ChemistryOpen最新文献_第5页

Bifunctional MOF-on-MOF-Derived CuCo₂O₄ for Oxygen Evolution Reaction Electrocatalysis and Supercapacitor Electrodes. 双功能mof -on- mof衍生CuCo2O4用于析氧反应、电催化和超级电容器电极。

IF 3.1 4区化学

ChemistryOpen Pub Date : 2025-07-31 DOI: 10.1002/open.202500180

Johnnys da Silva Hortêncio, Rafael A Raimundo, Allan J M Araújo, André Luiz Menezes de Oliveira, Daniel A Macedo, Sherlan Guimarães Lemos, Fausthon Fred da Silva

{"title":"Bifunctional MOF-on-MOF-Derived CuCo2O4 for Oxygen Evolution Reaction Electrocatalysis and Supercapacitor Electrodes.","authors":"Johnnys da Silva Hortêncio, Rafael A Raimundo, Allan J M Araújo, André Luiz Menezes de Oliveira, Daniel A Macedo, Sherlan Guimarães Lemos, Fausthon Fred da Silva","doi":"10.1002/open.202500180","DOIUrl":"https://doi.org/10.1002/open.202500180","url":null,"abstract":"The development of high-performance electrocatalysts for oxygen evolution reaction (OER) is still a challenge to produce green hydrogen. Thus, herein, a new bifunctional metal-organic frameworks (MOF)-derived CuCo2O4 is obtained, applied as OER electrocatalyst and electrode for supercapacitors. All physicochemical and morphological characterization indicates the formation of a pure spinel structure CuCo2O4 crystalline phase and coral reef-like morphology. X-ray photoelectron spectroscopy data showed major presence of Co3+ and Cu+ ions on the surface and high concentration of oxygen vacancies. OER electrocatalytic assays conducted in alkaline medium (1.0 M KOH) show a reduced overpotential (η) of 317 mV at 10 mA cm-2 and Tafel slope of only 49 mV dec-1, besides excellent electrochemical stability up to 12 h. The material is also studied for supercapacitors applications via cyclic voltammetry (CV) and galvanostatic charge-discharge (GCD) analysis. CuCo2O4 material presents specific capacity near 75 C g-1, at least ≈2.8 times higher than pristine CuO and Co3O4 at 1 A g-1. This results indicate the MOFs-derived CuCo2O4 as a promising bifunctional material for energy conversion and storage.","PeriodicalId":9831,"journal":{"name":"ChemistryOpen","volume":" ","pages":"e202500180"},"PeriodicalIF":3.1,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144759283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Low Levels of Zinc Exchanged into Cu-SSZ-13 Increase Methanol Production in the Partial Oxidation of Methane to Methanol. 低水平的锌交换成Cu-SSZ-13增加了甲烷部分氧化制甲醇的甲醇产量。

IF 3.1 4区化学

ChemistryOpen Pub Date : 2025-07-29 DOI: 10.1002/open.202500352

Motunrayo Ogunleye, Hridita Purba Saha, Ayman M Karim, Daniel F Shantz

{"title":"Low Levels of Zinc Exchanged into Cu-SSZ-13 Increase Methanol Production in the Partial Oxidation of Methane to Methanol.","authors":"Motunrayo Ogunleye, Hridita Purba Saha, Ayman M Karim, Daniel F Shantz","doi":"10.1002/open.202500352","DOIUrl":"https://doi.org/10.1002/open.202500352","url":null,"abstract":"Cu-SSZ-13 is currently used industrially for the selective catalytic reduction of nitric oxides and has shown potential for the direct oxidation of methane to methanol. Here, how exchanging a small amount of zinc into Cu-SSZ-13 impacts the methane to methanol activity is reported. Samples containing only zinc are catalytically inactive. By contrast, small levels of zinc (Zn/Al = 0.06 or less) lead to a marked increase in methanol production. In the best case, Cu,Zn-SSZ-13 (Cu/Al = 0.21, Zn/Al = 0.06) has a site time yield (STY) of 26.4 ± 0.42 mmol mol-Cu-h-1 and specific activity (SA) of 11.5 ± 0.18 μmol g-h-1. This is over an 80% increase in both STY and SA over Cu-SSZ-13 samples with comparable copper loadings (Cu/Al = 0.2-0.26). A similar, but slightly less significant improvement, is observed for Cu,Zn samples at a copper loading of ≈0.12, where 50% increase in methanol production over just copper samples is observed. Infrared spectroscopy results suggest that the presence of zinc makes the copper more electron-deficient, providing one possible explanation for the increased activity.","PeriodicalId":9831,"journal":{"name":"ChemistryOpen","volume":" ","pages":"e2500352"},"PeriodicalIF":3.1,"publicationDate":"2025-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144741341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Magnetic Nanoparticles: Synthesis and Applications in Life Sciences. 磁性纳米颗粒：合成及其在生命科学中的应用。

IF 3.1 4区化学

ChemistryOpen Pub Date : 2025-07-29 DOI: 10.1002/open.202500214

Kishore Chand, Erick S Vasquez-Guardado

{"title":"Magnetic Nanoparticles: Synthesis and Applications in Life Sciences.","authors":"Kishore Chand, Erick S Vasquez-Guardado","doi":"10.1002/open.202500214","DOIUrl":"https://doi.org/10.1002/open.202500214","url":null,"abstract":"Magnetic nanoparticles (MNPs) are multifunctional materials with superparamagnetic properties and tunable surface chemistries, making them valuable across diverse fields, such as biomedicine, environmental remediation, and agriculture. This review examines recent advancements in MNP synthesis, encompassing chemical, physical, and environmentally friendly methods while highlighting improvements in size, morphology, and composition control that enhance application-specific performance and environmental sustainability. The review discusses various architectures, including single-core, core-shell, hybrid composites, and stimuli-responsive systems, with an emphasis on their stability, scalability, and functionalization potential. In biomedical applications, MNPs show promise in targeted drug delivery, magnetic hyperthermia, and magnetic resonance imaging contrast enhancement, where biocompatibility, often achieved through green synthesis, is critical. In agriculture, iron oxide MNPs (Fe3O4) have been utilized as nanofertilizers and growth promoters, demonstrating the ability to improve seed germination, chlorophyll content, and root development in crops, such as maize and tomatoes, without exhibiting phytotoxicity. Despite these promising results, challenges remain in large-scale production, reproducibility, and regulatory acceptance. This review highlights the pivotal role of MNPs in advancing nanotechnology-driven solutions across the life sciences. Their evolving synthesis techniques, multifunctional properties, and cross-sector applications position MNPs as key enablers of next-generation technologies in diagnostics, therapeutics, environmental monitoring, and sustainable agriculture.","PeriodicalId":9831,"journal":{"name":"ChemistryOpen","volume":" ","pages":"e2500214"},"PeriodicalIF":3.1,"publicationDate":"2025-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144728321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Isolation, Characterization, and Wound-Healing Potential of β-D-Glucan from Lycoperdon pyriforme Schaeff. 梨形番茄β- d-葡聚糖的分离、表征及创面愈合潜力研究

IF 3.1 4区化学

ChemistryOpen Pub Date : 2025-07-27 DOI: 10.1002/open.202500131

Elif Yavuz-Dokgöz, Meltem Güleç, Burçin İzbudak, Onur Şahin, Ayça Bal-Öztürk

{"title":"Isolation, Characterization, and Wound-Healing Potential of β-D-Glucan from Lycoperdon pyriforme Schaeff.","authors":"Elif Yavuz-Dokgöz, Meltem Güleç, Burçin İzbudak, Onur Şahin, Ayça Bal-Öztürk","doi":"10.1002/open.202500131","DOIUrl":"https://doi.org/10.1002/open.202500131","url":null,"abstract":"Mushrooms have become a prominent focus in alternative medicine and are now the subject of increasingly detailed scientific investigation. This study explores the isolation, purification, and characterization of β-D-glucan from Lycoperdon pyriforme, with particular emphasis on its wound-healing potential. The aim of this research is to isolate, purify, and characterize β-glucan compounds from mushrooms collected in their natural habitat. Gel permeation chromatography (GPC), Fourier transform infrared spectroscopy (FTIR), and nuclear magnetic resonance (NMR) spectroscopy are employed to characterize the compound. In vitro cytotoxicity is assessed using NIH 3T3 cells, and surface morphology is evaluated via electron microscopy. Spectroscopic analyses (GPC, FTIR, and NMR) confirmed the presence of β-(1 → 3) and β-(1 → 6) linkages and indicated polydispersity in the isolated β-D-glucan. Cytotoxicity assays show no toxic effect on NIH 3T3 cells, even at 1000 μg/mL. Lower concentrations (20, 100, and 500 μg/mL) promoted cell migration and wound closure in scratch assays. Hemolytic activity remained below 5%. The findings suggest that β-D-glucan from Lycoperdon pyriforme may support wound healing due to its non-toxic, hemocompatible, and coagulation-promoting properties. Future studies will focus on elucidating its mechanisms of action and evaluating clinical efficacy.","PeriodicalId":9831,"journal":{"name":"ChemistryOpen","volume":" ","pages":"e2500131"},"PeriodicalIF":3.1,"publicationDate":"2025-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144728320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Quercetin-Loaded Graphene Oxide Nanoparticles Modulate Inflammatory Gene Expression and Enhance Cell Migration In Vitro. 槲皮素负载的氧化石墨烯纳米颗粒调节炎症基因表达并增强细胞体外迁移。

IF 2.5 4区化学

ChemistryOpen Pub Date : 2025-07-23 DOI: 10.1002/open.202500215

Hossain Alipour, Elnaz Tamjid, Mehrdad Behmanesh

{"title":"Quercetin-Loaded Graphene Oxide Nanoparticles Modulate Inflammatory Gene Expression and Enhance Cell Migration In Vitro.","authors":"Hossain Alipour, Elnaz Tamjid, Mehrdad Behmanesh","doi":"10.1002/open.202500215","DOIUrl":"https://doi.org/10.1002/open.202500215","url":null,"abstract":"Quercetin, a plant-derived flavonoid, shows promising wound-healing properties due to its antioxidant, anti-inflammatory, and antibacterial effects. However, its limited water solubility limits its use. This study aims to enhance quercetin's efficacy by loading it onto graphene oxide (GO) and evaluating its in vitro effects for wound healing. GO is synthesized and quercetin is loaded onto its surface. Cytotoxicity of GO, quercetin, and quercetin-loaded GO on human foreskin fibroblasts is determined. The expression levels of genes NF-κB, IL-1β, and TNF-α are measured using qPCR. Wound healing is assessed via a scratch assay. The minimum inhibitory concentration (MIC) and maximum bactericidal concentration (MBC) of GO and quercetin-loaded GO against E. coli and S. aureus are determined. Results show quercetin release is higher at pH 8.5 (59%) compared to pH 7.4 (40%). Cytotoxicity studies indicate that quercetin-loaded GO enhances biocompatibility. The scratch assay shows a significantly higher wound closure rate in the quercetin-loaded GO group after 48 h, than GO and quercetin alone (p < 0.05). Additionally, quercetin-loaded GO exhibits antibacterial activity with MIC values of 4.8 μg mL-1 for both bacteria. These findings suggest that quercetin-loaded GO is a promising candidate for wound healing.","PeriodicalId":9831,"journal":{"name":"ChemistryOpen","volume":" ","pages":"e2500215"},"PeriodicalIF":2.5,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144697714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

One-Pot Four-Component Synthesis of Novel Amino-Tetrahydro-Chromene Derivatives Anchored with Dual Triazole Moieties. 双三唑基新型氨基-四氢铬衍生物的一锅四组分合成。

IF 2.5 4区化学

ChemistryOpen Pub Date : 2025-07-23 DOI: 10.1002/open.202500247

Saeede Azhari, Mohammad Majid Mojtahedi, M Saeed Abaee

引用次数: 0

Lupeol as a Potential Inhibitor of NorA Efflux Pumps in Staphylococcus aureus: In Silico and In Vitro Evidence. Lupeol作为金黄色葡萄球菌NorA外排泵的潜在抑制剂：体内和体外证据。

IF 2.5 4区化学

ChemistryOpen Pub Date : 2025-07-22 DOI: 10.1002/open.202500227

Nara Juliana Santos Araújo, Camila Aparecida Pereira Silva, Vanessa Lima Bezerra, Cicera Datiane Morais Oliveira-Tintino, Gabriel Gonçalves de Alencar, Maria do Socorro Costa, Ana Raquel Pereira da Silva, Josefa Sayonara Dos Santos, Kamila Correa Camara, Heberty diTarso Fernandes Facundo, Lívia Pereira Ferreira, Henrique Douglas Melo Coutinho, José Maria Barbosa Filho, Carolina Bandeira Domiciano, José Bezerra de Araújo-Neto, Jacqueline Cosmo Andrade-Pinheiro

{"title":"Lupeol as a Potential Inhibitor of NorA Efflux Pumps in Staphylococcus aureus: In Silico and In Vitro Evidence.","authors":"Nara Juliana Santos Araújo, Camila Aparecida Pereira Silva, Vanessa Lima Bezerra, Cicera Datiane Morais Oliveira-Tintino, Gabriel Gonçalves de Alencar, Maria do Socorro Costa, Ana Raquel Pereira da Silva, Josefa Sayonara Dos Santos, Kamila Correa Camara, Heberty diTarso Fernandes Facundo, Lívia Pereira Ferreira, Henrique Douglas Melo Coutinho, José Maria Barbosa Filho, Carolina Bandeira Domiciano, José Bezerra de Araújo-Neto, Jacqueline Cosmo Andrade-Pinheiro","doi":"10.1002/open.202500227","DOIUrl":"https://doi.org/10.1002/open.202500227","url":null,"abstract":"Antimicrobial resistance remains one of the major challenges to global public health, compromising the effectiveness of treatments and contributing to increased morbidity and mortality associated with bacterial infections. Among the mechanisms involved, efflux pumps-such as NorA, expressed in resistant strains of Staphylococcus aureus-are particularly noteworthy. These transport proteins actively expel antibiotics from the cell, reducing their intracellular concentration. In this context, natural compounds have been explored as potential resistance inhibitors, with a focus on the triterpene lupeol, known for its pharmacological properties. This study evaluates the activity of lupeol against the NorA efflux pump using in vitro assays and in silico modeling. The minimum inhibitory concentration (MIC) is determined by broth microdilution, and pump inhibition is assessed via ethidium bromide-induced fluorescence. SYTOX Green assays indicated that lupeol does not compromise bacterial membrane integrity. Although lupeol presented a MIC ≥ 1024 μg mL-1, it demonstrates significant inhibition of NorA activity. Molecular docking reveals a binding energy of -7.112 kcal mol-1 and interactions with key residues of the protein, outperforming the CCCP control. These findings suggest that lupeol acts as a modulator of bacterial resistance, with potential application as a therapeutic adjuvant in the treatment of infections caused by multidrug-resistant S. aureus.","PeriodicalId":9831,"journal":{"name":"ChemistryOpen","volume":" ","pages":"e2500227"},"PeriodicalIF":2.5,"publicationDate":"2025-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144682051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Electrochemical and Nanomaterial-Based Strategies for Nonenzymatic Glucose Detection: A Review. 基于电化学和纳米材料的非酶葡萄糖检测策略：综述。

IF 2.5 4区化学

ChemistryOpen Pub Date : 2025-07-21 DOI: 10.1002/open.202500304

Reagan Aviha, Gymama Slaughter

{"title":"Electrochemical and Nanomaterial-Based Strategies for Nonenzymatic Glucose Detection: A Review.","authors":"Reagan Aviha, Gymama Slaughter","doi":"10.1002/open.202500304","DOIUrl":"https://doi.org/10.1002/open.202500304","url":null,"abstract":"Electrochemical glucose sensing technologies have undergone significant evolution, with continual advancements aimed at improving sensitivity, selectivity, and user convenience. This review systematically explores the development of emerging nonenzymatic glucose sensor designs. Nonenzymatic sensors are critically evaluated for their ability to overcome enzymatic limitations, leveraging novel materials and catalytic mechanisms. Additionally, the emergence of smartphone-integrated glucose monitoring systems is highlighted as the fifth generation, representing a paradigm shift toward personalized, real-time healthcare management. Emphasis is placed on the strategies employed to reduce the working electrode potential and enhance analytical performance. Key analytical metrics and real-sample applicability are evaluated, and persistent challenges including reliability, biocompatibility, and calibration-free operation are identified. Further, this review provides a critical perspective on the trajectory of electrochemical nonenzymatic glucose sensor technologies and outlines future directions toward the development of next-generation platforms for continuous and noninvasive glucose monitoring.","PeriodicalId":9831,"journal":{"name":"ChemistryOpen","volume":" ","pages":"e2500304"},"PeriodicalIF":2.5,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144673945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring the Anticancer, Anti-Inflammatory, and Antibiofilm Efficacy of Endemic Stachys longiflora: Insights into the Phytochemical Composition. 探索特有植物长花石竹的抗癌、抗炎和抗生物膜作用：植物化学成分的见解。

IF 2.5 4区化学

ChemistryOpen Pub Date : 2025-07-20 DOI: 10.1002/open.202500146

Ecem Güldar, Sevim Feyza Erdoğmuş, Cengiz Sarikurkcu

{"title":"Exploring the Anticancer, Anti-Inflammatory, and Antibiofilm Efficacy of Endemic Stachys longiflora: Insights into the Phytochemical Composition.","authors":"Ecem Güldar, Sevim Feyza Erdoğmuş, Cengiz Sarikurkcu","doi":"10.1002/open.202500146","DOIUrl":"https://doi.org/10.1002/open.202500146","url":null,"abstract":"This study investigates the phytochemical profile, antibiofilm, and anticancer properties of the endemic Stachys longiflora. Phytochemical analysis is performed using liquid chromatography coupled with electrospray ionization tandem mass spectrometry, identifying 19 compounds, with verbascoside as the major component (12 290 ± 21 μg g-1). The anticancer activity of the extract is assessed on MCF-7 breast cancer cells using the MTT assay. IC50 value is determined to be 5 mg mL-1. Oxidative stress parameters, including total oxidant and antioxidant status, along with inflammatory cytokine levels, are measured in cell lysates. The cytokines TNF-α, TGF-β, DEF-β, and IL-1β are found to be elevated in all treatment groups compared to the control. Antibiofilm activity against Staphylococcus aureus ATCC 25923 is evaluated using the MTT method and scanning electron microscopy. The minimum inhibitory concentration of the plant extract is determined to be 250 μg mL-1. Biofilm inhibition and biofilm eradication increase in parallel with the concentration of the plant extract. At 2× MIC, biofilm inhibition and eradication are 74.37 ± 1.39% and 44.99 ± 1.03%, respectively. These findings highlight Stachys longiflora as a promising source of bioactive compounds with significant antibiofilm and anticancer properties.","PeriodicalId":9831,"journal":{"name":"ChemistryOpen","volume":" ","pages":"e2500146"},"PeriodicalIF":2.5,"publicationDate":"2025-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144673966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advances in Molecularly Imprinted Polymers for Bone Biomarker Detection and Therapeutic Applications. 分子印迹聚合物在骨生物标志物检测及治疗中的应用进展。

IF 2.5 4区化学

ChemistryOpen Pub Date : 2025-07-17 DOI: 10.1002/open.202500127

Ren Yang, Xiaohan Ma, Mingcheng Xuan, Yingqi Ma, Jiexian Ding, David Y S Chau, Jonathan C Knowles, Feng Peng, Alessandro Poma

引用次数: 0