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Molecular Engineering L-Aspartate-Alpha-Decarboxylase to Enhance Catalytic Stability and Performance. 分子工程 L-天门冬氨酸-α-脱羧酶,提高催化稳定性和性能。
IF 2.5 4区 化学
ChemistryOpen Pub Date : 2024-10-25 DOI: 10.1002/open.202400236
Zihan Liu, Yiheng Liu, Qixuan Jiang, Haijun Xu, Luo Liu
{"title":"Molecular Engineering L-Aspartate-Alpha-Decarboxylase to Enhance Catalytic Stability and Performance.","authors":"Zihan Liu, Yiheng Liu, Qixuan Jiang, Haijun Xu, Luo Liu","doi":"10.1002/open.202400236","DOIUrl":"https://doi.org/10.1002/open.202400236","url":null,"abstract":"<p><p>L-aspartate-alpha-decarboxylase (ADC) catalyzes the decarboxylation of L-aspartate to produce β-alanine, which is the decisive step in the biosynthesis of β-alanine. However, the low catalytic stability and efficiency of ADC limit its industrial applications. In this study, a variant of ADC from Bacillus subtilis were used as a starting point for engineering. After constructing a random mutagenesis library by error-prone PCR, followed by high-throughput screening,four substitutions (S7 N, K63 N, A99T, and K113R) were identified. By screening saturation mutagenesis libraries on these positions and computational analysis, two recombined variants N3(S7 N/K63 N/I88 M/A99E/K113R/I126*) and Y1(S7Y/K63 N/I88 M/A99E/K113R/I126*) with improved performance were obtained. Compared to the wild type, the catalytic efficiency and catalytic stability of the best two variants were enhanced up to 95 %(variant N3) and up to 89 %(variant Y1), respectively. In addition, Y1 exhibited 3.37 times improved half-life and 2-fold improved total turnover number. Hydrophilicity analysis and molecular dynamics (MD) simulation revealed that the increased hydrophilicity and steric hindrance of key amino acid residues would affect the catalytic activity and stability. The improved catalytic performance of the variants could be attributed to their enhanced binding capacity to the substrate within the active pocket and the alleviation of mechanism-based inactivation.</p>","PeriodicalId":9831,"journal":{"name":"ChemistryOpen","volume":" ","pages":"e202400236"},"PeriodicalIF":2.5,"publicationDate":"2024-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142496039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Anxiolytic Efficacy of Indirubin: In Vivo Approach Along with Receptor Binding Profiling and Molecular Interaction with GABAergic Pathways. 吲哚鲁宾的抗焦虑功效:体内方法以及受体结合分析和与 GABA 能通路的分子相互作用。
IF 2.5 4区 化学
ChemistryOpen Pub Date : 2024-10-25 DOI: 10.1002/open.202400290
Ishrat Jahan Disha, Rubel Hasan, Shimul Bhuia, Siddique Akber Ansari, Irfan Aamer Ansari, Muhammad Torequl Islam
{"title":"Anxiolytic Efficacy of Indirubin: In Vivo Approach Along with Receptor Binding Profiling and Molecular Interaction with GABAergic Pathways.","authors":"Ishrat Jahan Disha, Rubel Hasan, Shimul Bhuia, Siddique Akber Ansari, Irfan Aamer Ansari, Muhammad Torequl Islam","doi":"10.1002/open.202400290","DOIUrl":"https://doi.org/10.1002/open.202400290","url":null,"abstract":"<p><p>Anxiety is a natural response to stress, characterized by feelings of worry, fear, or unease. The current research was conducted to investigate the anxiolytic effect of indirubin (IND) in different behavioral paradigms in Swiss albino mice. To observe the animal's behavioural response to assess anxiolytic activity, different tests were performed, such as the open-field (square cross, grooming, and rearing), swing, dark-light, and hole cross tests. The experimental mice were administered IND (5 and 10 mg/kg, p.o.), where diazepam (DZP) and vehicle were used as positive and negative controls, respectively. In addition, a combination treatment (DZP+IND-10) was provided to the animals to determine the modulatory effect of IND on DZP. Molecular docking approach was also conducted to determine the binding energy of IND with the GABA<sub>A</sub> receptor (α2 and α3 subunits) and pharmacokinetics were also estimated. The findings revealed that IND dose-dependently significantly (p<0.05) reduced the animal's movement exerting calming behavior like DZP. IND also demonstrated the highest docking score (-7.7 kcal/mol) against the α3 subunit, while DZP showed a lower docking value (-6.4 kcal/mol) than IND. The ADMET analysis revealed that IND has proper drug-likeness and pharmacokinetic characteristics. In conclusion, IND exerted anxiolytic effects through GABAergic Pathways.</p>","PeriodicalId":9831,"journal":{"name":"ChemistryOpen","volume":" ","pages":"e202400290"},"PeriodicalIF":2.5,"publicationDate":"2024-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142496035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Selective Electrochemical Conversion of CO2 into Methane on Ag-Decorated Copper Microsphere. Ag-Decorated Copper Microsphere 上二氧化碳到甲烷的选择性电化学转化。
IF 2.5 4区 化学
ChemistryOpen Pub Date : 2024-10-24 DOI: 10.1002/open.202400173
Rabin Dahal, Rohit Srivastava, Bishnu Prasad Bastakoti
{"title":"Selective Electrochemical Conversion of CO<sub>2</sub> into Methane on Ag-Decorated Copper Microsphere.","authors":"Rabin Dahal, Rohit Srivastava, Bishnu Prasad Bastakoti","doi":"10.1002/open.202400173","DOIUrl":"https://doi.org/10.1002/open.202400173","url":null,"abstract":"<p><p>We synthesized the silver-decorated copper microsphere via the hydrothermal method followed by photoreduction of silver ions. Sub 100 nm Ag nanoparticles anchored on the surface of Cu microspheres enhance the electrochemical performance and the selectivity of the CO<sub>2</sub> reduction into CH<sub>4</sub>. Incorporating Ag nanoparticles onto Cu lowers the charge transfer resistance, enhancing the catalyst's conductivity and active site and increasing the rate of CO<sub>2</sub> reduction. The faradaic efficiency of silver nanoparticles decorated copper microsphere for methane was 70.94 %, almost twice that of a copper microsphere (44 %). The electrochemical performance showed higher catalytic properties, stability, and faradaic efficiency of silver-decorated copper microspheres.</p>","PeriodicalId":9831,"journal":{"name":"ChemistryOpen","volume":" ","pages":"e202400173"},"PeriodicalIF":2.5,"publicationDate":"2024-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142496042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Novel BiOBr/CAU-17 Composite with Enhanced Photo-Catalytic Performance for Dye Degradation and Removal of Tetracycline Antibiotic Under Visible Light. 一种具有增强光催化性能的新型 BiOBr/CAU-17 复合材料,用于在可见光下降解染料和去除四环素类抗生素。
IF 2.5 4区 化学
ChemistryOpen Pub Date : 2024-10-23 DOI: 10.1002/open.202400195
Mansoor Akhtar, Shifa Ullah Khan, Ghulam Mustafa, Muhammad Ahmad, Tansir Ahamad
{"title":"A Novel BiOBr/CAU-17 Composite with Enhanced Photo-Catalytic Performance for Dye Degradation and Removal of Tetracycline Antibiotic Under Visible Light.","authors":"Mansoor Akhtar, Shifa Ullah Khan, Ghulam Mustafa, Muhammad Ahmad, Tansir Ahamad","doi":"10.1002/open.202400195","DOIUrl":"https://doi.org/10.1002/open.202400195","url":null,"abstract":"<p><p>In order to improve the low specific surface area and high recombinant light generation carriers of BiOBr, loading BiOBr onto suitable Metal Organic Frameworks (MOFs) is an effective strategy to unleash its efficient visible light response and intrinsic catalytic activity. In this study, using classic MOF CAU-17 as a precursor, using a straightforward co-precipitation technique, four BiOBr/CAU-17 composites with distinct MOF contents values BCAU-1, BCAU-2, BC, AU-3, and BCAU-4 were created, and their photo-catalytic characteristics were examined. The BCAU-2 composite exhibited much higher photo-catalytic degradation efficiency for Rhodamine B (RhB) and Tetracycline (TC) than the pristine materials, counter compositions, and early reported materials. XRD, SEM, TEM, XPS, and EDX results revealed the strong synergistic photo-catalytic effect of BiOBr and CAU-17. The photocatalytic degradation of TC was significantly enhanced by the BiOBr bimetal modification, with the 2 wt.% BiOBr/CAU-17 nanocomposite achieving an 87.2 % degradation of TC and 82 % Total Organic Carbon (TOC) removal within 60 min. The high photo-degradation efficiency of BCAU-2 composite should be attributed to the efficient transfer of photo-generated carriers at interfaces and the synergistic effect between BiOBr/CAU-17. Furthermore, the experiments on the capture of the active species proved that the main active free radicals involved in the degradation of RhB and TC are attributed to the photo-induced holes h<sup>+</sup> and ⋅ O<sub>2</sub> <sup>-</sup> under visible light. The catalyst's efficacy is corroborated by the outcomes of photoluminescence spectroscopy and photo current response. This study offers a new understanding for the design of green synthesis schemes for photo-catalytic dye degradation and removal of certain antibiotics from the aquatic environment.</p>","PeriodicalId":9831,"journal":{"name":"ChemistryOpen","volume":" ","pages":"e202400195"},"PeriodicalIF":2.5,"publicationDate":"2024-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142496034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Structural Variety in Transition Metal Complexes of Tripodal Ligands Containing Mixed Quinolyl and Pyridyl Donors. 含混合喹啉基和吡啶基配体的三足配体过渡金属配合物的结构变化。
IF 2.5 4区 化学
ChemistryOpen Pub Date : 2024-10-23 DOI: 10.1002/open.202400304
Bronte Carr, Timothy D Christopher, Tilo Söhnel, Lawrence R Gahan, Cassandra L Fleming, Allan G Blackman
{"title":"Structural Variety in Transition Metal Complexes of Tripodal Ligands Containing Mixed Quinolyl and Pyridyl Donors.","authors":"Bronte Carr, Timothy D Christopher, Tilo Söhnel, Lawrence R Gahan, Cassandra L Fleming, Allan G Blackman","doi":"10.1002/open.202400304","DOIUrl":"https://doi.org/10.1002/open.202400304","url":null,"abstract":"<p><p>The syntheses of the tripodal tetraamine ligands 2-(pyridin-2-yl)-N,N-bis(quinolin-2-ylmethyl)ethan-1-amine (DQPEA), N-(pyridin-2-ylmethyl)-2-(quinolin-2-yl)-N-(2-(quinolin-2-yl)ethyl)ethan-1-amine (DQEPMA), 2-(pyridin-2-yl)-N,N-bis(2-(quinolin-2-yl)ethyl)ethan-1-amine (DQEPEA), N,N-bis(pyridin-2-ylmethyl)-2-(quinolin-2-yl)ethan-1-amine (QEDPMA), and 2-(pyridin-2-yl)-N-(2-(pyridin-2-yl)ethyl)-N-(2-(quinolin-2-yl)ethyl)ethan-1-amine (QEDPEA) containing mixed quinolyl and pyridyl moieties are reported, with 2-vinylquinoline being used to attach quinolylethyl arms to the aliphatic N atom. X-ray crystal structures of [(Mn(DQPEA))<sub>2</sub>O<sub>2</sub>](ClO<sub>4</sub>)<sub>2</sub> ⋅ (CH<sub>3</sub>CN)<sub>2</sub>, [Cu(DQPEA)NCCH<sub>3</sub>](ClO<sub>4</sub>)<sub>2</sub>, [Zn(DQPEA)NCCH<sub>3</sub>](ClO<sub>4</sub>)<sub>2</sub>, [Pd(DQEPEA)Cl]Cl ⋅ 11H<sub>2</sub>O are detailed, with four, five, and six-coordination observed. In addition, the dimeric complex [(DPEA)Co(μ-OH)<sub>3</sub>Co(DPEA)](ClO<sub>4</sub>)<sub>3</sub> ⋅ 0.5H<sub>2</sub>O ⋅ MeCN containing the tridentate DPEA ligand formed by N-dealkylation of QEDPEA is reported. Calculations suggest that the very short Co…Co distance of 2.5946(6) Å in this complex is unlikely to be due to a Co-Co bond.</p>","PeriodicalId":9831,"journal":{"name":"ChemistryOpen","volume":" ","pages":"e202400304"},"PeriodicalIF":2.5,"publicationDate":"2024-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142496044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Functionalized Nanomaterials In Pancreatic Cancer Theranostics And Molecular Imaging. 功能化纳米材料在胰腺癌治疗和分子成像中的应用。
IF 2.5 4区 化学
ChemistryOpen Pub Date : 2024-10-21 DOI: 10.1002/open.202400232
Yoghalakshmi Nagarajan, Natarajan Chandrasekaran, Venkatachalam Deepa Parvathi
{"title":"Functionalized Nanomaterials In Pancreatic Cancer Theranostics And Molecular Imaging.","authors":"Yoghalakshmi Nagarajan, Natarajan Chandrasekaran, Venkatachalam Deepa Parvathi","doi":"10.1002/open.202400232","DOIUrl":"https://doi.org/10.1002/open.202400232","url":null,"abstract":"<p><p>Pancreatic cancer (PC) is one of the most fatal malignancies in the world. This lethality persists due to lack of effective and efficient treatment strategies. Pancreatic ductal adenocarcinoma (PDAC) is an aggressive epithelial malignancy which has a high incidence rate and contributes to overall cancer fatalities. As of 2022, pancreatic cancer contributes to about 3 % of all cancers globally. Over the years, research has characterised germline predisposition, the origin cell, precursor lesions, genetic alterations, structural alterations, transcriptional changes, tumour heterogeneity, metastatic progression, and the tumour microenvironment, which has improved the understanding of PDAC carcinogenesis. By using molecular-based target therapies, these fundamental advancements support primary prevention, screening, early detection, and treatment. The focus of this review is the use of targeted nanoparticles as an alternative to conventional pancreatic cancer treatment due to the various side effects of the latter. The principles of nanoparticle based cancer therapy is efficient targeting of tumour cells via enhanced permeability and retention (EPR) effects and decrease the chemotherapy side effects due to their non-specificity. To increase the efficiency of existing therapies and modify target nanoparticles, several molecular markers of pancreatic cancer cells have been identified. Thus pancreatic cancer cells can be detected using appropriately functionalized nanoparticles with specific signalling molecules. Once cancer has been identified, these nanoparticles can kill the tumour by inducing hyperthermia, medication delivery, immunotherapy or gene therapy. As potent co-delivery methods for adjuvants and tumor-associated antigens; nanoparticles (NPs) have demonstrated significant promise as delivery vehicles in cancer therapy. This ensures the precise internalization of the functionalized nanoparticle and thus also activates the immune system effectively against tumor cells. This review also discusses the immunological factors behind the uptake of functionalized nanoparticles in cancer therapies. Theranostics, which combine imaging and therapeutic chemicals in a single nanocarrier, are the next generation of medicines. Pancreatic cancer treatment may be revolutionised by the development of a tailored nanocarrier with diagnostic, therapeutic, and imaging capabilities. It is extremely difficult to incorporate various therapeutic modalities into a single nanocarrier without compromising the individual functionalities. Surface modification of nanocarriers with antibodies or proteins will enable to attain multifunctionality which increases the efficiency of pancreatic cancer therapy.</p>","PeriodicalId":9831,"journal":{"name":"ChemistryOpen","volume":" ","pages":"e202400232"},"PeriodicalIF":2.5,"publicationDate":"2024-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142459214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Impact of Hydrostatic Pressure on the Structural, Mechanical, Thermal, and Optoelectronic Characteristics of the RbV3Sb5 Kagome Compound: Ab initio Approach. 静水压力对 RbV3Sb5 Kagome 化合物的结构、机械、热和光电特性的影响:Ab initio Approach.
IF 2.5 4区 化学
ChemistryOpen Pub Date : 2024-10-21 DOI: 10.1002/open.202400291
Prianka Mondal, Md Raihan Islam, Mst Shamima Khanom, Farid Ahmed
{"title":"The Impact of Hydrostatic Pressure on the Structural, Mechanical, Thermal, and Optoelectronic Characteristics of the RbV<sub>3</sub>Sb<sub>5</sub> Kagome Compound: Ab initio Approach.","authors":"Prianka Mondal, Md Raihan Islam, Mst Shamima Khanom, Farid Ahmed","doi":"10.1002/open.202400291","DOIUrl":"https://doi.org/10.1002/open.202400291","url":null,"abstract":"<p><p>We studied the RbV<sub>3</sub>Sb<sub>5</sub> kagome compound's structural, mechanical, thermal, and optoelectronic properties. Mulliken and Hirshfeld population analysis found ionic and covalent connections in RbV<sub>3</sub>Sb<sub>5</sub>. The Born stability criterion shows that pure RbV<sub>3</sub>Sb<sub>5</sub> is mechanically stable. The precise measurement of 3.96 indicates that our sample has higher machinability at 20 GPa. Low anticipated hardness of RbV<sub>3</sub>Sb<sub>5</sub> suggests it can be used as a soft solid lubricant. Hardness ratings rise with pressure, however there are exceptions. Pressure causes large nonmonotonic changes in RbV<sub>3</sub>Sb<sub>5</sub>'s anisotropic characteristics. A comparable 20 GPa Zener anisotropic value, RbV<sub>3</sub>Sb<sub>5</sub> has the highest. The structure's projected Debye temperature at 0 GPa is 284.39 K, indicating softness. Dispersion curves with negative frequencies suggest ground state structural dynamical instability. The structure has no negative-energy phonon branches under 10 GPa stress. From band structure and density of state analysis, the structure behaves metallically under hydrostatic pressure. Also, the structure has maximal ultra-violet conductivity and absorption. The absorption coefficient, conductivity, and loss function plots show uniform patterns at all pressures. As pressure rises, these graphs' peaks blue shift.</p>","PeriodicalId":9831,"journal":{"name":"ChemistryOpen","volume":" ","pages":"e202400291"},"PeriodicalIF":2.5,"publicationDate":"2024-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142459217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Biosensor Based on the Immobilization of Laccase on β-Cyclodextrin Membrane for the Evaluation of Antioxidant Capacity in Real Samples. 基于在β-环糊精膜上固定漆酶的生物传感器,用于评估真实样品中的抗氧化能力
IF 2.5 4区 化学
ChemistryOpen Pub Date : 2024-10-21 DOI: 10.1002/open.202400228
Jorge Juárez-Gómez, Omar Alejandro Báez-Melga, Dafne Sarahia Guzmán-Hernández
{"title":"Biosensor Based on the Immobilization of Laccase on β-Cyclodextrin Membrane for the Evaluation of Antioxidant Capacity in Real Samples.","authors":"Jorge Juárez-Gómez, Omar Alejandro Báez-Melga, Dafne Sarahia Guzmán-Hernández","doi":"10.1002/open.202400228","DOIUrl":"https://doi.org/10.1002/open.202400228","url":null,"abstract":"<p><p>The optimization of a new amperometric biosensor for evaluating antioxidant capacity in real samples is reported. The biosensor is based on the immobilization of Laccase from Trametes versicolor on an electropolymerized β-cyclodextrin polymeric membrane on a glassy carbon electrode. The process of electropolymerization, which was successful even in the presence of the enzyme, was a key step in biosensor synthesis. Variables such as pH, temperature, and enzyme concentration were optimized using a factorial design with two levels for each factor. Different electrodes were constructed and tested using caffeic acid as a standard. The best biosensor is synthesized at pH 3.0 with 6 mg/mL of enzyme and 30 °C. The biosensor presented a response time of ≤30 seconds and good stability in its amperometric response. The biosensor was used to evaluate the antioxidant capacity of real samples. Infusions of green, black, red, and white tea were assessed. The biosensor showed excellent stability and good performance regarding response time, stability, and easy fabrication. The proposed biosensor is a good option for evaluating antioxidant capacity in real samples without sample pretreatment. It combines a simple fabrication methodology and a minimal extraction process for rapid and reliable phenolic content determination in real samples.</p>","PeriodicalId":9831,"journal":{"name":"ChemistryOpen","volume":" ","pages":"e202400228"},"PeriodicalIF":2.5,"publicationDate":"2024-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142459212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Conversion of Cellobiose to Formic Acid as a Biomass-Derived Renewable Hydrogen Source Using Solid Base Catalysts 使用固体基催化剂将纤维生物糖转化为甲酸,作为生物质衍生的可再生氢源。
IF 2.5 4区 化学
ChemistryOpen Pub Date : 2024-10-07 DOI: 10.1002/open.202400079
Ikuto Yoshiki, Prof. Atsushi Takagaki, Dr. Jun Tae Song, Prof. Motonori Watanabe, Prof. Tatsumi Ishihara
{"title":"Conversion of Cellobiose to Formic Acid as a Biomass-Derived Renewable Hydrogen Source Using Solid Base Catalysts","authors":"Ikuto Yoshiki,&nbsp;Prof. Atsushi Takagaki,&nbsp;Dr. Jun Tae Song,&nbsp;Prof. Motonori Watanabe,&nbsp;Prof. Tatsumi Ishihara","doi":"10.1002/open.202400079","DOIUrl":"10.1002/open.202400079","url":null,"abstract":"<p>Formic acid is considered a promising hydrogen carrier. Biomass-derived formic acid can be obtained by oxidative decomposition of sugars. This study explored the production of formic acid from cellobiose, a disaccharide consisting of <span>d</span>-glucose linked by β-glycosidic bonds using heterogeneous catalysts under mild reaction conditions. The use of alkaline earth metal oxide solid base catalysts like CaO and MgO in the presence of hydrogen peroxide could afford formic acid from cellobiose at 343 K. While CaO gave 14 % yield of formic acid, the oxide itself was converted to a harmful metal peroxide, CaO<sub>2</sub> after the reaction. In contrast, MgO could produce formic acid without the formation of the metal peroxide. The difficulty in selectively synthesizing formic acid from cellobiose using these solid base catalysts was due to the poor conversion of cellobiose to glucose. Using a combination of solid acid and base catalysts, a high formic acid yield of 33 % was obtained under mild reaction conditions due to the quantitative hydrolysis of cellobiose to glucose by a solid acid followed by the selective decomposition of glucose to formic acid by a solid base.</p>","PeriodicalId":9831,"journal":{"name":"ChemistryOpen","volume":"13 11","pages":""},"PeriodicalIF":2.5,"publicationDate":"2024-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/open.202400079","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142388414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Front Cover: Quantitative Spermidine Detection in Cosmetics using an Organic Transistor-Based Chemical Sensor (ChemistryOpen 10/2024) 封面:利用基于有机晶体管的化学传感器定量检测化妆品中的精胺(ChemistryOpen 10/2024)
IF 2.5 4区 化学
ChemistryOpen Pub Date : 2024-10-07 DOI: 10.1002/open.202481001
Dr. Yui Sasaki, Kohei Ohshiro, Miyuki Kato, Hikaru Tanaka, Akari Yamagami, Dr. Kazutake Hagiya, Prof. Dr. Tsuyoshi Minami
{"title":"Front Cover: Quantitative Spermidine Detection in Cosmetics using an Organic Transistor-Based Chemical Sensor (ChemistryOpen 10/2024)","authors":"Dr. Yui Sasaki,&nbsp;Kohei Ohshiro,&nbsp;Miyuki Kato,&nbsp;Hikaru Tanaka,&nbsp;Akari Yamagami,&nbsp;Dr. Kazutake Hagiya,&nbsp;Prof. Dr. Tsuyoshi Minami","doi":"10.1002/open.202481001","DOIUrl":"https://doi.org/10.1002/open.202481001","url":null,"abstract":"<p>A chemical sensor device based on an extended-gate-type organic transistor illustrated as a gold watch quantifies the target spermidine in cosmetics at μmol L−1 levels. The accuracy of the organic transistor-based chemical sensor is validated using a stational analytical instrument. Thus, the accurate recovery rates for spermidine in a commercial cosmetic ingredient product reveals the potential of the sensor for cosmetic analysis. More information can be found in the Research Article by Tsuyoshi Minami and co-workers (DOI: 10.1002/open.202400098).<figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure>\u0000 </p>","PeriodicalId":9831,"journal":{"name":"ChemistryOpen","volume":"13 10","pages":""},"PeriodicalIF":2.5,"publicationDate":"2024-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/open.202481001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142429343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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