ChemistryOpen最新文献_第6页

Synergistic Antiemetic Effects of Nerolidol on Domperidone, Hyoscine, and Ondansetron: In Vivo and in Silico Investigations on Receptor Binding Affinity. 奈拉利多对多潘立酮、东莨菪碱和昂丹司琼的协同止吐作用：体内和硅学受体结合亲和力研究

IF 2.5 4区化学

ChemistryOpen Pub Date : 2024-11-12 DOI: 10.1002/open.202400345

Sharmita Ghosh Situ, Md Shimul Bhuia, Raihan Chowdhury, Sakib Al Hasan, Siddique Akber Ansari, Irfan Aamer Ansari, Arman Ali, Muhammad Torequl Islam

{"title":"Synergistic Antiemetic Effects of Nerolidol on Domperidone, Hyoscine, and Ondansetron: In Vivo and in Silico Investigations on Receptor Binding Affinity.","authors":"Sharmita Ghosh Situ, Md Shimul Bhuia, Raihan Chowdhury, Sakib Al Hasan, Siddique Akber Ansari, Irfan Aamer Ansari, Arman Ali, Muhammad Torequl Islam","doi":"10.1002/open.202400345","DOIUrl":"https://doi.org/10.1002/open.202400345","url":null,"abstract":"The present study was designed to measure the potential antiemetic properties of nerolidol (NDL) via in vivo and in silico studies. To induce emesis copper sulfate pentahydrate (CuSO4.5H2O) was administered at a dose of 50 mg/kg (orally) to 2-day-old chicks. The test sample (NDL) was given at two doses of 50 and 100 mg/kg. b.w. orally. Additionally, aprepitant (16 mg/kg), domperidone (6 mg/kg), hyoscine (21 mg/kg), ondansetron (5 mg/kg), and diphenhydramine (10 mg/kg) were given also orally as positive controls. To observe the modulatory effects of the test sample, combination therapies with reference drugs were also administered to three different groups of animals. Molecular docking and visualization of ligand-receptor interaction were performed against several emesis-inducing receptors (5HT3, D2, D3, H1, and M1-M5) using diverse computational tools. Pharmacokinetics and drug-likeness of the selected ligands were also calculated. Findings demonstrated that NDL significantly (p <0.05) dose-dependently lessens the mean number of retches and delays the emetic onset in the chicks. The combined drug therapy with ondansetron exposed better antiemetic activity. In addition, in silico analysis, NDL has greater binding affinity (-7.3 kcal/mol) against M2 and M3 receptors. In conclusion, NDL exerted mild antiemetic activity with synergistic properties through muscarinic receptors.","PeriodicalId":9831,"journal":{"name":"ChemistryOpen","volume":" ","pages":"e202400345"},"PeriodicalIF":2.5,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142615608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Role of Active Site and CO₂-Interacting Surface Species in Dry Reforming of Methane over Strontium Promoted Ni Catalyst Supported by Lanthanum-Zirconia. 镧锆支撑的锶促进镍催化剂上甲烷干转化过程中活性位点和 CO2 相互作用表面物种的作用

IF 2.5 4区化学

ChemistryOpen Pub Date : 2024-11-06 DOI: 10.1002/open.202400151

Kenit Acharya, Ahmed S Al-Fatesh, Anis H Fakeeha, Ahmed E Abasaeed, Othman Alothman, Hammad Ahmad Jan, Naif Alarifi, Jehad K Abu-Dahrieh, Rawesh Kumar

{"title":"Role of Active Site and CO2-Interacting Surface Species in Dry Reforming of Methane over Strontium Promoted Ni Catalyst Supported by Lanthanum-Zirconia.","authors":"Kenit Acharya, Ahmed S Al-Fatesh, Anis H Fakeeha, Ahmed E Abasaeed, Othman Alothman, Hammad Ahmad Jan, Naif Alarifi, Jehad K Abu-Dahrieh, Rawesh Kumar","doi":"10.1002/open.202400151","DOIUrl":"https://doi.org/10.1002/open.202400151","url":null,"abstract":"In the context of global warming, the dry reforming of methane (DRM) has gained significant attention due to its ability to simultaneously deplete two greenhouse gases, i. e. CH4 and CO2, and generate syngas. Herein, strontium-promoted Lanthanum-zirconia supported Ni catalysts are investigated for DRM and characterized by X-ray diffraction, surface area and porosity, FTIR-RAMAN spectroscopy, and temperature-programmed experiments. The Ni/LaZr catalyst contains formate and oxycarbonate-like CO2-interacting species, while strontium-promoted catalysts have additional ionic CO3 2- species. The current catalyst system of 2 % strontium-promoted Ni/LaZr has active sites derived from three types of NiO: easily reducible, moderately interacted, and strongly interacted. During the DRM reaction over the current system, CO2 is a better oxidant than O2 for removing carbon deposits. Additionally, the catalysts attain higher reducibility under oxidizing gas (CO2) and reducing gas (H2) during the DRM reaction. For optimal hydrogen yield of approximately 60 % within 420 minutes of operation over Ni2Sr/LaZr catalyst, a balance between the population of active site Ni and CO2-interacting surface species is necessary.","PeriodicalId":9831,"journal":{"name":"ChemistryOpen","volume":" ","pages":"e202400151"},"PeriodicalIF":2.5,"publicationDate":"2024-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142582312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Rapid Synthesis of anti-1,3-Diamino-4-phenylbutan-2-ol Building Blocks via a Three-Component Oxyhomologation and a Two-Component Reducing System. 通过三组份氧合反应和双组分还原体系快速合成反-1,3-二氨基-4-苯基丁-2-醇构件。

IF 2.5 4区化学

ChemistryOpen Pub Date : 2024-10-30 DOI: 10.1002/open.202400279

Maria Chiara Cabua, Xuefeng He, Francesco Secci, Sandrine Deloisy, David J Aitken

引用次数: 0

Artificial Spidroin Nanogenerator-Based Articulus Wound Dressing. 基于人工蜘蛛网纳米发电机的关节伤口敷料。

IF 2.5 4区化学

ChemistryOpen Pub Date : 2024-10-30 DOI: 10.1002/open.202400257

Xiaoming Ma, Shuhuan Li, Bingbing Gao

引用次数: 0

One-Pot Synthesis and Characterization of Magnetic α-Fe₂O₃/CuO/CuFe₂O₄ Nanocomposite for Multifunctional Therapeutic Applications. 用于多功能治疗的磁性α-Fe2O3/CuO/CuFe2O4 纳米复合材料的一锅合成与表征。

IF 2.5 4区化学

ChemistryOpen Pub Date : 2024-10-30 DOI: 10.1002/open.202400277

Fahmida Akter Sahara, Mst Sabiha Sultana, Md Khairul Amin, Muhammad Shamim Al Mamun, Palash Kumar Dhar, Sagar Kumar Dutta

{"title":"One-Pot Synthesis and Characterization of Magnetic α-Fe2O3/CuO/CuFe2O4 Nanocomposite for Multifunctional Therapeutic Applications.","authors":"Fahmida Akter Sahara, Mst Sabiha Sultana, Md Khairul Amin, Muhammad Shamim Al Mamun, Palash Kumar Dhar, Sagar Kumar Dutta","doi":"10.1002/open.202400277","DOIUrl":"https://doi.org/10.1002/open.202400277","url":null,"abstract":"This study demonstrates a novel nanostructured drug delivery system utilizing α-Fe2O3/CuO/CuFe2O4 ternary nanocomposite for effective drug transport in sick tissues. Centella Asiatica plant extract was employed to synthesize the Fe2O3/CuO/CuFe2O4 nanocomposite via sol-gel auto combustion technique. The structural and morphological characteristics of the nanocomposite were investigated by XRD, FT-IR, SEM, EDX, and VSM for magnetic properties. The XRD analysis demonstrates the successful synthesis of Fe2O3/CuO/CuFe2O4 nanocomposite with an average crystallite size of 18.393 nm. The antioxidant and antifungal capabilities of this nanocomposite were assessed for its biological activity. A notable inhibitory zone was observed when tested against the Alternaria spp. and Bipolaris sorokiniana fungi. An IC50 value of 109.88 μg/ml was found in the DPPH test, indicating that the nanocomposite exhibited remarkable antioxidant characteristics. Subsequently, metronidazole was encapsulated with a success rate of 55.53 % at pH 1.2, while at pH 7.4 it gained 57.83 %. The drug release of nanocomposite at pH 1.2 after 330 min was 43.41 % and at pH 7.4 after 300 min it was 52.3 %. The results indicate its potential as an excellent candidate for drug delivery. Furthermore, pH was found to be an effective catalyst in the drug loading and release processes.","PeriodicalId":9831,"journal":{"name":"ChemistryOpen","volume":" ","pages":"e202400277"},"PeriodicalIF":2.5,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142543973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Macrocycle Unidirectional Transport Along a Linear Molecule by a Two-Step Chemical Reaction Sequence. 通过两步化学反应序列实现线性分子的大循环单向传输

IF 2.5 4区化学

ChemistryOpen Pub Date : 2024-10-29 DOI: 10.1002/open.202400244

Aldo C Catalán, Lucio Peña-Zarate, Ruy Cervantes, Alberto Vela, Jorge Tiburcio

{"title":"Macrocycle Unidirectional Transport Along a Linear Molecule by a Two-Step Chemical Reaction Sequence.","authors":"Aldo C Catalán, Lucio Peña-Zarate, Ruy Cervantes, Alberto Vela, Jorge Tiburcio","doi":"10.1002/open.202400244","DOIUrl":"https://doi.org/10.1002/open.202400244","url":null,"abstract":"Chemical systems displaying directional motions are relevant to the operation of artificial molecular machines. Herein we present the functioning of a molecule capable of transporting a cyclic species in a preferential direction. Our system is based on a linear, non-symmetric, positively charged molecule. This cation integrates into its structure two different reactive regions. On one side features a bulky ester group that can be exchanged by a smaller substituent; the other extreme contains an acid/base responsive moiety that plays a dual role, as part of the recognition motif and as a terminal group. In the acidic state, a dibenzo-24-crown-8 ether slides into the linear component attracted by the positively charged recognition site. It does this selectively through the extreme that contains the azepanium group, since the other side is sterically hindered. After base addition, intermolecular interactions are lost; however, the macrocycle is unable to escape from the linear component since the energy barrier to slide over the neutral azepane is too large. Therefore, a metastable mechanically interlocked molecule is formed. A second reaction, now on the ester functionality, exchanges the bulky mesityl for a methyl group, small enough to allow macrocycle dissociation, completing the directional transit of the ring along the track.","PeriodicalId":9831,"journal":{"name":"ChemistryOpen","volume":" ","pages":"e202400244"},"PeriodicalIF":2.5,"publicationDate":"2024-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142521114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Efficient Cleavage of pUC19 DNA by Tetraaminonaphthols. 四氨基萘酚对 pUC19 DNA 的高效裂解。

IF 2.5 4区化学

ChemistryOpen Pub Date : 2024-10-25 DOI: 10.1002/open.202400157

Catharina Kost, Ute Scheffer, Elisabeth Kalden, Michael Wilhelm Göbel

引用次数: 0

Highly Active and Durable Nanostructured Nickel-Molybdenum Coatings as Hydrogen Electrocatalysts via Solution Precursor Plasma Spraying. 通过溶液前驱体等离子喷涂技术将高活性和耐久性纳米结构镍钼涂层用作氢气电催化剂。

IF 2.5 4区化学

ChemistryOpen Pub Date : 2024-10-25 DOI: 10.1002/open.202400069

Xiuyu Wu, Alexis Piñeiro-García, Mouna Rafei, Alice Kuzhikandathil, Esdras J Canto-Aguilar, Eduardo Gracia-Espino

{"title":"Highly Active and Durable Nanostructured Nickel-Molybdenum Coatings as Hydrogen Electrocatalysts via Solution Precursor Plasma Spraying.","authors":"Xiuyu Wu, Alexis Piñeiro-García, Mouna Rafei, Alice Kuzhikandathil, Esdras J Canto-Aguilar, Eduardo Gracia-Espino","doi":"10.1002/open.202400069","DOIUrl":"https://doi.org/10.1002/open.202400069","url":null,"abstract":"The increasing demand for green hydrogen is driving the development of efficient and durable electrocatalysts for the hydrogen evolution reaction (HER). Nickel-molybdenum (NiMo) alloys are among the best HER electrocatalysts in alkaline electrolytes, and here we report a scalable solution precursor plasma spraying (SPPS) process to produce the highly active Ni4Mo electrocatalysts directly onto metallic substrates. The NiMo coating coated onto inexpensive Ni mesh revealed an excellent HER performance with an overpotential of only 26 mV at -10 mA cm-2 with a Tafel slope of 55 mV dec-1. Excellent operational stability with minimum changes in overpotential were also observed even after extensive 60 hour high-current stability test. In addition, we investigate the influence of different substrates over the catalytic performance and operational stability. We also proposed that a slow, but consistent, dissolution of Mo is the primary degradation mechanism of NiMo-based coatings. This unique SPPS approach enables the scalable production of exceptional NiMo electrocatalysts with remarkable activity and durability, positioning them as ideal cathode materials for practical applications in alkaline water electrolysers.","PeriodicalId":9831,"journal":{"name":"ChemistryOpen","volume":" ","pages":"e202400069"},"PeriodicalIF":2.5,"publicationDate":"2024-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142496038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Enhancing the Interfacial Property Between UHMWPE Fibers and Epoxy Through Polydopamine and SiO₂ Surface Modification. 通过聚多巴胺和二氧化硅表面改性增强超高分子量聚乙烯纤维与环氧树脂之间的界面性能。

IF 2.5 4区化学

ChemistryOpen Pub Date : 2024-10-25 DOI: 10.1002/open.202400131

Nengjun Ben, Sulun Jiang, Liping Zhao, Jiale Gong, Lu Shen, Kui Wang, Chenyang Tang

{"title":"Enhancing the Interfacial Property Between UHMWPE Fibers and Epoxy Through Polydopamine and SiO2 Surface Modification.","authors":"Nengjun Ben, Sulun Jiang, Liping Zhao, Jiale Gong, Lu Shen, Kui Wang, Chenyang Tang","doi":"10.1002/open.202400131","DOIUrl":"https://doi.org/10.1002/open.202400131","url":null,"abstract":"Here, a combination of dopamine self-polymerization and epoxy modified SiO2 (M-SiO2) grafting was proposed, with the purpose of increasing interfacial adhesion of UHMWPE fiber. Inspired by mussel adhesion, polydopamine (PDA) was deposited onto the surface of UHMWPE fiber to form a thin layer with amino and hydroxyl groups. M-SiO2 nanoparticles were then adhered to fiber surface via chemical reactions by a \"two-step\" or \"one-step\" technology. In the \"two-step\" technique, the M-SiO2 nanoparticles were adhered to the surface of PDA modified UHMWPE fiber via reactions between epoxy and amino groups. In the \"one-step\" method, M-SiO2 and dopamine were added into the UHMWPE/Tris solution at the same time. Surface morphology and thermal properties of various UHMWPE fibers were tested by SEM and TGA, respectively. Surface wettability of different UHMWPE fibers were evaluated by dynamic contact angle. The results proved that PDA and M-SiO2 were successfully adhered to the surface of UHMWPE fibers. The mechanical property of modified UHMWPE/Epoxy composites was investigated, and 43.7 % improvement was obtained, compared with unmodified UHMWPE/Epoxy composite. Additionally, micro-bond test revealed that the interfacial property (IFSS value) of modified UHMWPE fiber via the \"one-step\" method was 6.08 MPa, significantly higher than that of unmodified UHMWPE fiber (2.47 MPa).","PeriodicalId":9831,"journal":{"name":"ChemistryOpen","volume":" ","pages":"e202400131"},"PeriodicalIF":2.5,"publicationDate":"2024-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142496037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Rapid and Environmentally-Friendly Synthesis of Thiazolidinone Analogues in Deep Eutectic Solvent Complemented with Computational Studies. 在深共晶溶剂中快速、环保地合成噻唑烷酮类似物并进行计算研究。

IF 2.5 4区化学

ChemistryOpen Pub Date : 2024-10-25 DOI: 10.1002/open.202400198

Gobind Kumar, Pule Seboletswe, Nontobeko Gcabashe, Sanjeev Dhawan, Neha Manhas, Gaurav Bhargava, Rupesh Kumar, Parvesh Singh

引用次数: 0