ChemistryOpen最新文献_第2页

Tuning the Properties of 3D-Printed Electrochemical Devices by Using Different Fused Deposition Modeling Printers and Setups 通过使用不同的熔融沉积建模打印机和设置来调整3d打印电化学器件的性能。

IF 3 4区化学

ChemistryOpen Pub Date : 2026-09-24 DOI: 10.1002/open.70303

Gennaro Persico, Panagiota M. Kalligosfyri, Elena Lagreca, Vincenzo Ianniello, Concetta Di Natale, Michela Volgare, Antonio Cutolo, Filippo Defina, Waleed Alahmad, Abdulaziz K. Assaifan, Mariarosaria Bucci, Stefano Cinti

{"title":"Tuning the Properties of 3D-Printed Electrochemical Devices by Using Different Fused Deposition Modeling Printers and Setups","authors":"Gennaro Persico, Panagiota M. Kalligosfyri, Elena Lagreca, Vincenzo Ianniello, Concetta Di Natale, Michela Volgare, Antonio Cutolo, Filippo Defina, Waleed Alahmad, Abdulaziz K. Assaifan, Mariarosaria Bucci, Stefano Cinti","doi":"10.1002/open.70303","DOIUrl":"10.1002/open.70303","url":null,"abstract":"Although fused deposition modeling (FDM) 3D printing has emerged as an accessible and versatile approach for the fabrication of electrochemical sensors, the type of printer and manufacturing setup might affect the quality of the ultimate device. In this work, the electrochemical performance of conductive polylactic acid (PLA)-based printed sensors have been tuned by interrogating different cost classes and hardware configurations. Electrochemical behavior was investigated using cyclic voltammetry with both inner- and outer-sphere redox probes, namely potassium ferricyanide (III) and hexaammineruthenium (III) chloride, to evaluate surface accessibility and electron-transfer properties. Scanning electron microscopy and tensile tests were additionally performed to characterize electrode morphology and mechanical stability. Among the evaluated 3D printers, high-performance systems characterized by higher automation, improved motion control, and greater extrusion stability demonstrated satisfactory outcomes. In contrast, entry-level open-platform systems showed lower surface utilization and reduced electrochemical performance. The results demonstrate that all printing platforms were capable of producing sensors with electrochemical functionality, comparable mechanical properties, and well-defined architectures. However, despite negligible differences among PLA filaments, it is clear that printing time, automation, and hardware flexibility represent central factors in selecting the most suitable platform for next scaling of electrode manufacturing.","PeriodicalId":9831,"journal":{"name":"ChemistryOpen","volume":"15 10","pages":""},"PeriodicalIF":3.0,"publicationDate":"2026-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/open.70303","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149036612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Influence of d-Orbital Occupancy on Ligand Conformation and Crystal Packing in a Series of Mononuclear Transition Metal Complexes 一系列单核过渡金属配合物中d轨道占位对配体构象和晶体填充的影响。

IF 3 4区化学

ChemistryOpen Pub Date : 2026-09-23 DOI: 10.1002/open.70304

Regan F. Soballa, James P. Flood, Weibin Liang, Christopher E. Karlsen, Judith Stuparu, Ross A. Shalliker, Feng Li

{"title":"Influence of d-Orbital Occupancy on Ligand Conformation and Crystal Packing in a Series of Mononuclear Transition Metal Complexes","authors":"Regan F. Soballa, James P. Flood, Weibin Liang, Christopher E. Karlsen, Judith Stuparu, Ross A. Shalliker, Feng Li","doi":"10.1002/open.70304","DOIUrl":"10.1002/open.70304","url":null,"abstract":"A series of mononuclear metal complexes were synthesised incorporating either Mn(II), Co(II), Ni(II), Cu(II), or Zn(II) metal ions in conjunction with a newly reported ligand, tris((((1-phenyl-1H-imidazol-4-yl)methylene)amino)ethyl)ethane-1,2-diamine (L). Each of the presently reported metal complexes was characterised in solution and in the solid state. Single-crystal X-ray diffraction studies were used to examine how changes in the coordination sphere (and d-orbital occupancy) of each metal ion modify the crystal packing motif, ligand torsion, and the spatial orientation of pendant phenyl groups in the metal complexes. The results presented within demonstrated that the complexation of metal ions bearing different d-orbital occupancies generated separate packing motifs except for the isostructural Co(II) and Zn(II) complexes. These differing motifs gave rise to small variations in the octahedral distortion parameters, ligand arm torsion, and the positions of the pendant phenyl groups across the series. These findings illustrate how structural and electronic differences, arising from the choice of metal ion and the atomic composition of pendant groups, influence ligand conformation and crystal packing within mononuclear systems. Such simple mononuclear complexes may therefore provide a foundation upon which larger, more elaborate metallosupramolecular assemblies can be rationally constructed.","PeriodicalId":9831,"journal":{"name":"ChemistryOpen","volume":"15 10","pages":""},"PeriodicalIF":3.0,"publicationDate":"2026-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/open.70304","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149030081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Transcending Lipophilicity: Design of Oxotriphenylhexanoate (OTHO) Hydrogels Decorated With 9,10-Diphenylanthracene Fluorescent Probes via Late-Stage Polarity Swap 超越亲脂性：9,10-二苯基蒽荧光探针修饰的氧三苯基己酸（OTHO）水凝胶的后期极性交换设计。

IF 3 4区化学

ChemistryOpen Pub Date : 2026-09-23 DOI: 10.1002/open.70309

Michel Taheri, Mario Martos, Olivia Lundgren, Henrik Sundén

引用次数: 0

Multitechnique Physicochemical Characterization of Horse Hoof Trimmings as Sustainable and Untapped Keratin Source 马蹄屑作为可持续和未开发角蛋白来源的多技术理化特性研究

IF 3 4区化学

ChemistryOpen Pub Date : 2026-09-21 DOI: 10.1002/open.70300

Esther Trigueros, Lisa Rita Magnaghi, Lorenzo De Vita, Lavinia Rita Doveri, Michela Sturini, Chiara Milanese, Raffaela Biesuz

{"title":"Multitechnique Physicochemical Characterization of Horse Hoof Trimmings as Sustainable and Untapped Keratin Source","authors":"Esther Trigueros, Lisa Rita Magnaghi, Lorenzo De Vita, Lavinia Rita Doveri, Michela Sturini, Chiara Milanese, Raffaela Biesuz","doi":"10.1002/open.70300","DOIUrl":"https://doi.org/10.1002/open.70300","url":null,"abstract":"In the keratin-rich biomass scenario, horse hoof trimmings play a marginal role due to the limited volume and the scarce background on material features, despite added values such as cruelty-free, localized and routine production and traceability. This work presents a multitechnique characterization of horse hooves, including physicochemical, structural, thermal, and compositional analysis, providing a solid background knowledge of material features, mandatory for upcycling strategy definition. FT-IR, Raman spectroscopy, X-ray powder diffraction, SEM-EDX, thermogravimetric analysis, and elemental characterization are conducted on powdered samples obtained using various approaches. The material exhibited structural features typical of hard α-keratin, with semicrystalline organization and high thermal stability. A relatively high higher heating value (21.9 MJ kg−1) highlights its potential for energy recovery routes, while structural robustness suggests suitability for material-oriented valorization pathways. Lastly, the issue of metal contamination, attributable to shoeing practices, is systematically evaluated and correlated with shoeing habits, sampling region, and milling. Overall, this study positions horse hoof waste as a promising alternative keratin-based biomass and provides the necessary physicochemical framework to support its integration into circular bioeconomy strategies.","PeriodicalId":9831,"journal":{"name":"ChemistryOpen","volume":"15 10","pages":""},"PeriodicalIF":3.0,"publicationDate":"2026-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/open.70300","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149007476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cerium-Modified TiO2 Nanomaterials Derived From Upcycled Coffee Ground Waste for Photocatalytic Oxidation and Hydrogen Production via Photoreforming 从再生咖啡渣中提取铈修饰TiO2纳米材料用于光催化氧化和光重整制氢。

IF 3 4区化学

ChemistryOpen Pub Date : 2026-09-21 DOI: 10.1002/open.70293

Narimene Aoun, Elisa I. García-López, Bartolomeo Megna, Chiara Aliotta, Valeria La Parola, Ganna Kovtun, Teresa Cuberes, Giuseppe Marcì

{"title":"Cerium-Modified TiO2 Nanomaterials Derived From Upcycled Coffee Ground Waste for Photocatalytic Oxidation and Hydrogen Production via Photoreforming","authors":"Narimene Aoun, Elisa I. García-López, Bartolomeo Megna, Chiara Aliotta, Valeria La Parola, Ganna Kovtun, Teresa Cuberes, Giuseppe Marcì","doi":"10.1002/open.70293","DOIUrl":"10.1002/open.70293","url":null,"abstract":"The valorization of spent coffee ground wastes to prepare advanced materials offers a promising pathway toward sustainable materials engineering. In this work, spent coffee grounds were valorized by their utilization as a template for the synthesis of Ce-loaded TiO2 to be used as photocatalysts. The synthesis in the presence of the bio-derived sacrificial template in the absence of solvent promote a hierarchical porosity and surface area and an intimate contact between Ce and Ti precursors to improve the photocatalytic activity of the obtained composite material. Pure TiO2 is made up of nanoparticles that organize into fairly uniform spherical agglomerates of ca. 1 μm. When Ce is introduced, this ordered structure gradually changes giving rise to less regular larger aggregates, and at higher loadings (5% Ce) the spherical morphology is no longer observed. In all cases a mesoporous structure is present. The activity of the obtained solids as photocatalysts was tested in three different reactions: (i) the photo reforming of ethanol in aqueous suspension of the photocatalysts in the absence of oxygen, to obtain hydrogen; (ii) the 2-propanol oxidation in gas–solid regime, and (iii) the 5‑hydroxymethylfurfural (5‑HMF) oxidation in aqueous suspension of the solids.","PeriodicalId":9831,"journal":{"name":"ChemistryOpen","volume":"15 10","pages":""},"PeriodicalIF":3.0,"publicationDate":"2026-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13594559/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149015792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An Integrated Metabolomics and Bioactivity Approach to Characterize Salvia heldreichiana and Salvia tomentosa Extracts 鼠尾草和毛毛鼠尾草提取物的代谢组学和生物活性研究。

IF 3 4区化学

ChemistryOpen Pub Date : 2026-09-21 DOI: 10.1002/open.70302

Gokhan Zengin, Nilofar Nilofar, Alina Kalyniukova, Vasil Andruch, Giancarlo Angeles Flores, Paola Angelini, Roberto Venanzoni, Kubra Aslan, Ilhami Gulcin, Evren Yildiztugay

{"title":"An Integrated Metabolomics and Bioactivity Approach to Characterize Salvia heldreichiana and Salvia tomentosa Extracts","authors":"Gokhan Zengin, Nilofar Nilofar, Alina Kalyniukova, Vasil Andruch, Giancarlo Angeles Flores, Paola Angelini, Roberto Venanzoni, Kubra Aslan, Ilhami Gulcin, Evren Yildiztugay","doi":"10.1002/open.70302","DOIUrl":"10.1002/open.70302","url":null,"abstract":"The genus Salvia, widely known as sage, represents the largest group within the Lamiaceae family and includes numerous species with traditional uses. This study investigates the chemical composition, antioxidant activity, enzyme inhibition, and antibacterial activity of the aerial parts and roots of two Salvia species, Salvia heldreichiana, and Salvia tomentosa. For chemical analysis, ultraperformance liquid chromatography-quadrupole-time-of-flight mass spectrometry (LC–QTOF–MS) was used. LC–QTOF–MS analysis revealed that the extracts from the aerial parts of S. tomentosa had a higher number of metabolites than those of S. heldreichiana, including amino and organic acids, various phenolic compounds, and unknown metabolites. S. heldreichiana aerial parts water extract possessed the highest antioxidant activity in CUPRAC > FRAP > ABTS > DPPH > MCA > PBD. For the enzyme inhibition, S. heldreichiana root extracts exhibited the highest anti-AChE activity, particularly in Ethanol extracts (2.88 mg GALAE/g), while the highest anti-BChE activity was the ethanol extract of the aerial part (3.65 mg GALAE/g). Consequently, the ethanol/water aerial part extracts, with their superior antioxidant, phenolic, and multienzyme inhibitory profile, present themselves as best candidates of S. heldreichiana and S. tomentosa for further in vivo pharmacological evaluation and development.","PeriodicalId":9831,"journal":{"name":"ChemistryOpen","volume":"15 10","pages":""},"PeriodicalIF":3.0,"publicationDate":"2026-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13594774/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149015748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Anion-Controlled Speciation and Stability of Silylzinc Reagents 硅锌试剂的阴离子控制形态及稳定性。

IF 3 4区化学

ChemistryOpen Pub Date : 2026-09-15 DOI: 10.1002/open.70301

Zhili Duan, Konrad Koszinowski

{"title":"Anion-Controlled Speciation and Stability of Silylzinc Reagents","authors":"Zhili Duan, Konrad Koszinowski","doi":"10.1002/open.70301","DOIUrl":"10.1002/open.70301","url":null,"abstract":"Silylzinc reagents are valuable silicon-based nucleophiles, yet their molecular-level speciation and stability remain poorly understood. Here, we use a combination of electrospray ionization (ESI)-mass spectrometry, NMR spectroscopy, and X-ray crystallography to probe the speciation and coordination of (PhzMe3−zSi)ZnX·LiX·LiCl (z = 1–3; X = OOCtBu, Cl, Br, I) both in solution and the solid state. In the presence of N,N,Nꞌ,Nꞌ-tetramethylethylenediamine (TMEDA), the (Ph3Si)ZnX·LiX·LiCl reagents with X = Cl and I, respectively, afford complexes (Ph3Si)ZnX(TMEDA), whose approximately tetrahedral coordination geometry resembles that of related compounds described previously. In tetrahydrofuran solutions, ESI-mass spectrometry reveals the formation of mononuclear and polynuclear zincate species interconnected by Schlenk-type equilibria, closely resembling organozinc systems. Upon exposure to ambient atmosphere, time-resolved experiments uncover ligand-dependent degradation pathways likely involving protodemetalation and oxidation via O2 insertion into the Zn─Si bond, with silanol formation directly observed by NMR spectroscopy. The stability of the silylzinc reagents depends sensitively on the identity of the anion X−. In particular, pivalate (X = OOCtBu) coordination markedly suppresses decomposition, which we attribute to enhanced Li+ binding and aggregation effects, steric shielding, as well as proton scavenging. These findings provide a molecular-level understanding of silylzinc speciation and establish anion coordination as a key factor influencing their stability.","PeriodicalId":9831,"journal":{"name":"ChemistryOpen","volume":"15 9","pages":""},"PeriodicalIF":3.0,"publicationDate":"2026-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13576932/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148966762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development of a Gold Nanoparticle-Assisted Multiplex Polymerase Chain Reaction Assay for Selected Hospital-Acquired Infections-Associated Bacterial and Fungal Pathogens 金纳米颗粒辅助多重聚合酶链反应测定选定的医院获得性感染相关细菌和真菌病原体的发展。

IF 3 4区化学

ChemistryOpen Pub Date : 2026-09-15 DOI: 10.1002/open.70294

Kubra Aslan, Emre Erden Kopar, Serap Evran

{"title":"Development of a Gold Nanoparticle-Assisted Multiplex Polymerase Chain Reaction Assay for Selected Hospital-Acquired Infections-Associated Bacterial and Fungal Pathogens","authors":"Kubra Aslan, Emre Erden Kopar, Serap Evran","doi":"10.1002/open.70294","DOIUrl":"10.1002/open.70294","url":null,"abstract":"In this study, development and optimization of a multiplex PCR assay for the simultaneous amplification of selected bacterial and fungal targets were performed. Source of hospital-acquired infections-specific, (Staphylococcus aureus, Klebsiella pneumoniae, Pseudomonas aeruginosa, Candida albicans, Fusarium oxysporum, and Scedosporium prolificans) primer sets targeting conserved genomic regions were systematically evaluated for potential nonspecific interactions, cross-reactivity, and structural stability using in silico tools and empirical analyses. Multiplex PCR conditions were optimized using genomic DNA from reference strains under controlled laboratory conditions, with particular emphasis on annealing temperature, MgCl2 concentration, and primer balance. In addition, the effect of gold nanoparticles (AuNPs) on amplification performance was investigated. The inclusion of 1.0 nM 10 nm AuNPs enhanced overall amplification efficiency, with a more pronounced improvement observed for fungal targets. Overall, this study establishes an analytical proof of concept for a nanoparticle-assisted multiplex PCR configuration capable of simultaneously amplifying multiple bacterial and fungal targets in a single reaction.","PeriodicalId":9831,"journal":{"name":"ChemistryOpen","volume":"15 9","pages":""},"PeriodicalIF":3.0,"publicationDate":"2026-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13578920/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148975757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Integrative In Silico Profiling of Major Phytochemicals From a Sclerocarya birrea–Nauclea latifolia–Piper longum Mixture: Docking, Molecular Dynamics, ADMET, and Ligand-Based Target Prediction on Shared Pathways in Type 2 Diabetes Mellitus and Alzheimer's Disease 来自硬核-大叶核-长叶胡椒混合物的主要植物化学物质的集成硅分析：对接、分子动力学、ADMET和基于配体的2型糖尿病和阿尔茨海默病共享通路的靶标预测。

IF 3 4区化学

ChemistryOpen Pub Date : 2026-09-15 DOI: 10.1002/open.70299

Jean Philippe Djientcheu Tientcheu, Erman Salih İstifli

{"title":"Integrative In Silico Profiling of Major Phytochemicals From a Sclerocarya birrea–Nauclea latifolia–Piper longum Mixture: Docking, Molecular Dynamics, ADMET, and Ligand-Based Target Prediction on Shared Pathways in Type 2 Diabetes Mellitus and Alzheimer's Disease","authors":"Jean Philippe Djientcheu Tientcheu, Erman Salih İstifli","doi":"10.1002/open.70299","DOIUrl":"10.1002/open.70299","url":null,"abstract":"Type 2 diabetes mellitus (T2DM) and Alzheimer's disease (AD) converge through metabolic dysfunction, inflammation, and impaired neuronal signaling, providing a rationale for multi-target intervention. This study aimed to identify phytochemicals from a Sclerocarya birrea–Nauclea latifolia–Piper longum mixture that may modulate this disease axis. Seven constituents were screened against AChE, BACE1, DPP4, glucokinase, GSK3β, and TACE using molecular docking and MM-GBSA rescoring. Prioritized complexes underwent triplicate 100-ns molecular dynamics simulations, post-MD MM-GBSA analysis, physicochemical/ADMET profiling, and ligand-based target prediction. Quercetin pentamethyl ether (QR-PME) emerged as the principal computational hit: its GSK3β and TACE complexes maintained stable structural and energetic behavior, with mean binding free energy estimates of −30.07 ± 0.06 and −34.24 ± 0.07 kcal/mol, respectively, matching those of the reference inhibitors (−30.05 ± 0.07 and −34.08 ± 0.06 kcal/mol). QR-PME satisfied Lipinski criteria and showed predicted intestinal absorption, although CYP inhibition liability and low blood–brain barrier permeability remain concerns. ABCG2 was its top predicted target, suggesting an experimentally unresolved link to amyloid-β transport. These findings generate a testable hypothesis that QR-PME may engage the metabolic–inflammatory–tau network connecting T2DM and AD, supporting biochemical, cellular, pharmacokinetic, and in vivo validation before its therapeutic applicability can be established.","PeriodicalId":9831,"journal":{"name":"ChemistryOpen","volume":"15 9","pages":""},"PeriodicalIF":3.0,"publicationDate":"2026-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13576934/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148966858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of Antifungal Activity of Chromenoquinoline Derivatives Synthesized in the Medium Temperature Water Using Isinglass–Bassorin Cryogel as a Sustainable Catalyst 以isingglass - bassorin低温凝胶为可持续催化剂在中温水中合成的铬喹啉衍生物的抑菌活性评价。

IF 3 4区化学

ChemistryOpen Pub Date : 2026-09-14 DOI: 10.1002/open.70297

Shahrzad Abdolmohammadi, Behrooz Mirza, Sina Azadi, Zinatossadat Hossaini

{"title":"Evaluation of Antifungal Activity of Chromenoquinoline Derivatives Synthesized in the Medium Temperature Water Using Isinglass–Bassorin Cryogel as a Sustainable Catalyst","authors":"Shahrzad Abdolmohammadi, Behrooz Mirza, Sina Azadi, Zinatossadat Hossaini","doi":"10.1002/open.70297","DOIUrl":"10.1002/open.70297","url":null,"abstract":"Our team subscribes to using contemporary, ecologically sound, and sustainable catalysts to produce a range of chromenoquinolines. This was accomplished utilizing the environmentally friendly heterogeneous catalyst isinglass-bassorin (IG-BR) cryogel in aqueous media at room temperature in a one-pot three-component reaction involving 4-hydroxycoumarin, aromatic aldehydes, and 3,4-(methylenedioxy)aniline. The two main significant advantages of this innovative and practical method are the use of water as an ecologically friendly medium and the IG-BR cryogel as a strong and recyclable heterogeneous catalyst (for at least 4 cycles) that conforms with green chemistry principles to produce target compounds in a brief reaction time (4–5 h) and high product yields (89%–93%). Additionally, all target compounds demonstrated superior inhibition zones at doses of 50 and 75 μg/mL when tested for antifungal activity in vitro against three types of fungal pathogens in comparison with two common antifungal medications.","PeriodicalId":9831,"journal":{"name":"ChemistryOpen","volume":"15 9","pages":""},"PeriodicalIF":3.0,"publicationDate":"2026-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13575500/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148966771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0