Cell reports最新文献_第2页

Multivalent nanoparticles activate T-dependent antibody response via antigen presentation by both B cells and dendritic cells. 多价纳米颗粒通过B细胞和树突状细胞的抗原呈递激活t依赖性抗体反应。

IF 6.9 1区生物学

Cell reports Pub Date : 2026-05-04 DOI: 10.1016/j.celrep.2026.117332

Xuejing Ma, Chang Guo, Runhan Li, Zhiyu Gao, Penghui Ma, Wenjun Wang, Keyan Bao, Xueli Zhang, Han Wang, Ping Zhu, George Fu Gao, Mingzhao Zhu, Zhaolin Hua, Baidong Hou

引用次数: 0

Multi-omics integration maps CHH methylation and gene regulatory networks across heat, drought, and salt stress in rice. 多组学整合绘制了水稻在高温、干旱和盐胁迫下CHH甲基化和基因调控网络。

IF 6.9 1区生物学

Cell reports Pub Date : 2026-05-04 DOI: 10.1016/j.celrep.2026.117352

Weijun Guo, Ruihong Qu, Dongwei Li, Shang Xie, Hanlin Liu, Yichao Mao, Liwen Yang, Cong Li, Weixuan Wang, Jian Tian, Xiaofeng Gu, Li Pu

{"title":"Multi-omics integration maps CHH methylation and gene regulatory networks across heat, drought, and salt stress in rice.","authors":"Weijun Guo, Ruihong Qu, Dongwei Li, Shang Xie, Hanlin Liu, Yichao Mao, Liwen Yang, Cong Li, Weixuan Wang, Jian Tian, Xiaofeng Gu, Li Pu","doi":"10.1016/j.celrep.2026.117352","DOIUrl":"https://doi.org/10.1016/j.celrep.2026.117352","url":null,"abstract":"Plant phenotypes arise from complex interactions among genetic, epigenetic, and environmental factors. Deciphering the molecular mechanisms responsible for phenotypic variation requires comprehensive multi-omics approaches that integrate diverse genomic, transcriptomic, and environmental datasets. Here, we perform high-throughput phenotyping of rice subspecies cultivars (Nip and 93-11), covering key growth stages under heat, drought, and salt stress. Using the EfficientNet framework, we generate image embeddings for cultivar classification and stress-type identification. Whole-genome bisulfite sequencing (WGBS) identifies elevated CHH methylation under heat and drought stresses but reduced levels under salt stress at ripening. Furthermore, we construct a multi-omics network and uncover heat-responsive subnetworks. Within this, OsCam3 emerges as a key regulator of heat stress responses in both Nip and 93-11. Additionally, OsCam3 underwent different selection in the japonica and indica subpopulations. Altogether, our study highlights the interplay among epigenetic, transcriptional, and phenotypic factors in shaping stress responses, providing valuable genetic resources for future climate-resilient rice breeding.","PeriodicalId":9798,"journal":{"name":"Cell reports","volume":"45 5","pages":"117352"},"PeriodicalIF":6.9,"publicationDate":"2026-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147834419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

PARP1-specific inhibitor displays PARP1-detrapping activity. parp1特异性抑制剂显示parp1脱除活性。

IF 6.9 1区生物学

Cell reports Pub Date : 2026-05-04 DOI: 10.1016/j.celrep.2026.117350

Kira Schützenhofer, Ellen Laker, Kyle Tsang, Domagoj Baretić, Marcin J Suskiewicz, Florian F H Zobel, Michael D R Simmons, Chatrin Chatrin, Rebecca Smith, Ivan Ahel

{"title":"PARP1-specific inhibitor displays PARP1-detrapping activity.","authors":"Kira Schützenhofer, Ellen Laker, Kyle Tsang, Domagoj Baretić, Marcin J Suskiewicz, Florian F H Zobel, Michael D R Simmons, Chatrin Chatrin, Rebecca Smith, Ivan Ahel","doi":"10.1016/j.celrep.2026.117350","DOIUrl":"https://doi.org/10.1016/j.celrep.2026.117350","url":null,"abstract":"The successful use of PARP inhibitors against primarily homologous recombination-deficient tumors relies on their ability to inhibit the catalytic activity of PARP1 and PARP2, leading to their retention at sites of DNA damage, known as PARP \"trapping.\" Different PARP inhibitors vary in their trapping ability and thus in their resulting toxicity. Here, we develop an inducible complementation system for the expression of tagged PARP1 variants to assess the impact of different mutations in the PARP1 catalytic site on ADP-ribosylation (ADPr) activity, trapping, and cell survival. Testing these cell lines for their behavior and sensitivity to different PARP inhibitors, we find that saruparib, a first-in-class PARP1-specific inhibitor, promotes the release of certain PARP1 catalytic mutants and resistance to this inhibitor. We also characterize a PARP1 catalytic mutant with intact mono(ADP-ribosyl)ation activity but devoid of poly(ADP-ribosyl)ation, enabling us to demonstrate a significant contribution of mono(ADP-ribosyl)ation toward PARP1 release from sites of DNA damage.","PeriodicalId":9798,"journal":{"name":"Cell reports","volume":"45 5","pages":"117350"},"PeriodicalIF":6.9,"publicationDate":"2026-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147833492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Maternal hyperglycemia disrupts cardiomyocyte maturation via aberrant nucleotide metabolism and suppression of AMPK signaling. 母体高血糖通过异常核苷酸代谢和AMPK信号抑制破坏心肌细胞成熟。

IF 6.9 1区生物学

Cell reports Pub Date : 2026-05-04 DOI: 10.1016/j.celrep.2026.117321

Haruko Nakano, Naofumi Kawahira, Alexander Vesprey, Atsushi Nakano

{"title":"Maternal hyperglycemia disrupts cardiomyocyte maturation via aberrant nucleotide metabolism and suppression of AMPK signaling.","authors":"Haruko Nakano, Naofumi Kawahira, Alexander Vesprey, Atsushi Nakano","doi":"10.1016/j.celrep.2026.117321","DOIUrl":"https://doi.org/10.1016/j.celrep.2026.117321","url":null,"abstract":"Glucose serves not only as an energy source but also as a signaling molecule for organ growth. Intrauterine hyperglycemia elevates the risk of congenital heart defects independently of genetic factors, although its underlying mechanisms remain unclear. In this study, we investigated the impact of maternal hyperglycemia on cardiac development using a diabetic pregnancy mouse model and pluripotent stem cell-derived cardiomyocytes. Multi-modal analysis revealed that hyperglycemia disrupts mitochondrial structure and function in fetal hearts even before overt malformations appear, indicating that mitochondrial immaturity is an early signature of diabetic embryopathy. Metabolomic profiling revealed nucleotide imbalance and subsequent AMP-activated protein kinase (AMPK) suppression-contrasting with reports of increased AMPK activity observed in hyperglycemic neural tube defects. Notably, pharmacological activation of AMPK restored cardiomyocyte and mitochondrial function under high-glucose conditions in vitro. Our findings demonstrate that high glucose inhibits cardiomyocyte maturation through dysregulated nucleotide metabolism and AMPK suppression, advancing understanding of hyperglycemia-induced cardiac developmental defects.","PeriodicalId":9798,"journal":{"name":"Cell reports","volume":"45 5","pages":"117321"},"PeriodicalIF":6.9,"publicationDate":"2026-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147834370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Accumulated sotorasib-bound KRAS^G12C reactivates the MAPK pathway and drives sotorasib resistance via the DHX9-RAC1-PAK1 axis. 积累的sotorasib结合KRASG12C重新激活MAPK途径，并通过DHX9-RAC1-PAK1轴驱动sotorasib抗性。

IF 6.9 1区生物学

Cell reports Pub Date : 2026-05-04 DOI: 10.1016/j.celrep.2026.117338

Gongmin Zhu, Lijiao Pei, Jue Li, Chenliang Zhang, Di Ye, Jielang Li, Qiulin Tang, Huixi Huang, Huanji Xu, Feng Bi

{"title":"Accumulated sotorasib-bound KRASG12C reactivates the MAPK pathway and drives sotorasib resistance via the DHX9-RAC1-PAK1 axis.","authors":"Gongmin Zhu, Lijiao Pei, Jue Li, Chenliang Zhang, Di Ye, Jielang Li, Qiulin Tang, Huixi Huang, Huanji Xu, Feng Bi","doi":"10.1016/j.celrep.2026.117338","DOIUrl":"https://doi.org/10.1016/j.celrep.2026.117338","url":null,"abstract":"Sotorasib has introduced new therapeutic opportunities for Kirsten rat sarcoma viral oncogene homolog (KRAS)G12C-mutant tumors, but resistance emerging within months poses a major clinical challenge. Mitogen-activated protein kinase (MAPK) pathway reactivation is a key driver of sotorasib resistance, yet its mechanisms remain incompletely elucidated. We observe that MAPK pathway reactivation following sotorasib treatment is largely independent of RAS activity and instead driven by accumulation of sotorasib-bound KRASG12C (soto-KRASG12C). Mechanistically, accumulated soto-KRASG12C promotes activation of the Rac family small GTPase 1 (RAC1)- p21-activated kinase 1 (PAK1) axis through interaction with DExD/H-box helicase 9 (DHX9), thereby reactivating the MAPK pathway. DHX9 shuttles between the nucleus and cytoplasm, and its interaction with soto-KRASG12C results in its cytoplasmic retention. Co-treatment with an Son of Sevenless 1 (SOS1) inhibitor also leads to sustained suppression of soto-KRASG12C levels. Furthermore, combining sotorasib with either a DHX9 inhibitor or an SOS1 inhibitor significantly enhances its anti-tumor efficacy in both KRASG12C-mutant and sotorasib-resistant models. These findings provide previously uncharacterized mechanistic insights to guide therapeutic strategies aimed at overcoming sotorasib resistance.","PeriodicalId":9798,"journal":{"name":"Cell reports","volume":"45 5","pages":"117338"},"PeriodicalIF":6.9,"publicationDate":"2026-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147834295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Alveolar macrophages inhibit emphysematous pathology via expression of carbonic anhydrase 4. 肺泡巨噬细胞通过表达碳酸酐酶4抑制肺气肿病理。

IF 6.9 1区生物学

Cell reports Pub Date : 2026-05-04 DOI: 10.1016/j.celrep.2026.117315

John J Ponessa, Jianya Peng, Marissa N Schroeter, Arman Sawhney, Krupa Chavan, Juan Inclan Rico, Vanessa Espinosa, Fei Chen, Nicholas J Shubin, Tania Wong Fok Lung, Alexander Lemenze, Amariliz Rivera, William C Gause, Mark C Siracusa

{"title":"Alveolar macrophages inhibit emphysematous pathology via expression of carbonic anhydrase 4.","authors":"John J Ponessa, Jianya Peng, Marissa N Schroeter, Arman Sawhney, Krupa Chavan, Juan Inclan Rico, Vanessa Espinosa, Fei Chen, Nicholas J Shubin, Tania Wong Fok Lung, Alexander Lemenze, Amariliz Rivera, William C Gause, Mark C Siracusa","doi":"10.1016/j.celrep.2026.117315","DOIUrl":"https://doi.org/10.1016/j.celrep.2026.117315","url":null,"abstract":"Chronic obstructive pulmonary disease (COPD) including emphysema is the fourth leading cause of death worldwide. Therapies to treat COPD remain limited and fail to prevent disease progression. Alveolar macrophages (AMs) reside in the alveoli of the lung and are ideally positioned to encounter inhaled particles and pathogens. Despite exposure to these stimuli, AMs exhibit specialized phenotypes that restrict inflammation to prevent lung damage. Here, we demonstrate that AMs express high levels of the surface-bound enzyme carbonic anhydrase 4 (Car4). Deletion of Car4 on AMs results in increased susceptibility to emphysematous pathology, and therapeutic treatment with Car4 is sufficient to prevent emphysema-like disease. Consistent with murine studies, reduced levels of human Car4 (CA4) distinguish COPD patients with emphysema from those without. Mechanistically, murine and human Car4 directly inhibit neutrophil elastase, which promotes destruction of alveolar walls and drives emphysema. Collectively, these studies reveal the existence of a lung-specific elastase inhibitor that protects the elastin-containing walls of the alveoli and provides important therapeutic insight into a disease that affects 300 million individuals globally.","PeriodicalId":9798,"journal":{"name":"Cell reports","volume":"45 5","pages":"117315"},"PeriodicalIF":6.9,"publicationDate":"2026-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147834339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A human endometrium-on-chip platform for functional assessment of luminal epithelial receptivity. 用于腔上皮接受性功能评估的人子宫内膜芯片平台。

IF 6.9 1区生物学

Cell reports Pub Date : 2026-04-30 DOI: 10.1016/j.celrep.2026.117349

Aslı Ak, Dorian Luijkx, Daniel Carvalho, Louise Hosty, Linda Stevens Brentjens, Whitney van de Vin, Barry Jutten, Bert Delvoux, Willem Voncken, Andrea Romano, Stefan Giselbrecht, Ron van Golde, Erik Vrij

{"title":"A human endometrium-on-chip platform for functional assessment of luminal epithelial receptivity.","authors":"Aslı Ak, Dorian Luijkx, Daniel Carvalho, Louise Hosty, Linda Stevens Brentjens, Whitney van de Vin, Barry Jutten, Bert Delvoux, Willem Voncken, Andrea Romano, Stefan Giselbrecht, Ron van Golde, Erik Vrij","doi":"10.1016/j.celrep.2026.117349","DOIUrl":"https://doi.org/10.1016/j.celrep.2026.117349","url":null,"abstract":"Successful embryo implantation requires timely acquisition of endometrial receptivity, yet the epithelial mechanisms governing this transition remain poorly understood and difficult to study in humans. Current clinical assessments rely largely on transcriptomic markers, despite limited evidence that these predict functional implantation outcomes. Here, we present a human endometrium-on-chip model that enables controlled hormonal priming and quantitative measurement of blastoid attachment to patient-derived luminal epithelium. We show that hormonally primed epithelial monolayers maintain attachment competence across extended progesterone exposure, indicating a sustained permissive state rather than a sharply defined window of implantation. Single-cell RNA sequencing reveals a continuous maturation trajectory that is decoupled from functional adhesion. The model further recapitulates localized epithelial remodeling at blastoid contact sites. Together, this system provides a mechanistic framework to interrogate epithelial determinants of implantation, challenges marker-based definitions of receptivity, and offers a foundation for future diagnostic and personalized applications in medically assisted reproduction.","PeriodicalId":9798,"journal":{"name":"Cell reports","volume":"45 5","pages":"117349"},"PeriodicalIF":6.9,"publicationDate":"2026-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147811662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

mRNA delivery of mosaic-8 pan-sarbecovirus RBD vaccines elicits distinct antibody epitope signatures. 嵌合-8泛sarbecvirus RBD疫苗的mRNA递送可引起不同的抗体表位特征。

IF 6.9 1区生物学

Cell reports Pub Date : 2026-04-30 DOI: 10.1016/j.celrep.2026.117335

Alexander A Cohen, Jennifer R Keeffe, Lusineh Manasyan, Indeever Madireddy, Ange-Célia I Priso Fils, Kim-Marie A Dam, Haley E Stober, Rory A Hills, Woohyun J Moon, Paulo J C Lin, Mark R Howarth, Magnus A G Hoffmann, Pamela J Bjorkman

{"title":"mRNA delivery of mosaic-8 pan-sarbecovirus RBD vaccines elicits distinct antibody epitope signatures.","authors":"Alexander A Cohen, Jennifer R Keeffe, Lusineh Manasyan, Indeever Madireddy, Ange-Célia I Priso Fils, Kim-Marie A Dam, Haley E Stober, Rory A Hills, Woohyun J Moon, Paulo J C Lin, Mark R Howarth, Magnus A G Hoffmann, Pamela J Bjorkman","doi":"10.1016/j.celrep.2026.117335","DOIUrl":"10.1016/j.celrep.2026.117335","url":null,"abstract":"Protein-based mosaic-8 nanoparticles displaying eight SARS-like betacoronavirus (sarbecovirus) receptor-binding domains (RBDs) elicited broadly cross-reactive antibodies that could protect from zoonotic spillovers. Here, we extend the mosaic-8 concept to mRNA by encoding membrane-bound RBD quartets (four linked RBDs) as dual quartet RBD-mRNA and dual quartet RBD-EABR-mRNA, the latter leveraging ESCRT- and ALIX-binding region (EABR) technology for display on cell surfaces and secreted virus-like particles. Compared with protein-based mosaic-8, mRNA-encoded mosaic-8 induced equivalent or enhanced antibody breadth, neutralization potencies, and conserved epitope targeting, while eliciting enhanced T cell responses and more balanced IgG subclass profiles consistent with potentially superior Fc effector functions. Finally, systems serology-polyclonal epitope mapping (SySPEM) revealed distinct IgG-subclass-specific epitope signatures across mRNA, EABR-mRNA, and protein vaccines, demonstrating that the mode of antigen display can shape epitope recognition. Successful conversion of a multivalent protein vaccine to mRNA platforms informs the design of broadly protective vaccines and advances mosaic-8 toward clinical development.","PeriodicalId":9798,"journal":{"name":"Cell reports","volume":"45 5","pages":"117335"},"PeriodicalIF":6.9,"publicationDate":"2026-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147811626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A conserved motif tunes Sidekick condensate dynamics to control tricellular junction recruitment during epithelial remodeling. 一个保守的基序调节Sidekick凝聚动力学来控制上皮重塑过程中的三细胞连接募集。

IF 6.9 1区生物学

Cell reports Pub Date : 2026-04-30 DOI: 10.1016/j.celrep.2026.117336

Hiroyuki Uechi, Daxiao Sun, Yuki Saeki, Tetsuya Hiraiwa, Alf Honigmann, Anthony A Hyman, Erina Kuranaga

{"title":"A conserved motif tunes Sidekick condensate dynamics to control tricellular junction recruitment during epithelial remodeling.","authors":"Hiroyuki Uechi, Daxiao Sun, Yuki Saeki, Tetsuya Hiraiwa, Alf Honigmann, Anthony A Hyman, Erina Kuranaga","doi":"10.1016/j.celrep.2026.117336","DOIUrl":"https://doi.org/10.1016/j.celrep.2026.117336","url":null,"abstract":"The tricellular junction, where three or more cells contact, comprises specific proteins regulating epithelial morphogenesis and homeostasis. It remains elusive how these proteins are confined to tricellular junctions to function. We reveal that the intracellular domain of the adhesive transmembrane protein Sidekick forms condensates and contributes to its accumulation at tricellular junctions. Fly genetics and in vitro reconstitution indicate that condensation alone is not sufficient for targeting but promotes stable accumulation of Sidekick at physiological concentrations. We identify a conserved motif whose deletion increases condensate dynamics and leads to mislocalization of Sidekick during epithelial junction remodeling. Mislocalization is accompanied by disturbed recruitment of Sidekick-associating proteins involved in junction dynamics to tricellular junctions and leads to delay in junction formation. These findings suggest that condensates with relatively low internal dynamics stabilize Sidekick localization under tissue dynamics, which assists recruitment of junction dynamics-regulating proteins and ensures epithelial remodeling.","PeriodicalId":9798,"journal":{"name":"Cell reports","volume":"45 5","pages":"117336"},"PeriodicalIF":6.9,"publicationDate":"2026-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147811651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A cis-regulatory variant in ZmABI45 modulates drought tolerance and adaptation by escaping ZmbHLH80 repression in maize. ZmABI45的顺式调控变异通过摆脱ZmbHLH80的抑制来调节玉米的抗旱性和适应性。

IF 6.9 1区生物学

Cell reports Pub Date : 2026-04-29 DOI: 10.1016/j.celrep.2026.117334

Xuyang Liu, Yue Hu, Sen Xie, Keyu Tao, Youyu Zhao, Yaxuan Lu, Huaijun Tang, Yanjun Zhang, Yongxiang Li, Dengfeng Zhang, Guanhua He, Zhenju Li, Tianyu Wang, Chunhui Li, Yu Li

{"title":"A cis-regulatory variant in ZmABI45 modulates drought tolerance and adaptation by escaping ZmbHLH80 repression in maize.","authors":"Xuyang Liu, Yue Hu, Sen Xie, Keyu Tao, Youyu Zhao, Yaxuan Lu, Huaijun Tang, Yanjun Zhang, Yongxiang Li, Dengfeng Zhang, Guanhua He, Zhenju Li, Tianyu Wang, Chunhui Li, Yu Li","doi":"10.1016/j.celrep.2026.117334","DOIUrl":"https://doi.org/10.1016/j.celrep.2026.117334","url":null,"abstract":"Drought stress during flowering severely threatens maize productivity by disrupting the synchrony of male and female flowering, while its genetic basis remains poorly understood. Through a genome-wide association study (GWAS) and quantitative trait locus (QTL) analysis, we identify an ABI3 transcription factor gene ZmABI45 as a key regulator of drought-induced anthesis-silking interval (ASI). We characterize a 12-bp insertion or deletion (indel) in the promoter of ZmABI45, demonstrating that its deletion allele enhances drought tolerance by escaping transcriptional repression by ZmbHLH80. Overexpression of ZmABI45 significantly shortens ASI and improves grain yield under drought. ZmABI45 activates stress-responsive genes under drought and suppresses growth-related processes under normal conditions. Evolutionary and ecological analyses further indicate that the drought-tolerance haplotype has been selected during modern maize breeding and shows a geographic distribution correlated with low-precipitation areas. Our work highlights how cis-regulatory variation fine-tunes stress adaptation and provides a valuable gene resource for breeding drought-resilient maize.","PeriodicalId":9798,"journal":{"name":"Cell reports","volume":"45 5","pages":"117334"},"PeriodicalIF":6.9,"publicationDate":"2026-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147811688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0