ChemistryOpen最新文献

{"title":"Nucleic Acid Specificity, Cellular Localization and Reduced Toxicities of Thiazole Orange-Neomycin Conjugates","authors":"Antwine W. McFarland Jr.,&nbsp;Lawrence P. Fernando,&nbsp;Patrick Kellish,&nbsp;Sandra P. Story,&nbsp;Gretchen B. Schober,&nbsp;Sunil Kumar,&nbsp;Changjun Gong,&nbsp;Ada King,&nbsp;Xianchang Gong,&nbsp;Alain S. Leutou,&nbsp;Dev P. Arya","doi":"10.1002/open.202400189","DOIUrl":"10.1002/open.202400189","url":null,"abstract":"<p>Selective binding of small molecule ligands to nucleic acids with high affinity and limited toxicity remains an important goal in the development of compounds that can probe DNA or RNA in cells. Thiazole orange is a cell semi-permeant, fluorescent cyanine dye, with low background noise, that binds several forms of nucleic acids. However, thiazole orange can exhibit cytotoxicity when used at high concentration and/or with prolonged exposure. Neomycin is a non-fluorescent antibiotic with affinity for several forms of nucleic acids, but does not readily enter mammalian cells. Conjugation of neomycin with thiazole orange can exploit the properties of each individual compound, yielding a small molecule that could be used for nontoxic application in cellular analysis by microscopic imaging. We demonstrate that conjugation of neomycin with thiazole orange increases the cell permeability of neomycin, decreases the cytotoxicity of thiazole orange, and exhibits a greater degree of intracellular RNA targeted localization in the nucleolus, when compared to thiazole orange. Relative to thiazole orange, the conjugated compounds showed a much higher degree of stabilization of the nucleic acids as reflected in a greater denaturation temperature. Ultimately, our studies indicate that the conjugated thiazole orange-neomycin compounds can be used as an RNA targeted, less cytotoxic alternative for cellular labeling.</p>","PeriodicalId":9831,"journal":{"name":"ChemistryOpen","volume":"14 4","pages":""},"PeriodicalIF":2.5,"publicationDate":"2024-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/open.202400189","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142892335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Innovative Progress of LSPR-Based Dark-Field Scattering Spectral Imaging in the Biomedical Assay at the Single-Particle Level","authors":"Yang Shi,&nbsp;Lixiang Wang,&nbsp;Lingling Li,&nbsp;Chen Feng,&nbsp;Yue Cao","doi":"10.1002/open.202400017","DOIUrl":"10.1002/open.202400017","url":null,"abstract":"<p>The growing demand for detection and sensing in the biomedical field is placing higher demands on technology. In clinical testing, it is expected to be able to realize both rapid large-field imaging and analysis of single particles (or single molecules or single cells), and it is expected to be able to grasp both the unique individuality of single particles in time and space during the complex reaction process, as well as the regular correlation between single particles in the same population distribution. Supported and promoted by the theory of localized surface plasmon resonance (LSPR), dark-field microscopy, as a single-particle optical imaging technique with a very high signal-to-noise ratio, provides a powerful new means to address the above clinical detection needs. This review will focus on the innovative applications of dark-field microscopy in biomedical-related assays in the past five years, introducing the basic principles and listing the impressing works. We also summarize how dark-field microscopy has been combined with other techniques, including surface-enhanced Raman scattering, fluorescence, colorimetry, electrochemistry, etc., to witness the joint progress and promotion of detection methods in the future. It also provides an outlook on the current challenges and future trends in this field.</p>","PeriodicalId":9831,"journal":{"name":"ChemistryOpen","volume":"14 3","pages":""},"PeriodicalIF":2.5,"publicationDate":"2024-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/open.202400017","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142892327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Selective Synthesis of Tetrahydroisoquinoline and Piperidine Scaffolds by Oxidative Ring Opening/Ring Closing Protocols of Substituted Indenes and Cyclopentenes.","authors":"Anas Semghouli, László Drahos, Jianlin Han, Loránd Kiss, Melinda Nonn","doi":"10.1002/open.202400475","DOIUrl":"https://doi.org/10.1002/open.202400475","url":null,"abstract":"<p><p>Novel tetrahydroisoquinoline and piperidine derivatives were selectively synthesized from substituted indenes or cyclopentenes. The process starts with an oxidative cleavage of the ring olefin bond, which gives reactive diformyl intermediates. By a ring-closing step using chiral (R) or (S) α-methylbenzylamine under a reductive amination protocol facilitated ring formation with ring expansion of the corresponding nitrogen-containing heterocycles. The stereocontrolled methodology enabled accurate control of the stereochemistry of the final products. Additionally, the synthesized amino acid derivatives possessing an aryl moiety in their structure may be relevant building blocks for foldamer chemistry.</p>","PeriodicalId":9831,"journal":{"name":"ChemistryOpen","volume":" ","pages":"e202400475"},"PeriodicalIF":2.5,"publicationDate":"2024-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142892256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Theoretical and Electrochemical Evaluation of Cannabis Sativa L. Extracts as Corrosion Inhibitors for Mild Steel in Acidic Medium.","authors":"Salima Haddou, Kaoutar Zaidi, Omar Dagdag, Asmae Hbika, Mohamed Adil Mahraz, Mohamed Bouhrim, Ali S Alqahtani, Omar M Noman, Hansang Kim, Abdelouahad Aouniti, Belkheir Hammouti, Abdelkrim Chahine","doi":"10.1002/open.202400273","DOIUrl":"https://doi.org/10.1002/open.202400273","url":null,"abstract":"<p><p>The corrosion of metals in acidic environments remains a significant challenge, driving the search for sustainable and eco-friendly inhibitors derived from natural sources. This study evaluates the corrosion inhibition potential of three extracts from Cannabis sativa L., namely ethanol extract (EET), hexane extract (EHX), and dichloromethane extract (EDM), for mild steel in a 1 M HCl acidic medium. The investigation employed weight loss (WL) measurements, electrochemical impedance spectroscopy (EIS), and potentiodynamic polarization (PDP) techniques. To understand their inhibitive performance, density functional theory (DFT) was used. For a more comprehensive theoretical analysis, Monte Carlo (MC) and molecular dynamics (MD) simulations were used. The corrosion inhibition efficiency increased with the increase of EET, EHX, and EDM concentrations up to 91 %, 89 %, and 83 %, respectively, obtained at 308 K for a 0.8 g/L concentration. Polarization studies classify EET, EHX, and EDM as mixed-type inhibitors with a predominantly anodic effect, functioning through adsorption on the metal surface. The adsorption of these extracts on mild steel conforms to the Langmuir isotherm model, with adsorption equilibrium constants (K_ads) of 3.0143 M, 5.1245 M, and 2.2009 M for EET, EHX, and EDM, respectively, highlighting their potential as effective corrosion inhibitors. The EET extract exhibits a high activation energy (E_a) of 101.70 kJ/mol, while the EHX and EDM extracts show E_a values of 79.05 kJ/mol and 82.93 kJ/mol, respectively, all significantly higher than the E_a of blank, which is 30.23 kJ/mol, indicating that the extracts effectively inhibit corrosion by increasing the activation energy, with EET being the most potent inhibitor. Theoretical approaches based on DFT, MC, and MD simulations clearly explain the mode of adsorption of the majority of molecules on the metal surface. The inhibition process may result from a synergistic intermolecular effect of the major compounds in the extract, which interact at various active adsorption sites on the metal surface. Simulations indicate that catechin dihydrate in EET (52.42 %), linoleic acid in EHX (42.92 %), and naringenin in EDM (41.92 %) are close to the metal surface, suggesting strong interactions with the material. The results obtained from experimental measurements and theoretical calculations agree, highlighting the potential for developing more sustainable corrosion inhibitors based on plant-derived compounds.</p>","PeriodicalId":9831,"journal":{"name":"ChemistryOpen","volume":" ","pages":"e202400273"},"PeriodicalIF":2.5,"publicationDate":"2024-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142881407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Terpyridine Based 1,2,3-Triazol-1,4-diyl-Fluoroionophore-A Fluorometric Study Towards 3d Metal Ions in Acetonitrile.","authors":"Thomas Schwarze, Holger Müller, Eric Sperlich, Alexandra Kelling, Hans-Jürgen Holdt","doi":"10.1002/open.202400403","DOIUrl":"https://doi.org/10.1002/open.202400403","url":null,"abstract":"<p><p>In this paper, we report on the sensing role of the 1,2,3-triazol unit in a 1,4-diyl arrangement in a fully π-conjugated fluorescent probe 1 (cf. Scheme 1) towards the fluorometric detection of 3d metal ions. The 1,2,3-triazol-1,4-diyl-fluoroionophore 1 was designed in a donor(D)-acceptor(A) arrangement with a 1,2,3-triazol unit as a π-linker between a terpyridine (A) ionophore and a diethylaminocoumarin (D) fluorophore to study the fluorescence behavior towards the divalent 3d metal ions Mn²⁺, Fe²⁺, Co²⁺, Ni²⁺, Cu²⁺ and Zn²⁺. This fluoroionophore 1 is based on an intramolecular charge transfer (ICT) and shows a moderate quantum yield (φ_f) of 0.508 in acetonitrile. A modulation of the ICT process in 1 through Fe²⁺, Co²⁺, Cu²⁺, Ni²⁺ and Zn²⁺ leads to a small red shift of the lowest energetically lying absorption UV/Vis absorption band and to a very strong 3d metal ion induced fluorescence quenching. It should be considered, that the installation of a 1,2,3-triazole unit as a fully π-linker in ICT probes originates no ratiometric fluorescence response towards Fe²⁺, Co²⁺, Cu²⁺, Ni²⁺ and Zn²⁺.</p>","PeriodicalId":9831,"journal":{"name":"ChemistryOpen","volume":" ","pages":"e202400403"},"PeriodicalIF":2.5,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142863419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integration of Design of Experiments, Analysis of Variance and Response Surface Methodology in Assessing Heterogeneous Catalysts Processes: A Minireview","authors":"Carlos Esteban Aristizábal-Alzate,&nbsp;Eva Castillejos-López,&nbsp;Ana Belén Dongil,&nbsp;Manuel Romero-Sáez","doi":"10.1002/open.202400148","DOIUrl":"10.1002/open.202400148","url":null,"abstract":"<p>This work reviews the application of Analysis of Variance (ANOVA), Design of Experiments (DOE), and Response Surface Methodology (RSM) in heterogeneous catalysis, based on an analysis of recent scientific literature. Heterogeneous catalysis plays a key role in various industries, guiding chemical reactions, optimizing the performance of different processes and/or prioritizing products, and ANOVA, DOE and RSM are valuable tools to understand the intricate relationships between catalyst properties, process variables and reaction responses. This understanding facilitates improvements in catalysts performance and selectivity, thereby optimizing processes. Drawing insights from recent studies, this minireview highlights the different applications of ANOVA-based experimental designs and RSM optimization techniques in catalytic process evaluation. Therefore, this review provides valuable insights into these current statistical methodologies applied to heterogeneous catalysis research, informing the relevance and future directions of the research in the field.</p>","PeriodicalId":9831,"journal":{"name":"ChemistryOpen","volume":"14 1","pages":""},"PeriodicalIF":2.5,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11726655/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142827350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Design of MnOx/TiO2 Nanostructures for Photocatalytic Removal of 2,4-D Herbicide","authors":"Angeles Mantilla,&nbsp;Sandra Cipagauta Díaz,&nbsp;Enrique Samaniego Benitez,&nbsp;Francisco Javier Tzompantzi Morales,&nbsp;Michelle Navarrete Magaña","doi":"10.1002/open.202400154","DOIUrl":"10.1002/open.202400154","url":null,"abstract":"<p>The research and modification of semiconductors through different synthesis routes allow obtaining materials with optimal properties to induce new energy levels and improve charge separation efficiency. In this context, the sol-gel method was used to synthesize TiO₂-based materials doped with different percentages of MnO_x to evaluate their photocatalytic activity in the degradation of the herbicide 2,4-dichlorophenoxyacetic acid (2,4-D) in water under UV irradiation. Characterization results revealed a reduction in crystallite size to 7.2 nm. Adding MnO_x enhanced the optical absorption of TiO₂, resulting in a shift toward the red end of the spectrum of the forbidden energy band. The photocatalytic activity increased significantly with the percentage of MnO_x, reaching a maximum degradation of 70 % in 6 hours with the 3 MnTi material. This increase was attributed to the synthesis method, which facilitated the formation of nanostructured heterojunctions mainly composed of TiO₂ and MnO₂, reducing the recombination of electron-hole pairs. TEM analysis confirmed these structures. A reaction mechanism for the 3 MnTi material is proposed, considering the mobility of charge carriers and the photooxidation processes of the pollutant.</p>","PeriodicalId":9831,"journal":{"name":"ChemistryOpen","volume":"14 1","pages":""},"PeriodicalIF":2.5,"publicationDate":"2024-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11726695/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142817376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"dl-Limonene as an Alternative Sustainable Solvent to Xylenes for the Industrial Preparation of Release Formulations.","authors":"Giuseppe D'Orazio, Rosa Ragone, Antonino Rizzuti, Francesca Serena Abatematteo, Alessandra Ciampa, Giuseppe Ghisa, Michela Casini, Mario Latronico, Vito Gallo, Piero Mastrorilli, Biagia Musio","doi":"10.1002/open.202400259","DOIUrl":"https://doi.org/10.1002/open.202400259","url":null,"abstract":"<p><p>Many industrial processes use aromatic hydrocarbons as solvents, including benzene, toluene, ethylbenzene, and xylene (BTEX). However, their use is discouraged due to their toxicological profile. Research is ongoing to find alternative more sustainable solvents. This work explores the adoption of dl-limonene as an alternative to BTEX for the industrial preparation of release formulations containing carnauba wax to be employed in the peelable foils industry. A preliminary chemical-physical characterization of carnauba wax was carried out using spectroscopic (ATR-FTIR, NMR) and thermal analyses (DSC). Based on the chemical composition found for the carnauba wax used in the present study, different solvent mixtures and different concentrations of carnauba wax were tested to obtain a clear and stable solution. The most promising formulations were subjected to a coating test on a solid substrate (polyethylene terephthalate, PET) on a laboratory scale, followed by a peeling test to assess the resulting peeling strength. The dl-limonene/ethyl acetate mixture in the 9 : 1 ratio has been identified as the most suitable to completely solubilize carnauba wax (0.38 wt/vol %) and obtain an adequate release performance. The results of these experiments were then used to set up and successfully perform an industrial-scale coating test.</p>","PeriodicalId":9831,"journal":{"name":"ChemistryOpen","volume":" ","pages":"e202400259"},"PeriodicalIF":2.5,"publicationDate":"2024-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142806130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Front Cover: Protein Quakes in Redox Metalloenzymes: Clues to Molecular Enzyme Conductivity Triggered by Binding of Small Substrate Molecules (ChemistryOpen 12/2024)","authors":"Henrik Bohr,&nbsp;Irene Shim,&nbsp;Jens Ulstrup,&nbsp;Xinxin Xiao","doi":"10.1002/open.202481201","DOIUrl":"https://doi.org/10.1002/open.202481201","url":null,"abstract":"<p><b>Redox metalloenzymes</b> often show no electrochemistry, while the enzyme substrate triggers electrocatalysis. For example two-centre Cu nitrite reductase in the biological nitrogen cycle shows voltammetry only when NO₂^- is present. NO₂^- also triggers STM conductivity, while AFM discloses major conformational expansion.The front cover offers an <i>ab initio</i> quantum chemical rationale based on 740-atom enzyme fragments. NO₂^- induces conformational reorganization throughout the protein and frontier orbital delocalization strongly promoting electronic conductivity. More information can be found in the Research Article by Jens Ulstrup and co-workers (DOI: 10.1002/open.202400190).<figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure>\u0000 </p>","PeriodicalId":9831,"journal":{"name":"ChemistryOpen","volume":"13 12","pages":""},"PeriodicalIF":2.5,"publicationDate":"2024-12-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/open.202481201","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143186451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Review on Leaching of Spent Lithium Battery Cathode Materials Adopting Deep Eutectic Solvents","authors":"Chongyu Li,&nbsp;Jianjiao Jin,&nbsp;Zhang Yuan,&nbsp;Chenyun Zhang,&nbsp;Liangqin Wu,&nbsp;Chu Wang","doi":"10.1002/open.202400258","DOIUrl":"10.1002/open.202400258","url":null,"abstract":"<p>As a result of the swift surge in the adoption of electric vehicles, the quantity of spent lithium-ion power batteries has been growing at an exponential rate. Improper handling of these batteries can lead to the waste of strategic metal resources and pose risks to the environment and human health. Without doubt, it is essential to scientifically recover and reuse these spent power batteries, particularly by recovering positive electrode materials. Currently, there are several methods for recovering positive electrode materials, including pyrometallurgy, hydrometallurgy, bioleaching, and deep eutectic solvents (DESs) leaching. This review concetrated on the emerging technology of DESs leaching for positive electrode materials in spent lithium-ion battery. It provided an overview of the latest advancements in DESs leaching, considering factors such as acidity, reducibility, and coordination of DESs. The current technical status was analyzed and discussed, while also addressing the challenges and prospects for the development of DESs recovery in spent Li-ion power batteries. This work aims to offer practical guidance and serve as a foundation for additional studies and widespread implementation of DESs leaching for positive electrode materials.</p>","PeriodicalId":9831,"journal":{"name":"ChemistryOpen","volume":"14 4","pages":""},"PeriodicalIF":2.5,"publicationDate":"2024-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/open.202400258","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142784266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}