Cell reports最新文献_第7页

MetA is a ''thermal fuse'' that inhibits growth and protects Escherichia coli at elevated temperatures. MetA是一种“热保险丝”，在高温下抑制生长并保护大肠杆菌。

IF 7.5 1区生物学

Cell reports Pub Date : 2025-01-28 Epub Date: 2025-01-18 DOI: 10.1016/j.celrep.2025.115257

Severin J Schink, Zara Gough, Elena Biselli, Mariel Garcia Huiman, Yu-Fang Chang, Markus Basan, Ulrich Gerland

引用次数: 0

CPSF1 inhibition promotes widespread use of intergenic polyadenylation sites and impairs glycolysis in prostate cancer cells.

IF 7.5 1区生物学

Cell reports Pub Date : 2025-01-28 Epub Date: 2025-01-22 DOI: 10.1016/j.celrep.2024.115211

Kiel T Tietz, Braedan M McCluskey, Conor R Miller, Yingming Li, Sarah A Munro, Scott M Dehm

{"title":"CPSF1 inhibition promotes widespread use of intergenic polyadenylation sites and impairs glycolysis in prostate cancer cells.","authors":"Kiel T Tietz, Braedan M McCluskey, Conor R Miller, Yingming Li, Sarah A Munro, Scott M Dehm","doi":"10.1016/j.celrep.2024.115211","DOIUrl":"10.1016/j.celrep.2024.115211","url":null,"abstract":"Localized prostate cancer can be cured by radiation or surgery, but advanced prostate cancer continues to be a clinical challenge. Altered alternative polyadenylation occurs in numerous cancers and can downregulate tumor-suppressor genes and upregulate oncogenes. We found that the cleavage and polyadenylation specificity factor (CPSF) complex factor CPSF1 is upregulated in patients with advanced prostate cancer, with high CPSF1 expression correlating with worse progression-free survival. Knockdown of CPSF1 selectively inhibited the growth of prostate cancer cells and reduced glycolytic output. Evaluating the changes in global poly(A) site usage in prostate cancer cells following CPSF1 knockdown revealed widespread usage of intergenic poly(A) sites distal to annotated 3' UTRs, which lengthened 3' UTRs and decreased levels of thousands of mRNAs, including key glycolysis genes. These findings uncover a role for CPSF1 in the suppression of intergenic poly(A) sites in prostate cancer and nominate CPSF1 as a therapeutic target in advanced prostate cancer.","PeriodicalId":9798,"journal":{"name":"Cell reports","volume":"44 1","pages":"115211"},"PeriodicalIF":7.5,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143028046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A nonsecretory antimicrobial peptide mediates inflammatory organ damage in Drosophila renal tubules. 一种非分泌性抗菌肽介导果蝇肾小管的炎症性器官损伤。

IF 7.5 1区生物学

Cell reports Pub Date : 2025-01-28 Epub Date: 2024-12-23 DOI: 10.1016/j.celrep.2024.115082

Ayano Oi, Natsuki Shinoda, Shun Nagashima, Masayuki Miura, Fumiaki Obata

引用次数: 0

Anti-herpetic tau preserves neurons via the cGAS-STING-TBK1 pathway in Alzheimer's disease. 抗疱疹tau通过cGAS-STING-TBK1通路在阿尔茨海默病中保存神经元。

IF 7.5 1区生物学

Cell reports Pub Date : 2025-01-28 Epub Date: 2025-01-02 DOI: 10.1016/j.celrep.2024.115109

Vanesa R Hyde, Chaoming Zhou, Juan R Fernandez, Krishnashis Chatterjee, Pururav Ramakrishna, Amanda Lin, Gregory W Fisher, Orhan Tunç Çeliker, Jill Caldwell, Omer Bender, Peter Joseph Sauer, Jose Lugo-Martinez, Daniel Z Bar, Leonardo D'Aiuto, Or A Shemesh

{"title":"Anti-herpetic tau preserves neurons via the cGAS-STING-TBK1 pathway in Alzheimer's disease.","authors":"Vanesa R Hyde, Chaoming Zhou, Juan R Fernandez, Krishnashis Chatterjee, Pururav Ramakrishna, Amanda Lin, Gregory W Fisher, Orhan Tunç Çeliker, Jill Caldwell, Omer Bender, Peter Joseph Sauer, Jose Lugo-Martinez, Daniel Z Bar, Leonardo D'Aiuto, Or A Shemesh","doi":"10.1016/j.celrep.2024.115109","DOIUrl":"10.1016/j.celrep.2024.115109","url":null,"abstract":"Alzheimer's disease (AD) diagnosis relies on the presence of extracellular β-amyloid (Aβ) and intracellular hyperphosphorylated tau (p-tau). Emerging evidence suggests a potential link between AD pathologies and infectious agents, with herpes simplex virus 1 (HSV-1) being a leading candidate. Our investigation, using metagenomics, mass spectrometry, western blotting, and decrowding expansion pathology, detects HSV-1-associated proteins in human brain samples. Expression of the herpesvirus protein ICP27 increases with AD severity and strongly colocalizes with p-tau but not with Aβ. Modeling in human brain organoids shows that HSV-1 infection elevates tau phosphorylation. Notably, p-tau reduces ICP27 expression and markedly decreases post-infection neuronal death from 64% to 7%. This modeling prompts investigation into the cGAS-STING-TBK1 pathway products, nuclear factor (NF)-κB and IRF-3, which colocalizes with ICP27 and p-tau in AD. Furthermore, experimental activation of STING enhances tau phosphorylation, while TBK1 inhibition prevents it. Together, these findings suggest that tau phosphorylation acts as an innate immune response in AD, driven by cGAS-STING.","PeriodicalId":9798,"journal":{"name":"Cell reports","volume":" ","pages":"115109"},"PeriodicalIF":7.5,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142926818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The glial UDP-glycosyltransferase Ugt35b regulates longevity by maintaining lipid homeostasis in Drosophila. 胶质udp -糖基转移酶Ugt35b通过维持果蝇脂质稳态来调节寿命。

IF 7.5 1区生物学

Cell reports Pub Date : 2025-01-28 Epub Date: 2024-12-24 DOI: 10.1016/j.celrep.2024.115099

Lihong Sheng, Jianpeng Gao, Qingyuan Wei, Ye Gong, Zhi-Xiang Xu

引用次数: 0

Pathogenic role for CD101-negative neutrophils in the type I interferon-mediated immunopathogenesis of tuberculosis. cd101阴性中性粒细胞在I型干扰素介导的结核病免疫发病机制中的致病作用。

IF 7.5 1区生物学

Cell reports Pub Date : 2025-01-28 Epub Date: 2024-12-17 DOI: 10.1016/j.celrep.2024.115072

Mohd Saqib, Shreya Das, Tanvir N Nafiz, Elizabeth McDonough, Poornima Sankar, Lokesh K Mishra, Ximeng Zhang, Yi Cai, Selvakumar Subbian, Bibhuti B Mishra

{"title":"Pathogenic role for CD101-negative neutrophils in the type I interferon-mediated immunopathogenesis of tuberculosis.","authors":"Mohd Saqib, Shreya Das, Tanvir N Nafiz, Elizabeth McDonough, Poornima Sankar, Lokesh K Mishra, Ximeng Zhang, Yi Cai, Selvakumar Subbian, Bibhuti B Mishra","doi":"10.1016/j.celrep.2024.115072","DOIUrl":"10.1016/j.celrep.2024.115072","url":null,"abstract":"Neutrophils are vital for immunity against Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB), yet their heterogeneous nature suggests a complex role in TB pathogenesis. Here, we identify two distinct neutrophil populations based on CD101 expression, highlighting their divergent roles in TB. CD101-negative (CD101-ve) neutrophils, which resemble immature, pro-inflammatory granulocytes, exhibit reduced Mtb phagocytosis compared to their mature, CD101-positive (CD101+ve) counterparts. Our findings reveal that type I interferons (IFN-Is) suppress neutrophil Mtb uptake and drive the recruitment of CD101-ve neutrophils to the lungs. Infiltration of these cells promotes Mtb extracellular persistence, exacerbates epithelial damage, and impairs surfactant production. Furthermore, we demonstrate that granulocyte colony-stimulating factor (G-CSF) and chemokine receptor CXCR2 are essential for the pulmonary accumulation of CD101-ve neutrophils. Our study uncovers a pathogenic role for CD101-ve neutrophils in TB and highlights the IFN-I-dependent recruitment of this functionally compromised immature neutrophil as a driver of TB immunopathogenesis.","PeriodicalId":9798,"journal":{"name":"Cell reports","volume":"44 1","pages":"115072"},"PeriodicalIF":7.5,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142853146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Metabolic transcriptomics dictate responses of cone photoreceptors to retinitis pigmentosa. 代谢转录组学指示视锥光感受器对视网膜色素变性的反应。

IF 7.5 1区生物学

Cell reports Pub Date : 2025-01-28 Epub Date: 2024-12-21 DOI: 10.1016/j.celrep.2024.115160

Sang Joon Lee, Douglas Emery, Eric Vukmanic, Yekai Wang, Xiaoqin Lu, Wei Wang, Enzo Fortuny, Robert James, Henry J Kaplan, Yongqing Liu, Jianhai Du, Douglas C Dean

引用次数: 0

SLC7A5 is required for cancer cell growth under arginine-limited conditions. SLC7A5是癌细胞在精氨酸限制条件下生长所必需的。

IF 7.5 1区生物学

Cell reports Pub Date : 2025-01-28 Epub Date: 2025-01-03 DOI: 10.1016/j.celrep.2024.115130

Kyle N Dunlap, Austin Bender, Alexis Bowles, Alex J Bott, Joshua Tay, Allie H Grossmann, Jared Rutter, Gregory S Ducker

{"title":"SLC7A5 is required for cancer cell growth under arginine-limited conditions.","authors":"Kyle N Dunlap, Austin Bender, Alexis Bowles, Alex J Bott, Joshua Tay, Allie H Grossmann, Jared Rutter, Gregory S Ducker","doi":"10.1016/j.celrep.2024.115130","DOIUrl":"10.1016/j.celrep.2024.115130","url":null,"abstract":"Tumor cells must optimize metabolite acquisition between synthesis and uptake from a microenvironment characterized by hypoxia, lactate accumulation, and depletion of many amino acids, including arginine. We performed a metabolism-focused functional screen using CRISPR-Cas9 to identify pathways and factors that enable tumor growth in an arginine-depleted environment. Our screen identified the SLC-family transporter SLC7A5 as required for growth, and we hypothesized that this protein functions as a high-affinity citrulline transporter. Using isotope tracing experiments, we show that citrulline uptake and metabolism into arginine are dependent upon expression of SLC7A5. Pharmacological inhibition of SLC7A5 blocks growth under low-arginine conditions across a diverse group of cancer cell lines. Loss of SLC7A5 reduces tumor growth and citrulline import in a mouse tumor model. We identify a conditionally essential role for SLC7A5 in arginine metabolism, and we propose that SLC7A5-targeting therapeutic strategies in cancer may be effective in the context of arginine limitation.","PeriodicalId":9798,"journal":{"name":"Cell reports","volume":"44 1","pages":"115130"},"PeriodicalIF":7.5,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142930800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

IL-21 shapes the B cell response in a context-dependent manner. IL-21以上下文依赖的方式塑造B细胞反应。

IF 7.5 1区生物学

Cell reports Pub Date : 2025-01-28 Epub Date: 2025-01-09 DOI: 10.1016/j.celrep.2024.115190

Youngjun Kim, Francesca Manara, Simon Grassmann, Kalina T Belcheva, Kanelly Reyes, Hyunu Kim, Stephanie Downs-Canner, William T Yewdell, Joseph C Sun, Jayanta Chaudhuri

引用次数: 0

Tumor-induced metabolic immunosuppression: Mechanisms and therapeutic targets. 肿瘤诱导的代谢免疫抑制：机制和治疗靶点。

IF 7.5 1区生物学

Cell reports Pub Date : 2025-01-28 Epub Date: 2025-01-10 DOI: 10.1016/j.celrep.2024.115206

Jean-Ehrland Ricci

引用次数: 0