore, we developed an AUHK109R-mRNA lipid nanoparticles (LNPs) therapeutic strategy, which effectively inhibits tumor growth by restoring leucine catabolism and inhibiting mTOR activation in vivo. In summary, our findings uncover DLAT’s unexpected role as an acetyltransferase for AUH, suppressing leucine catabolism. Restoring leucine catabolism with AUHK109R-mRNA LNP effectively inhibits HCC development, highlighting a novel direction for cancer research.","PeriodicalId":9840,"journal":{"name":"Cell metabolism","volume":"214 1","pages":""},"PeriodicalIF":29.0,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143653795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dietary timing enhances exercise by modulating fat-muscle crosstalk via adipocyte AMPKα2 signaling 饮食时间通过脂肪细胞AMPKα2信号调节脂肪-肌肉串扰来增强运动

IF 29 1区生物学

Cell metabolism Pub Date : 2025-03-14 DOI: 10.1016/j.cmet.2025.02.007

Jianghui Chen, Jing Xiang, Meiyu Zhou, Rongfeng Huang, Jianxin Zhang, Yuanting Cui, Xiaoqing Jiang, Yang Li, Runchao Zhou, Haoran Xin, Jie Li, Lihua Li, Sin Man Lam, Jianfang Zhu, Yanxiu Chen, Qingyuan Yang, Zhifu Xie, Guanghou Shui, Fang Deng, Zhihui Zhang, Min-Dian Li

{"title":"Dietary timing enhances exercise by modulating fat-muscle crosstalk via adipocyte AMPKα2 signaling","authors":"Jianghui Chen, Jing Xiang, Meiyu Zhou, Rongfeng Huang, Jianxin Zhang, Yuanting Cui, Xiaoqing Jiang, Yang Li, Runchao Zhou, Haoran Xin, Jie Li, Lihua Li, Sin Man Lam, Jianfang Zhu, Yanxiu Chen, Qingyuan Yang, Zhifu Xie, Guanghou Shui, Fang Deng, Zhihui Zhang, Min-Dian Li","doi":"10.1016/j.cmet.2025.02.007","DOIUrl":"https://doi.org/10.1016/j.cmet.2025.02.007","url":null,"abstract":"Feeding rhythms regulate exercise performance and muscle energy metabolism. However, the mechanisms regulating adipocyte functions remain unclear. Here, using multi-omics analyses, involving (phospho-)proteomics and lipidomics, we found that day-restricted feeding (DRF) regulates diurnal rhythms of the mitochondrial proteome, neutral lipidome, and nutrient-sensing pathways in mouse gonadal white adipose tissue (GWAT). Adipocyte-specific knockdown of Prkaa2 (the gene encoding AMPKα2) impairs physical endurance. This defect is associated with altered rhythmicity in acyl-coenzyme A (CoA) metabolism-related genes, a loss of rhythmicity in the GWAT lipidome, and circadian remodeling of serum metabolites—in particular, lactate and succinate. We also found that adipocyte Prkaa2 regulates muscle clock genes during DRF. Notably, oral administration of the AMPK activator C29 increases endurance and muscle functions in a time-of-day manner, which requires intact adipocyte AMPKα2 signaling. Collectively, our work defines adipocyte AMPKα2 signaling as a critical regulator of circadian metabolic coordination between fat and muscle, thereby enhancing exercise performance.","PeriodicalId":9840,"journal":{"name":"Cell metabolism","volume":"8 1","pages":""},"PeriodicalIF":29.0,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143618558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0