偶氮苯DNA插入剂/环糊精伪轮烷：从光开关手性和荧光到DNA熔化控制。

IF 3.1 4区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

ChemistryOpen Pub Date : 2025-08-20 DOI:10.1002/open.202500382

Olivier Abodja, Astrid Walrant, Sergii Rudiuk, Mathieu Morel, Damien Baigl

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引用次数: 0

摘要

伪轮烷是可逆互锁的分子，至少有一个线性分子螺纹成一个大环，与轮烷相反，具有有利的解离能力。环糊精因其低聚糖性质、圆锥形状、两亲性和生物相容性等特点，构成了吸引大环宿主构建这种动态结构的物质。本研究表明，使用偶氮苯DNA插入物作为客体，可以构建具有几种显著性质的伪轮烷，包括光控组装/拆卸、光可逆手性和荧光，以及通过插入物主客体络合影响双链DNA熔化温度的能力。

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Azobenzene DNA Intercalator/Cyclodextrin Pseudo-Rotaxane: From Photoswitchable Chirality and Fluorescence to DNA Melting Control.

Pseudo-rotaxanes are reversibly interlocked molecules with at least one linear molecule threaded into a macrocycle and, contrary to rotaxanes, an advantageous ability to be dissociated. Cyclodextrins constitute attracting macrocyclic host entities to build such dynamic structures for their oligosaccharide nature, conic shape, amphiphilic character and biocompatibility. Here we show that using an azobenzene DNA intercalator as a guest allows to build a pseudo-rotaxane combining several remarkable properties, including light-controlled assembly/disassembly, photoreversible chirality and fluorescence, as well as the capability to affect the melting temperature of double-stranded DNA through intercalator host-guest complexation.

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来源期刊

ChemistryOpen CHEMISTRY, MULTIDISCIPLINARY-

CiteScore

4.80

自引率

4.30%

发文量

143

审稿时长

1 months

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