{"title":"SiO<sub>2</sub>@Benzothiazole-Cl@Fc as an Efficient Heterogeneous Catalyst for the Synthesis of 1,3,5-Trisubstituted Pyrazoles by A<sup>3</sup> Coupling.","authors":"Fadhil Faez Sead, Vicky Jain, Roopashree R, Aditya Kashyap, Suman Saini, Girish Chandra Sharma, Pushpa Negi Bhakuni, Mosstafa Kazemi, Ramin Javahershenas","doi":"10.1002/open.202500024","DOIUrl":null,"url":null,"abstract":"<p><p>This research introduces the preparation and analysis of a newly heterogeneous catalyst developed silica nanospheres supporting a ferrocene-containing ionic liquid (IL) (SiO<sub>2</sub>@Benzothiazole-Cl@Fc) for the A3 coupling reaction. The catalyst facilitates the efficient synthesis of 1,3,5-trisubstituted pyrazoles from aromatic hydrazides, aldehydes, and aromatic alkynes. Incorporating ferrocene enhances the catalytic activity. Comprehensive characterization techniques, including NMR, Fourier transform infrared, transmission electron microscopy, energy-dispersive X-ray spectroscopy, and scanning electron microscopy, confirm the successful functionalization of silica nanospheres. The catalytic performance was evaluated under various reaction conditions, demonstrating high yields and selectivity for the desired pyrazole products. This work highlights the potential of ferrocene-based ILs in green chemistry applications, providing a sustainable approach to synthesizing valuable heterocyclic compounds.</p>","PeriodicalId":9831,"journal":{"name":"ChemistryOpen","volume":" ","pages":"e2500024"},"PeriodicalIF":2.5000,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"ChemistryOpen","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.1002/open.202500024","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 0
Abstract
This research introduces the preparation and analysis of a newly heterogeneous catalyst developed silica nanospheres supporting a ferrocene-containing ionic liquid (IL) (SiO2@Benzothiazole-Cl@Fc) for the A3 coupling reaction. The catalyst facilitates the efficient synthesis of 1,3,5-trisubstituted pyrazoles from aromatic hydrazides, aldehydes, and aromatic alkynes. Incorporating ferrocene enhances the catalytic activity. Comprehensive characterization techniques, including NMR, Fourier transform infrared, transmission electron microscopy, energy-dispersive X-ray spectroscopy, and scanning electron microscopy, confirm the successful functionalization of silica nanospheres. The catalytic performance was evaluated under various reaction conditions, demonstrating high yields and selectivity for the desired pyrazole products. This work highlights the potential of ferrocene-based ILs in green chemistry applications, providing a sustainable approach to synthesizing valuable heterocyclic compounds.
期刊介绍：
ChemistryOpen is a multidisciplinary, gold-road open-access, international forum for the publication of outstanding Reviews, Full Papers, and Communications from all areas of chemistry and related fields. It is co-owned by 16 continental European Chemical Societies, who have banded together in the alliance called ChemPubSoc Europe for the purpose of publishing high-quality journals in the field of chemistry and its border disciplines. As some of the governments of the countries represented in ChemPubSoc Europe have strongly recommended that the research conducted with their funding is freely accessible for all readers (Open Access), ChemPubSoc Europe was concerned that no journal for which the ethical standards were monitored by a chemical society was available for such papers. ChemistryOpen fills this gap.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
