ChemistryOpen最新文献

Identifying the Elusive Dimerization Product Interfering with Methylsulfonato-Group Labeling of Cysteines in Proteins. 鉴定干扰蛋白质中半胱氨酸甲基磺酸基标记的难以捉摸的二聚化产物。

IF 3.1 4区化学

ChemistryOpen Pub Date : 2025-10-07 DOI: 10.1002/open.202500314

Leonardo Passerini, René Dekkers, Karthick Babu Sai Sankar Gupta, Mark Overhand, Martina Huber

引用次数: 0

Preparation of Hierarchically Structured Perlite NPs/Metformin-Co (II) System to Catalyze the Green Synthesis of Pyrazolopyranopyrimidines. 层次化珍珠岩NPs/二甲双胍- co （II）体系的制备及绿色合成吡唑吡喃嘧啶的研究。

IF 3.1 4区化学

ChemistryOpen Pub Date : 2025-10-06 DOI: 10.1002/open.202500407

Jalal Reihani Shurbakhlu, Leila Moradi, Abdulhamid Dehghani

引用次数: 0

Betaine-Conjugated ß-Peptide Foldamers: Influence of Quaternary Charge on Self-Organization and MorphologyFormation. 甜菜碱共轭ß-肽折叠体：第四元电荷对自组织和形态形成的影响。

IF 3.1 4区化学

ChemistryOpen Pub Date : 2025-09-26 DOI: 10.1002/open.202500340

Nikolett Varró, Eszter Erdei, Dóra Bogdán, Eszter Kalydi, Ruth Deme, Balázs Balogh, Imola Cs Szigyártó, Tamás Beke-Somfai, Zoltán Varga, Pál Szabó, István M Mándity

{"title":"Betaine-Conjugated ß-Peptide Foldamers: Influence of Quaternary Charge on Self-Organization and MorphologyFormation.","authors":"Nikolett Varró, Eszter Erdei, Dóra Bogdán, Eszter Kalydi, Ruth Deme, Balázs Balogh, Imola Cs Szigyártó, Tamás Beke-Somfai, Zoltán Varga, Pál Szabó, István M Mándity","doi":"10.1002/open.202500340","DOIUrl":"https://doi.org/10.1002/open.202500340","url":null,"abstract":"The modification of well-known β-peptide helices has been achieved by the application of N-terminal betaine conjugation. The 3D self-organization of oligomers formed by [1S,2S]-2-aminocyclopentanecarboxylic acid (ACPC), [1R,2R]-2-aminocyclohexanecarboxylic acid (ACHC), and an alternating heterochiral homooligomer of [1S,2S]-ACPC and [1R,2R]-ACPC was studied. Results of NMR, ECD, FT-IR, and molecular modeling showed that for [1S,2S]-ACPC pentamer (1), the betaine conjugation did not affect the folding to an H12 helix. In contrast, for the [1R,2R]-ACHC tetramer (2) betaine conjugation notably influenced the folding, and an H14 helix was observed instead of the expected H10 helix. In addition, this is the first observation of self-association for an H12 helix forming β-peptide. Based on TEM images, this association leads to vesicle morphologies. For the alternating heterochiral homooligomer [1S,2S]-ACPC and the [1R,2R]-ACPC pentamer (3), betaine conjugation enhances the solubility of the system. Moreover, the formation of an expected E-strand can be anticipated, since self-association was found in the form of a fibrin net-like structure in TEM images. Betaine conjugates described herein open a new area of bioactive peptide foldamer construction, since the introduced quaternary charges may lead to important receptor-ligand interactions, while potential material science applications can also be realized.","PeriodicalId":9831,"journal":{"name":"ChemistryOpen","volume":" ","pages":"e202500340"},"PeriodicalIF":3.1,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145173960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Vibrational Spectroscopy of Tungsten(VI) Chlorides: WCl₆ and WOCl₄. 钨（VI）氯化物：WCl6和WOCl4的振动光谱。

IF 3.1 4区化学

ChemistryOpen Pub Date : 2025-09-26 DOI: 10.1002/open.202500338

Stewart F Parker, Talha Nasir

引用次数: 0

Identification of D-Fructose Dehydration Products by Infrared Multiphoton Dissociation Mass Spectrometry: The Spectral Signature of An Elusive 5-Hydroxymethylfurfural Isomer. 用红外多光子解离质谱法鉴定d -果糖脱水产物：一个难以捉摸的5-羟甲基糠醛异构体的光谱特征。

IF 3.1 4区化学

ChemistryOpen Pub Date : 2025-09-25 DOI: 10.1002/open.202500437

Caterina Fraschetti, Massimiliano Aschi, Andreina Ricci, Roberta Astolfi, Antonello Filippi

{"title":"Identification of D-Fructose Dehydration Products by Infrared Multiphoton Dissociation Mass Spectrometry: The Spectral Signature of An Elusive 5-Hydroxymethylfurfural Isomer.","authors":"Caterina Fraschetti, Massimiliano Aschi, Andreina Ricci, Roberta Astolfi, Antonello Filippi","doi":"10.1002/open.202500437","DOIUrl":"https://doi.org/10.1002/open.202500437","url":null,"abstract":"A combined Electrospray Infrared MultiPhoton Dissociation Mass Spectrometry (ESI-IRMPD-MS) and Density Functional Theory (DFT) investigation has allowed to elucidate the structural features of the species arising from the triple dehydration of D-fructose in the gas phase. The experimental workflow involves measuring and comparing the IRMPD spectra of different ionic populations: protonated 5-hydroxymethylfurfural [HMF·H]+ and the ionic species coming from the triple dehydration of the ammonium-D-fructose complex ([Fru·NH4]+). The IR-photon induced fragmentation of [Fru·NH4]+ reveals the coexistence of two ionic populations, which arise from of two independent not intercrossing fragmentation pathways of the ionic precursor. One population exhibits an IRMPD spectrum matching with the ([HMF·H]+) one and corresponding to a carbonyl-protonated structure. The second ionic product is its C2-protonated protomer, which lies 75 kJ/mol above the global minimum. The presence of a less stable protomer is most likely due to its gas-phase kinetic trapping. These findings contribute to a more refined understanding of gas-phase carbohydrate dehydration and isomer formation at the molecular level.","PeriodicalId":9831,"journal":{"name":"ChemistryOpen","volume":" ","pages":"e202500437"},"PeriodicalIF":3.1,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145147997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Batch Heterogeneous Catalytic Selective Hydrogenation of Vegetable Oils Over Lindlar Catalyst: Kinetic Modeling Supported by Reaction Mechanisms. Lindlar催化剂上植物油间歇式多相催化选择性加氢：反应机理支持的动力学模型。

IF 3.1 4区化学

ChemistryOpen Pub Date : 2025-09-24 DOI: 10.1002/open.202500369

Enza Pellegrino, Katia Gallucci, Nicoletta Cancrini, Andrea Di Giuliano

{"title":"Batch Heterogeneous Catalytic Selective Hydrogenation of Vegetable Oils Over Lindlar Catalyst: Kinetic Modeling Supported by Reaction Mechanisms.","authors":"Enza Pellegrino, Katia Gallucci, Nicoletta Cancrini, Andrea Di Giuliano","doi":"10.1002/open.202500369","DOIUrl":"https://doi.org/10.1002/open.202500369","url":null,"abstract":"Heterogeneous catalytic selective hydrogenation (HCSH) of vegetable oils is a reactive pathway to maximize the fraction of monounsaturated oleic acid, a component of industrial interest, thanks to its stability and low-temperature properties. Kinetics of HCSH is usually interpreted by pseudo-first order laws, as previously done by this research group with data from batch tests on canola oil (Lindlar catalyst, 120-180 °C, 0.4-1.2 MPa): the pseudo-first order kinetics could interpret the observed phenomenon only by variable selectivities (i.e., ratios of kinetic constants). The present work proposes a refined modeling by Hougen-Watson approach. Detailed reaction mechanisms were hypothesized, challenging the following alternatives: (i) H2 adsorption on the catalyst occured (Hinshelwood-Langmuir) or not (Eley-Rideal), (ii) H2 adsorption was molecular or dissociative, (iii) H2 adsorption was competitive or not with fatty acids adsorption, and (iv) reaction intermediates were formed or not. Six reaction mechanisms were developed with related kinetic rate laws for HCSH. Their kinetic parameters were regressed for the abovementioned experimental data by a purposely developed MATLAB script. The best mechanism was chosen based on the highest explained variance ( <math> <semantics> <mrow><msup><mi>R</mi> <mrow><mn>2</mn></mrow> </msup> </mrow> <annotation>$R^{2}$</annotation></semantics> </math> ) and the lowest number of parameters. Chemical-physical meaningfulness of regressed parameters for the best model was checked by comparison with the literature.","PeriodicalId":9831,"journal":{"name":"ChemistryOpen","volume":" ","pages":"e202500369"},"PeriodicalIF":3.1,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145130067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Performance of Commercial pH-Sensitive Ion-Selective Field Effect Transistors. 商用ph敏感离子选择场效应晶体管的性能。

IF 3.1 4区化学

ChemistryOpen Pub Date : 2025-09-24 DOI: 10.1002/open.202500361

Nandor Ziebart, Alexander Gießel, Thomas Walther

{"title":"The Performance of Commercial pH-Sensitive Ion-Selective Field Effect Transistors.","authors":"Nandor Ziebart, Alexander Gießel, Thomas Walther","doi":"10.1002/open.202500361","DOIUrl":"https://doi.org/10.1002/open.202500361","url":null,"abstract":"pH-sensitive ion-selective field effect transistors (ISFETs) are commercially available nowadays, offering high robustness, resolution, accuracy, and durability. A crucial drawback is their high price and permanent power demand. Incorporating commercially available small-sized ISFET sensors into battery-powered devices requires a thorough evaluation and the development of strategies to reduce power consumption. In this work, a direct comparison of three different commercial ISFETs is presented using a newly developed evaluation process that aims to investigate long-term performance. The different behaviors in conditioning, linearity, accuracy, response times, and long-term stability in detail are discussed. Furthermore, strategies to decrease power consumption are presented by adjusting the operating conditions and introducing an OnOff-protocol. It is found that all ISFETs have limitations in their overall performance with the best performers being 1) Winsense, with the highest slope of 59.7 mV pH-1; 2) Microsens, with the highest potential output precision under the recommended working point conditions (±0.01-0.03 pH) with SD and reduced working conditions (± 0.01 pH) with WD; and 3) Sentron, with the highest stability under both power-reducing strategies. With the combination of both power-reducing strategies, the ISFET's power demand is reduced by 98.8%.","PeriodicalId":9831,"journal":{"name":"ChemistryOpen","volume":" ","pages":"e202500361"},"PeriodicalIF":3.1,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145136811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Selective Vapor-Phase Formic Acid Decomposition Over Carbon-Supported Rhenium Catalysts with Metallic, Carbide, and Oxide Rhenium Phases. 选择性气相甲酸分解的碳负载铼催化剂与金属，碳化物和氧化铼相。

IF 3.1 4区化学

ChemistryOpen Pub Date : 2025-09-22 DOI: 10.1002/open.202500412

Claudio Contreras-Díaz, Verónica Naharro-Ovejero, Claudio Araya-López, Juan Seguel, Marcos Flores, Vicente Diaz, Néstor Escalona, Ana Belén Dongil

{"title":"Selective Vapor-Phase Formic Acid Decomposition Over Carbon-Supported Rhenium Catalysts with Metallic, Carbide, and Oxide Rhenium Phases.","authors":"Claudio Contreras-Díaz, Verónica Naharro-Ovejero, Claudio Araya-López, Juan Seguel, Marcos Flores, Vicente Diaz, Néstor Escalona, Ana Belén Dongil","doi":"10.1002/open.202500412","DOIUrl":"https://doi.org/10.1002/open.202500412","url":null,"abstract":"Formic acid is obtained as a byproduct of biomass pyrolysis and is used as a liquid organic hydrogen carrier due to its low decomposition temperature, enabling hydrogen production under mild conditions with noble metals. The decomposition of FA in the vapor phase using different rhenium phases (metal, carbide, and oxide) supported on graphite and carbon nanotubes was studied within a temperature range of 80-220 °C, in a fixed-bed reactor with a space velocity of 651 mL gcat h-1. The catalysts were characterized by N2 adsorption-desorption, H2-temperature-programmed reduction, transmission electron microscopy, temperature programmed desorption-ammonia, temperature programmed reaction-methanol, X-ray diffraction, and X-ray photoelectron spectroscopy. Graphite-supported catalysts achieved higher activity than carbon nanotube-supported ones, due to the higher rhenium dispersion on graphite. Catalytic reactions revealed that ReC/G exhibited superior performance at lower temperatures per active site, attributed to the rhenium carbide phase. High selectivity toward CO2 was observed across all catalysts, except for ReOx/G at lower temperatures, where differences in active site characteristics likely influenced performance. ReC/G displayed the highest intrinsic activity, highlighting rhenium carbide as a more active phase than metallic or oxide rhenium.","PeriodicalId":9831,"journal":{"name":"ChemistryOpen","volume":" ","pages":"e202500412"},"PeriodicalIF":3.1,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145124240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Buffer-Mediated Catalyst-Free Strecker Reaction Toward Enzymatic Implementation. 缓冲介质介导的酶促无催化剂streker反应。

IF 3.1 4区化学

ChemistryOpen Pub Date : 2025-09-21 DOI: 10.1002/open.202500389

Péter Magyar, Szilárd Újvári, Zsófia Molnár, Zoltán Orgován, Diána Balogh-Weiser, Blanka Eszter Nagy, Diana Maria Scrob, László Poppe, Péter Ábrányi-Balogh

引用次数: 0

Impact of Seasonal Variation on Antioxidant, Enzyme Inhibitory, and Anti-Inflammatory Potentials of Cistus creticus Leaf Extracts. 季节变化对山楂叶提取物抗氧化、酶抑制和抗炎活性的影响。

IF 3.1 4区化学

ChemistryOpen Pub Date : 2025-09-21 DOI: 10.1002/open.202500362

Khalil Guelifet, Mokhtar Benmohamed, Khaled Kherraz, Latifa Khattabi, Barbara Sawicka, Ayomide Victor Atoki, Abderrazek Ferhat, Lilya Harchaoui, Mohamed Amine Ferhat, Wafa Zahnit, Afaf Khadra Bendrihem, Mohammed Messaoudi

{"title":"Impact of Seasonal Variation on Antioxidant, Enzyme Inhibitory, and Anti-Inflammatory Potentials of Cistus creticus Leaf Extracts.","authors":"Khalil Guelifet, Mokhtar Benmohamed, Khaled Kherraz, Latifa Khattabi, Barbara Sawicka, Ayomide Victor Atoki, Abderrazek Ferhat, Lilya Harchaoui, Mohamed Amine Ferhat, Wafa Zahnit, Afaf Khadra Bendrihem, Mohammed Messaoudi","doi":"10.1002/open.202500362","DOIUrl":"https://doi.org/10.1002/open.202500362","url":null,"abstract":"This study investigates the influence of seasonal variation onthe phytochemicalcomposition and biological activities of Cistus creticus leaf extracts collected during spring, summer, autumn, and winter. Extracts are analyzed for phenolic and flavonoid contents and evaluated for antioxidant, enzyme inhibitory, anti-inflammatory, analgesic, antimicrobial, and photoprotective properties. Pronounced seasonal differences are observed. Spring and summer extracts, enriched in bioactive compounds, exhibit the strongest pharmacological potential, including notable antioxidant effects, potent enzyme inhibition, and high photoprotective capacity. The spring extract further demonstrates significant in vivo anti-inflammatory and analgesic effects, while the winter extract displays superior in vitro anti-inflammatory activity. These findings highlight the critical role of harvest season in modulating both phytochemical composition and bioefficacy. The superior performance of spring and summer extracts underscores the potential of C. creticus as a valuable natural source of antioxidants, enzyme inhibitors, and photoprotective agents. Overall, this work supports the strategic use of seasonal optimization to enhance the therapeutic and cosmeceutical applications of C. creticus.","PeriodicalId":9831,"journal":{"name":"ChemistryOpen","volume":" ","pages":"e202500362"},"PeriodicalIF":3.1,"publicationDate":"2025-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145112079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0