Cell metabolism最新文献_第7页

The gut microbiota alleviates depression by remodeling gut-brain energy metabolism 肠道微生物群通过重塑肠-脑能量代谢来缓解抑郁症

IF 29 1区生物学

Cell metabolism Pub Date : 2026-03-31 DOI: 10.1016/j.cmet.2026.03.002

Cheng-Lin Lu, Jing Ren, Yueshiyuan Lei, Xiao-Ying Lian, Hao-Tian Jiang, Fang Guo, Liang-Yu Chen, Jia-Wen Mo, Hongyun Mao, Jun Fan, Guangyan Wu, Wan-Qian Ye, You-Lu Wen, Haitao Sun, Yan He, Jiubo Zhao, Xiong Cao

{"title":"The gut microbiota alleviates depression by remodeling gut-brain energy metabolism","authors":"Cheng-Lin Lu, Jing Ren, Yueshiyuan Lei, Xiao-Ying Lian, Hao-Tian Jiang, Fang Guo, Liang-Yu Chen, Jia-Wen Mo, Hongyun Mao, Jun Fan, Guangyan Wu, Wan-Qian Ye, You-Lu Wen, Haitao Sun, Yan He, Jiubo Zhao, Xiong Cao","doi":"10.1016/j.cmet.2026.03.002","DOIUrl":"https://doi.org/10.1016/j.cmet.2026.03.002","url":null,"abstract":"Although peripheral-brain crosstalk regulates energy metabolism, its role in depression remains unclear. Here, we used metabolic profiling to reveal elevated fecal creatine alongside reduced plasma and cerebrospinal fluid creatine in both patients with depression and mouse depression models. Exogenous creatine produced antidepressant-like effects mediated by gut microbiota. Bifidobacterium pseudolongum was identified as a significantly reduced gut bacterial species in depression, correlating with impaired creatine absorption. Subsequent supplementation with Bifidobacterium enhanced the antidepressant effects of creatine. Mechanistically, B. pseudolongum-derived acetate promoted the creatine transporter (Slc6a8) expression in intestinal epithelial cells via histone acetylation. The Slc6a8 mediated the antidepressant-like effects of creatine. Neuronal creatine deficiency influenced energetic metabolism and neurophysiological function. In patients with depression taking antidepressants, co-administration of creatine and Bifidobacterium increased plasma creatine levels and reduced depression scores. These findings identify the Bifidobacterium-creatine combination as a promising antidepressant strategy and highlight the critical role of gut-brain energy metabolism in depression.","PeriodicalId":9840,"journal":{"name":"Cell metabolism","volume":"103 1","pages":""},"PeriodicalIF":29.0,"publicationDate":"2026-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147586418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lactate-driven mitochondrial pretenders hijack hippocampal function after excessive exercise 乳酸驱动的线粒体伪装者在过度运动后劫持海马功能

IF 29 1区生物学

Cell metabolism Pub Date : 2026-03-27 DOI: 10.1016/j.cmet.2026.03.010

Filip J. Larsen

引用次数: 0

Maltol induces diabetic fragility fractures by disrupting the balance of bone remodeling 麦芽糖醇通过破坏骨重塑平衡诱发糖尿病性脆性骨折

IF 29 1区生物学

Cell metabolism Pub Date : 2026-03-27 DOI: 10.1016/j.cmet.2026.03.001

Jinyang Wang, Ziyuan Wang, Jinyi Feng, Ying Zhang, Lizheng Yao, Yiran Zhang, Ruijie Zhang, Jingyi Cai, Hao Yu, Songhan Deng, Xinrui Chen, Rui Liang, Caoxin Huang, Jia Li, Xuejun Li, Qinxi Li, Xiulin Shi

{"title":"Maltol induces diabetic fragility fractures by disrupting the balance of bone remodeling","authors":"Jinyang Wang, Ziyuan Wang, Jinyi Feng, Ying Zhang, Lizheng Yao, Yiran Zhang, Ruijie Zhang, Jingyi Cai, Hao Yu, Songhan Deng, Xinrui Chen, Rui Liang, Caoxin Huang, Jia Li, Xuejun Li, Qinxi Li, Xiulin Shi","doi":"10.1016/j.cmet.2026.03.001","DOIUrl":"https://doi.org/10.1016/j.cmet.2026.03.001","url":null,"abstract":"Type 2 diabetes is a major risk factor for fragility fractures, yet the contributors to skeletal fragility remain unclear. Through integrated clinical metabolomics, in vivo, and in vitro analyses, we identify maltol—a widely used food additive—as a previously unrecognized risk factor for hyperglycemia-associated bone fragility. Metabolomic profiling of femoral neck tissue from individuals with fragility fractures showed diabetes-associated maltol accumulation, and elevated circulating maltol levels correlated with increased fracture incidence. Mechanistically, maltol inhibits osteoblast differentiation via Wnt/β-catenin and promotes osteoclast maturation through nuclear factor κB (NF-κB) signaling, disrupting bone remodeling. These effects are amplified under hyperglycemia, while insulin reversal of glucose levels mitigates maltol-induced skeletal deterioration in mouse models. Given the widespread use of maltol in processed foods, these findings suggest that food additive safety should consider metabolic context and call for disease-specific dietary exposure guidelines to reduce fracture risk in diabetes.","PeriodicalId":9840,"journal":{"name":"Cell metabolism","volume":"15 1","pages":""},"PeriodicalIF":29.0,"publicationDate":"2026-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147518785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Analog of prolactin-releasing peptide reduces body weight primarily through sustained fatty acid oxidation rather than hypophagia 催乳素释放肽类似物主要通过持续的脂肪酸氧化而不是吞咽来减轻体重

IF 29 1区生物学

Cell metabolism Pub Date : 2026-03-24 DOI: 10.1016/j.cmet.2026.03.009

Claire H. Feetham, Sam Groom, Linu M. John, Berit Ostergaard Christoffersen, Valeria Collabolletta, David Lyons, Antony Adamson, Sofia Lundh, Marina Kjærgaard Gerstenberg, Mads Tang-Christensen, Kilian W. Conde-Frieboes, Anna Secher, Ann Maria Kruse Hansen, Simon M. Luckman

引用次数: 0

The many pathways driving liver inflammation in MASH MASH中驱动肝脏炎症的多种途径

IF 29 1区生物学

Cell metabolism Pub Date : 2026-03-23 DOI: 10.1016/j.cmet.2026.02.018

Herbert Tilg, Timon E. Adolph, Stefano Romeo, Rohit Loomba

引用次数: 0

Tissue and CD4 T cell subset dependence on the amino acid transporter SLC38A1 组织和CD4 T细胞亚群对氨基酸转运体SLC38A1的依赖性

IF 29 1区生物学

Cell metabolism Pub Date : 2026-03-23 DOI: 10.1016/j.cmet.2026.02.016

Ayaka Sugiura, Katherine L. Beier, Channing Chi, Darren R. Heintzman, Xiang Ye, Melissa M. Wolf, Andrew R. Patterson, Jacqueline-Yvonne Cephus, Hanna S. Hong, Jeffrey M. Perera, Costas A. Lyssiotis, Dawn C. Newcomb, Jeffrey C. Rathmell

引用次数: 0

Exercise as a therapeutic intervention for long-lasting and chronic diseases 运动作为长期和慢性疾病的治疗干预

IF 29 1区生物学

Cell metabolism Pub Date : 2026-03-23 DOI: 10.1016/j.cmet.2026.02.017

Mark A. Febbraio, Bente Klarlund Pedersen

引用次数: 0

Plasma proteomic signature of frailty in 50,506 adults 50,506名成年人的血浆蛋白质组学特征

IF 29 1区生物学

Cell metabolism Pub Date : 2026-03-16 DOI: 10.1016/j.cmet.2026.02.013

Xueqing Jia, Weijing Gao, Hampus Hagelin, Yanjie Zhao, Jingyun Zhang, Xingqi Cao, Liming Zhang, Youheng Wu, Lina Ma, Liangkai Chen, Liang Sun, Huan Guo, Cuntai Zhang, Juulia Jylhävä, Zixin Hu, Emiel O. Hoogendijk, Sara Hägg, Zuyun Liu

{"title":"Plasma proteomic signature of frailty in 50,506 adults","authors":"Xueqing Jia, Weijing Gao, Hampus Hagelin, Yanjie Zhao, Jingyun Zhang, Xingqi Cao, Liming Zhang, Youheng Wu, Lina Ma, Liangkai Chen, Liang Sun, Huan Guo, Cuntai Zhang, Juulia Jylhävä, Zixin Hu, Emiel O. Hoogendijk, Sara Hägg, Zuyun Liu","doi":"10.1016/j.cmet.2026.02.013","DOIUrl":"https://doi.org/10.1016/j.cmet.2026.02.013","url":null,"abstract":"Proteomics enables the systematic elucidation of biological mechanisms underlying frailty. Through a large proteome-wide association study of 2,911 plasma proteins from 50,506 UK Biobank participants, we identified 1,339 proteins significantly associated with frailty, highlighting collagen-containing extracellular matrix and vesicle lumen pathways. Replication in the TwinGene study confirmed partial but consistent associations. Mendelian randomization analyses identified five potentially causal proteins for frailty. Moreover, we developed a proteomic frailty score (PFS) that showed strong predictive performance for 199 incident diseases across 13 categories and broad responsiveness to 84 modifiable risk factors. Longitudinal analyses revealed accelerated PFS progression with advancing age and increasing baseline frailty severity. An online tool (<ce:inter-ref xlink:href=\"https://zipoa.shinyapps.io/frailty/\" xlink:type=\"simple\">https://zipoa.shinyapps.io/frailty/</ce:inter-ref>) was created for public PFS calculation. Finally, we observed a biphasic pattern of frailty-associated proteomic dysregulation across the lifespan, with peaks at ages ∼50 and ∼63. Together, we establish PFS as a biomarker of biological aging while identifying critical windows and molecular targets for frailty interventions.","PeriodicalId":9840,"journal":{"name":"Cell metabolism","volume":"21 1","pages":""},"PeriodicalIF":29.0,"publicationDate":"2026-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147465716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Metabolic polygenic risk scores for prediction of obesity, type 2 diabetes, and related morbidities 代谢多基因风险评分预测肥胖、2型糖尿病及相关疾病

IF 29 1区生物学

Cell metabolism Pub Date : 2026-03-16 DOI: 10.1016/j.cmet.2026.02.009

Min Seo Kim, Qiuli Chen, Yang Sui, Xiong Yang, Shaoqi Wang, Lu-Chen Weng, So Mi Jemma Cho, Satoshi Koyama, Xinyu Zhu, Kang Yu, Xingyu Chen, Rufan Zhang, Wanqing Yin, Shuangqiao Liao, Zhaoqi Liu, Fowzan S. Alkuraya, Pradeep Natarajan, Patrick T. Ellinor, Akl C. Fahed, Minxian Wang

{"title":"Metabolic polygenic risk scores for prediction of obesity, type 2 diabetes, and related morbidities","authors":"Min Seo Kim, Qiuli Chen, Yang Sui, Xiong Yang, Shaoqi Wang, Lu-Chen Weng, So Mi Jemma Cho, Satoshi Koyama, Xinyu Zhu, Kang Yu, Xingyu Chen, Rufan Zhang, Wanqing Yin, Shuangqiao Liao, Zhaoqi Liu, Fowzan S. Alkuraya, Pradeep Natarajan, Patrick T. Ellinor, Akl C. Fahed, Minxian Wang","doi":"10.1016/j.cmet.2026.02.009","DOIUrl":"https://doi.org/10.1016/j.cmet.2026.02.009","url":null,"abstract":"Obesity and type 2 diabetes (T2D) are metabolic diseases with shared pathophysiology. Traditional polygenic risk scores (PRSs) have focused on these conditions individually, yet the single-disease approach falls short in capturing the full dimension of metabolic dysfunction. We derived a biologically enriched metabolic PRS (MetPRS), a composite score that uses multi-ancestry genome-wide association studies of 20 metabolic traits from over 8.5 million individuals. MetPRS, optimized to predict obesity (O-MetPRS) and T2D (D-MetPRS), outperformed existing PRSs in predicting obesity and T2D across six ancestries. O-MetPRS and D-MetPRS effectively identify individuals at high risk for metabolic multimorbidity and predict clinical outcomes, including GLP-1 receptor agonist initiation. O-MetPRS and D-MetPRS showed an ∼2-fold increased risk of GLP-1 receptor agonist initiation for the top decile versus the middle quintile. The biologically enriched MetPRS has the potential to add an extra layer of information to disease prediction and management approaches for metabolic diseases.","PeriodicalId":9840,"journal":{"name":"Cell metabolism","volume":"95 1","pages":""},"PeriodicalIF":29.0,"publicationDate":"2026-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147465717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Large-scale metaproteomics of human gut microbiota reveals microbial functions in metabolic diseases and aging 人类肠道菌群的大规模宏蛋白质组学揭示了微生物在代谢疾病和衰老中的功能

IF 29 1区生物学

Cell metabolism Pub Date : 2026-03-13 DOI: 10.1016/j.cmet.2026.02.012

Shuang Liang, Yingying Sun, Zelei Miao, Bang-yan Li, Ziyuan Xing, Yuting Xie, Enci Cai, Sainan Li, Pu Liu, Min Yang, Menglei Shuai, Wanglong Gou, Wenhao Jiang, Youming Wang, Huanhuan Gao, Ke Zhang, Jing Yu, Xue Cai, Xingbing Wang, Yi Zhu, Yu-ming Chen, Ju-Sheng Zheng, Tiannan Guo

{"title":"Large-scale metaproteomics of human gut microbiota reveals microbial functions in metabolic diseases and aging","authors":"Shuang Liang, Yingying Sun, Zelei Miao, Bang-yan Li, Ziyuan Xing, Yuting Xie, Enci Cai, Sainan Li, Pu Liu, Min Yang, Menglei Shuai, Wanglong Gou, Wenhao Jiang, Youming Wang, Huanhuan Gao, Ke Zhang, Jing Yu, Xue Cai, Xingbing Wang, Yi Zhu, Yu-ming Chen, Ju-Sheng Zheng, Tiannan Guo","doi":"10.1016/j.cmet.2026.02.012","DOIUrl":"https://doi.org/10.1016/j.cmet.2026.02.012","url":null,"abstract":"The protein-level functionalities of the human gut microbiota in large populations, and their associations with host factors, remain unexplored. This study reports a metaproteomic study of 1,967 fecal samples from 1,399 middle-aged and elderly Chinese individuals, identifying microbial functions linked to 44 phenotypes. We uncover aging-associated functional shifts in carbon metabolism and energy production driven by species within the Bacillota, Bacteroidota, Actinomycetota, and Pseudomonadota. Across metabolic diseases, we observe the consistent depletion of Bacillota species and their proteins involved in carbohydrate, energy, amino acid metabolism, and short-chain fatty acid production. We also identify medication-associated features across diabetes, hypertension, and dyslipidemia. Validated in an independent cohort, Megasphaera elsdenii emerged as a hub species in type 2 diabetes. Experimental validation indicates that M. elsdenii is promoted by antidiabetic drugs and may regulate glucose homeostasis through butyrate production. This study provides protein-level evidence of microbial functions in health and disease, highlighting potential therapeutic targets.","PeriodicalId":9840,"journal":{"name":"Cell metabolism","volume":"100 1","pages":""},"PeriodicalIF":29.0,"publicationDate":"2026-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147447598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0