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Cell Metabolism 20th anniversary Voices: Part 3 of 3 细胞代谢20周年纪念声音：三集之三
IF 29 1区 生物学
Cell metabolism Pub Date : 2025-06-03 DOI: 10.1016/j.cmet.2025.05.006
Matthew Potthoff, Rana K. Gupta, Changhan Lee, Jonathan Z. Long, Jonathan R. Brestoff, Katrien de Bock
{"title":"Cell Metabolism 20th anniversary Voices: Part 3 of 3","authors":"Matthew Potthoff, Rana K. Gupta, Changhan Lee, Jonathan Z. Long, Jonathan R. Brestoff, Katrien de Bock","doi":"10.1016/j.cmet.2025.05.006","DOIUrl":"https://doi.org/10.1016/j.cmet.2025.05.006","url":null,"abstract":"This year, <em>Cell Metabolism</em> is celebrating its 20th anniversary! We are taking this opportunity to highlight authors that have published with us as they developed, and keep developing, their research careers. In 2005, <em>Cell Metabolism</em> was just starting an exciting journey to become a reference forum for interdisciplinary, high-quality metabolism studies. Throughout these years, it has been an honor to feature in our issues articles from these investigators and their labs that have contributed to both consolidating and expanding the metabolism field.","PeriodicalId":9840,"journal":{"name":"Cell metabolism","volume":"30 1","pages":""},"PeriodicalIF":29.0,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144202238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Testing the carbohydrate-insulin model: Some aspects are consistent, but overall the data do not support the model 测试碳水化合物-胰岛素模型：某些方面是一致的，但总体数据不支持模型
IF 29 1区 生物学
Cell metabolism Pub Date : 2025-06-03 DOI: 10.1016/j.cmet.2025.04.011
John R. Speakman, Ying Liu
{"title":"Testing the carbohydrate-insulin model: Some aspects are consistent, but overall the data do not support the model","authors":"John R. Speakman, Ying Liu","doi":"10.1016/j.cmet.2025.04.011","DOIUrl":"https://doi.org/10.1016/j.cmet.2025.04.011","url":null,"abstract":"<h2>Section snippets</h2><section><section><h2>Main text</h2>Thank you for the opportunity to respond to the letter by Ludwig and colleagues<sup>1</sup> generated in response to our paper where we tested some predictions of the carbohydrate-insulin model (CIM).<sup>2</sup> The CIM proposes that obesity arises because high glycemic-load (GL) diets cause a set of hormonal changes that shift substrate partitioning toward fat storage, leading to greater hunger and elevated food intake. A prediction of this model is that as the GL of a meal increases (meal 1), it will lead to a</section></section><section><section><h2>Declaration of interests</h2>The authors declare no competing interests.</section></section>","PeriodicalId":9840,"journal":{"name":"Cell metabolism","volume":"5 1","pages":""},"PeriodicalIF":29.0,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144202289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Time to exercise! Boosting exercise performance via AMPK signaling 是时候锻炼了！通过AMPK信号传导提高运动表现
IF 29 1区 生物学
Cell metabolism Pub Date : 2025-06-03 DOI: 10.1016/j.cmet.2025.05.003
Tinh-Hai Collet, Charna Dibner
{"title":"Time to exercise! Boosting exercise performance via AMPK signaling","authors":"Tinh-Hai Collet, Charna Dibner","doi":"10.1016/j.cmet.2025.05.003","DOIUrl":"https://doi.org/10.1016/j.cmet.2025.05.003","url":null,"abstract":"Body physiology follows the daily rhythm driven by the circadian system, which underlies the emerging concept of chrono-medicine. In this issue, Chen et al.<span><span><sup>1</sup></span></span> report that feeding timing modulates adipocyte AMP-activated protein kinase (AMPK) α2 signaling to enhance exercise performance in mice, paving the way for chronotherapeutic approaches of AMPK activators such as metformin.","PeriodicalId":9840,"journal":{"name":"Cell metabolism","volume":"8 1","pages":""},"PeriodicalIF":29.0,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144202291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
GLP-1RAs for peripheral artery disease: A remarkable STRIDE in the right direction GLP-1RAs治疗外周动脉疾病：朝着正确方向迈出的一大步
IF 29 1区 生物学
Cell metabolism Pub Date : 2025-06-03 DOI: 10.1016/j.cmet.2025.05.001
Subodh Verma, David A. Hess
{"title":"GLP-1RAs for peripheral artery disease: A remarkable STRIDE in the right direction","authors":"Subodh Verma, David A. Hess","doi":"10.1016/j.cmet.2025.05.001","DOIUrl":"https://doi.org/10.1016/j.cmet.2025.05.001","url":null,"abstract":"With the rising prevalence of T2D worldwide, peripheral artery disease (PAD) now affects &gt;230 million individuals globally. In the recent STRIDE trial, Bonaca et al.<span><span><sup>1</sup></span></span> demonstrated that semaglutide improved walking capacity and hemodynamic parameters and slowed PAD progression in patients with T2D. These results reveal an unanticipated vasculoprotective benefit of GLP-1RAs.","PeriodicalId":9840,"journal":{"name":"Cell metabolism","volume":"13 1","pages":""},"PeriodicalIF":29.0,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144202293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Testing the carbohydrate-insulin model: The data are supportive! 测试碳水化合物-胰岛素模型：数据是支持的！
IF 29 1区 生物学
Cell metabolism Pub Date : 2025-06-03 DOI: 10.1016/j.cmet.2025.04.010
David S. Ludwig, Jennie C. Brand-Miller, Cara B. Ebbeling, Mark I. Friedman, Nicholas G. Norwitz, Adrian Soto-Mota
{"title":"Testing the carbohydrate-insulin model: The data are supportive!","authors":"David S. Ludwig, Jennie C. Brand-Miller, Cara B. Ebbeling, Mark I. Friedman, Nicholas G. Norwitz, Adrian Soto-Mota","doi":"10.1016/j.cmet.2025.04.010","DOIUrl":"https://doi.org/10.1016/j.cmet.2025.04.010","url":null,"abstract":"<h2>Section snippets</h2><section><section><h2>Main text</h2>Mean body weight continues to rise worldwide despite intensive prevention and treatment focused on energy restriction, leading to formulation of new models of obesity pathogenesis. In the carbohydrate-insulin model (CIM),<sup>1</sup> a diet high in glycemic load (GL) (the multiplicative product of glycemic index [GI] and carbohydrate amount) initiates a sequence of hormonal responses that shift substrate partitioning<sup>2</sup> toward energy storage and away from oxidation in lean tissues. Thus, the CIM provides an</section></section><section><section><h2>Acknowledgments</h2>This work was done without financial sponsorship.</section></section><section><section><h2>Declaration of interests</h2>J.B.M. is a co-author of books based on the glycemic index of foods, oversees a glycemic index testing service at the University of Sydney, and is a consultant for the China National Research Institute of Food and Fermentation Industries, the Novo Foundation, and Zoe Global. She was President of the Glycemic Index Foundation from 2002 to 2024. D.S.L received royalties for books on obesity and nutrition that recommend a reduced-glycemic load diet. N.G.N. received royalties for a ketogenic diet</section></section>","PeriodicalId":9840,"journal":{"name":"Cell metabolism","volume":"4 1","pages":""},"PeriodicalIF":29.0,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144202290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
CROSsing the Rubicon: Brainstem peroxide levels drive sleep-wake dynamics 跨越卢比孔河：脑干过氧化氢水平驱动睡眠-觉醒动力学
IF 29 1区 生物学
Cell metabolism Pub Date : 2025-06-03 DOI: 10.1016/j.cmet.2025.05.005
Nicole M. Gilette, Jonathan O. Lipton
{"title":"CROSsing the Rubicon: Brainstem peroxide levels drive sleep-wake dynamics","authors":"Nicole M. Gilette, Jonathan O. Lipton","doi":"10.1016/j.cmet.2025.05.005","DOIUrl":"https://doi.org/10.1016/j.cmet.2025.05.005","url":null,"abstract":"A crucial goal of sleep science is to uncover the molecular mechanisms that translate sleep need into neural pathways that discharge sleep/wake transitions. In a new study, Tian et al.<span><span><sup>1</sup></span></span> provide support in living animals that peroxide in the substantia nigra is a critical driver of these states.","PeriodicalId":9840,"journal":{"name":"Cell metabolism","volume":"168 1","pages":""},"PeriodicalIF":29.0,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144202221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Monoclonal antibody therapy for PCOS? 单克隆抗体治疗多囊卵巢综合征？
IF 29 1区 生物学
Cell metabolism Pub Date : 2025-06-03 DOI: 10.1016/j.cmet.2025.05.002
David H. Abbott, Daniel A. Dumesic
{"title":"Monoclonal antibody therapy for PCOS?","authors":"David H. Abbott, Daniel A. Dumesic","doi":"10.1016/j.cmet.2025.05.002","DOIUrl":"https://doi.org/10.1016/j.cmet.2025.05.002","url":null,"abstract":"There is no cure for polycystic ovary syndrome (PCOS), only treatment for its highly prevalent reproductive, cardiometabolic, and psychological symptoms. Early signs of PCOS appear during infancy. This enabled Cotellessa et al.<span><span><sup>1</sup></span></span> to develop and administer neutralizing antibody therapy during infancy in a female mouse model to eradicate PCOS symptomology.","PeriodicalId":9840,"journal":{"name":"Cell metabolism","volume":"7 1","pages":""},"PeriodicalIF":29.0,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144202239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nicotinic acid riboside maintains NAD+ homeostasis and ameliorates aging-associated NAD+ decline 烟酸核糖体维持NAD+体内平衡并改善与衰老相关的NAD+下降
IF 29 1区 生物学
Cell metabolism Pub Date : 2025-05-22 DOI: 10.1016/j.cmet.2025.05.004
Won-Suk Song, Xiyu Shen, Kang Du, Cuauhtemoc B. Ramirez, Sang Hee Park, Yang Cao, Johnny Le, Hosung Bae, Joohwan Kim, Yujin Chun, Nikki Joyce Khong, Marie Kim, Sunhee Jung, Wonsuk Choi, Miranda L. Lopez, Zaid Said, Zehan Song, Sang-Guk Lee, Dequina Nicholas, Yo Sasaki, Qin Yang
{"title":"Nicotinic acid riboside maintains NAD+ homeostasis and ameliorates aging-associated NAD+ decline","authors":"Won-Suk Song, Xiyu Shen, Kang Du, Cuauhtemoc B. Ramirez, Sang Hee Park, Yang Cao, Johnny Le, Hosung Bae, Joohwan Kim, Yujin Chun, Nikki Joyce Khong, Marie Kim, Sunhee Jung, Wonsuk Choi, Miranda L. Lopez, Zaid Said, Zehan Song, Sang-Guk Lee, Dequina Nicholas, Yo Sasaki, Qin Yang","doi":"10.1016/j.cmet.2025.05.004","DOIUrl":"https://doi.org/10.1016/j.cmet.2025.05.004","url":null,"abstract":"(Cell Metabolism <em>37</em>, 1–16.e1–e4; July 1, 2025)","PeriodicalId":9840,"journal":{"name":"Cell metabolism","volume":"72 1","pages":""},"PeriodicalIF":29.0,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144114361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dietary-timing-induced gut microbiota diurnal oscillations modulate inflammatory rhythms in rheumatoid arthritis 饮食时间诱导的肠道微生物群昼夜振荡调节类风湿关节炎的炎症节律
IF 29 1区 生物学
Cell metabolism Pub Date : 2025-05-22 DOI: 10.1016/j.cmet.2025.05.007
Fopei Ma, Zhuang Li, Haihua Liu, Shixian Chen, Songyuan Zheng, Junqing Zhu, Hao Shi, Haixin Ye, Zhantu Qiu, Lei Gao, Bingqi Han, Qian Yang, Xing Wang, Yang Zhang, Lifang Cheng, Huijie Fan, Shuaijun Lv, Xiaoshan Zhao, Hongwei Zhou, Juan Li, Mukeng Hong
{"title":"Dietary-timing-induced gut microbiota diurnal oscillations modulate inflammatory rhythms in rheumatoid arthritis","authors":"Fopei Ma, Zhuang Li, Haihua Liu, Shixian Chen, Songyuan Zheng, Junqing Zhu, Hao Shi, Haixin Ye, Zhantu Qiu, Lei Gao, Bingqi Han, Qian Yang, Xing Wang, Yang Zhang, Lifang Cheng, Huijie Fan, Shuaijun Lv, Xiaoshan Zhao, Hongwei Zhou, Juan Li, Mukeng Hong","doi":"10.1016/j.cmet.2025.05.007","DOIUrl":"https://doi.org/10.1016/j.cmet.2025.05.007","url":null,"abstract":"(Cell Metabolism <em>36</em>, 2367–2382.e1–e5; November 5, 2024)","PeriodicalId":9840,"journal":{"name":"Cell metabolism","volume":"38 1","pages":""},"PeriodicalIF":29.0,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144114389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Semaglutide effects on energy balance are mediated by Adcyap1+ neurons in the dorsal vagal complex 半马鲁肽对能量平衡的影响是由迷走背复合体中的Adcyap1+神经元介导的
IF 29 1区 生物学
Cell metabolism Pub Date : 2025-05-22 DOI: 10.1016/j.cmet.2025.04.018
Júlia Teixidor-Deulofeu, Sebastian Blid Sköldheden, Ferran Font-Gironès, Andrej Feješ, Johan Ruud, Linda Engström Ruud
{"title":"Semaglutide effects on energy balance are mediated by Adcyap1+ neurons in the dorsal vagal complex","authors":"Júlia Teixidor-Deulofeu, Sebastian Blid Sköldheden, Ferran Font-Gironès, Andrej Feješ, Johan Ruud, Linda Engström Ruud","doi":"10.1016/j.cmet.2025.04.018","DOIUrl":"https://doi.org/10.1016/j.cmet.2025.04.018","url":null,"abstract":"The use of the GLP-1R agonist semaglutide is revolutionizing the treatment of obesity, yet its mechanistic effects on energy balance remain elusive. Here, we demonstrate that reactivation of semaglutide-responsive dorsal vagal complex neurons mimics the drug’s effects of reducing food intake and body weight and promoting fat utilization and conditioned taste aversion. We observe that many of the semaglutide-activated area postrema (AP) and nucleus of the solitary tract (NTS) neurons express <em>Adcyap1</em> mRNA, and ablation of AP/NTS <em>Adcyap1</em><sup>+</sup> neurons largely reverses semaglutide’s effects on energy balance acutely in lean mice and in subchronically treated obese mice. Semaglutide-activated AP/NTS <em>Adcyap1</em><sup>+</sup> neurons promote the loss of fat rather than lean mass, with only a modest effect on conditioned taste aversion. Furthermore, NTS <em>Adcyap1</em><sup>+</sup> neurons are engaged by GLP-1R-expressing AP neurons and are necessary for semaglutide-induced activation of several downstream satiety-related structures. Selective targeting of semaglutide-responsive <em>Adcyap1</em><sup>+</sup> neurons holds potential for improved future anti-obesity treatments.","PeriodicalId":9840,"journal":{"name":"Cell metabolism","volume":"79 1","pages":""},"PeriodicalIF":29.0,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144114385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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