ChemistryOpen最新文献_第6页

Evaluation of the Antioxidant, Anticancer, and Antibacterial Activities of Flower and Leaf Extracts of Chrysanthemum indicum. 菊花花和叶提取物的抗氧化、抗癌和抗菌活性评价。

IF 2.5 4区化学

ChemistryOpen Pub Date : 2025-06-05 DOI: 10.1002/open.202500252

Tarad Abalkhail, Noorah A Alkubaisi, Ibrahim M Aziz, Mashail Fahad Alsayed, Hissah Abdulrahman Alodaini, Amal Saad Al-Shenifi, Mohamed A Farrag

{"title":"Evaluation of the Antioxidant, Anticancer, and Antibacterial Activities of Flower and Leaf Extracts of Chrysanthemum indicum.","authors":"Tarad Abalkhail, Noorah A Alkubaisi, Ibrahim M Aziz, Mashail Fahad Alsayed, Hissah Abdulrahman Alodaini, Amal Saad Al-Shenifi, Mohamed A Farrag","doi":"10.1002/open.202500252","DOIUrl":"https://doi.org/10.1002/open.202500252","url":null,"abstract":"Chrysanthemum has been studied for its anti-inflammatory, antibacterial, anticancer, antioxidant, and other pharmacological properties. However, there is little knowledge about the methanol-pharmaceutical activities of Chrysanthemum indicum leaves and flowers. This study is designed to assess the in vitro antioxidant, anticancer, and antibacterial activities of C. indicum extracts. The flowers and leaves of C. indicum are extracted. Gas chromatography-mass spectrometry is used to analyze the chemical components. The antioxidant activity is evaluated using 2,2-diphenyl-1-picrilhidrazine (DPPH) and 2,2'-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) assays. Cytotoxic effect against A549 cell line is identified. The antibacterial properties are evaluated against both Gram-positive and Gram-negative bacteria. Antioxidant activity is detected and observed to be maximum at higher concentrations. The IC50 values of flowers and leaves are 77.19 ± 2.4 and 101.94 ± 2.34 μg mL-1, respectively, in the DPPH method, whereas the ABTS assay shows 93.21 ± 3.42 and 98.22 ± 3.34 μg mL-1, respectively. The flower extract has more cytotoxic activity than the leaves (P < 0.05). The IC50 values for flowers and leaves are 72.49 ± 3.14 and 102.54 ± 4.17 μg mL-1, respectively. Furthermore, the flower and leaf extracts exhibit the most pronounced antibacterial activity. These results provide a strong basis for further research into its potential therapeutic uses as well as opportunities for the creation of natural pharmaceutical products.","PeriodicalId":9831,"journal":{"name":"ChemistryOpen","volume":" ","pages":"e2500252"},"PeriodicalIF":2.5,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144233341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Porous CeO₂/CuO Heterostructure for Efficient Hydrogen Evolution Reaction in an Acidic Medium. 酸性介质中高效析氢反应的多孔CeO2/CuO异质结构

IF 2.5 4区化学

ChemistryOpen Pub Date : 2025-06-05 DOI: 10.1002/open.202500115

Binod Raj Kc, Samira Munkaila, Bishnu Prasad Bastakoti

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β-Cyclodextrin Inclusion Complexes with Model Pentapeptides: Role of the Tyrosine Position within the Peptide Chain. 具有模型五肽的β-环糊精包合物：酪氨酸在肽链中的作用。

IF 2.5 4区化学

ChemistryOpen Pub Date : 2025-06-05 DOI: 10.1002/open.202500223

Martina Dragone, Gianluca D'Abrosca, Antonia D'Aniello, Domenico Alberga, Getasew Shitaye, Rinaldo Grazioso, Stefano Tomassi, Luigi Russo, Roberto Fattorusso, Salvatore Di Maro, Giuseppe F Mangiatordi, Michele Saviano, Gaetano Malgieri, Carla Isernia, Rosa Iacovino

{"title":"β-Cyclodextrin Inclusion Complexes with Model Pentapeptides: Role of the Tyrosine Position within the Peptide Chain.","authors":"Martina Dragone, Gianluca D'Abrosca, Antonia D'Aniello, Domenico Alberga, Getasew Shitaye, Rinaldo Grazioso, Stefano Tomassi, Luigi Russo, Roberto Fattorusso, Salvatore Di Maro, Giuseppe F Mangiatordi, Michele Saviano, Gaetano Malgieri, Carla Isernia, Rosa Iacovino","doi":"10.1002/open.202500223","DOIUrl":"https://doi.org/10.1002/open.202500223","url":null,"abstract":"Peptide's applications frequently present problems of solubility, stability, activity, or membrane permeability. To overcome these issues, cyclodextrins (CDs) can be used to form inclusion complexes with peptide hydrophobic parts; alkyl-chains or aromatic-rings inclusion strongly influences the interacting peptide properties. The study of model tripeptides has revealed that, among the three aromatic amino acids, tyrosine is the best suited to be included within CDs. The interaction with β-CD of five model peptides (Tyr1-5), each constituted by one tyrosine and four alanines, is reported: the tyrosine occupies one of the five position within each peptide chain. Among natural CDs, β-CD has been chosen as it is the most economic, used, and only moderately toxic; its cavity size is the best suited to accommodate the tyrosine ring. Stoichiometry and affinity of each complex are evaluated and in silico and experimental data to describe the molecular determinants of each interaction are combined. The data further defines the role of the aromatic ring position in dictating the stability of formed complexes and demonstrates Tyr3, with its central Tyr, as the most stable complex. Noteworthy, the interaction with β-CD induces Tyr3 to assume a U-shaped conformation representing a nice example of conformation stabilization upon formation of inclusion complexes.","PeriodicalId":9831,"journal":{"name":"ChemistryOpen","volume":" ","pages":"e2500223"},"PeriodicalIF":2.5,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144233343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Front Cover: Flexible Screen-Printed Electrochemical Sensor for Alkaline Phosphatase Detection in Biofluids for Biomedical Applications (ChemistryOpen 6/2025) 封面：用于生物医学应用的生物体液中碱性磷酸酶检测的柔性丝网印刷电化学传感器（chemyopen 6/2025）

IF 2.5 4区化学

ChemistryOpen Pub Date : 2025-06-04 DOI: 10.1002/open.202580601

Panagiota M. Kalligosfyri, Antonella Miglione, Alessia Esposito, Raghad Alhardan, Gabriella Iula, Iclal Atay, Ibrahim A. Darwish, Sevinc Kurbanoglu, Stefano Cinti

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Asymmetric Ketocyanine Dyes with an Extended Polymethine Chain. 具有延伸聚甲基链的不对称酮菁染料。

IF 2.5 4区化学

ChemistryOpen Pub Date : 2025-06-04 DOI: 10.1002/open.202500096

Sviatoslava O Melnychuk, Sergii V Popov, Serhii B Babii, Andrii V Kulinich

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Ibuprofen-Functionalized Alkyl α-hydroxy Methacrylate-Based Polymers. 布洛芬功能化烷基α-羟基甲基丙烯酸酯基聚合物。

IF 2.5 4区化学

ChemistryOpen Pub Date : 2025-06-04 DOI: 10.1002/open.202500038

Burcu Balaban, Seckin Altuncu, Aleyna Esenturk, Simay Denizkusu, Ece Sabuncu, Hande Sipahi, Duygu Avci

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CORRIGENDUM TO: Enzyme-Substrate Complex Formation and Electron Transfer in Nitrogenase-Like Dark-Operative Protochlorophyllide Oxidoreductase (DPOR). 勘误表：酶-底物复合物的形成和电子转移在氮酶样暗操作原叶绿内酯氧化还原酶（DPOR）。

IF 2.5 4区化学

ChemistryOpen Pub Date : 2025-06-01 DOI: 10.1002/open.202500275

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Quantifying Molecular Properties of Hexagonal Water Clusters. 六方水团簇的分子性质定量分析。

IF 2.5 4区化学

ChemistryOpen Pub Date : 2025-06-01 DOI: 10.1002/open.202500149

Giuseppe Lanza

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The Impact of Conjugation Mode and Site on Tubulysin Antibody-Drug-Conjugate Efficacy and Stability. 偶联方式和位点对微管溶素抗体-药物偶联效力和稳定性的影响。

IF 2.5 4区化学

ChemistryOpen Pub Date : 2025-05-28 DOI: 10.1002/open.202400522

Sayumi Yamazoe, Qinqin Cheng, Srikanth Kotapati, Vangipuram S Rangan, Mei-Chen Sung, Madhura Deshpande, Aarti Jashnani, Cong Qiang, Michael J Smith, Chin Pan, Gavin Dollinger, Arvind Rajpal, Pavel Strop, Chetana Rao

{"title":"The Impact of Conjugation Mode and Site on Tubulysin Antibody-Drug-Conjugate Efficacy and Stability.","authors":"Sayumi Yamazoe, Qinqin Cheng, Srikanth Kotapati, Vangipuram S Rangan, Mei-Chen Sung, Madhura Deshpande, Aarti Jashnani, Cong Qiang, Michael J Smith, Chin Pan, Gavin Dollinger, Arvind Rajpal, Pavel Strop, Chetana Rao","doi":"10.1002/open.202400522","DOIUrl":"https://doi.org/10.1002/open.202400522","url":null,"abstract":"Antibody-drug conjugates (ADCs) represent a prominent class of biotherapeutics engineered to selectively deliver cytotoxic payloads to tumors, thereby facilitating targeted cell killing. While first-generation ADCs, created by conjugating payloads to surface-accessible lysine or hinge-cysteine residues, have achieved clinical success, several site-specific ADCs with defined drug-to-antibody ratios are currently under clinical investigation. Herein, the efficacy, stability, and pharmacokinetics of ADCs generated by attaching the drug linker to surface-exposed lysine residues, hinge-cysteine residues, and the C'E loop in the CH2 domain (mediated by bacterial transglutaminase) using a tubulysin payload are compared. In N87 xenograft mice, the order of efficacy is C'E loop > hinge-cysteine > lysine-conjugated ADCs. Among the three ADCs evaluated, the site-specific ADC demonstrates superior in vivo stability (minimal payload-linker deconjugation and limited payload metabolism/deacetylation) and favorable pharmacokinetics (longer half-life, low clearance, high exposure). In contrast, the lysine-conjugated ADC exhibits the least stability and poorest pharmacokinetics, which directly correlate with its efficacy. Further investigation into cysteine-engineered site-specific ADCs with payloads conjugated at various sites confirms that both the conjugation chemistry and the site of conjugation significantly influence the in vivo stability and pharmacokinetics of site-specific ADCs.","PeriodicalId":9831,"journal":{"name":"ChemistryOpen","volume":" ","pages":"e2400522"},"PeriodicalIF":2.5,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144157055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Hybrid Perovskite Solar Cells: A Disruptive Technology for Hydrogen Production through Photocatalytic Water Splitting. 混合钙钛矿太阳能电池：一种颠覆性的光催化水分解制氢技术。

IF 2.5 4区化学

ChemistryOpen Pub Date : 2025-05-24 DOI: 10.1002/open.202500181

S Akin Olaleru, Nithyadharseni Palaniyandy, Bhekie B Mamba, Bonex W Mwakikunga

{"title":"Hybrid Perovskite Solar Cells: A Disruptive Technology for Hydrogen Production through Photocatalytic Water Splitting.","authors":"S Akin Olaleru, Nithyadharseni Palaniyandy, Bhekie B Mamba, Bonex W Mwakikunga","doi":"10.1002/open.202500181","DOIUrl":"https://doi.org/10.1002/open.202500181","url":null,"abstract":"Perovskite solar cells (PSCs) have recently emerged as a viable technology for photovoltaic applications, offering high efficiency and cost-effective manufacturing. Beyond generating electricity, PSCs can also facilitate hydrogen production through water splitting. This article provides a comprehensive review of current research on PSCs for hydrogen production, highlighting their potential as a transformative technology in this field. The challenges and opportunities associated with using PSCs for hydrogen production are discussed, including their stability and efficiency under various operating conditions. The impact of device design, system integration, and materials engineering on PSC performance for hydrogen production is also examined. Furthermore, an overview of hydrogen demand is provided and how PSCs can be integrated with other renewable energy sources to contribute to a sustainable energy future through green hydrogen production is explored. The analysis suggests that hydrogen production using PSCs has the potential to become a groundbreaking technology, significantly impacting the energy sector and the transition to low-carbon energy.","PeriodicalId":9831,"journal":{"name":"ChemistryOpen","volume":" ","pages":"e2500181"},"PeriodicalIF":2.5,"publicationDate":"2025-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144136025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0