Cell reports最新文献_第2页

Tissue-colonizing disseminated tumor cells secrete prostaglandin E2 to promote NK cell dysfunction and evade anti-metastatic immunity. 组织定殖的播散性肿瘤细胞分泌前列腺素 E2，促进 NK 细胞功能失调，逃避抗转移免疫。

IF 7.5 1区生物学

Cell reports Pub Date : 2024-11-13 DOI: 10.1016/j.celrep.2024.114855

Anna-Marie Pedde, Hyunu Kim, Sainitin Donakonda, Tobias Baumann, Felix Bayerl, Philippa Meiser, Anna Hirschberger, Christine Klement, Simon Grassmann, Rupert Öllinger, Norbert Hüser, Daniel Hartmann, Melanie Laschinger, Joseph A Trapani, Alfred Zippelius, Tobias Bald, Gabriela M Wiedemann, Roland Rad, Joseph C Sun, Bastian Höchst, Jan P Böttcher

{"title":"Tissue-colonizing disseminated tumor cells secrete prostaglandin E2 to promote NK cell dysfunction and evade anti-metastatic immunity.","authors":"Anna-Marie Pedde, Hyunu Kim, Sainitin Donakonda, Tobias Baumann, Felix Bayerl, Philippa Meiser, Anna Hirschberger, Christine Klement, Simon Grassmann, Rupert Öllinger, Norbert Hüser, Daniel Hartmann, Melanie Laschinger, Joseph A Trapani, Alfred Zippelius, Tobias Bald, Gabriela M Wiedemann, Roland Rad, Joseph C Sun, Bastian Höchst, Jan P Böttcher","doi":"10.1016/j.celrep.2024.114855","DOIUrl":"https://doi.org/10.1016/j.celrep.2024.114855","url":null,"abstract":"Natural killer (NK) cells are critical for anti-metastatic immunity and can eliminate metastasizing tumor cells within circulation and sites of metastatic seeding. Here, we show that disseminated tumor cells (DTCs) colonizing the mouse lung secrete prostaglandin E2 (PGE2) to locally induce NK cell dysfunction, allowing outgrowing metastases to escape immune control and establish metastatic disease. Mechanistically, PGE2 signaling through its receptors EP2 and EP4 mediates NK cell dysfunction, which leads to reprogramming of NK cell gene expression and results in impaired production of anti-metastatic cytokines. In human cancer patients, the PGE2-EP2/EP4 axis is associated with NK cell dysfunction within distant organ metastases. Disabling EP2/EP4 signaling in NK cells prevents their dysfunction in DTC-colonized lungs and achieves effective NK cell-mediated control of metastatic disease. Our findings reveal a suppressive signaling axis exploited by metastasizing tumor cells to escape immune control in distant organs that could be targeted for metastatic cancer therapy.","PeriodicalId":9798,"journal":{"name":"Cell reports","volume":"43 11","pages":"114855"},"PeriodicalIF":7.5,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142615395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A maternal high-fat diet predisposes to infant lung disease via increased neutrophil-mediated IL-6 trans-signaling. 母体高脂肪饮食通过增加中性粒细胞介导的 IL-6 跨信号转导易导致婴儿肺部疾病。

IF 7.5 1区生物学

Cell reports Pub Date : 2024-11-12 DOI: 10.1016/j.celrep.2024.114974

Bodie Curren, Tufael Ahmed, Ridwan B Rashid, Ismail Sebina, Md Al Amin Sikder, Daniel R Howard, Mariah Alorro, Md Ashik Ullah, Alec Bissell, Muhammed Mahfuzur Rahman, Michael A Pearen, Grant A Ramm, Antiopi Varelias, Stefan Rose-John, Kelli P A MacDonald, Robert Hoelzle, Páraic Ó Cuív, Kirsten M Spann, Paul G Dennis, Simon Phipps

{"title":"A maternal high-fat diet predisposes to infant lung disease via increased neutrophil-mediated IL-6 trans-signaling.","authors":"Bodie Curren, Tufael Ahmed, Ridwan B Rashid, Ismail Sebina, Md Al Amin Sikder, Daniel R Howard, Mariah Alorro, Md Ashik Ullah, Alec Bissell, Muhammed Mahfuzur Rahman, Michael A Pearen, Grant A Ramm, Antiopi Varelias, Stefan Rose-John, Kelli P A MacDonald, Robert Hoelzle, Páraic Ó Cuív, Kirsten M Spann, Paul G Dennis, Simon Phipps","doi":"10.1016/j.celrep.2024.114974","DOIUrl":"https://doi.org/10.1016/j.celrep.2024.114974","url":null,"abstract":"A poor maternal diet during pregnancy predisposes the infant to severe lower respiratory tract infections (sLRIs), which, in turn, increases childhood asthma risk; however, the underlying mechanisms remain poorly understood. Here, we show that the offspring of high-fat diet (HFD)-fed mothers (HFD-reared pups) developed an sLRI following pneumovirus inoculation in early life and subsequent asthma in later life upon allergen exposure. Prior to infection, HFD-reared pups developed microbial dysbiosis and low-grade systemic inflammation (LGSI), characterized by hyperneutropoiesis in the liver and elevated inflammatory cytokine expression, most notably granulocyte-colony stimulating factor (G-CSF), interleukin-17A (IL-17A), IL-6 and soluble IL-6 receptor (sIL-6R) (indicative of IL-6 trans-signaling) in the circulation and multiple organs but most prominently the liver. Inhibition of IL-6 trans-signaling using sgp130Fc transgenic mice or via specific genetic deletion of IL-6Ra on neutrophils conferred protection against both diseases. Taken together, our findings suggest that a maternal HFD induces neonatal LGSI that predisposes to sLRI and subsequent asthma via neutrophil-mediated IL-6 trans-signaling.","PeriodicalId":9798,"journal":{"name":"Cell reports","volume":"43 11","pages":"114974"},"PeriodicalIF":7.5,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142615897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Karyotype evolution in response to chemoradiotherapy and upon recurrence of esophageal adenocarcinomas. 食管腺癌化疗反应和复发时的核型演变。

IF 7.5 1区生物学

Cell reports Pub Date : 2024-11-12 DOI: 10.1016/j.celrep.2024.114981

Karen van der Sluis, Johanna W van Sandick, Willem J Koemans, Tom van den Bosch, Annegien Broeks, Dennis Peters, Iris M Seignette, Christian R Rausch, Erik van Dijk, Petur Snaebjornsson, José G van den Berg, Nicole C T van Grieken, Bauke Ylstra, Beatriz Carvalho, Daniël M Miedema, Liudmila L Kodach

{"title":"Karyotype evolution in response to chemoradiotherapy and upon recurrence of esophageal adenocarcinomas.","authors":"Karen van der Sluis, Johanna W van Sandick, Willem J Koemans, Tom van den Bosch, Annegien Broeks, Dennis Peters, Iris M Seignette, Christian R Rausch, Erik van Dijk, Petur Snaebjornsson, José G van den Berg, Nicole C T van Grieken, Bauke Ylstra, Beatriz Carvalho, Daniël M Miedema, Liudmila L Kodach","doi":"10.1016/j.celrep.2024.114981","DOIUrl":"https://doi.org/10.1016/j.celrep.2024.114981","url":null,"abstract":"The genome of esophageal adenocarcinoma (EAC) is highly unstable and might evolve over time. Here, we track karyotype evolution in EACs in response to treatment and upon recurrence through multi-region and longitudinal analysis. To this end, we introduce L-PAC (low-purity inference of absolute copy-number alterations [CNAs]), a bio-informatics technique that allows inference of absolute CNAs of low-purity samples by leveraging the information of high-purity samples from the same cancer. Quantitative analysis of matched absolute CNAs reveals that the amount of karyotype evolution induced by chemoradiotherapy (CRT) is predictive for early recurrence and depends on the initial level of karyotype intra-tumor heterogeneity. We observe that CNAs acquired in response to CRT are partially reversed back to the initial state upon recurrence. Hence, CRT alters the fitness landscape to which tumors can adjust by adapting their karyotype. Together, our results indicate that karyotype plasticity contributes to the therapy resistance of EACs.","PeriodicalId":9798,"journal":{"name":"Cell reports","volume":"43 11","pages":"114981"},"PeriodicalIF":7.5,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142613652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Idiothetic representations are modulated by availability of sensory inputs and task demands in the hippocampal-septal circuit. 在海马-隔膜回路中，白痴表象受感官输入的可用性和任务要求的调节。

IF 7.5 1区生物学

Cell reports Pub Date : 2024-11-12 DOI: 10.1016/j.celrep.2024.114980

Guillaume Etter, Suzanne van der Veldt, Coralie-Anne Mosser, Michael E Hasselmo, Sylvain Williams

引用次数: 0

PP2A licenses the FANCD2/FANCI complex for chromosome loading. PP2A 许可 FANCD2/FANCI 复合物装载染色体。

IF 7.5 1区生物学

Cell reports Pub Date : 2024-11-12 DOI: 10.1016/j.celrep.2024.114971

Di Yang, Fengxiang Bai, David Lopez Martinez, Hannan Xu, Ai Johjima-Murata, Lily Jiaqi Cao, Martin A Cohn

引用次数: 0

Cancer-associated fibroblasts maintain critical pancreatic cancer cell lipid homeostasis in the tumor microenvironment. 癌症相关成纤维细胞在肿瘤微环境中维持着关键的胰腺癌细胞脂质平衡。

IF 7.5 1区生物学

Cell reports Pub Date : 2024-11-12 DOI: 10.1016/j.celrep.2024.114972

Xu Han, Michelle Burrows, Laura C Kim, Jimmy P Xu, Will Vostrejs, Tran Ngoc Van Le, Carson Poltorack, Yanqing Jiang, Edna Cukierman, Ben Z Stanger, Kim A Reiss, Sydney M Shaffer, Clementina Mesaros, Brian Keith, M Celeste Simon

{"title":"Cancer-associated fibroblasts maintain critical pancreatic cancer cell lipid homeostasis in the tumor microenvironment.","authors":"Xu Han, Michelle Burrows, Laura C Kim, Jimmy P Xu, Will Vostrejs, Tran Ngoc Van Le, Carson Poltorack, Yanqing Jiang, Edna Cukierman, Ben Z Stanger, Kim A Reiss, Sydney M Shaffer, Clementina Mesaros, Brian Keith, M Celeste Simon","doi":"10.1016/j.celrep.2024.114972","DOIUrl":"https://doi.org/10.1016/j.celrep.2024.114972","url":null,"abstract":"Pancreatic ductal adenocarcinoma (PDAC) is an aggressive malignancy with abundant cancer-associated fibroblasts (CAFs) creating hallmark desmoplasia that limits oxygen and nutrient delivery. This study explores the importance of lipid homeostasis under stress. Exogenous unsaturated lipids, rather than de novo synthesis, sustain PDAC cell viability by relieving endoplasmic reticulum (ER) stress under nutrient scarcity. Furthermore, CAFs are less hypoxic than adjacent malignant cells in vivo, nominating them as a potential source of unsaturated lipids. CAF-conditioned medium promotes PDAC cell survival upon nutrient and oxygen deprivation, an effect reversed by delipidation. Lysophosphatidylcholines (LPCs) are particularly enriched in CAF-conditioned medium and preferentially taken up by PDAC cells, where they are converted to phosphatidylcholine (PC) to sustain membrane integrity. Blocking LPC-to-PC conversion inhibits PDAC cell survival and increases ER stress. These findings show a critical lipid \"cross-feeding\" mechanism that promotes PDAC cell survival, offering a potential metabolic target for treatment.","PeriodicalId":9798,"journal":{"name":"Cell reports","volume":"43 11","pages":"114972"},"PeriodicalIF":7.5,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142615863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A bacterial expression cloning screen reveals single-stranded DNA-binding proteins as potent desicco-protectants. 细菌表达克隆筛选发现单链 DNA 结合蛋白是有效的脱盐保护剂。

IF 7.5 1区生物学

Cell reports Pub Date : 2024-11-11 DOI: 10.1016/j.celrep.2024.114956

Jonathan D Hibshman, Courtney M Clark-Hachtel, Kerry S Bloom, Bob Goldstein

{"title":"A bacterial expression cloning screen reveals single-stranded DNA-binding proteins as potent desicco-protectants.","authors":"Jonathan D Hibshman, Courtney M Clark-Hachtel, Kerry S Bloom, Bob Goldstein","doi":"10.1016/j.celrep.2024.114956","DOIUrl":"https://doi.org/10.1016/j.celrep.2024.114956","url":null,"abstract":"Desiccation kills most cells. Some proteins have been identified to help certain cells survive desiccation, but many protein protectants are likely to be unknown. Moreover, the mechanisms ensuring protection of key cellular components are incompletely understood. We devised an expression-cloning approach to discover further protectants. We expressed cDNA libraries from two species of tardigrades in E. coli, and we subjected the bacteria to desiccation to select for survivors. Sequencing the populations of surviving bacteria revealed enrichment of mitochondrial single-stranded DNA-binding proteins (mtSSBs) from both tardigrade species. Expression of mtSSBs in bacteria improved desiccation survival as strongly as the best tardigrade protectants known to date. We found that DNA-binding activity of mtSSBs was necessary and sufficient to improve the desiccation tolerance of bacteria. Although tardigrade mtSSBs were among the strongest protectants we found, single-stranded DNA binding proteins in general offered some protection. These results identify single-stranded DNA-binding proteins as potent desicco-protectants.","PeriodicalId":9798,"journal":{"name":"Cell reports","volume":"43 11","pages":"114956"},"PeriodicalIF":7.5,"publicationDate":"2024-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142615862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A platform of functional studies of ESCC-associated gene mutations identifies the roles of TGFBR2 in ESCC progression and metastasis. ESCC 相关基因突变的功能研究平台确定了 TGFBR2 在 ESCC 进展和转移中的作用。

IF 7.5 1区生物学

Cell reports Pub Date : 2024-11-10 DOI: 10.1016/j.celrep.2024.114952

Jian Wang, Jiajia Du, Xiangmeng Luo, Linjie Guo, Yixin Liu, Jianfeng Zhou, Yang Zou, Zhenghao Lu, Xiangyu Pan, Xuelan Chen, Ailing Zhong, Xudong Wan, Lu Wang, Hongyu Liu, Siqi Dai, Shiyu Zhang, Xingyu Xiong, Ping Tan, Manli Wang, Baohong Wu, Qi Zhang, Yingjie Wang, Mengsha Zhang, Runda Lu, Huahang Lin, Yuan Li, Yaxin Li, Zongkai Han, Longqi Chen, Bing Hu, Yu Liu, Feifei Na, Chong Chen

{"title":"A platform of functional studies of ESCC-associated gene mutations identifies the roles of TGFBR2 in ESCC progression and metastasis.","authors":"Jian Wang, Jiajia Du, Xiangmeng Luo, Linjie Guo, Yixin Liu, Jianfeng Zhou, Yang Zou, Zhenghao Lu, Xiangyu Pan, Xuelan Chen, Ailing Zhong, Xudong Wan, Lu Wang, Hongyu Liu, Siqi Dai, Shiyu Zhang, Xingyu Xiong, Ping Tan, Manli Wang, Baohong Wu, Qi Zhang, Yingjie Wang, Mengsha Zhang, Runda Lu, Huahang Lin, Yuan Li, Yaxin Li, Zongkai Han, Longqi Chen, Bing Hu, Yu Liu, Feifei Na, Chong Chen","doi":"10.1016/j.celrep.2024.114952","DOIUrl":"https://doi.org/10.1016/j.celrep.2024.114952","url":null,"abstract":"Genomics studies have detected numerous genetic alterations in esophageal squamous cell carcinoma (ESCC). However, the functions of these mutations largely remain elusive, partially due to a lack of feasible animal models. Here, we report a convenient platform with CRISPR-Cas9-mediated introduction of genetic alterations and orthotopic transplantation to generate a series of primary ESCC models in mice. With this platform, we validate multiple frequently mutated genes, including EP300, FAT1/2/4, KMT2D, NOTCH2, and TGFBR2, as tumor-suppressor genes in ESCC. Among them, TGFBR2 loss dramatically promotes tumorigenesis and multi-organ metastasis. Paradoxically, TGFBR2 deficiency leads to Smad3 activation, and disruption of Smad3 partially restrains the progression of Tgfbr2-mutated tumors. Drug screening with tumor organoids identifies that pinaverium bromide represses Smad3 activity and restrains Tgfbr2-deficient ESCC. Our studies provide a highly efficient platform to investigate the in vivo functions of ESCC-associated mutations and develop potential treatments for this miserable malignancy.","PeriodicalId":9798,"journal":{"name":"Cell reports","volume":"43 11","pages":"114952"},"PeriodicalIF":7.5,"publicationDate":"2024-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142615904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Domestication-selected COG4-OsbZIP23 module regulates chilling tolerance in rice. 驯化选择的 COG4-OsbZIP23 模块调控水稻的耐寒性。

IF 7.5 1区生物学

Cell reports Pub Date : 2024-11-10 DOI: 10.1016/j.celrep.2024.114965

Shenli Sun, Dongfeng Liu, Wei Luo, Zhitao Li, Jinglei Feng, Yalong Guo, Kang Chong, Yunyuan Xu

{"title":"Domestication-selected COG4-OsbZIP23 module regulates chilling tolerance in rice.","authors":"Shenli Sun, Dongfeng Liu, Wei Luo, Zhitao Li, Jinglei Feng, Yalong Guo, Kang Chong, Yunyuan Xu","doi":"10.1016/j.celrep.2024.114965","DOIUrl":"https://doi.org/10.1016/j.celrep.2024.114965","url":null,"abstract":"Identifying excellent natural variations is the foundation for breeding. Several major genes of quantitative trait loci for chilling tolerance at the seedling stage (qCTS) have been identified. However, less is known about the dual elite modules for the tolerance. Here, we report the major gene of qCTS1-2, Chilling-tolerance in Geng/japonica rice 4 (COG4), encoding the transcription factor ENAC1, coupled with OsbZIP23 to positively regulate chilling tolerance. The haplotype analysis and geographical distribution show that most of the chilling-tolerant japonica varieties carry Var9(CT) at -317 in COG4 (COG4jap). The COG4jap promoter is preferentially bound by cold-induced OsbZIP23 to cause a higher expression of COG4jap compared to COG4ind, which promotes multiple pathways for the tolerance. Both COG4jap and OsbZIP23jap are artificially selected and retained in japonica varieties during domestication. These results not only reveal the regulatory mechanism of OsbZIP23jap-COG4jap module but also provide valuable variations for molecular design breeding.","PeriodicalId":9798,"journal":{"name":"Cell reports","volume":"43 11","pages":"114965"},"PeriodicalIF":7.5,"publicationDate":"2024-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142615882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Aberrant zonal recycling of germinal center B cells impairs appropriate selection in lupus. 红斑狼疮患者生殖中心 B 细胞的分区循环异常会影响适当的选择。

IF 7.5 1区生物学

Cell reports Pub Date : 2024-11-10 DOI: 10.1016/j.celrep.2024.114978

Gina M Sanchez, Eden S Hirsch, Arthur VanValkenburg, Daniel P Mayer, Komi Gbedande, Rebecca L Francis, Wenzhi Song, Olivia Q Antao, Kyleigh E Brimmer, Alexander Lemenze, Robin Stephens, W Evan Johnson, Jason S Weinstein

{"title":"Aberrant zonal recycling of germinal center B cells impairs appropriate selection in lupus.","authors":"Gina M Sanchez, Eden S Hirsch, Arthur VanValkenburg, Daniel P Mayer, Komi Gbedande, Rebecca L Francis, Wenzhi Song, Olivia Q Antao, Kyleigh E Brimmer, Alexander Lemenze, Robin Stephens, W Evan Johnson, Jason S Weinstein","doi":"10.1016/j.celrep.2024.114978","DOIUrl":"https://doi.org/10.1016/j.celrep.2024.114978","url":null,"abstract":"Autoimmune diseases such as lupus are characterized by polyclonal B cell activation, leading to the production of autoantibodies. The mechanism leading to B cell dysregulation is unclear; however, the defect may lie in selection within germinal centers (GCs). GC B cells cycle between proliferation and mutation in the dark zone and selection in the light zone (LZ). Temporal assessment of GCs from mice with either persistent infection or lupus showed an accumulation of LZ B cells. Yet, only in lupus, GC B cells exhibited reduced proliferation and progressive loss of MYC and FOXO1, which regulate zonal recycling and differentiation. As lupus progressed, decreased mutational frequency and repertoire diversity were associated with reduced responsiveness to CD40 signaling, despite accumulation of plasma cells. Collectively, these findings suggest that lupus disease progression coincides with an intrinsic defect in LZ B cell signaling, altering the zonal recycling, selection, and differentiation of autoreactive B cells.","PeriodicalId":9798,"journal":{"name":"Cell reports","volume":"43 11","pages":"114978"},"PeriodicalIF":7.5,"publicationDate":"2024-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142615913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0