ChemistryOpen最新文献_第9页

Crystal Structure-Activity Relationship of Some MeO Phenylacrylonitriles: Dual Antimicrobial-Cytotoxic Effects and in Silico Perspectives. 一些MeO苯基丙烯腈的晶体结构-活性关系：双重抗菌-细胞毒作用和硅透视。

IF 2.5 4区化学

ChemistryOpen Pub Date : 2025-06-12 DOI: 10.1002/open.202500280

Leyla Babali Özen, Öner Ekici, Furkan Özen, Süleyman Berberler, Gül Özkan, Betül Yılmaz Öztürk, Pınar Oztopcu-Vatan, Cansu Filik İşçen, Günseli Turgut Cin

{"title":"Crystal Structure-Activity Relationship of Some MeO Phenylacrylonitriles: Dual Antimicrobial-Cytotoxic Effects and in Silico Perspectives.","authors":"Leyla Babali Özen, Öner Ekici, Furkan Özen, Süleyman Berberler, Gül Özkan, Betül Yılmaz Öztürk, Pınar Oztopcu-Vatan, Cansu Filik İşçen, Günseli Turgut Cin","doi":"10.1002/open.202500280","DOIUrl":"https://doi.org/10.1002/open.202500280","url":null,"abstract":"Herein, methoxy-substituted phenylacrylonitrile derivatives 2(a-c) are synthesized via Knoevenagel condensation and characterized using fourier-transform infrared spectroscopy, nuclear magnetic resonance spectroscopy, and X-ray crystallography (for 2a and 2b). Although compounds 2a and 2b have previously been reported in terms of their structural features, their dual antimicrobial and anticancer activities, as well as crystallographic structure-activity relationships, have not yet been investigated. Notably, no earlier studies assessed their selective cytotoxicity using both cancerous (MCF-7) and healthy (L929) cell lines-a gap addressed in this work. Molecular docking analyzes reveal strong binding affinities to biological targets, including penicillin binding protein 2 (PBP2) (-8.4 kcal mol-1 for 2c) and CDK1/Cks2 (-9.5 kcal mol-1 for 2c), highlighting their dual-action potential. Antimicrobial assays against nine bacterial strains show minimum inhibitory concentration values ranging from 2.5 to 25 mg mL-1, with 2c exhibiting notable activity against gram-positive bacteria. Cytotoxicity assays demonstrate potent effects against MCF-7 cells (IC50: 34 μM for 2b, 44 μM for 2a), while 2c shows broader but moderate activity. The integration of crystallographic, docking, and biological assays underscores the therapeutic potential of these derivatives, with 2(a,b) emerging as selective candidates for breast cancer treatment.","PeriodicalId":9831,"journal":{"name":"ChemistryOpen","volume":" ","pages":"e2500280"},"PeriodicalIF":2.5,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144282671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Design, Synthesis, Biological Evaluation, and In Silico Study of Tetrahydropyridines as Prospective Monoamine Oxidase Inhibitors. 四氢吡啶作为前瞻性单胺氧化酶抑制剂的设计、合成、生物学评价和硅研究。

IF 2.5 4区化学

ChemistryOpen Pub Date : 2025-06-12 DOI: 10.1002/open.202400516

Obaid Ur Rehman Khan, Bilal Ahmad Khan, Syeda Shamila Hamdani, Saquib Jalil, Peter A Sidhom, Khalid Elfaki Ibrahim, Tarad Abalkhail, Jamshed Iqbal, Hatem Tallima, Tamer Shoeib, Mahmoud A A Ibrahim

{"title":"Design, Synthesis, Biological Evaluation, and In Silico Study of Tetrahydropyridines as Prospective Monoamine Oxidase Inhibitors.","authors":"Obaid Ur Rehman Khan, Bilal Ahmad Khan, Syeda Shamila Hamdani, Saquib Jalil, Peter A Sidhom, Khalid Elfaki Ibrahim, Tarad Abalkhail, Jamshed Iqbal, Hatem Tallima, Tamer Shoeib, Mahmoud A A Ibrahim","doi":"10.1002/open.202400516","DOIUrl":"https://doi.org/10.1002/open.202400516","url":null,"abstract":"The potentiality of monoamine oxidase (MAO) enzymes to break monoamine neurotransmitters makes them efficacious druggable targets. Molecules having MAO-A inhibition characteristics are utilized as antidepressants while molecules with MAO-B inhibition prospective are utilized to treat Parkinson's and Alzheimer's diseases. Herein, we have shown how the selective inhibition of both isozymes can be attained by varying the substitution of electron-withdrawing and donating groups on the phenyl rings of tetrahydropyridines, i. e., ethyl 1,2,6-triaryl-4-(arylamino)-1,2,5,6-tetrahydropyridine-3-carboxylate (4 a-4 o). The structures of these piperidines (4 a-4 o) were unambiguously established by different spectro-analytical techniques, including 1H- and 13C-NMR. Among the synthesized compounds, compounds 4 l and 4 n were identified as the most promising inhibitors of MAO-A and MAO-B, with IC50 values of 0.40±0.05 and 1.01±0.03 μM, respectively, compared with positive controls, namely clorgyline and l-deprenyl, with IC50 values of 0.0045±0.0003 and 0.0196±0.001 μM, respectively. The binding interactions of the most potent derivatives within the binding pocket of the MAO-A and MAO-B enzymes were predicted by molecular docking studies. Binding mode analysis revealed the capacity of compounds 4 l and 4 n to exhibit a hydrogen bond with PHE177 of MAO-A and GLN206 of MAO-B, respectively.","PeriodicalId":9831,"journal":{"name":"ChemistryOpen","volume":" ","pages":"e202400516"},"PeriodicalIF":2.5,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144282672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Efficient Synthesis of 1-Chloroimidazo[1,2-a:4,5-c']dipyridines, Versatile Synthons for Position-1 Functionalisation with Various Reagents. 1-氯咪唑[1,2-a:4,5-c']二吡啶的高效合成：1位功能化的多用途试剂

IF 2.5 4区化学

ChemistryOpen Pub Date : 2025-06-12 DOI: 10.1002/open.202500178

Romain Dussart, Mélanie Pénichon, Pierre-Olivier Delaye, Cécile Enguehard-Gueiffier

引用次数: 0

Synthesis and Characterization of Co(II), Cu(II), and Ni(II) Complexes of 2,2′-Bipyridine-4,4′-Dicarboxamide Ligands: Antibacterial Evaluation Against Resistant Bacteria and Enzyme Inhibition 2,2′-联吡啶-4,4′-二甲酰胺配体Co（II）、Cu（II）和Ni（II）配合物的合成与表征：对耐药菌的抗菌评价及酶抑制作用

IF 3.1 4区化学

ChemistryOpen Pub Date : 2025-06-09 DOI: 10.1002/open.202500097

Hussein Alchurak, Aseel Almadhoun, İsmail Yılmaz, Raneem Mamoun Ali Nour, Müslüm Kuzu, Hasan Solmaz

{"title":"Synthesis and Characterization of Co(II), Cu(II), and Ni(II) Complexes of 2,2′-Bipyridine-4,4′-Dicarboxamide Ligands: Antibacterial Evaluation Against Resistant Bacteria and Enzyme Inhibition","authors":"Hussein Alchurak, Aseel Almadhoun, İsmail Yılmaz, Raneem Mamoun Ali Nour, Müslüm Kuzu, Hasan Solmaz","doi":"10.1002/open.202500097","DOIUrl":"10.1002/open.202500097","url":null,"abstract":"In this study, two new 2,2′-bipyridine-4,4′-dicarboxamide ligands, namely N4,N4′-bis(pyridin-2-ylmethyl)-[2,2′-bipyridine]-4,4′-dicarboxamide (L1) and N4,N4′-bis(piperidin-2-ylmethyl)-[2,2′-bipyridine]-4,4′-dicarboxamide (L2), and their Co(II), Cu(II), and Ni(II) complexes are synthesized and characterized. Elemental analysis, Fourier transform infrared spectroscopy, nuclear magnetic resonance, and mass techniques confirmed the structures of the synthesized compounds. The L1 structure is also determined by single-crystal X-ray diffraction. Antibacterial activities of ligands and metal complexes against resistant strains are investigated. The L2-Co complex demonstrates promising antibacterial qualities against these resistant strains, which is noteworthy. Additionally, enzyme inhibition studies are conducted to assess their potential therapeutic applications. The results show that the L2-Ni complex had the strongest inhibitory effect with IC50 values of 1.35 μM for lipase enzyme, 4.33 μM for acetylcholinesterase enzyme, and 6.42 μM for butyrylcholinesterase.","PeriodicalId":9831,"journal":{"name":"ChemistryOpen","volume":"14 9","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://chemistry-europe.onlinelibrary.wiley.com/doi/epdf/10.1002/open.202500097","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144246621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

High-Performance Oxidation and Nanomolar Detection of Phenylhydrazine Using a 6-Hydroxyflavone-Based Molecular Electrocatalyst Functionalized Multiwalled Carbon Nanotube in Batch Injection Analysis. 基于6-羟基黄酮的分子电催化剂功能化多壁碳纳米管在间歇注射分析中高效氧化和纳米摩尔检测苯肼。

IF 2.5 4区化学

ChemistryOpen Pub Date : 2025-06-09 DOI: 10.1002/open.202500140

Valisireddy Lavanya, Kannappan Santhakumar, Annamalai Senthil Kumar

{"title":"High-Performance Oxidation and Nanomolar Detection of Phenylhydrazine Using a 6-Hydroxyflavone-Based Molecular Electrocatalyst Functionalized Multiwalled Carbon Nanotube in Batch Injection Analysis.","authors":"Valisireddy Lavanya, Kannappan Santhakumar, Annamalai Senthil Kumar","doi":"10.1002/open.202500140","DOIUrl":"https://doi.org/10.1002/open.202500140","url":null,"abstract":"The development of simple and rapid methods for preparing redox-active molecular catalyst-functionalized carbon electrodes for electrocatalytic applications is a significant research area. 6-Hydroxyflavone (HFLA), a naturally occurring flavonoid with known anxiolytic properties, also acts as a noncompetitive inhibitor of cytochrome. This study focuses on the in situ functionalization of multiwalled carbon nanotubes (MWCNTs) with redox-active HFLA, resulting in a modified electrode denoted as GCE/MWCNT@HFLA-Redox, where HFLA-Redox represents the redox-active product of HFLA. The constructed-modified electrode exhibits a well-defined and stable surface-confined redox response at E° of 0.55 V versus Ag/AgCl, with a surface excess of 6.26 × 10-9 mol cm-2 in a pH 2 KCl-HCl solution. The modified electrode is characterized by Fourier transform infrared, Raman, UV-vis, field-emission scanning electron microscopy, high-resolution mass spectrometry (organic extract), and control electrochemical studies. This GCE/MWCNT@HFLA-Redox electrode selectively oxidizes phenylhydrazine (PhHyd) in a pH 2 KCl-HCl solution. A screen-printed-modified electrode facilitates highly selective electrocatalytic oxidation of PhHyd via amperometric i-t measurements and batch injection analysis, without interference from hydrazine or other common electroactive species. This method exhibits an excellent linear calibration curve (200 nM to 2 μM), demonstrating a high-current sensitivity of 0.413 μA μM-1 cm-2 and a detection limit of 7 nM (signal-to-noise ratio of 3).","PeriodicalId":9831,"journal":{"name":"ChemistryOpen","volume":" ","pages":"e2500140"},"PeriodicalIF":2.5,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144257461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring Unspecific Peroxygenase Selectivity with Diverse Hydrocarbon Substrates. 探索不同碳氢化合物底物对非特异性过氧酶的选择性。

IF 2.5 4区化学

ChemistryOpen Pub Date : 2025-06-09 DOI: 10.1002/open.202400521

Essi Rytkönen, Nina Hakulinen, Janne Jänis, Juha Rouvinen

{"title":"Exploring Unspecific Peroxygenase Selectivity with Diverse Hydrocarbon Substrates.","authors":"Essi Rytkönen, Nina Hakulinen, Janne Jänis, Juha Rouvinen","doi":"10.1002/open.202400521","DOIUrl":"https://doi.org/10.1002/open.202400521","url":null,"abstract":"Unspecific peroxygenases (UPOs) are enzymes capable of oxidising various substrates using hydrogen peroxide as a co-substrate. UPOs have gained interest due to their broad substrate specificity, which includes relatively inexpensive precursors for valuable compounds, such as pharmaceuticals and chemical building blocks. In this study, the activity of a panel of 30 UPOs toward aliphatic and aromatic hydrocarbons was screened to assess variation in substrate selectivity. Most of the studied UPOs were able to oxidise the substrates efficiently, producing 2-5 products via hydrogen abstraction or epoxidation. Overall trends were observed, such as the preference for aromatic oxidation over benzylic hydroxylation in the case of toluene, while the opposite was observed with ethylbenzene. Different UPOs could also be categorized based on their reaction profiles with all substrates. Selectivity was generally low, as oxyfunctionalization reactions led to mixtures of products that were further oxidised. However, styrene and cyclohexene were converted rather exclusively to their epoxide products. The results indicate that the substrate scope of UPOs includes various types of hydrocarbons, which are oxidised depending on the individual enzyme's active site. They also hold potential for producing chemicals for industrial purposes more sustainably, but their selectivity should first be improved through protein engineering.","PeriodicalId":9831,"journal":{"name":"ChemistryOpen","volume":" ","pages":"e202400521"},"PeriodicalIF":2.5,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144246610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Fuel-Driven Lock-and-Key System 一种燃料驱动的锁-钥匙系统。

IF 3.1 4区化学

ChemistryOpen Pub Date : 2025-06-09 DOI: 10.1002/open.202500042

Shilin Zhang, Yanan Zhu, Hailiang Ni, Ping Hu, Yibin Sun

引用次数: 0

Anti-Inflammatory/Antioxidant Features of Adipose Tissue Mesenchymal Stem Cells Conditioned Media for Doped TiO2 Nanoparticles in Induced Inflammation 脂肪组织间充质干细胞条件培养基中掺杂TiO2纳米颗粒诱导炎症的抗炎/抗氧化特性

IF 3.1 4区化学

ChemistryOpen Pub Date : 2025-06-09 DOI: 10.1002/open.202500261

Ahmed A. Abd-Rabou, Ahmed M. Youssef, Mohamed I. El-Khonezy, Soheir E. Kotob, Mohamed S. Kishta

{"title":"Anti-Inflammatory/Antioxidant Features of Adipose Tissue Mesenchymal Stem Cells Conditioned Media for Doped TiO2 Nanoparticles in Induced Inflammation","authors":"Ahmed A. Abd-Rabou, Ahmed M. Youssef, Mohamed I. El-Khonezy, Soheir E. Kotob, Mohamed S. Kishta","doi":"10.1002/open.202500261","DOIUrl":"10.1002/open.202500261","url":null,"abstract":"The fundamental purpose of this work is to determine the anti-inflammatory/antioxidant activity of stem cell conditioned medium enhanced by mono- or dual-doped TiO2 nanoparticles. The transmission electron microscope, X-ray diffraction, and energy-dispersive X-ray analyses are used to characterize the nanoparticles. Isolation/characterization of adipose tissue mesenchymal stem cells (AD-MSCs) is done. In vitro assays reveal that protein denaturation and proteinase induction are significantly increased with lipopolysaccharide (LPS) comparable to control, while treatments significantly decrease the induction compared to LPS. In vitro assays reveal decreasing in hydroxyl radical scavenging and DPPH radical scavenging activities with LPS, while treatments significantly increase the activity compared to LPS. Induction with LPS decreases in vitro catalase (CAT), superoxide dismutase (SOD), and glutathione peroxidase (GPx) expression levels and enzyme activities are significantly compared to controls, while treatments significantly increase the CAT expression compared to LPS. Induction with LPS increases the in vitro interleukin 4 (IL4), IL6, IL10, and tumor necrosis factor α expression levels, and their activities significantly decline with treatment compared to controls, while treatments significantly decline expression compared to LPS. The anti-inflammatory and antioxidant properties of AD-MSC-conditioned medium enhanced with mono- or dual-doped TiO2 nanoparticles are identified in this investigation. To sum up, the work has shown that mono- and dual-doped TiO2 can inhibit the inflammation caused by LPS in vitro.","PeriodicalId":9831,"journal":{"name":"ChemistryOpen","volume":"14 8","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://chemistry-europe.onlinelibrary.wiley.com/doi/epdf/10.1002/open.202500261","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144246608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of the Sedative Activity of Naringenin: In Vivo Study with Pharmacokinetics and Molecular Docking Insights. 柚皮素镇静活性的评价：体内药代动力学和分子对接研究。

IF 2.5 4区化学

ChemistryOpen Pub Date : 2025-06-08 DOI: 10.1002/open.202500114

Dipu Bishwas, Md Shimul Bhuia, Salehin Sheikh, Mohammed Alfaifi, Abdul Malik, Nikhat J Siddiqui, Divya Jain, Mehedi Hasan Bappi, Muhammad Torequl Islam

{"title":"Evaluation of the Sedative Activity of Naringenin: In Vivo Study with Pharmacokinetics and Molecular Docking Insights.","authors":"Dipu Bishwas, Md Shimul Bhuia, Salehin Sheikh, Mohammed Alfaifi, Abdul Malik, Nikhat J Siddiqui, Divya Jain, Mehedi Hasan Bappi, Muhammad Torequl Islam","doi":"10.1002/open.202500114","DOIUrl":"https://doi.org/10.1002/open.202500114","url":null,"abstract":"This research is designed to investigate the sedative effects of naringenin (NAR) and diazepam against thiopental sodium-induced sleeping mice. NAR (5 and 10 mg kg), diazepam (DZP) (2 mg kg), flumazenil (FLN) (0.1 mg kg), and their combinations are administered intraperitoneally to mice. After 30 min, sleep is induced with intraperitoneal thiopental sodium (20 mg kg), and sleep latency and duration are measured. In silico analysis investigates the role of GABA receptors. NAR significantly reduces sleep latency and prolongs sleep duration in a dose-dependent manner, with the combination of NAR-10 and DZP-2 showing a synergistic effect. The combination of the antagonist (FLN) (NAR-10 and FLN-0.1) indicates that latency increases and sleep duration decreases compared to NAR-10 alone. Furthermore, in silico docking studies corroborates these results, demonstrating a significant binding affinity of NAR (-8.3 kcal mol), which is comparable to the standard ligand DZP (-8.7 kcal mol) and FLN (-7.0 kcal mol) for the GABAA (6X3X) receptor, indicating a GABAergic mechanism. Pharmacokinetics and toxicity evaluations confirm NAR's potential as a safe therapeutic agent, with a high LD50 (2000 mg kg) and minimal toxicity. These findings highlight NAR's potential as a GABAergic sedative agent, requiring further research before being used clinically to treat sleep disorders.","PeriodicalId":9831,"journal":{"name":"ChemistryOpen","volume":" ","pages":"e2500114"},"PeriodicalIF":2.5,"publicationDate":"2025-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144246609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gas Chromatography-Mass Spectrometry Analysis, Genoprotective, and Antioxidant Potential of Curio Radicans (L. f.) P.V. Heath. Curio Radicans的气相色谱-质谱分析、基因保护和抗氧化潜力（L. f.）pv健康。

IF 2.5 4区化学

ChemistryOpen Pub Date : 2025-06-08 DOI: 10.1002/open.202500175

Muhammad Naseer, Muhammad Adil, Sarir Ahmad, Mikhlid H Almutari, Abdulwahed Fahad Alrefaei, Sajid Ali, Fayyaz Asad

{"title":"Gas Chromatography-Mass Spectrometry Analysis, Genoprotective, and Antioxidant Potential of Curio Radicans (L. f.) P.V. Heath.","authors":"Muhammad Naseer, Muhammad Adil, Sarir Ahmad, Mikhlid H Almutari, Abdulwahed Fahad Alrefaei, Sajid Ali, Fayyaz Asad","doi":"10.1002/open.202500175","DOIUrl":"https://doi.org/10.1002/open.202500175","url":null,"abstract":"Natural substances play a crucial role in modern medicine by targeting cellular pathways associated with diseases. Medicinal plants, rich in bioactive compounds, offer promising therapeutic potential. This study examines the phytochemicals and biological activity of Curio radicans extracts. Gas chromatography-mass spectrometry analysis identifies 29 compounds in the ethanolic extract and 7 in the ethyl acetate extract. The ethanolic extract contains 3,4-Bis (Methoxycarbonyl)furan (15.76%) and 4-Imidazolidinone (14.17%), while the ethyl acetate extract is dominated by Diisooctyl phthalate (49.25%). Genoprotective activity, using the comet assay on human lymphocytes, demonstrates significant dose-dependent reductions in H2O2-induced DNA damage. The ethyl acetate extract reduces total comet score (TCS) from 265.3 ± 20.4 to 33.0 ± 4.3 at 100 mg/100 mL (p < 0.0001), outperforming the ethanolic extract, which reduced TCS from 226.7 ± 41.6 to 44.0 ± 7.2 (p < 0.001). Antioxidant activity, assessed via the DPPH method, reveals moderate activity for the ethyl acetate extract (72.61 ± 1.65%, IC50: 137.58 μg/ml) and lower activity for the ethanolic extract (67.52 ± 0.44%, IC50: 156.52 μg/ml). These findings underscore the therapeutic potential of C. radicans, particularly the ethyl acetate extract, which demonstrates genoprotective effects. Researchers should focus on isolating active compounds and exploring their potential in drug development.","PeriodicalId":9831,"journal":{"name":"ChemistryOpen","volume":" ","pages":"e2500175"},"PeriodicalIF":2.5,"publicationDate":"2025-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144246620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0