ChemistryOpenPub Date : 2024-09-23DOI: 10.1002/open.202400058
Öznur Eyilcim, Fulya Günay, Yuk Yin Ng, Özlem Ulucan Açan, Zuhal Turgut, Ömer Tahir Günkara
{"title":"Design, Synthesis, Biological Evaluation and Molecular Docking Studies of a New Series of Maleimide Derivatives.","authors":"Öznur Eyilcim, Fulya Günay, Yuk Yin Ng, Özlem Ulucan Açan, Zuhal Turgut, Ömer Tahir Günkara","doi":"10.1002/open.202400058","DOIUrl":"https://doi.org/10.1002/open.202400058","url":null,"abstract":"<p><p>A series of novel maleimide derivatives were synthesized, with various heterocyclic compounds serving as side chains in the synthesis process. The structural characteristics of these compounds were elucidated through the application of <sup>1</sup>H-NMR spectroscopy, <sup>13</sup>C-NMR (APT) spectroscopy, and high-resolution mass spectrometry (HRMS). The anti-cancer potential of these compounds was subsequently assessed in vitro, utilizing two distinct breast cancer cell lines, namely MDA-MB-231 and MCF-7, via MTT assay. Among the 12 newly synthesized compounds, 4 a, 4 b, 4 c, 4 d, 5 a, 5 b, 5 c and 5 d were determined to show the most promising anti-cancer activity against both breast cancer cell lines. Moreover, the morphological changes induced in the cells following a 24-hour incubation period with these compounds were observed using light microscopy. Additionally, molecular dynamics simulations were conducted to assess the stability of the bound conformations of the compounds to the target protein GSK-3β as obtained through molecular docking calculations.</p>","PeriodicalId":9831,"journal":{"name":"ChemistryOpen","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142307200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
ChemistryOpenPub Date : 2024-09-12DOI: 10.1002/open.202400094
R. A. Humann, T. K. Smith
{"title":"Potential Trypanocidal Activity of Glycerol Analogues","authors":"R. A. Humann, T. K. Smith","doi":"10.1002/open.202400094","DOIUrl":"https://doi.org/10.1002/open.202400094","url":null,"abstract":"Glycerol, a versatile and ubiquitous compound, plays a vital role in a plethora of metabolic pathways in both prokaryotes and eukarotyes. Relatively few glycerol analogues have previously been explored for their use as glycerol kinase inhibitors, in addition to their therapeutic potential, however their use as (pro)‐drugs in the context of parasitic diseases such as trypanosomiasis is unreported. The literature on glycerol metabolism and particular its synergic anti‐profilation behaviour with salicylhydroxamic acid (SHAM) in <jats:italic>Trypanosoma brucei</jats:italic> is extensive. However, utiliation of glycerol analogues has not been explored as possible superior combinatory compounds. This report describes the synthesis of various glycerol analogues and their subsequent biochemical pheotypic analysis for their effect on lipid metabolism and their possible synergic activity with SHAM on <jats:italic>Trypanosoma brucei</jats:italic>. The glycerol analogues caused morphological changes;, including detached flagella, cytokinesis defects and ‘big‐eye’ phenotype. All four compounds either matched or marginally increased the toxicity of SHAM when used in combination against <jats:italic>Trypanosoma brucei</jats:italic>. However, the compounds exhibited mostly an antagonistic relationship with SHAM rather than synergistic. This research highlights the potential of small molecule glycerol analogues for their combination use with SHAM for the treatment of parasitic disease, such as trypanosomiasis.","PeriodicalId":9831,"journal":{"name":"ChemistryOpen","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142218881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
ChemistryOpenPub Date : 2024-09-10DOI: 10.1002/open.202400166
Hengameh Farahmandazad, Simone Asperti, Ruud Kortlever, Earl Goetheer, Wiebren de Jong
{"title":"Effect of Halide Anions on Electrochemical CO2 Reduction in Non‐Aqueous Choline Solutions using Ag and Au Electrodes","authors":"Hengameh Farahmandazad, Simone Asperti, Ruud Kortlever, Earl Goetheer, Wiebren de Jong","doi":"10.1002/open.202400166","DOIUrl":"https://doi.org/10.1002/open.202400166","url":null,"abstract":"In this study, the effect of halide anions on the selectivity of the CO<jats:sub>2</jats:sub> reduction reaction to CO was investigated in choline‐based ethylene glycol solutions containing different halides (ChCl : EG, ChBr : EG, ChI : EG). The CO<jats:sub>2</jats:sub>RR was studied using silver (Ag) and gold (Au) electrodes in a compact H‐cell. Our findings reveal that chloride effectively suppresses the hydrogen evolution reaction and enhances the selectivity of carbon monoxide production on both Ag and Au electrodes, with relatively high selectivity values of 84 % and 62 %, respectively. Additionally, the effect of varying ethylene glycol content in the choline chloride‐containing electrolyte (ChCl : EG 1 : X, X=2, 3, 4) was investigated to improve the current density during CO<jats:sub>2</jats:sub>RR on the Ag electrode. We observed that a mole ratio of 1 : 4 exhibited the highest current density with a comparable faradaic efficiency toward CO. Notably, an evident surface reconstruction process took place on the Ag surface in the presence of Cl<jats:sup>−</jats:sup> ions, whereas on Au, this phenomenon was less pronounced. Overall, this study provides new insights into anion‐induced surface restructuring of Ag and Au electrodes during CO<jats:sub>2</jats:sub>RR, and its consequences on the reduction performance on such surfaces in non‐aqueous electrolytes.","PeriodicalId":9831,"journal":{"name":"ChemistryOpen","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142218882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
ChemistryOpenPub Date : 2024-09-09DOI: 10.1002/open.202400174
Md Kawsar, Md Sahadat Hossain, Sumaiya Akter, Md Farhad Ali, Newaz Mohammed Bahadur, Samina Ahmed
{"title":"Synthesis and Characterization of Nano-Crystallite Triple Super Phosphate (TSP) from Marine Mollusk Waste: Babylonia japonica, Oliva sayana, and Conasprella bermudensis.","authors":"Md Kawsar, Md Sahadat Hossain, Sumaiya Akter, Md Farhad Ali, Newaz Mohammed Bahadur, Samina Ahmed","doi":"10.1002/open.202400174","DOIUrl":"https://doi.org/10.1002/open.202400174","url":null,"abstract":"<p><p>The study aims to synthesize nano-crystallite TSP using renewable, low-cost, waste marine mollusk from three different species such as Babylonia japonica, Oliva sayana, and Conasprella bermudensis. The molar ratio of phosphate to calcium in triple superphosphate [TSP, Ca(H<sub>2</sub>PO<sub>4</sub>)<sub>2</sub>.H<sub>2</sub>O] significantly impacts its properties and fertilizer performance, in this case, we kept the ratio to 2. Raw TSP has a high phosphate content and lower calcium content. The synthesized TSP was analyzed using various techniques including TGA, XRD, EDX, FT-IR, and SEM. The study utilized multiple XRD model equations to analyze crystallite size ( <math> <semantics><mrow><mo><</mo> <mn>100</mn> <mspace></mspace> <mspace></mspace> <mi>n</mi> <mi>m</mi></mrow> <annotation>${char60 100hskip0.17emhskip0.17em{rm n}{rm m}}$</annotation> </semantics> </math> ), with all models except the Liner straight-line method providing higher estimates for synthesized TSP. Furthermore, the values for stress (2×10<sup>7</sup> to 4×10<sup>7</sup> N/m<sup>2</sup>), strain (4×10<sup>-4</sup> to 9×10<sup>-4</sup>), as well as energy density (4.54×10<sup>3</sup> to 16.27×10<sup>3</sup> J/m<sup>3</sup>) were also calculated for the synthesized product. However, the preferential growth calculation indicates that (010), (021), and (020) planes are the most thermodynamically stable planes for the growth of the synthesized TSP. Apart from that, FTIR result confirms that CaO, -OH, as well as PO<sub>4</sub> <sup>3-</sup> functional groups are present in the synthesized products. This research suggests that marine mollusks can be utilized as a calcium precursor for P-fertilizer and 60 % phosphoric acid, thereby reducing production costs by eliminating additional dehydrating. Additionally, waste marine mollusk shells could be utilized as an alternative to the production of phosphate-based fertilizer.</p>","PeriodicalId":9831,"journal":{"name":"ChemistryOpen","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142153241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
ChemistryOpenPub Date : 2024-09-09DOI: 10.1002/open.202400052
Dr. Claudia Aguilar, Mayra García, Dr. Carlos Montalvo, Francisco Anguebes, Dr. Mohamed Abatal, Dr. Julia Cerón, Dr. Rosa Cerón, Dr. Sandra Figueroa, Dr. Alejandro Ruiz, Dr. Marcela Rangel
{"title":"The Staged Photocatalytic Reactor in the Removal of Acetaminophen: Aspects of Adsorption and Photocatalysis","authors":"Dr. Claudia Aguilar, Mayra García, Dr. Carlos Montalvo, Francisco Anguebes, Dr. Mohamed Abatal, Dr. Julia Cerón, Dr. Rosa Cerón, Dr. Sandra Figueroa, Dr. Alejandro Ruiz, Dr. Marcela Rangel","doi":"10.1002/open.202400052","DOIUrl":"10.1002/open.202400052","url":null,"abstract":"<p>The efficiency of a staged photocatalytic reactor prototype was evaluated on a semi-pilot scale with the removal of acetaminophen, for which anatase particles were synthesized by Sol-Gel and impregnated on rectangular plates of clay. X-ray diffraction and Energy Dispersive X-ray Fluorescence patterns show that the final composite is made up of Al<sub>2</sub>O<sub>3</sub> (14 %), SiO<sub>2</sub> (41 %), CaO (3 %) TiO<sub>2</sub> (34 %), and Fe<sub>2</sub>O<sub>3</sub> (7 %). The impregnation method favors the dispersion of Anatase on the surface of the adsorbent. TiO<sub>2</sub>-Anatase/Clay, classified as a macro-porous solid with H3-type hysteresis loops by N<sub>2</sub> physisorption. Adsorption processes are improved when using TiO<sub>2</sub>-Anatase/Clay compared to using TiO<sub>2</sub>-Anatase. The external mass transfer has a greater influence on the removal rate. The dimensionless parameters of the Biot number indicate there are no limitations due to the diffusive effect on the interior of the particle. The evaluation of the kinetic data under the Langmuir-Hinshelwood equation shows a decrease in efficiency as the initial concentration increases. The acetaminophen molecule shows destabilization in the structure of the aromatic ring with a visible decrease in the signals of this functional group evaluated by High-Performance Liquid Chromatography and Raman Spectroscopy.</p>","PeriodicalId":9831,"journal":{"name":"ChemistryOpen","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/open.202400052","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142153242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
ChemistryOpenPub Date : 2024-09-09DOI: 10.1002/open.202400185
Ramin Javahershenas, Jianlin Han, Mosstafa Kazemi, Peter J Jervis
{"title":"Recent Advances in the Application of 2-Aminobenzothiazole to the Multicomponent Synthesis of Heterocycles.","authors":"Ramin Javahershenas, Jianlin Han, Mosstafa Kazemi, Peter J Jervis","doi":"10.1002/open.202400185","DOIUrl":"https://doi.org/10.1002/open.202400185","url":null,"abstract":"<p><p>Heterocycles are a vital class of compounds in numerous fields, including drug discovery, agriculture, and materials science. Efficient methods for the synthesis of heterocycles remain critical for meeting the demands of these industries. Recent advances in multicomponent reactions (MCRs) utilizing 2-aminobenzothiazole (ABT) have shown promising results for the formation of heterocycles. The versatility of 2-aminobenzothiazole in this context has enabled the rapid and efficient construction of diverse heterocyclic structures. Various synthetic methodologies and reactions involving 2-aminobenzothiazole are discussed, highlighting its importance as a valuable building block in the synthesis of complex heterocycles. The potential applications of these heterocycles in drug discovery and material science are also explored. Overall, this review provides a comprehensive overview of the current state of research in the field and offers insights into the future directions of this promising area of study. We highlight the potential of ABT as a versatile and sustainable starting material in heterocyclic synthesis via MCRs, with significant implications for the chemical industry.</p>","PeriodicalId":9831,"journal":{"name":"ChemistryOpen","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142153240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
ChemistryOpenPub Date : 2024-09-09DOI: 10.1002/open.202400127
Yuanyong Yao, Tao Wu, Meng Zhang, Daihua Fu, Hai Yang, Shixue Chen
{"title":"An Improved Test Method for Assaying the Inhibition of Bioflavonoids on Xanthine Oxidase Activity in vitro.","authors":"Yuanyong Yao, Tao Wu, Meng Zhang, Daihua Fu, Hai Yang, Shixue Chen","doi":"10.1002/open.202400127","DOIUrl":"https://doi.org/10.1002/open.202400127","url":null,"abstract":"<p><p>The difference on inhibitory effects of bioflavonoids inhibiting XOD activity assayed by varying test methods cause of us to be further in consideration. The reported test method creating a micro-environment surrounding XOD in the absence of ⋅O<sub>2</sub> <sup>-</sup>, which is seemly different from the assay in vivo. So, the vitro test method for assaying XOD activity is necessary to be improved for selection of potential inhibitors in the presence of ⋅O<sub>2</sub> <sup>-</sup>. The inhibitory results demonstrated that bioflavonoids of MY, DMY, QUE and LUT are capable to be on effective IC<sub>50</sub> values, but others are not. As well, their resulting inhibitions determined by the improved test method are much less than that reported in the literature, indicating that their chemical affinities with XOD become weaker. Moreover, DMY assayed on the inhibitions of XOD in the improved test method performs to be a better inhibitor, as compared to the assay of the reported test methods. Abasing on the transformation of DMY into MY in the presence of ⋅O<sub>2</sub> <sup>-</sup>, the good inhibition of DMY on XOD activity can be explained by the synergistic effect of MY.</p>","PeriodicalId":9831,"journal":{"name":"ChemistryOpen","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142153226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Medicinal Perspective of 2,4-Thiazolidinediones Derivatives: An Insight into Recent Advancements.","authors":"Sneha Gupta, Sumeet Jha, Supriya Rani, Pinky Arora, Shubham Kumar","doi":"10.1002/open.202400147","DOIUrl":"https://doi.org/10.1002/open.202400147","url":null,"abstract":"<p><p>2,4-Thiazolidinedione derivatives represent nitrogen-containing heterocyclic compounds utilized in type 2 diabetes mellitus management. Recent advances in medicinal chemistry have unveiled diverse therapeutic potentials and structural modifications of these derivatives. This review delves into novel TZD derivatives, encompassing their synthesis, structure-activity relationships, and pharmacokinetic profiles. Various therapeutic potentials of TZDs are explored, including anticancer, antimicrobial, anti-inflammatory, antioxidant, anticonvulsant, antihyperlipidemic, anticorrosive, and antitubercular activities. Additionally, it addresses mitigating side effects associated with marketed TZD derivatives such as weight gain, oedema, fractures, and congestive heart failure in type 2 diabetes mellitus management. The review elaborates on in vivo, in vitro, and ex vivo studies supporting different biological activities, alongside predicting ADME and drug-likeness properties of TZDs. Computational studies are also integrated to elucidate binding modes and affinities of novel TZD derivatives. Furthermore, a plethora of novel TZD derivatives with varied and enhanced therapeutic potentials are presented, warranting further evaluation of their biological activities.</p>","PeriodicalId":9831,"journal":{"name":"ChemistryOpen","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142153239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
ChemistryOpenPub Date : 2024-09-09DOI: 10.1002/open.202400203
Buzuayehu Abebe, Bontu Kefale, Guta Amenu, Leta Guta, C R Ravikumar, Taymour A Hamdalla, S Giridhar Reddy, Dereje Tsegaye, H C Ananda Murthy
{"title":"Cobalt-Doped ZnO Nanocomposits for Efficient Dye Degradation: Charge Transfer.","authors":"Buzuayehu Abebe, Bontu Kefale, Guta Amenu, Leta Guta, C R Ravikumar, Taymour A Hamdalla, S Giridhar Reddy, Dereje Tsegaye, H C Ananda Murthy","doi":"10.1002/open.202400203","DOIUrl":"https://doi.org/10.1002/open.202400203","url":null,"abstract":"<p><p>Doping enhances the optical properties of high-band gap zinc oxide nanoparticles (ZnO NPs), essential for their photocatalytic activity. We used the combustion approach to synthesize cobalt-doped ZnO heterostructure (CDZO). By creating a mid-edge level, it was possible to tune the indirect band gap of the ZnO NPs from 3.1 eV to 1.8 eV. The red shift and reduction in the intensity of the photoluminescence (PL) spectra resulted from hindrances in electron-hole recombination and sp-d exchange interactions. These improved optical properties expanded the absorption of solar light and enhanced charge transfer. The field emission scanning electron microscopy (FESEM) image and elemental mapping analysis confirmed the CDZO's porous nature and the dopant's uniform distribution. The porosity, nanoscale size (25-55 nm), and crystallinity of the CDZO were further verified by high-resolution transmission electron microscopy (HRTEM) and selected area electron image analysis. The photocatalytic activity of the CDZO exhibited much greater efficiency (k=0.131 min<sup>-1</sup>) than that of ZnO NPs (k=0.017 min<sup>-1</sup>). Therefore, doped heterostructures show great promise for industrial-scale environmental remediation applications.</p>","PeriodicalId":9831,"journal":{"name":"ChemistryOpen","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142153227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
ChemistryOpenPub Date : 2024-09-09DOI: 10.1002/open.202480901
Dr. Takashi Nomura, Prof. Eiji Minami, Prof. Haruo Kawamoto
{"title":"Front Cover: Microwave Effect in Hydrolysis of Levoglucosan with a Solid Acid Catalyst for Pyrolysis-Based Cellulose Saccharification (ChemistryOpen 9/2024)","authors":"Dr. Takashi Nomura, Prof. Eiji Minami, Prof. Haruo Kawamoto","doi":"10.1002/open.202480901","DOIUrl":"https://doi.org/10.1002/open.202480901","url":null,"abstract":"<p><b>The front cover</b> shows the pyrolysis-based saccharification of cellulosic biomass such as wood, which consists of levoglucosan production by fast pyrolysis followed by hydrolysis of levoglucosan to glucose as a key intermediate for the production of biochemicals and biofuels. In this study, levoglucosan is efficiently hydrolyzed to glucose by solid acid catalyst under microwave irradiation. More details can be found in the Research Article by Haruo Kawamoto, Takashi Nomura, and Eiji Minami (DOI: 10.1002/open.202300311).<figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure>\u0000 </p>","PeriodicalId":9831,"journal":{"name":"ChemistryOpen","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/open.202480901","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142160197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}