Synthesis and Characterization of Co(II), Cu(II), and Ni(II) Complexes of 2,2'-Bipyridine-4,4'-Dicarboxamide Ligands: Antibacterial Evaluation Against Resistant Bacteria and Enzyme Inhibition.

IF 2.5 4区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

ChemistryOpen Pub Date : 2025-06-09 DOI:10.1002/open.202500097

Hussein Alchurak, Aseel Almadhoun, İsmail Yılmaz, Raneem Mamoun Ali Nour, Müslüm Kuzu, Hasan Solmaz

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引用次数: 0

Abstract

In this study, two new 2,2'-bipyridine-4,4'-dicarboxamide ligands, namely N4,N4'-bis(pyridin-2-ylmethyl)-[2,2'-bipyridine]-4,4'-dicarboxamide (L1) and N4,N4'-bis(piperidin-2-ylmethyl)-[2,2'-bipyridine]-4,4'-dicarboxamide (L2), and their Co(II), Cu(II), and Ni(II) complexes are synthesized and characterized. Elemental analysis, Fourier transform infrared spectroscopy, nuclear magnetic resonance, and mass techniques confirmed the structures of the synthesized compounds. The L1 structure is also determined by single-crystal X-ray diffraction. Antibacterial activities of ligands and metal complexes against resistant strains are investigated. The L2-Co complex demonstrates promising antibacterial qualities against these resistant strains, which is noteworthy. Additionally, enzyme inhibition studies are conducted to assess their potential therapeutic applications. The results show that the L2-Ni complex had the strongest inhibitory effect with IC₅₀ values of 1.35 μM for lipase enzyme, 4.33 μM for acetylcholinesterase enzyme, and 6.42 μM for butyrylcholinesterase.

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2,2′-联吡啶-4,4′-二甲酰胺配体Co（II）、Cu（II）和Ni（II）配合物的合成与表征：对耐药菌的抗菌评价及酶抑制作用

本研究合成了两种新的2,2′-联吡啶-4,4′-二羧基酰胺配体，即N4，N4′-双（吡啶-2-甲基）-[2,2′-联吡啶]-4,4′-二羧基酰胺（L1）和N4，N4′-双（吡啶-2-基甲基）-[2,2′-联吡啶]-4,4′-二羧基酰胺（L2）及其Co（II）、Cu（II）和Ni（II）配合物。元素分析、傅里叶变换红外光谱、核磁共振和质量技术证实了合成化合物的结构。L1的结构也由单晶x射线衍射测定。研究了配体和金属配合物对耐药菌株的抑菌活性。值得注意的是，L2-Co复合物对这些耐药菌株具有良好的抗菌特性。此外，进行酶抑制研究以评估其潜在的治疗应用。结果表明，L2-Ni配合物对脂肪酶、乙酰胆碱酯酶和丁基胆碱酯酶的IC50值分别为1.35 μM、4.33 μM和6.42 μM，具有最强的抑制作用。

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来源期刊

ChemistryOpen CHEMISTRY, MULTIDISCIPLINARY-

CiteScore

4.80

自引率

4.30%

发文量

143

审稿时长

1 months

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