Cell reports最新文献_第8页

Paralogous mutations in the Plasmodium falciparum surface anion channel associate with reduced protection due to sickle hemoglobin. 恶性疟原虫表面阴离子通道的旁系突变与镰状血红蛋白引起的保护作用降低有关。

IF 7.7 1区生物学

Cell reports Pub Date : 2026-10-06 DOI: 10.1016/j.celrep.2026.117938

Annie J Forster, James Docker, Katie Healey, Zhipeng Zhang, Amy Trebes, David Buck, William L Hamilton, Lucas Amenga-Etego, Alexander J Mentzer, Alfred Amambua-Ngwa, Gavin Band

{"title":"Paralogous mutations in the Plasmodium falciparum surface anion channel associate with reduced protection due to sickle hemoglobin.","authors":"Annie J Forster, James Docker, Katie Healey, Zhipeng Zhang, Amy Trebes, David Buck, William L Hamilton, Lucas Amenga-Etego, Alexander J Mentzer, Alfred Amambua-Ngwa, Gavin Band","doi":"10.1016/j.celrep.2026.117938","DOIUrl":"https://doi.org/10.1016/j.celrep.2026.117938","url":null,"abstract":"Genome-wide association studies of pathogens can uncover new aspects of infection biology and inform interventions. Here, we sequence Plasmodium falciparum genomes from 831 infections of Gambian children, identifying an association with disease severity on chromosome 1 which replicates in Kenyan infections. We then incorporate previously published data from the Gambia, Ghana, Mali, and Kenya in a meta-analysis of association between parasite variation and host sickle hemoglobin (HbS; N = 6,289), revealing several associations beyond the four previously implicated Plasmodium falciparum sickle-associated loci. Prominent among these are mutations affecting the C-terminal of CLAG3, the major parasite nutrient uptake channel, which are shared between two paralogs and estimated to halve the protective effect of HbS. Further loci, including two members of the FIKK kinase family, are also implicated. Our findings indicate the parasite evolutionary response to HbS is more complex than previously understood, opening new functional and epidemiological questions about this important host-parasite interaction.","PeriodicalId":9798,"journal":{"name":"Cell reports","volume":"45 10","pages":"117938"},"PeriodicalIF":7.7,"publicationDate":"2026-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149126823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Differential formation of nitrate-responsive mycobacterial intracytoplasmic membranes during Mycobacterium tuberculosis infection. 结核分枝杆菌感染期间硝酸反应性分枝杆菌胞质内膜的差异形成。

IF 7.7 1区生物学

Cell reports Pub Date : 2026-10-05 DOI: 10.1016/j.celrep.2026.118078

Camille Keck, Stéphane Tachon, Fadel Sayes, Daniele Musiani, Quentin Giai Gianetto, Mariette Matondo, Matthijn Vos, Roland Brosch, Jost Enninga

{"title":"Differential formation of nitrate-responsive mycobacterial intracytoplasmic membranes during Mycobacterium tuberculosis infection.","authors":"Camille Keck, Stéphane Tachon, Fadel Sayes, Daniele Musiani, Quentin Giai Gianetto, Mariette Matondo, Matthijn Vos, Roland Brosch, Jost Enninga","doi":"10.1016/j.celrep.2026.118078","DOIUrl":"https://doi.org/10.1016/j.celrep.2026.118078","url":null,"abstract":"Subcellular compartmentalization of metabolic processes is a main feature of prokaryotic and eukaryotic architecture. Environmental bacteria generate intracytoplasmic membranes (ICMs) as a crucial strategy to adapt their metabolism to environmental changes. While pathogenic intracellular bacteria also perceive various stressful stimuli during host interactions, the subsequent re-organization of their internal architecture has not been explored. Using cryo-electron tomography, we show that Mycobacterium tuberculosis (Mtb), a major human pathogen, is able to form ICMs outside and inside host cells in a strain-dependent manner. We characterize these Mycobacterial intracytoplasmic Membranes (MIMs) as nitrate-induced structures. Furthermore, we uncover that MIM formation in Mtb during macrophage infection correlates with limited cellular inflammatory responses. Our findings reveal a cytoplasmic structure in Mtb and link it to a functional mechanism that enables the bacterium to adapt to its intracellular niche.","PeriodicalId":9798,"journal":{"name":"Cell reports","volume":"45 10","pages":"118078"},"PeriodicalIF":7.7,"publicationDate":"2026-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149104638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Gata4-Loxl2 axis controls ECM remodeling to enable scar-free spinal cord regeneration in zebrafish. Gata4-Loxl2轴控制ECM重塑，使斑马鱼无疤痕脊髓再生。

IF 7.7 1区生物学

Cell reports Pub Date : 2026-10-05 DOI: 10.1016/j.celrep.2026.118050

Nicolas P Noel, Vânia F Lima Fernandes, Andrew Kjar, Paige E Pfotenhauer, Hyosung Kim, Mawusi P Sefogbe, Eman A Akam-Baxter, Ethan S Lippmann, Valentina Cigliola

{"title":"A Gata4-Loxl2 axis controls ECM remodeling to enable scar-free spinal cord regeneration in zebrafish.","authors":"Nicolas P Noel, Vânia F Lima Fernandes, Andrew Kjar, Paige E Pfotenhauer, Hyosung Kim, Mawusi P Sefogbe, Eman A Akam-Baxter, Ethan S Lippmann, Valentina Cigliola","doi":"10.1016/j.celrep.2026.118050","DOIUrl":"https://doi.org/10.1016/j.celrep.2026.118050","url":null,"abstract":"Spinal cord injury in mammals triggers fibrotic scar formation that impedes axon regrowth, whereas zebrafish regenerate and recover motor function without persistent fibrosis. Here, we identify the transcription factor Gata4 as a regulator of regeneration-associated extracellular matrix (ECM) remodeling. Following injury, gata4 is induced predominantly in ependymo-radial glial cells (ERGs). Gata4 preserves ERG identity and suppresses a fibroblast-like transcriptional program enriched for ECM genes. Loss of Gata4 increases expression of the collagen cross-linking enzyme Loxl2b, resulting in excessive collagen cross-linking, matrix stiffening, and a regeneration-inhibitory ECM environment. These changes delay glial and axonal bridging and impair motor recovery. Pharmacological inhibition of Loxl2b rescues ECM organization, tissue bridging, and functional recovery. Injury-induced gata4 expression depends in part on Hif-1α signaling and activation of an injury-responsive cis-regulatory element. Together, these findings identify a Gata4-Loxl2b axis linking glial cell state to ECM mechanics during spinal cord regeneration.","PeriodicalId":9798,"journal":{"name":"Cell reports","volume":"45 10","pages":"118050"},"PeriodicalIF":7.7,"publicationDate":"2026-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149104703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Palmitate puts ACLY in shape to reprogram macrophages. 棕榈酸酯使ACLY成形以重编程巨噬细胞。

IF 7.7 1区生物学

Cell reports Pub Date : 2026-10-05 DOI: 10.1016/j.celrep.2026.118061

Bin Huang, Chengqian Yin

引用次数: 0

Single-cell transcriptomic reference map of human peripheral blood γδ T cells from 1 year to 90 years reveals major changes before adulthood. 从1岁到90岁的人外周血γδ T细胞单细胞转录组参考图揭示了成年前的主要变化。

IF 7.7 1区生物学

Cell reports Pub Date : 2026-10-05 DOI: 10.1016/j.celrep.2026.118069

Tao Yang, Ximena León-Lara, Vicente Almeida, Ziqing Wang, Yusuf E Abu, Anika Janssen, Charlotte Kleine-Wechelmann, Ahmed Hassan, Zheng Song, Moana Marilyn Dempsey, Martin Boehne, Constantin von Kaisenberg, Immo Prinz, Reinhold Förster, Likai Tan, Sarina Ravens

{"title":"Single-cell transcriptomic reference map of human peripheral blood γδ T cells from 1 year to 90 years reveals major changes before adulthood.","authors":"Tao Yang, Ximena León-Lara, Vicente Almeida, Ziqing Wang, Yusuf E Abu, Anika Janssen, Charlotte Kleine-Wechelmann, Ahmed Hassan, Zheng Song, Moana Marilyn Dempsey, Martin Boehne, Constantin von Kaisenberg, Immo Prinz, Reinhold Förster, Likai Tan, Sarina Ravens","doi":"10.1016/j.celrep.2026.118069","DOIUrl":"https://doi.org/10.1016/j.celrep.2026.118069","url":null,"abstract":"γδ T cells have an unconventional biology as they develop as functional cells in the thymus, to thereafter adapt to postnatal cues and persist into adulthood in peripheral blood. Single-cell transcriptomics enables investigation of underlying molecular programs of γδ T cell effector functions in health and disease. However, the effect of age is often underestimated, and control transcriptome datasets of young healthy individuals are rare. Here, we generate a cost-effective single-cell transcriptomic reference of peripheral blood γδ T cells (106,711 cells) from 223 individuals from 1 year to 90 years, with improved coverage of infancy, childhood, and adolescence. Our analysis reveals that the most pronounced compositional and transcriptional changes of γδ T cells occur before adulthood, followed by relative stabilization of major states across adulthood. Together, our study provides a resource of single-cell transcriptomes of healthy individuals to investigate human γδ T cells in various diseases in future studies.","PeriodicalId":9798,"journal":{"name":"Cell reports","volume":"45 10","pages":"118069"},"PeriodicalIF":7.7,"publicationDate":"2026-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149104724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An extramedullary bone model of metastatic dormancy reveals an increased rate of metastatic reactivation upon distant insults. 转移性休眠的髓外骨模型显示远处损伤后转移性再激活率增加。

IF 7.7 1区生物学

Cell reports Pub Date : 2026-10-01 DOI: 10.1016/j.celrep.2026.118088

Stefania Di Blasio, Tatiana Rizou, Laurie J Gay, Nicolas Rabas, Xuanxuan Fan, Xing-Yu Liu, Victoria L Bridgeman, Ernesto Rodriguez, Probir Chakravarty, Thomas Snoeks, Adam Karoutas, Felipe S Rodrigues, Elodie Montaudon, Cristina Lo Celso, Elisabetta Marangoni, Dominique Bonnet, Bin-Zhi Qian, Ander Abarrategi, Ilaria Malanchi

{"title":"An extramedullary bone model of metastatic dormancy reveals an increased rate of metastatic reactivation upon distant insults.","authors":"Stefania Di Blasio, Tatiana Rizou, Laurie J Gay, Nicolas Rabas, Xuanxuan Fan, Xing-Yu Liu, Victoria L Bridgeman, Ernesto Rodriguez, Probir Chakravarty, Thomas Snoeks, Adam Karoutas, Felipe S Rodrigues, Elodie Montaudon, Cristina Lo Celso, Elisabetta Marangoni, Dominique Bonnet, Bin-Zhi Qian, Ander Abarrategi, Ilaria Malanchi","doi":"10.1016/j.celrep.2026.118088","DOIUrl":"https://doi.org/10.1016/j.celrep.2026.118088","url":null,"abstract":"Bone metastatic relapse can emerge years after cancer diagnosis, driven by the reactivation of disseminated tumor cells (DTCs) that remain dormant in secondary organs. This behavior is controlled by the tissue microenvironment. We developed a tuneable, skeletal progenitor-based engineered extramedullary (EM) bone model in mice that closely mimics endogenous bone and induces dormancy in metastatic breast cancer cells. Within EM bone, cancer cells remained quiescent, with occasional transient proliferative episodes. Because the model integrates with host vasculature and permits controlled release of specific factors, it enables investigation of systemic influences on dormancy. Systemic inflammation, which increases bone marrow cell production, raised the proliferative fraction of dormant cells in EM bone and increased metastatic incidence in endogenous bone. We also identified high-mobility group box 2 (HMGB2) as a factor that promotes overt metastasis and is present in human bone metastases. Therefore, EM bone represents a powerful platform for studying metastatic dormancy.","PeriodicalId":9798,"journal":{"name":"Cell reports","volume":" ","pages":"118088"},"PeriodicalIF":7.7,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149104697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Spontaneous lytic reactivation drives a persistent B cell-vector pathway for epithelial dissemination of the Epstein-Barr virus. 自发裂解再激活驱动eb病毒上皮传播的持久B细胞载体途径。

IF 7.7 1区生物学

Cell reports Pub Date : 2026-10-01 DOI: 10.1016/j.celrep.2026.118124

Di Ngoc Kha Vo, Ching-Tzu Chang, Ha Phan Thanh Ho, Hsueh-Hung Huang, Remy Poirey, Li-Syuan Wu, Yat-Yuen Lim, Henri-Jacques Delecluse, Ming-Han Tsai

引用次数: 0

Gut microbiota induces mammary gland sIgA production to alleviate S. aureus mastitis. 肠道菌群诱导乳腺sIgA产生缓解金黄色葡萄球菌乳腺炎。

IF 7.7 1区生物学

Cell reports Pub Date : 2026-10-01 DOI: 10.1016/j.celrep.2026.118115

Zhaoqi He, Yue Zhang, Chunhui Feng, Tianqi Xie, Kun Zhu, Weijie Yuan, Yixiao Liu, Pingan Xie, Naisheng Zhang, Caijun Zhao, Wenchao Bian, Xiaoyu Hu, Yunhe Fu

引用次数: 0

Lacticaseibacillus rhamnosus GG enhances gefitinib efficacy and reduces treatment-related toxicity via propionyl-L-carnitine regulation. 鼠李糖乳杆菌GG增强吉非替尼疗效，并通过丙炔-左旋肉碱调节降低治疗相关毒性。

IF 7.7 1区生物学

Cell reports Pub Date : 2026-10-01 DOI: 10.1016/j.celrep.2026.118068

Siyuan Shen, Xi Xie, Liting Lu, Wenyao Ma, Haiyang Tu, Jiachao Zhang

{"title":"Lacticaseibacillus rhamnosus GG enhances gefitinib efficacy and reduces treatment-related toxicity via propionyl-L-carnitine regulation.","authors":"Siyuan Shen, Xi Xie, Liting Lu, Wenyao Ma, Haiyang Tu, Jiachao Zhang","doi":"10.1016/j.celrep.2026.118068","DOIUrl":"https://doi.org/10.1016/j.celrep.2026.118068","url":null,"abstract":"Gefitinib improves outcomes in patients with EGFR-mutant non-small cell lung cancer; however, treatment-related gastrointestinal and hepatic toxicity can limit its long-term use. Here, we investigate whether probiotic strains can improve gefitinib efficacy while reducing treatment-associated toxicity. Among the tested strains, Lacticaseibacillus rhamnosus GG (LGG) shows the strongest enhancement of gefitinib efficacy while reducing intestinal and hepatic injury without altering systemic gefitinib exposure. Metabolomic analyses identify propionyl-L-carnitine as an LGG-associated metabolite detected in both LGG culture and LGG-treated mice. Propionyl-L-carnitine treatment reproduces the antitumor effects of LGG and is associated with altered mitochondrial metabolism, decreased NF-κB/IL-6 signaling, and increased apoptosis. A gut-liver-tumor organ-on-a-chip model further supports these effects. LGG treatment also improves short-chain fatty acid profiles, intestinal barrier markers, and bile acid-related metabolism. Together, these findings suggest that LGG may represent a microbiota-based strategy to enhance gefitinib response while limiting treatment-associated toxicity.","PeriodicalId":9798,"journal":{"name":"Cell reports","volume":"45 10","pages":"118068"},"PeriodicalIF":7.7,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149104782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lysosomal multi-omics reveals altered sphingolipid catabolism associated with lysosomal dysfunction in the aging brain. 溶酶体多组学揭示了与衰老大脑中溶酶体功能障碍相关的鞘脂分解代谢改变。

IF 7.7 1区生物学

Cell reports Pub Date : 2026-10-01 DOI: 10.1016/j.celrep.2026.118065

Chinmoy Sarkar, Yi Chen, Dexter Ph Nguyen, Mehari M Weldemariam, Yulemni Morel, Amir Mehrabani-Tabari, Nikki Gorny, Olivia Pettyjohn-Robin, Nivedita Hegdekar, Sagarina Thapa, Sazia Arefin Kachi, Sabrina Bustos, Stephanie Zalesak-Kravec, Christina Williams, Nicholas Leahy, Renee Ti Chou, Shilpa D Kumar, Carrie McCracken, Thomas A Blanpied, Mariusz Karbowski, Jace W Jones, Maureen A Kane, Michael P Cummings, Marta M Lipinski

{"title":"Lysosomal multi-omics reveals altered sphingolipid catabolism associated with lysosomal dysfunction in the aging brain.","authors":"Chinmoy Sarkar, Yi Chen, Dexter Ph Nguyen, Mehari M Weldemariam, Yulemni Morel, Amir Mehrabani-Tabari, Nikki Gorny, Olivia Pettyjohn-Robin, Nivedita Hegdekar, Sagarina Thapa, Sazia Arefin Kachi, Sabrina Bustos, Stephanie Zalesak-Kravec, Christina Williams, Nicholas Leahy, Renee Ti Chou, Shilpa D Kumar, Carrie McCracken, Thomas A Blanpied, Mariusz Karbowski, Jace W Jones, Maureen A Kane, Michael P Cummings, Marta M Lipinski","doi":"10.1016/j.celrep.2026.118065","DOIUrl":"10.1016/j.celrep.2026.118065","url":null,"abstract":"Lipids dynamically reside in multiple intracellular locations, and their organellar distribution is important for function. During brain aging, lysosomal lipid changes have been noted, but lipid identity, interactions, and functional relevance have not been characterized. We used mass spectrometry to assess longitudinal changes in the lipidome and proteome of lysosomal fractions from the murine cortex, from 3 to 24 months, followed by multi-omics factor analysis (MOFA) to identify factors underlying lysosomal aging. Our data uncover an age-dependent increase in lysosomal abundance of lipid and protein myelin components and suggest altered sphingolipid catabolism favoring degradation of sphingomyelins over glycosphingolipids. We experimentally corroborate MOFA predictions to demonstrate that age-dependent accumulation of myelin-derived glycosphingolipids is associated with lysosomal enlargement and dysfunction and is most pronounced in microglia. Our findings suggest that age-related lysosomal lipidome changes resemble those observed in lysosomal storage diseases and underscore the importance of organelle-specific analyses for elucidating lipid function.","PeriodicalId":9798,"journal":{"name":"Cell reports","volume":"45 10","pages":"118065"},"PeriodicalIF":7.7,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149104779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0