Cerebral Cortex (New York, NY)最新文献_第6页

Quantitative MRI maps of human neocortex explored using cell type-specific gene expression analysis 利用细胞类型特异性基因表达分析，探索人类新皮层的定量MRI图谱

Cerebral Cortex (New York, NY) Pub Date : 2019-06-09 DOI: 10.1101/2022.04.07.487457

L. Edwards, P. McColgan, Saskia Helbling, A. Zarkali, L. Vaculčiaková, K. Pine, F. Dick, N. Weiskopf

{"title":"Quantitative MRI maps of human neocortex explored using cell type-specific gene expression analysis","authors":"L. Edwards, P. McColgan, Saskia Helbling, A. Zarkali, L. Vaculčiaková, K. Pine, F. Dick, N. Weiskopf","doi":"10.1101/2022.04.07.487457","DOIUrl":"https://doi.org/10.1101/2022.04.07.487457","url":null,"abstract":"Quantitative MRI (qMRI) allows extraction of reproducible and robust parameter maps. However, the connection to underlying biological substrates remains murky, especially in the complex, densely packed cortex. We investigated associations in human neocortex between qMRI parameters and neocortical cell types by comparing the spatial distribution of the qMRI parameters longitudinal relaxation rate (R1), effective transverse relaxation rate (R2∗), and magnetization transfer saturation (MTsat) to gene expression from the Allen Human Brain Atlas, then combining this with lists of genes enriched in specific cell types found in the human brain. As qMRI parameters are magnetic field strength-dependent, the analysis was performed on MRI data at 3T and 7T. All qMRI parameters significantly covaried with genes enriched in GABA- and glutamatergic neurons, i.e. they were associated with cytoarchitecture. The qMRI parameters also significantly covaried with the distribution of genes enriched in astrocytes (R2∗ at 3T, R1 at 7T), endothelial cells (R1 and MTsat at 3T), microglia (R1 and MTsat at 3T, R1 at 7T), and oligodendrocytes (R1 at 7T). These results advance the potential use of qMRI parameters as biomarkers for specific cell types.","PeriodicalId":9825,"journal":{"name":"Cerebral Cortex (New York, NY)","volume":"10 1","pages":"5704 - 5716"},"PeriodicalIF":0.0,"publicationDate":"2019-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73250313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Distinct roles for the anterior temporal lobe and angular gyrus in the spatiotemporal cortical semantic network 前颞叶和角回在时空皮层语义网络中的不同作用

Cerebral Cortex (New York, NY) Pub Date : 2019-02-08 DOI: 10.1101/544114

S. Farahibozorg, R. Henson, A. Woollams, O. Hauk

{"title":"Distinct roles for the anterior temporal lobe and angular gyrus in the spatiotemporal cortical semantic network","authors":"S. Farahibozorg, R. Henson, A. Woollams, O. Hauk","doi":"10.1101/544114","DOIUrl":"https://doi.org/10.1101/544114","url":null,"abstract":"It is now well recognised that human semantic knowledge is supported by a large neural network distributed over multiple brain regions, but the dynamic organisation of this network remains unknown. Some studies have proposed that a central semantic hub coordinates this network. We explored the possibility of different types of semantic hubs; namely “representational hubs”, whose neural activity is modulated by semantic variables, and “connectivity hubs”, whose connectivity to distributed areas is modulated by semantic variables. We utilised the spatio-temporal resolution of source-estimated Electro-/Magnetoencephalography data in a word-concreteness task (17 participants, 12 female) in order to: (i) find representational hubs at different timepoints based on semantic modulation of evoked brain activity in source space; (ii) identify connectivity hubs among left Anterior Temporal Lobe (ATL), Angular Gyrus (AG), Middle Temporal Gyrus and Inferior Frontal Gyrus based on their functional connectivity to the whole cortex, in particular sensory-motor-limbic systems; and (iii) explicitly compare network models with and without an intermediate hub linking sensory input to other candidate hub regions using Dynamic Causal Modelling (DCM) of evoked responses. ATL’s activity was modulated as early as 150ms post-stimulus, while both ATL and AG showed modulations of functional connectivity with sensory-motor-limbic areas from 150-450ms. DCM favoured models with one intermediate hub, namely ATL in an early time window and AG in a later time-window. Our results support ATL as a single representational hub with an early onset, but suggest that both ATL and AG function as connectivity hubs depending on the stage of semantic processing.","PeriodicalId":9825,"journal":{"name":"Cerebral Cortex (New York, NY)","volume":"59 1","pages":"4549 - 4564"},"PeriodicalIF":0.0,"publicationDate":"2019-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80250616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 17

Learning in Visual Regions as Support for the Bias in Future Value-Driven Choice 视觉区域学习对未来价值驱动选择偏差的支持

Cerebral Cortex (New York, NY) Pub Date : 2019-01-21 DOI: 10.1101/523340

Sara Jahfari, J. Theeuwes, T. Knapen

{"title":"Learning in Visual Regions as Support for the Bias in Future Value-Driven Choice","authors":"Sara Jahfari, J. Theeuwes, T. Knapen","doi":"10.1101/523340","DOIUrl":"https://doi.org/10.1101/523340","url":null,"abstract":"Reinforcement learning can bias decision-making towards the option with the highest expected outcome. Cognitive learning theories associate this bias with the constant tracking of stimulus values and the evaluation of choice outcomes in the striatum and prefrontal cortex. Decisions however first require processing of sensory input, and to-date, we know far less about the interplay between learning and perception. This fMRI study (N=43), relates visual BOLD responses to value-beliefs during choice, and, signed prediction errors after outcomes. To understand these relationships, which co-occurred in the striatum, we sought relevance by evaluating the prediction of future value-based decisions in a separate transfer phase where learning was already established. We decoded choice outcomes with a 70% accuracy with a supervised machine learning algorithm that was given trial-by-trial BOLD from visual regions alongside more traditional motor, prefrontal, and striatal regions. Importantly, this decoding of future value-driven choice outcomes again highligted an important role for visual activity. These results raise the intriguing possibility that the tracking of value in visual cortex is supportive for the striatal bias towards the more valued option in future choice.","PeriodicalId":9825,"journal":{"name":"Cerebral Cortex (New York, NY)","volume":"48 1","pages":"2005 - 2018"},"PeriodicalIF":0.0,"publicationDate":"2019-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78190576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

In Vivo Assay of Cortical Microcircuitry in Frontotemporal Dementia: A Platform for Experimental Medicine Studies 额颞叶痴呆皮层微电路的体内检测:一个实验医学研究平台

Cerebral Cortex (New York, NY) Pub Date : 2018-09-13 DOI: 10.1101/416388

A. Shaw, L. Hughes, R. Moran, I. Coyle-Gilchrist, T. Rittman, J. Rowe

引用次数: 22

Neural Dynamics of Associative Learning during Human Sleep 人类睡眠中联想学习的神经动力学

Cerebral Cortex (New York, NY) Pub Date : 2018-07-19 DOI: 10.1093/cercor/bhz197

Andrés Canales-Johnson, E. Merlo, T. Bekinschtein, A. Arzi

引用次数: 8

Dopamine Signaling Modulates the Stability and Integration of Intrinsic Brain Networks 多巴胺信号调节大脑内在网络的稳定性和整合

Cerebral Cortex (New York, NY) Pub Date : 2018-01-31 DOI: 10.1101/252528

G. Shafiei, Y. Zeighami, C. Clark, J. Coull, A. Nagano-Saito, M. Leyton, A. Dagher, B. Mišić

{"title":"Dopamine Signaling Modulates the Stability and Integration of Intrinsic Brain Networks","authors":"G. Shafiei, Y. Zeighami, C. Clark, J. Coull, A. Nagano-Saito, M. Leyton, A. Dagher, B. Mišić","doi":"10.1101/252528","DOIUrl":"https://doi.org/10.1101/252528","url":null,"abstract":"Dopaminergic projections are hypothesized to stabilize neural signaling and neural representations, but how they shape regional information processing and large-scale network interactions remains unclear. Here we investigated effects of lowered dopamine levels on within-region temporal signal variability (measured by sample entropy) and between-region functional connectivity (measured by pairwise temporal correlations) in the healthy brain at rest. The acute phenylalanine and tyrosine depletion (APTD) method was used to decrease dopamine synthesis in 51 healthy participants who underwent resting-state functional MRI (fMRI) scanning. Functional connectivity and regional signal variability were estimated for each participant. Multivariate partial least squares (PLS) analysis was used to statistically assess changes in signal variability following APTD as compared to the balanced control treatment. The analysis captured a pattern of increased regional signal variability following dopamine depletion. Changes in hemodynamic signal variability were concomitant with changes in functional connectivity, such that nodes with greatest increase in signal variability following dopamine depletion also experienced greatest decrease in functional connectivity. Our results suggest that dopamine may act to stabilize neural signaling, particularly in networks related to motor function and orienting attention towards behaviorally-relevant stimuli. Moreover, dopaminedependent signal variability is critically associated with functional embedding of individual areas in large-scale networks.","PeriodicalId":9825,"journal":{"name":"Cerebral Cortex (New York, NY)","volume":"13 1","pages":"397 - 409"},"PeriodicalIF":0.0,"publicationDate":"2018-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78268712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 83

Network-Based Asymmetry of the Human Auditory System 基于网络的人类听觉系统不对称性

Cerebral Cortex (New York, NY) Pub Date : 2018-01-22 DOI: 10.1101/251827

B. Mišić, Richard F. Betzel, A. Griffa, M. D. de Reus, Ye He, X. Zuo, M. P. van den Heuvel, P. Hagmann, O. Sporns, R. Zatorre

{"title":"Network-Based Asymmetry of the Human Auditory System","authors":"B. Mišić, Richard F. Betzel, A. Griffa, M. D. de Reus, Ye He, X. Zuo, M. P. van den Heuvel, P. Hagmann, O. Sporns, R. Zatorre","doi":"10.1101/251827","DOIUrl":"https://doi.org/10.1101/251827","url":null,"abstract":"Converging evidence from activation, connectivity and stimulation studies suggests that auditory brain networks are lateralized. Here we show that these findings can be at least partly explained by the asymmetric network embedding of the primary auditory cortices. Using diffusion-weighted imaging in three independent datasets, we investigate the propensity for left and right auditory cortex to communicate with other brain areas by quantifying the centrality of the auditory network across a spectrum of communication mechanisms, from shortest path communication to diffusive spreading. Across all datasets, we find that the right auditory cortex is better integrated in the connectome, facilitating more efficient communication with other areas, with much of the asymmetry driven by differences in communication pathways to the opposite hemisphere. Critically, the primacy of the right auditory cortex emerges only when communication is conceptualized as a diffusive process, taking advantage of more than just the topologically shortest paths in the network. Altogether, these results highlight how the network configuration and embedding of a particular region may contribute to its functional lateralization.","PeriodicalId":9825,"journal":{"name":"Cerebral Cortex (New York, NY)","volume":"14 1","pages":"2655 - 2664"},"PeriodicalIF":0.0,"publicationDate":"2018-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91345688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 46

STDP Forms Associations between Memory Traces in Networks of Spiking Neurons STDP在尖峰神经元网络中形成记忆痕迹之间的联系

Cerebral Cortex (New York, NY) Pub Date : 2017-09-14 DOI: 10.1101/188938

C. Pokorny, M. Ison, Arjun Rao, R. Legenstein, C. Papadimitriou, W. Maass

{"title":"STDP Forms Associations between Memory Traces in Networks of Spiking Neurons","authors":"C. Pokorny, M. Ison, Arjun Rao, R. Legenstein, C. Papadimitriou, W. Maass","doi":"10.1101/188938","DOIUrl":"https://doi.org/10.1101/188938","url":null,"abstract":"Memory traces and associations between them are fundamental for cognitive brain function. Neuron recordings suggest that distributed assemblies of neurons in the brain serve as memory traces for spatial information, real-world items, and concepts. However, there is conflicting evidence regarding neural codes for associated memory traces. Some studies suggest the emergence of overlaps between assemblies during an association, while others suggest that the assemblies themselves remain largely unchanged and new assemblies emerge as neural codes for associated memory items. Here we study the emergence of neural codes for associated memory items in a generic computational model of recurrent networks of spiking neurons with a data-based rule for spike-timing-dependent plasticity (STDP). The model depends critically on two parameters, which control the excitability of neurons and the scale of initial synaptic weights. By modifying these two parameters, the model can reproduce both experimental data from the human brain on the fast formation of associations through emergent overlaps between assemblies, and rodent data where new neurons are recruited to encode the associated memories. Hence our findings suggest that the brain can use both of these two neural codes for associations, and dynamically switch between them during consolidation.","PeriodicalId":9825,"journal":{"name":"Cerebral Cortex (New York, NY)","volume":"71 1","pages":"952 - 968"},"PeriodicalIF":0.0,"publicationDate":"2017-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73920023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 14

Body Topography Parcellates Human Sensory and Motor Cortex 人体地形将人的感觉和运动皮层包裹起来

Cerebral Cortex (New York, NY) Pub Date : 2017-02-10 DOI: 10.1093/cercor/bhx026

E. Kuehn, Juliane Dinse, Estrid Jakobsen, X. Long, A. Schäfer, P. Bazin, A. Villringer, M. Sereno, D. Margulies

{"title":"Body Topography Parcellates Human Sensory and Motor Cortex","authors":"E. Kuehn, Juliane Dinse, Estrid Jakobsen, X. Long, A. Schäfer, P. Bazin, A. Villringer, M. Sereno, D. Margulies","doi":"10.1093/cercor/bhx026","DOIUrl":"https://doi.org/10.1093/cercor/bhx026","url":null,"abstract":"Abstract The cytoarchitectonic map as proposed by Brodmann currently dominates models of human sensorimotor cortical structure, function, and plasticity. According to this model, primary motor cortex, area 4, and primary somatosensory cortex, area 3b, are homogenous areas, with the major division lying between the two. Accumulating empirical and theoretical evidence, however, has begun to question the validity of the Brodmann map for various cortical areas. Here, we combined in vivo cortical myelin mapping with functional connectivity analyses and topographic mapping techniques to reassess the validity of the Brodmann map in human primary sensorimotor cortex. We provide empirical evidence that area 4 and area 3b are not homogenous, but are subdivided into distinct cortical fields, each representing a major body part (the hand and the face). Myelin reductions at the hand–face borders are cortical layer-specific, and coincide with intrinsic functional connectivity borders as defined using large-scale resting state analyses. Our data extend the Brodmann model in human sensorimotor cortex and suggest that body parts are an important organizing principle, similar to the distinction between sensory and motor processing.","PeriodicalId":9825,"journal":{"name":"Cerebral Cortex (New York, NY)","volume":"356 1","pages":"3790 - 3805"},"PeriodicalIF":0.0,"publicationDate":"2017-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77603584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 60

In Vivo Evidence of Reduced Integrity of the Gray-White Matter Boundary in Autism Spectrum Disorder. 自闭症谱系障碍中灰质-白质边界完整性降低的体内证据。

Cerebral Cortex (New York, NY) Pub Date : 2017-02-01 DOI: 10.1093/cercor/bhw404

Derek Sayre Andrews, Thomas A Avino, Maria Gudbrandsen, Eileen Daly, Andre Marquand, Clodagh M Murphy, Meng-Chuan Lai, Michael V Lombardo, Amber N V Ruigrok, Steven C Williams, Edward T Bullmore, The Mrc Aims Consortium, John Suckling, Simon Baron-Cohen, Michael C Craig, Declan G M Murphy, Christine Ecker

{"title":"In Vivo Evidence of Reduced Integrity of the Gray-White Matter Boundary in Autism Spectrum Disorder.","authors":"Derek Sayre Andrews, Thomas A Avino, Maria Gudbrandsen, Eileen Daly, Andre Marquand, Clodagh M Murphy, Meng-Chuan Lai, Michael V Lombardo, Amber N V Ruigrok, Steven C Williams, Edward T Bullmore, The Mrc Aims Consortium, John Suckling, Simon Baron-Cohen, Michael C Craig, Declan G M Murphy, Christine Ecker","doi":"10.1093/cercor/bhw404","DOIUrl":"10.1093/cercor/bhw404","url":null,"abstract":"<p><p>Atypical cortical organization and reduced integrity of the gray-white matter boundary have been reported by postmortem studies in individuals with autism spectrum disorder (ASD). However, there are no in vivo studies that examine these particular features of cortical organization in ASD. Hence, we used structural magnetic resonance imaging to examine differences in tissue contrast between gray and white matter in 98 adults with ASD and 98 typically developing controls, to test the hypothesis that individuals with ASD have significantly reduced tissue contrast. More specifically, we examined contrast as a percentage between gray and white matter tissue signal intensities (GWPC) sampled at the gray-white matter boundary, and across different cortical layers. We found that individuals with ASD had significantly reduced GWPC in several clusters throughout the cortex (cluster, P < 0.05). As expected, these reductions were greatest when tissue intensities were sampled close to gray-white matter interface, which indicates a less distinct gray-white matter boundary in ASD. Our in vivo findings of reduced GWPC in ASD are therefore consistent with prior postmortem findings of a less well-defined gray-white matter boundary in ASD. Taken together, these results indicate that GWPC might be utilized as an in vivo proxy measure of atypical cortical microstructural organization in future studies.</p>","PeriodicalId":9825,"journal":{"name":"Cerebral Cortex (New York, NY)","volume":"41 1","pages":"877-887"},"PeriodicalIF":0.0,"publicationDate":"2017-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6093436/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76713396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0