Cell metabolism最新文献_第6页

O-GlcNAcylation-mediated endothelial metabolic memory contributes to cardiac damage via small extracellular vesicles O-GlcNAcylation 介导的内皮代谢记忆通过细胞外小泡导致心脏损伤

IF 29 1区生物学

Cell metabolism Pub Date : 2025-04-02 DOI: 10.1016/j.cmet.2025.03.006

Mingge Ding, Rui Shi, Yanyan Du, Pan Chang, Tian Gao, Dema De, Yunan Chen, Man Li, Jun Li, Ke Li, Shuli Cheng, Xiaoming Gu, Juan Li, Shumiao Zhang, Na Feng, Jianzheng Liu, Min Jia, Rong Fan, Jianming Pei, Chao Gao, Feng Fu

{"title":"O-GlcNAcylation-mediated endothelial metabolic memory contributes to cardiac damage via small extracellular vesicles","authors":"Mingge Ding, Rui Shi, Yanyan Du, Pan Chang, Tian Gao, Dema De, Yunan Chen, Man Li, Jun Li, Ke Li, Shuli Cheng, Xiaoming Gu, Juan Li, Shumiao Zhang, Na Feng, Jianzheng Liu, Min Jia, Rong Fan, Jianming Pei, Chao Gao, Feng Fu","doi":"10.1016/j.cmet.2025.03.006","DOIUrl":"https://doi.org/10.1016/j.cmet.2025.03.006","url":null,"abstract":"Diabetic individuals with well-controlled blood glucose still have an increased risk of heart failure. This process may be mediated by metabolic memory, a phenomenon showing that hyperglycemia has long-term negative effects even after normoglycemia. Here, we found that despite later normoglycemia with insulin, long-term diabetes-derived plasma small extracellular vesicle (sEV) miR-15-16 exhibited sustained deleterious effects on cardiomyocytes and induced cardiac dysfunction in healthy animals, displaying a memory feature. Artery endothelial cells were the primary origin of sEV miR-15-16. Mechanistically, the continuous sEV miR-15-16 release is due to the sustained activation of CaMK2a following the high glucose-elicited positive feedback loop of CaMK2a/O-GlcNAcylation in endothelial cells. In patients with diabetes, elevated sEV miR-15-16 was significantly associated with cardiac dysfunction, regardless of blood glucose or HbA1c. Together, our findings demonstrate that diabetes-induced O-GlcNAcylation and activation of CaMK2a mediate endothelial metabolic memory, which induces continuous release of sEV miR-15-16 and subsequent cardiac damage.","PeriodicalId":9840,"journal":{"name":"Cell metabolism","volume":"10 1","pages":""},"PeriodicalIF":29.0,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143758395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Cell Metabolism 20th anniversary Voices: Part 1 of 3 细胞代谢20周年纪念声音：三集之一

IF 29 1区生物学

Cell metabolism Pub Date : 2025-04-01 DOI: 10.1016/j.cmet.2025.03.005

Zoltan Arany, Bao-Liang Song, Roberto Coppari, Jiandie Lin, Nada Kalaany, Gregory Steinberg

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Feeling the pressure: PIEZO2-positive sensory neurons regulate adipose function 感受压力：piezo2阳性感觉神经元调节脂肪功能

IF 29 1区生物学

Cell metabolism Pub Date : 2025-04-01 DOI: 10.1016/j.cmet.2025.03.007

Henrique Camara, Brian I. Park, Yu-Hua Tseng

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Can we talk? The cryptic communications of hepatic stellate cells in lipid metabolism 我们能谈谈吗？肝星状细胞在脂质代谢中的隐性通讯

IF 29 1区生物学

Cell metabolism Pub Date : 2025-04-01 DOI: 10.1016/j.cmet.2025.03.008

Scott L. Friedman

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Embracing the unknown: Proteomic insights into the human microbiome 拥抱未知：人类微生物组的蛋白质组学见解

IF 29 1区生物学

Cell metabolism Pub Date : 2025-04-01 DOI: 10.1016/j.cmet.2025.02.003

Shuqin Zeng, Alexandre Almeida, Dezhi Mu, Shaopu Wang

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Ceramide-induced FGF13 impairs systemic metabolic health 神经酰胺诱导的FGF13损害全身代谢健康

IF 29 1区生物学

Cell metabolism Pub Date : 2025-03-31 DOI: 10.1016/j.cmet.2025.03.002

Jamal Naderi, Amanda Kelsey Johnson, Himani Thakkar, Bhawna Chandravanshi, Alec Ksiazek, Ajay Anand, Vinnyfred Vincent, Aaron Tran, Anish Kalimireddy, Pratibha Singh, Ayushi Sood, Aasthika Das, Chad Lamar Talbot, Isabella A. Distefano, J. Alan Maschek, James Cox, Ying Li, Scott A. Summers, Donald J. Atkinson, Tursun Turapov, Bhagirath Chaurasia

{"title":"Ceramide-induced FGF13 impairs systemic metabolic health","authors":"Jamal Naderi, Amanda Kelsey Johnson, Himani Thakkar, Bhawna Chandravanshi, Alec Ksiazek, Ajay Anand, Vinnyfred Vincent, Aaron Tran, Anish Kalimireddy, Pratibha Singh, Ayushi Sood, Aasthika Das, Chad Lamar Talbot, Isabella A. Distefano, J. Alan Maschek, James Cox, Ying Li, Scott A. Summers, Donald J. Atkinson, Tursun Turapov, Bhagirath Chaurasia","doi":"10.1016/j.cmet.2025.03.002","DOIUrl":"https://doi.org/10.1016/j.cmet.2025.03.002","url":null,"abstract":"Ceramide accumulation impairs adipocytes’ ability to efficiently store and utilize nutrients, leading to energy and glucose homeostasis deterioration. Using a comparative transcriptomic screen, we identified the non-canonical, non-secreted fibroblast growth factor FGF13 as a ceramide-regulated factor that impairs adipocyte function. Obesity robustly induces FGF13 expression in adipose tissue in mice and humans and is positively associated with glycemic indices of type 2 diabetes. Pharmacological or genetic inhibition of ceramide biosynthesis reduces FGF13 expression. Using mice with loss and gain of function of FGF13, we demonstrate that FGF13 is both necessary and sufficient to impair energy and glucose homeostasis independent of ceramides. Mechanistically, FGF13 exerts these effects by inhibiting mitochondrial content and function, metabolic elasticity, and caveolae formation, which cumulatively impairs glucose utilization and thermogenesis. These studies suggest the therapeutic potential of targeting FGF13 to prevent and treat metabolic diseases.","PeriodicalId":9840,"journal":{"name":"Cell metabolism","volume":"53 1","pages":""},"PeriodicalIF":29.0,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143736964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gang of 3: How the Krebs cycle-linked metabolites itaconate, succinate, and fumarate regulate macrophages and inflammation 3组：克雷布斯循环相关代谢产物衣康酸酯、琥珀酸酯和富马酸酯如何调节巨噬细胞和炎症

IF 29 1区生物学

Cell metabolism Pub Date : 2025-03-31 DOI: 10.1016/j.cmet.2025.03.004

Eva M. Pålsson-McDermott, Luke A.J. O’Neill

引用次数: 0

Intermittent fasting boosts sexual behavior by limiting the central availability of tryptophan and serotonin 间歇性禁食通过限制色氨酸和血清素的中枢可用性来促进性行为

IF 29 1区生物学

Cell metabolism Pub Date : 2025-03-28 DOI: 10.1016/j.cmet.2025.03.001

Kan Xie, Chengfeng Wang, Enzo Scifo, Brandon Pearson, Devon Ryan, Kristin Henzel, Astrid Markert, Kristina Schaaf, Xue Mi, Xin Tian, Jiajia Jia, Meiqin Wang, Stefan Bonn, Manuel Schölling, Christoph Möhl, Daniele Bano, Yu Zhou, Dan Ehninger

{"title":"Intermittent fasting boosts sexual behavior by limiting the central availability of tryptophan and serotonin","authors":"Kan Xie, Chengfeng Wang, Enzo Scifo, Brandon Pearson, Devon Ryan, Kristin Henzel, Astrid Markert, Kristina Schaaf, Xue Mi, Xin Tian, Jiajia Jia, Meiqin Wang, Stefan Bonn, Manuel Schölling, Christoph Möhl, Daniele Bano, Yu Zhou, Dan Ehninger","doi":"10.1016/j.cmet.2025.03.001","DOIUrl":"https://doi.org/10.1016/j.cmet.2025.03.001","url":null,"abstract":"Aging affects reproductive capabilities in males through physiological and behavioral alterations, including endocrine changes and decreased libido. In this study, we investigated the influence of intermittent fasting (IF) on these aging-related declines, using male C57BL/6J mice. Our findings revealed that IF significantly preserved reproductive success in aged mice, not by improving traditional reproductive metrics such as sperm quality or endocrine functions but by enhancing mating behavior. This behavioral improvement was attributed to IF’s ability to counter age-dependent increases in serotonergic inhibition, primarily through the decreased supply of the serotonin precursor tryptophan from the periphery to the brain. Our research underscores the potential of dietary interventions like IF in mitigating age-associated declines in male reproductive health and suggests a novel approach to managing conditions related to reduced sexual desire, highlighting the complex interplay between diet, metabolism, and reproductive behavior.","PeriodicalId":9840,"journal":{"name":"Cell metabolism","volume":"59 1","pages":""},"PeriodicalIF":29.0,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143723811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Discovery of a potent allosteric activator of DGKQ that ameliorates obesity-induced insulin resistance via the sn-1,2-DAG-PKCε signaling axis 发现一种有效的DGKQ变构激活剂，可通过sn-1,2- dag - pkcε信号轴改善肥胖诱导的胰岛素抵抗

IF 29 1区生物学

Cell metabolism Pub Date : 2025-03-26 DOI: 10.1016/j.cmet.2025.03.010

Zu-Guo Zheng, Yin-Yue Xu, Wen-Ping Liu, Yang Zhang, Chong Zhang, Han-Ling Liu, Xiao-Yu Zhang, Run-Zhou Liu, Yi-Ping Zhang, Meng-Ying Shi, Hua Yang, Ping Li

引用次数: 0

Remote limb ischemic conditioning alleviates steatohepatitis via extracellular vesicle-mediated muscle-liver crosstalk 远端肢体缺血调节通过细胞外囊泡介导的肌肝串扰减轻脂肪性肝炎

IF 29 1区生物学

Cell metabolism Pub Date : 2025-03-20 DOI: 10.1016/j.cmet.2025.02.009

Yichao Zhao, Ling Gao, Jianqing Chen, Jingze Wei, Guanqiao Lin, Kewei Hu, Wubin Zhao, Weijun Wei, Wei Huang, Lingchen Gao, Ancai Yuan, Kun Qian, Alex F. Chen, Jun Pu

{"title":"Remote limb ischemic conditioning alleviates steatohepatitis via extracellular vesicle-mediated muscle-liver crosstalk","authors":"Yichao Zhao, Ling Gao, Jianqing Chen, Jingze Wei, Guanqiao Lin, Kewei Hu, Wubin Zhao, Weijun Wei, Wei Huang, Lingchen Gao, Ancai Yuan, Kun Qian, Alex F. Chen, Jun Pu","doi":"10.1016/j.cmet.2025.02.009","DOIUrl":"https://doi.org/10.1016/j.cmet.2025.02.009","url":null,"abstract":"Metabolic dysfunction-associated steatohepatitis (MASH) is an advanced form of liver disease with adverse outcomes. Manipulating interorgan communication is considered a promising strategy for managing metabolic disease, including steatohepatitis. Here, we report that remote limb ischemic conditioning (RIC), a clinically validated therapy for distant organ protection by transient muscle ischemia, significantly alleviated steatohepatitis in different mouse models. The beneficial effect of limb ischemic conditioning was mediated by muscle-to-liver transfer of small extracellular vesicles (sEVs) and their cargo microRNAs, leading to elevation of miR-181d-5p in the liver. Hepatic miR-181d-5p overexpression faithfully mirrored the molecular and histological benefits of limb ischemic conditioning by suppressing nuclear receptor 4A3 (NR4A3). Furthermore, circulating EVs from human volunteers undergoing limb ischemic conditioning improved steatohepatitis and transcriptomic perturbations in primary human hepatocytes and animal models. Our data underscore the translational potential of limb ischemic conditioning for steatohepatitis management and extend our understanding of muscle-liver crosstalk.","PeriodicalId":9840,"journal":{"name":"Cell metabolism","volume":"56 1","pages":""},"PeriodicalIF":29.0,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143660408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0