ChemistryOpen最新文献_第4页

Simple and Rapid Microwave-Assisted Suzuki-Miyaura Cross-coupling in Betaine/Glycerol Natural Eutectic Solvent. 甜菜碱/甘油天然共晶溶剂的简单快速微波辅助Suzuki-Miyaura交联。

IF 2.5 4区化学

ChemistryOpen Pub Date : 2025-06-17 DOI: 10.1002/open.202500138

Chefikou Salami, Leslie Boudesocque-Delaye, Pierre-Olivier Delaye, Emilie Thiery

{"title":"Simple and Rapid Microwave-Assisted Suzuki-Miyaura Cross-coupling in Betaine/Glycerol Natural Eutectic Solvent.","authors":"Chefikou Salami, Leslie Boudesocque-Delaye, Pierre-Olivier Delaye, Emilie Thiery","doi":"10.1002/open.202500138","DOIUrl":"https://doi.org/10.1002/open.202500138","url":null,"abstract":"For some years now, eutectic solvents have been seen as an alternative to conventional organic solvents and ionic liquids. When the components are of natural origin, they meet the challenges of green chemistry. Although eutectic solvents are used in many synthetic reactions today, few references reported their use in microwave-assisted reactions. To explore their potential and diversify their applications, Suzuki-Miyaura coupling was studied in eutectic solvents under microwave irradiation. After optimization using a design of experiment based on response surface methodology, the most efficient conditions were found to be betaine: glycerol (1:4, mol mol-1) as eutectic solvent, PdCl2dppf.CH2Cl2 as catalyst, Na2CO3 as base, and microwave heating at 129 °C for 15 min. The results showed an increase in reactivity with very rapid reaction kinetics. Furthermore, the catalyst in the eutectic solvent was recycled, and a gram-scale reaction was performed as an example. Finally, this new methodology was evaluated using CHEM21 metrics.","PeriodicalId":9831,"journal":{"name":"ChemistryOpen","volume":" ","pages":"e2500138"},"PeriodicalIF":2.5,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144315980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Aqueous Binders for Electrochemically Stable VOPO₄ 2H₂O Anodes for Li-Ion Storage. 电化学稳定的vopo42h2o阳极用于锂离子存储的水性粘合剂。

IF 2.5 4区化学

ChemistryOpen Pub Date : 2025-06-17 DOI: 10.1002/open.202500102

Alexander Beutl, Andrea Paolella, Yuri Surace, Qixiang Jiang, Marcus Jahn, Artur Tron

{"title":"Aqueous Binders for Electrochemically Stable VOPO4 2H2O Anodes for Li-Ion Storage.","authors":"Alexander Beutl, Andrea Paolella, Yuri Surace, Qixiang Jiang, Marcus Jahn, Artur Tron","doi":"10.1002/open.202500102","DOIUrl":"https://doi.org/10.1002/open.202500102","url":null,"abstract":"The use of polyvinylidene difluoride (PVDF) binder dissolved in toxic N-methyl pyrrolidone (NMP) organic solvent needs to be decreased during the manufacturing battery process to improve safety. Therefore, the development of aqueous-based binders for negative and positive electrodes is necessary to make the production environmentally friendly. This study reports the performance of hydrothermal VOPO4 2H2O anode material in combination with aqueous-based binders such as sodium carboxymethylcellulose (CMC), polyacrylic acid (PAA) and their mixture CMC-PAA (1:1 wt%). The aqueous binders are compared to standard PVDF as a reference binder. The cells with aqueous- and PVDF-based electrodes are tested by galvanostatic, cyclic voltammetry, and electrochemical impedance spectroscopy measurements. When the CMC-PAA aqueous binder is used, the electrode displays the most stable electrochemical performances due to a uniform distribution of the VOPO4 with strong adhesion to the current collector for long-term cycle life. A stable, solid electrolyte interphase layer is formed when the mixture of CMC-PAA is used instead of a standard PVDF-based binder. In addition, these samples display stable cycling life at different rate capabilities due to the facilitated lithium-ion diffusion and electronic conductivity.","PeriodicalId":9831,"journal":{"name":"ChemistryOpen","volume":" ","pages":"e2500102"},"PeriodicalIF":2.5,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144315978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hemp-Derived Iron Oxide Nanoparticles for Biomedical Applications: Synthesis, Characterization, and Therapeutic Potential. 用于生物医学应用的大麻衍生氧化铁纳米颗粒：合成、表征和治疗潜力。

IF 2.5 4区化学

ChemistryOpen Pub Date : 2025-06-17 DOI: 10.1002/open.202500189

Nesrin Korkmaz, Rizvan İmamoğlu, Ahmet Karadağ, Ebru Şahin Yıldırım, Yusuf Ceylan, Fatih Şen

{"title":"Hemp-Derived Iron Oxide Nanoparticles for Biomedical Applications: Synthesis, Characterization, and Therapeutic Potential.","authors":"Nesrin Korkmaz, Rizvan İmamoğlu, Ahmet Karadağ, Ebru Şahin Yıldırım, Yusuf Ceylan, Fatih Şen","doi":"10.1002/open.202500189","DOIUrl":"https://doi.org/10.1002/open.202500189","url":null,"abstract":"Iron oxide nanoparticles (IONPs) have emerged as the most widely synthesized metal nanoparticles in sustainable chemistry due to their unique magnetic properties, excellent biocompatibility, biodegradability, and non-toxicity. In this study, IONPs are successfully synthesized via a rapid, sustainable, and environmentally friendly green synthesis approach using Cannabis sativa L. leaf extract. X-ray diffraction analysis determined that the synthesized NPs had an average particle size of 18.8 nm, while transmission electron microscopy images reveal a spherical morphology with sizes ranging from 12 to 21 nm. Fourier-transform infrared spectroscopy analysis confirmed the presence of cannabinoids, terpenoids, and flavonoids, which are believed to play a crucial role in the formation and stabilization of IONPs. Its photocatalytic potential is demonstrated through the degradation of bromophenol blue dye. Additionally, the NPs exhibited significant antibacterial and antifungal activity against various microbial species, along with promising anticancer effects on cancer cell lines. In conclusion, this study provides a promising foundation for advancing the large-scale, commercial production of IONPs through green synthesis methods. By offering an eco-friendly and efficient alternative to conventional nanoparticle synthesis, the findings contribute significantly to the growing body of research in sustainable nanotechnology.","PeriodicalId":9831,"journal":{"name":"ChemistryOpen","volume":" ","pages":"e2500189"},"PeriodicalIF":2.5,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144315979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neuroprotective Efficacy of Microwave-Assisted Synthetized 2-(5-Cyclopropyl-6-Thioxo-1,3,5-Thiadiazinan-3-Yl) Acetic Acid in Mitigating Cognitive Deficits in Pentylenetetrazole-Induced Mice Model. 微波辅助合成的2-（5-环丙基-6-硫氧基-1,3,5-噻二嗪-3-基）乙酸减轻戊四唑诱导的小鼠认知缺陷的神经保护作用。

IF 2.5 4区化学

ChemistryOpen Pub Date : 2025-06-17 DOI: 10.1002/open.202500083

Tahir Iqbal, Murad A Mubaraki, Ahmad Khushal, Amena Arif, Fozia Fozia, Shahid Ali Shah, Ijaz Ahmad, Rasool Khan, Najeeb Ur Rehman, Ziaullah Ziaullah

{"title":"Neuroprotective Efficacy of Microwave-Assisted Synthetized 2-(5-Cyclopropyl-6-Thioxo-1,3,5-Thiadiazinan-3-Yl) Acetic Acid in Mitigating Cognitive Deficits in Pentylenetetrazole-Induced Mice Model.","authors":"Tahir Iqbal, Murad A Mubaraki, Ahmad Khushal, Amena Arif, Fozia Fozia, Shahid Ali Shah, Ijaz Ahmad, Rasool Khan, Najeeb Ur Rehman, Ziaullah Ziaullah","doi":"10.1002/open.202500083","DOIUrl":"https://doi.org/10.1002/open.202500083","url":null,"abstract":"Oxidative stress is a major contributor to neurodegenerative diseases, triggering inflammation that ultimately leads to nerve cell death. This study aims to synthesize and characterize 2-(5-cyclopropyl-6-thioxo-1,3,5-thiadiazinan-3-yl) acetic acid COX-2 and scrutinize the neuroprotective efficacy in a pentylenetetrazole-induced mice model of epilepsy in a mice model. The compound is synthesized via microwave-assisted method and characterized by infrared, nuclear magnetic resonance, and electron ionization mass Spectroscopy. The vivo experiments involve behavioral assessments (Morris water maze and Y-maze tests) and biochemical analyses (antioxidant enzymes and inflammatory markers). Treatment with the synthesized compound significantly restores antioxidant enzyme levels (catalase, peroxidase peroxidation, superoxide dismutase, and glutathione), reduces lipid peroxidation, improves cognitive performance, and suppresses the expression of inflammatory proteins (p-JNK, TNF-α, and COX-2). These findings suggest that 2-(5-cyclopropyl-6-thioxo-1,3,5-thiadiazinan-3-yl) acetic acid possesses strong antioxidant, anti-inflammatory, and neuroprotective properties, making it a promising candidate for the treatment of oxidative stress-related neurodegenerative disorders.","PeriodicalId":9831,"journal":{"name":"ChemistryOpen","volume":" ","pages":"e2500083"},"PeriodicalIF":2.5,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144324546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synergistic Effects of K₂CO₃ and Melamine on Enhancing the Performance of Date Stone-Derived Supercapacitors. K2CO3和三聚氰胺对提高枣石基超级电容器性能的协同效应。

IF 2.5 4区化学

ChemistryOpen Pub Date : 2025-06-16 DOI: 10.1002/open.202500271

Atif Saeed Alzahrani

引用次数: 0

Nephroprotective Effects of Fraxinus Hookeri Wenz. Against Renal Toxicity and DNA Oxidative Damages Induced by CCl₄ in Rats. 黄曲霉的肾保护作用。CCl4对大鼠肾毒性及DNA氧化损伤的影响。

IF 2.5 4区化学

ChemistryOpen Pub Date : 2025-06-16 DOI: 10.1002/open.202400515

Raheela Sarwar, Bashir Ahmad, Ayman M Al-Qaaneh, Shumaila Rauf, Laiba Ahmad, Mounir M Bekhit, Said Hassan, Nadeem Ullah, Gokhan Zengin, Arshad Farid

{"title":"Nephroprotective Effects of Fraxinus Hookeri Wenz. Against Renal Toxicity and DNA Oxidative Damages Induced by CCl4 in Rats.","authors":"Raheela Sarwar, Bashir Ahmad, Ayman M Al-Qaaneh, Shumaila Rauf, Laiba Ahmad, Mounir M Bekhit, Said Hassan, Nadeem Ullah, Gokhan Zengin, Arshad Farid","doi":"10.1002/open.202400515","DOIUrl":"https://doi.org/10.1002/open.202400515","url":null,"abstract":"Recognizing the therapeutic value of the Genus Fraxinus worldwide, this study evaluates the antioxidant potential of Fraxinus hookeri Wenz. (F. hookeri) against CCl4-induced nephrotoxicity in rats. Forty-eight rats are randomly allocated into eight groups (six rats each). Antioxidant enzymes, genotoxicity, urine and serum markers, and tissue histopathology are assessed to determine their nephroprotective effects. The Control group remains untreated, while the DMSO group receives vehicle olive oil intraperitoneally and DMSO orally (3 ml/kg). All other groups, except Control and DMSO, are given CCl4 (3 ml/kg, i.p., in 30% olive oil) twice weekly for 4 weeks. The CCl4 group receives only CCl4. The Rutin group receives reference drug Rutin orally (50 mg/kg). MEFH100 and MEFH200 groups are given MEFH at 100 and 200 mg/kg, respectively, and NHFH100 and NHFH200 receive NHFH at the same doses. Rutin and F. hookeri treatment effectively (P < 0.05) restore urine and serum markers disrupted by CCl4. CCl4 reduced (p < 0.05) antioxidant enzymes (CAT, SOD, POD) and increased TBAR levels and DNA damage, which are reversed by cotreatment with F. hookeri and Rutin. Histopathological improvements (P < 0.05) are also observed with F. hookeri. The results indicate that F. hookeri enhances antioxidant defenses, supporting its potential against CCl4-induced nephrotoxicity.","PeriodicalId":9831,"journal":{"name":"ChemistryOpen","volume":" ","pages":"e2400515"},"PeriodicalIF":2.5,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144301202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Electrochemical Reduction of CO₂ in a Zero-Gap Electrolyzer Cell on a Metal Molecular Electrocatalyst. 金属分子电催化剂上零间隙电解槽中CO2的电化学还原。

IF 2.5 4区化学

ChemistryOpen Pub Date : 2025-06-16 DOI: 10.1002/open.202400488

Simphiwe L Ndlangamandla, Shankara G Radhakrishnan

引用次数: 0

Crystal Structure-Activity Relationship of Some MeO Phenylacrylonitriles: Dual Antimicrobial-Cytotoxic Effects and in Silico Perspectives. 一些MeO苯基丙烯腈的晶体结构-活性关系：双重抗菌-细胞毒作用和硅透视。

IF 2.5 4区化学

ChemistryOpen Pub Date : 2025-06-12 DOI: 10.1002/open.202500280

Leyla Babali Özen, Öner Ekici, Furkan Özen, Süleyman Berberler, Gül Özkan, Betül Yılmaz Öztürk, Pınar Oztopcu-Vatan, Cansu Filik İşçen, Günseli Turgut Cin

{"title":"Crystal Structure-Activity Relationship of Some MeO Phenylacrylonitriles: Dual Antimicrobial-Cytotoxic Effects and in Silico Perspectives.","authors":"Leyla Babali Özen, Öner Ekici, Furkan Özen, Süleyman Berberler, Gül Özkan, Betül Yılmaz Öztürk, Pınar Oztopcu-Vatan, Cansu Filik İşçen, Günseli Turgut Cin","doi":"10.1002/open.202500280","DOIUrl":"https://doi.org/10.1002/open.202500280","url":null,"abstract":"Herein, methoxy-substituted phenylacrylonitrile derivatives 2(a-c) are synthesized via Knoevenagel condensation and characterized using fourier-transform infrared spectroscopy, nuclear magnetic resonance spectroscopy, and X-ray crystallography (for 2a and 2b). Although compounds 2a and 2b have previously been reported in terms of their structural features, their dual antimicrobial and anticancer activities, as well as crystallographic structure-activity relationships, have not yet been investigated. Notably, no earlier studies assessed their selective cytotoxicity using both cancerous (MCF-7) and healthy (L929) cell lines-a gap addressed in this work. Molecular docking analyzes reveal strong binding affinities to biological targets, including penicillin binding protein 2 (PBP2) (-8.4 kcal mol-1 for 2c) and CDK1/Cks2 (-9.5 kcal mol-1 for 2c), highlighting their dual-action potential. Antimicrobial assays against nine bacterial strains show minimum inhibitory concentration values ranging from 2.5 to 25 mg mL-1, with 2c exhibiting notable activity against gram-positive bacteria. Cytotoxicity assays demonstrate potent effects against MCF-7 cells (IC50: 34 μM for 2b, 44 μM for 2a), while 2c shows broader but moderate activity. The integration of crystallographic, docking, and biological assays underscores the therapeutic potential of these derivatives, with 2(a,b) emerging as selective candidates for breast cancer treatment.","PeriodicalId":9831,"journal":{"name":"ChemistryOpen","volume":" ","pages":"e2500280"},"PeriodicalIF":2.5,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144282671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Design, Synthesis, Biological Evaluation, and In Silico Study of Tetrahydropyridines as Prospective Monoamine Oxidase Inhibitors. 四氢吡啶作为前瞻性单胺氧化酶抑制剂的设计、合成、生物学评价和硅研究。

IF 2.5 4区化学

ChemistryOpen Pub Date : 2025-06-12 DOI: 10.1002/open.202400516

Obaid Ur Rehman Khan, Bilal Ahmad Khan, Syeda Shamila Hamdani, Saquib Jalil, Peter A Sidhom, Khalid Elfaki Ibrahim, Tarad Abalkhail, Jamshed Iqbal, Hatem Tallima, Tamer Shoeib, Mahmoud A A Ibrahim

{"title":"Design, Synthesis, Biological Evaluation, and In Silico Study of Tetrahydropyridines as Prospective Monoamine Oxidase Inhibitors.","authors":"Obaid Ur Rehman Khan, Bilal Ahmad Khan, Syeda Shamila Hamdani, Saquib Jalil, Peter A Sidhom, Khalid Elfaki Ibrahim, Tarad Abalkhail, Jamshed Iqbal, Hatem Tallima, Tamer Shoeib, Mahmoud A A Ibrahim","doi":"10.1002/open.202400516","DOIUrl":"https://doi.org/10.1002/open.202400516","url":null,"abstract":"The potentiality of monoamine oxidase (MAO) enzymes to break monoamine neurotransmitters makes them efficacious druggable targets. Molecules having MAO-A inhibition characteristics are utilized as antidepressants while molecules with MAO-B inhibition prospective are utilized to treat Parkinson's and Alzheimer's diseases. Herein, we have shown how the selective inhibition of both isozymes can be attained by varying the substitution of electron-withdrawing and donating groups on the phenyl rings of tetrahydropyridines, i. e., ethyl 1,2,6-triaryl-4-(arylamino)-1,2,5,6-tetrahydropyridine-3-carboxylate (4 a-4 o). The structures of these piperidines (4 a-4 o) were unambiguously established by different spectro-analytical techniques, including 1H- and 13C-NMR. Among the synthesized compounds, compounds 4 l and 4 n were identified as the most promising inhibitors of MAO-A and MAO-B, with IC50 values of 0.40±0.05 and 1.01±0.03 μM, respectively, compared with positive controls, namely clorgyline and l-deprenyl, with IC50 values of 0.0045±0.0003 and 0.0196±0.001 μM, respectively. The binding interactions of the most potent derivatives within the binding pocket of the MAO-A and MAO-B enzymes were predicted by molecular docking studies. Binding mode analysis revealed the capacity of compounds 4 l and 4 n to exhibit a hydrogen bond with PHE177 of MAO-A and GLN206 of MAO-B, respectively.","PeriodicalId":9831,"journal":{"name":"ChemistryOpen","volume":" ","pages":"e202400516"},"PeriodicalIF":2.5,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144282672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Efficient Synthesis of 1-Chloroimidazo[1,2-a:4,5-c']dipyridines, Versatile Synthons for Position-1 Functionalisation with Various Reagents. 1-氯咪唑[1,2-a:4,5-c']二吡啶的高效合成：1位功能化的多用途试剂

IF 2.5 4区化学

ChemistryOpen Pub Date : 2025-06-12 DOI: 10.1002/open.202500178

Romain Dussart, Mélanie Pénichon, Pierre-Olivier Delaye, Cécile Enguehard-Gueiffier

引用次数: 0