Cell reports最新文献

Macrophage NRF1 promotes mitochondrial protein turnover via the ubiquitin proteasome system to limit mitochondrial stress and inflammation. 巨噬细胞NRF1通过泛素蛋白酶体系统促进线粒体蛋白周转，限制线粒体应激和炎症。

IF 6.9 1区生物学

Cell reports Pub Date : 2026-05-07 DOI: 10.1016/j.celrep.2026.117403

Jiawei Yan, Xin Zhang, Huiying Wang, Xinglong Jia, Ruohong Wang, Shuangyang Wu, Zheng-Jiang Zhu, Minjia Tan, Tiffany Horng

引用次数: 0

Virtual flying experience changes neural responses to seeing wings. 虚拟飞行体验改变了看到翅膀的神经反应。

IF 6.9 1区生物学

Cell reports Pub Date : 2026-05-07 DOI: 10.1016/j.celrep.2026.117320

Ziyi Xiong, Yiyang Cai, Xiaosha Wang, Kunlin Wei, Yanchao Bi

{"title":"Virtual flying experience changes neural responses to seeing wings.","authors":"Ziyi Xiong, Yiyang Cai, Xiaosha Wang, Kunlin Wei, Yanchao Bi","doi":"10.1016/j.celrep.2026.117320","DOIUrl":"https://doi.org/10.1016/j.celrep.2026.117320","url":null,"abstract":"The human brain visually processes body parts in the occipitotemporal cortex (OTC), a category-selective organization proposed to reflect evolutionary salience. Using virtual reality (VR), we investigated how the OTC adapts to artificial body parts-virtual wings-that transcend evolutionary constraints. Participants underwent a week of VR training (four sessions), learning to control virtual wings via upper-limb movements with simulated visual feedback of flight. Comparing pre- and post-VR neural responses to wing images shows changes in the OTC, characterized by (1) increased bilateral wing-selective activation, (2) enhanced multi-voxel representational similarity between wings and upper limbs in the right OTC, and (3) strengthened task-dependent functional coupling (psychophysiological interaction) of wing stimuli between the right OTC and frontoparietal high-level somatosensory and motor associate regions. These findings show that the OTC incorporates illusionary effectors into body representations that transcend lower-level sensorimotor congruence, highlighting its role in the abstract, functional-semantic coding of visual inputs.","PeriodicalId":9798,"journal":{"name":"Cell reports","volume":" ","pages":"117320"},"PeriodicalIF":6.9,"publicationDate":"2026-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147855985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Distinct supraspinal neural pathways underlie licking-induced alleviation of pain sensation and aversion in male mice. 不同的椎骨上神经通路是舔舐引起的疼痛感觉和厌恶减轻的基础。

IF 6.9 1区生物学

Cell reports Pub Date : 2026-05-07 DOI: 10.1016/j.celrep.2026.117363

Hao-Di Tang, Hong-Bin Wang, Yuncheng Luo, Rong Luo, Jiao Jiao, Jia-Xin Yao, Fan Zhang, Li-Mei Yi, Xin Li, Fan Lei, Xia Zhang, Tao Zhu, Ruotian Jiang

{"title":"Distinct supraspinal neural pathways underlie licking-induced alleviation of pain sensation and aversion in male mice.","authors":"Hao-Di Tang, Hong-Bin Wang, Yuncheng Luo, Rong Luo, Jiao Jiao, Jia-Xin Yao, Fan Zhang, Li-Mei Yi, Xin Li, Fan Lei, Xia Zhang, Tao Zhu, Ruotian Jiang","doi":"10.1016/j.celrep.2026.117363","DOIUrl":"https://doi.org/10.1016/j.celrep.2026.117363","url":null,"abstract":"Licking as a form of tactile input is widely employed to assess pain levels, suggesting that it may be a restorative behavior in response to injury. However, the exact brain neural mechanisms underlying licking-induced analgesia remain to be elucidated. In this study, we establish a mouse research paradigm to investigate licking-induced analgesia and report that licking behavior significantly reduces pain sensation and pain-related aversion in male mice by triggering the activation of glutamatergic neurons within the gracile nucleus (Gr). Furthermore, we describe the efferent projections from the Gr to the zona incerta (ZI). Importantly, glutamatergic and GABAergic ZI neurons with Gr input (GrZI) neuronal ensembles are efferent to the hindlimb region of the primary somatosensory cortex (S1HL) and the ventral tegmental area (VTA), which regulate the sensory and affective components of licking-induced analgesia, respectively. These findings unveil critical cross-modal supraspinal pathways that enable tactile input to differentially regulate the sensory and affective components of nociception.","PeriodicalId":9798,"journal":{"name":"Cell reports","volume":"45 5","pages":"117363"},"PeriodicalIF":6.9,"publicationDate":"2026-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147855939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Loss of pyruvate carboxylase suppresses lethality in propionic acidemia. 丙酮酸羧化酶的丧失抑制丙酸血症的致死率。

IF 6.9 1区生物学

Cell reports Pub Date : 2026-05-07 DOI: 10.1016/j.celrep.2026.117357

Jasmine Encarnacion, Susanna Scafidi, Michael J Wolfgang

引用次数: 0

Multi-omics analysis uncovers the molecular basis of "golden-thread" formation in Phoebe zhennan stems. 多组学分析揭示了真南茎中“金线”形成的分子基础。

IF 6.9 1区生物学

Cell reports Pub Date : 2026-05-05 DOI: 10.1016/j.celrep.2026.117359

Lingfei Kong, Qin Song, Shaoming Liang, Heng Huang, Hongbin Wei, Shunqin Zhu, Yubo Wang, Haoran Lin, Yijin Chen, Ruiying Su, Li Huang, Hanyu Chen, Yinfei Peng, Zhengjie Zhao, Yiling Li, Deyan Wang, Jiale Zhao, Benwen Chen, Hengxing Zhu, Qianli Dai, Yuansong Guo, Huadong Luo, Mingguo Hou, Bin Zhao, Tao Ma, Keming Luo

{"title":"Multi-omics analysis uncovers the molecular basis of \"golden-thread\" formation in Phoebe zhennan stems.","authors":"Lingfei Kong, Qin Song, Shaoming Liang, Heng Huang, Hongbin Wei, Shunqin Zhu, Yubo Wang, Haoran Lin, Yijin Chen, Ruiying Su, Li Huang, Hanyu Chen, Yinfei Peng, Zhengjie Zhao, Yiling Li, Deyan Wang, Jiale Zhao, Benwen Chen, Hengxing Zhu, Qianli Dai, Yuansong Guo, Huadong Luo, Mingguo Hou, Bin Zhao, Tao Ma, Keming Luo","doi":"10.1016/j.celrep.2026.117359","DOIUrl":"https://doi.org/10.1016/j.celrep.2026.117359","url":null,"abstract":"Phoebe zhennan is an endangered and endemic tree species in China, renowned for its distinctive \"golden-thread nanmu\" wood with exceptional economic, ecological, and cultural value. However, the molecular basis underlying this unique wood trait remains poorly understood. Here, we report a telomere-to-telomere genome assembly of P. zhennan, spanning 919.42 Mb with a contig N50 of 84.44 Mb. Integrated metabolomic analyses identify morin, a flavonol compound, as a major contributor to the \"golden-thread\" phenotype. Functional characterization through enzymatic assays and transient overexpression reveals that PzF3'HL plays a central role in morin biosynthesis. Transcriptomic and single-nucleus RNA sequencing (RNA-seq) analyses further demonstrate age-dependent and xylem-specific activation of flavonoid pathway genes, driving flavonoid accumulation. Additionally, we reconstruct potential regulatory networks involved in flavonoid biosynthesis in P. zhennan stems. These findings provide critical insights into the genetic and biochemical mechanisms of \"golden-thread nanmu\" formation, offering valuable resources for the conservation and molecular breeding of P. zhennan.","PeriodicalId":9798,"journal":{"name":"Cell reports","volume":"45 5","pages":"117359"},"PeriodicalIF":6.9,"publicationDate":"2026-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147834389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Glucocorticoid receptor and RUNX transcription factors cooperatively drive CD8 T cell dysfunction in human cancer. 糖皮质激素受体和RUNX转录因子共同驱动人类癌症中CD8 T细胞功能障碍。

IF 6.9 1区生物学

Cell reports Pub Date : 2026-05-05 DOI: 10.1016/j.celrep.2026.117367

Christopher J Ward, Soura Chakraborty, Sanu K Shaji, Clara Veiga-Villauriz, Aws Al-Deka, Qiuchen Zhao, Jhuma Pramanik, Xi Chen, Bidesh Mahata

{"title":"Glucocorticoid receptor and RUNX transcription factors cooperatively drive CD8 T cell dysfunction in human cancer.","authors":"Christopher J Ward, Soura Chakraborty, Sanu K Shaji, Clara Veiga-Villauriz, Aws Al-Deka, Qiuchen Zhao, Jhuma Pramanik, Xi Chen, Bidesh Mahata","doi":"10.1016/j.celrep.2026.117367","DOIUrl":"https://doi.org/10.1016/j.celrep.2026.117367","url":null,"abstract":"Glucocorticoids are potent immune regulators, yet how cortisol controls human CD8 T cell function remains poorly defined. Here, we show that cortisol reshapes the transcriptional landscape of human CD8 T cells through cooperation between the glucocorticoid receptor (GR) and RUNX transcription factors. Integrative RNA sequencing (RNA-seq) and chromatin immunoprecipitation followed by sequencing (ChIP-seq) analyses identified genome-wide cortisol-responsive immunoregulatory genes, and NR3C1 deletion confirmed GR dependency. GR chromatin occupancy was enriched at RUNX motifs rather than canonical glucocorticoid response elements, and co-immunoprecipitation confirmed a ligand-dependent interaction between GR and RUNX3, requiring the N-terminal activation function-1 (AF1) domain of GR and the C-terminal region of RUNX3. Single-cell transcriptomic analyses across multiple solid tumors revealed consistent enrichment of GR-RUNX co-regulated genes in tumor-infiltrating CD8 T cells, predominantly within the predysfunctional state. These findings identify RUNX3 as a critical non-canonical GR partner and uncover a therapeutically actionable mechanism by which endogenous glucocorticoids drive CD8 T cell dysfunction in human cancer.","PeriodicalId":9798,"journal":{"name":"Cell reports","volume":"45 5","pages":"117367"},"PeriodicalIF":6.9,"publicationDate":"2026-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147834342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The tomato methyl-CpG-binding domain SlMBD5 promotes seed germination by repressing the gibberellin catabolism gene SlGA2ox4. 番茄甲基cpg结合域SlMBD5通过抑制赤霉素分解代谢基因SlGA2ox4促进种子萌发。

IF 6.9 1区生物学

Cell reports Pub Date : 2026-05-05 DOI: 10.1016/j.celrep.2026.117342

Shiyang Zhang, Ruie Liu, Zhifeng Zeng, Yu Ma, Jian Wu, Linzhu Li, Yu Bo, Jian-Kang Zhu, Caixi Zhang, Zhaobo Lang

{"title":"The tomato methyl-CpG-binding domain SlMBD5 promotes seed germination by repressing the gibberellin catabolism gene SlGA2ox4.","authors":"Shiyang Zhang, Ruie Liu, Zhifeng Zeng, Yu Ma, Jian Wu, Linzhu Li, Yu Bo, Jian-Kang Zhu, Caixi Zhang, Zhaobo Lang","doi":"10.1016/j.celrep.2026.117342","DOIUrl":"https://doi.org/10.1016/j.celrep.2026.117342","url":null,"abstract":"Seed germination is a crucial transition in spermatophytes, regulated by gibberellins (GAs). GA levels are controlled by GA2-oxidases (GA2ox), but how DNA methylation participates in this regulation remains unclear. Here, we identified the tomato methyl-CpG-binding domain (MBD) protein SlMBD5 as a regulator of seed germination. The slmbd5 mutant exhibits delayed germination and reduced GA4/GA7 levels, which can be rescued by exogenous GA4+7 application. Transcriptomic and biochemical analyses revealed that SlMBD5 represses the GA catabolism gene SlGA2ox4 by directly binding to its hypermethylated promoter. Furthermore, we show that SlMBD5 interacts with the histone methylation reader SlEBS, forming a functional complex that promotes the transcriptional repression of SlGA2ox4. Consistent with the model that SIMBD5 promotes seed germination through its repression of SlGA2ox4, the slmbd5/slga2ox4 double mutant shows partially restored germination. This study thus reveals an SlMBD5-SlEBS module that regulates GA homeostasis to modulate seed germination in tomato.","PeriodicalId":9798,"journal":{"name":"Cell reports","volume":"45 5","pages":"117342"},"PeriodicalIF":6.9,"publicationDate":"2026-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147833654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tissue-specific tolerance mechanisms and lymph node co-drainage shape T cell immunity in the upper digestive system and pancreatic cancer progression. 组织特异性耐受机制和淋巴结共同引流在上消化系统和胰腺癌进展中塑造T细胞免疫。

IF 6.9 1区生物学

Cell reports Pub Date : 2026-05-05 DOI: 10.1016/j.celrep.2026.117324

Yixuan D Zhou, Peter Wang, Emily Schaffer, Macy R Komnick, Hailey Brown, Gwen M Taylor, Kay L Fiske, Colin Sheehan, Terence S Dermody, Alexander Muir, Daria Esterházy

{"title":"Tissue-specific tolerance mechanisms and lymph node co-drainage shape T cell immunity in the upper digestive system and pancreatic cancer progression.","authors":"Yixuan D Zhou, Peter Wang, Emily Schaffer, Macy R Komnick, Hailey Brown, Gwen M Taylor, Kay L Fiske, Colin Sheehan, Terence S Dermody, Alexander Muir, Daria Esterházy","doi":"10.1016/j.celrep.2026.117324","DOIUrl":"https://doi.org/10.1016/j.celrep.2026.117324","url":null,"abstract":"The liver, pancreas, and duodenum share lymph nodes (LNs), providing a unique system to examine how tissue origin of self-antigens shapes T cell fate. Comparing mice expressing ovalbumin (OVA) from distinct subcellular compartments, we found that cytosolic OVA from the liver or pancreas, but not gut, was immunologically ignored. High-dose hepatic-secreted OVA triggered antigen-specific T cell deletion, whereas secreted pancreatic and intestinal OVA induced regulatory T (Treg) cells, revealing immunological ignorance, clonal deletion, and Treg cell generation as tissue-specific tolerance mechanisms. Of these, LN co-drainage only influenced Treg cell induction, establishing gut-pancreas-liver axes: intestinal viral infection rendered hepatocyte- and exocrine pancreas-specific T cells inflammatory and liver injury promoted pancreas- and gut-directed responses. These self-reactive T cells caused tissue destruction but enhanced pancreatic tumor control when neoantigen OVA was secreted, but not cytosolic. Thus, LN co-drainage and tissue-specific tolerance mechanisms jointly shape immune homeostasis and disease susceptibility in the upper digestive system.","PeriodicalId":9798,"journal":{"name":"Cell reports","volume":"45 5","pages":"117324"},"PeriodicalIF":6.9,"publicationDate":"2026-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147833718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cohesin complex cooperates with PU.1 at super-enhancers to regulate the differentiation and identity of conventional dendritic cells. 内聚蛋白复合物与PU.1在超增强子上协同调节常规树突状细胞的分化和身份。

IF 6.9 1区生物学

Cell reports Pub Date : 2026-05-05 DOI: 10.1016/j.celrep.2026.117331

Pallawi Choubey, Amit Kumar, Sreeparna Podder, Sunil Kumar Raghav, Kushagra Bansal

{"title":"Cohesin complex cooperates with PU.1 at super-enhancers to regulate the differentiation and identity of conventional dendritic cells.","authors":"Pallawi Choubey, Amit Kumar, Sreeparna Podder, Sunil Kumar Raghav, Kushagra Bansal","doi":"10.1016/j.celrep.2026.117331","DOIUrl":"https://doi.org/10.1016/j.celrep.2026.117331","url":null,"abstract":"The dendritic cell (DC) network consists of two major subsets: conventional (cDC) and plasmacytoid (pDC). cDCs undergo chromatin reorganization during their differentiation from hematopoietic progenitors to establish a cDC-specific gene expression program. However, the requirement of architectural protein complex cohesin in cDC differentiation is poorly understood. Herein, we report that ablation of SMC3 or STAG2 subunits of the cohesin complex in DC-restricted progenitors leads to a decrease in cDC and an increase in pDC compartment size. Cohesin controls cDC function, such as antigen presentation and expression of co-stimulatory molecules. Cohesin loss represses the expression of cDC identity genes and de-represses the pDC-specific transcriptional signature in cDCs and pre-DCs. Mechanistically, cohesin promotes PU.1 binding at super-enhancers and supports chromatin loops favoring cDC differentiation. Notably, cohesin-deficient DCs disturb the steady-state hematopoiesis, leading to myeloid hyperplasia. Our results reveal a transcriptional node involving cohesin, PU.1, and super-enhancers in the regulation of the lineage-specific gene expression program in cDCs.","PeriodicalId":9798,"journal":{"name":"Cell reports","volume":"45 5","pages":"117331"},"PeriodicalIF":6.9,"publicationDate":"2026-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147834330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pan-cancer neurotransmitter receptor alterations define neuroregulatory subtypes with prognostic significance. 泛癌神经递质受体改变定义了具有预后意义的神经调节亚型。

IF 6.9 1区生物学

Cell reports Pub Date : 2026-05-05 DOI: 10.1016/j.celrep.2026.117340

Shangyi Luo, Shupei Qiao, Li Liu, Zhuang Xiong, Lei Guo, Xin Hao, Xue Zhang, Yajing Zhang

{"title":"Pan-cancer neurotransmitter receptor alterations define neuroregulatory subtypes with prognostic significance.","authors":"Shangyi Luo, Shupei Qiao, Li Liu, Zhuang Xiong, Lei Guo, Xin Hao, Xue Zhang, Yajing Zhang","doi":"10.1016/j.celrep.2026.117340","DOIUrl":"https://doi.org/10.1016/j.celrep.2026.117340","url":null,"abstract":"Cancer neuroscience highlights the critical role of neural signaling in tumors, yet a pan-cancer understanding of neuroregulatory dysregulation is lacking. We systematically characterized 130 neurotransmitter receptor (NTR) genes across 9,125 tumors from 33 cancer types. Our analysis revealed heterogeneous NTR mutations, with 17 cancer types showing elevated rates. Notably, amplification of the muscarinic receptor gene CHRM2 exhibited mutual exclusivity with the clinically actionable gene ERBB2, suggesting its potential as a therapeutic target. NTR expression was widely dysregulated and associated with altered DNA methylation, microRNA (miRNA) expression, and patient prognosis. Unsupervised clustering identified five recurrent neuroregulatory subtypes with distinct clinical and molecular features across cancers. Using low-grade glioma and liver cancer as examples, we validated that the S4 and S1 subtypes were consistently correlated with aggressive disease and poor outcomes in these two cancers, respectively. This study establishes a foundational framework for advancing cancer neuroscience and targeting neuroregulatory signaling in cancer therapy.","PeriodicalId":9798,"journal":{"name":"Cell reports","volume":"45 5","pages":"117340"},"PeriodicalIF":6.9,"publicationDate":"2026-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147834360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0