Cs2CO3-N， n -二甲基乙酰胺促进芳基甲酸与a-溴酯的亲核取代酯化反应。

IF 3.1 4区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

ChemistryOpen Pub Date : 2025-05-13 DOI:10.1002/open.202500129

Xinyan Song, Mingxin Li, Haihong Bao, Mohan Hao, Hanxiang Wang, Yu Tian, Yue Wu, Yun Zhou, Ruiying Wan, Wei Li, Haixing Guan

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引用次数: 0

摘要

本文报道了在Cs2CO3-DMA体系催化下芳基甲酸与α-溴酯之间发生的亲核取代反应。该反应在温和的条件下发生，产生多种有价值的乳酸衍生物（34个例子），收率从良好到优异（高达97%）。一些微妙的因素，如Cs2CO3、底物和溶剂之间的离子偶极相互作用，可能会显著影响SN2反应的动力学。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Cs₂CO₃-N,N-Dimethylacetamide-Promoted Esterification of Arylformic Acids with a-Bromo Esters via Nucleophilic Substitution.

Herein, a nucleophilic substitution reaction between arylformic acids and α-bromo esters, facilitated by a Cs₂CO₃-DMA system, is reported. This reaction occurs under mild conditions, yielding a diverse range of valuable lactic acid derivatives (34 examples) with good to excellent yields (up to 97%). Subtle factors, such as the ion-dipole interactions between Cs₂CO₃, the substrates, and the solvent, may significantly influence the dynamics of the S_N2 reaction.

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来源期刊

ChemistryOpen CHEMISTRY, MULTIDISCIPLINARY-

CiteScore

4.80

自引率

4.30%

发文量

143

审稿时长

1 months

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