Cell reportsPub Date : 2025-04-03DOI: 10.1016/j.celrep.2025.115520
Dongsheng Bai, Jinmin Yang, Xiaohui Xue, Yun Gao, Yan Wang, Mengge Cui, Bo He, Hu Zeng, Huifen Xiang, Zijian Guo, Lan Zhu, Juan Gao, Chenxu Zhu, Fuchou Tang, Chengqi Yi
{"title":"Single-cell 5-hydroxymethylcytosine landscapes of mouse early embryos at single-base resolution.","authors":"Dongsheng Bai, Jinmin Yang, Xiaohui Xue, Yun Gao, Yan Wang, Mengge Cui, Bo He, Hu Zeng, Huifen Xiang, Zijian Guo, Lan Zhu, Juan Gao, Chenxu Zhu, Fuchou Tang, Chengqi Yi","doi":"10.1016/j.celrep.2025.115520","DOIUrl":"https://doi.org/10.1016/j.celrep.2025.115520","url":null,"abstract":"<p><p>DNA methylation and hydroxymethylation are extensively reprogrammed during mammalian early embryogenesis, and studying their regulatory functions requires comprehensive DNA hydroxymethylation maps at base resolution. Here, we develop single-cell 5-hydroxymethylcytosine (5hmC) chemical-assisted C-to-T conversion-enabled sequencing (schmC-CATCH), a method leveraging selective 5hmC labeling for a quantitative, base-resolution, genome-wide landscape of the DNA hydroxymethylome in mouse gametes and preimplantation embryos spanning from the zygote to blastocyst stage. We revealed that, in addition to late zygotic stages, onset of ten-eleven translocation (TET)-mediated DNA hydroxymethylation initiates immediately after fertilization and is characterized by the distinct 5hmC patterns on the parental genomes shaped by TET3 demethylase. We identified persistent clusters of 5hmC hotspots throughout early embryonic stages, which are highly associated with young retroelements. 5hmC is also associated with different regulatory elements, indicating a potential regulatory function during early embryogenesis. Collectively, our work elucidates the dynamics of active DNA demethylation during mouse preimplantation development and provides a valuable resource for functional studies of epigenetic reprogramming in early embryos.</p>","PeriodicalId":9798,"journal":{"name":"Cell reports","volume":"44 4","pages":"115520"},"PeriodicalIF":7.5,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143787994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Cell reportsPub Date : 2025-04-03DOI: 10.1016/j.celrep.2025.115502
Holly Merta, Kaitlynn Gov, Tadamoto Isogai, Blessy Paul, Achinta Sannigrahi, Arun Radhakrishnan, Gaudenz Danuser, W Mike Henne
{"title":"Spatial proteomics of ER tubules reveals CLMN, an ER-actin tether at focal adhesions that promotes cell migration.","authors":"Holly Merta, Kaitlynn Gov, Tadamoto Isogai, Blessy Paul, Achinta Sannigrahi, Arun Radhakrishnan, Gaudenz Danuser, W Mike Henne","doi":"10.1016/j.celrep.2025.115502","DOIUrl":"https://doi.org/10.1016/j.celrep.2025.115502","url":null,"abstract":"<p><p>The endoplasmic reticulum (ER) is structurally and functionally diverse, yet how its functions are organized within morphological subdomains is incompletely understood. Utilizing TurboID-based proximity labeling and CRISPR knockin technologies, we map the proteomic landscape of the human ER network. Sub-organelle proteomics reveals enrichments of proteins into ER tubules, sheets, and the nuclear envelope. We uncover an ER-enriched actin-binding protein, calmin/CLMN, and define it as an ER-actin tether that localizes to focal adhesions adjacent to ER tubules. Mechanistically, we find that CLMN depletion perturbs adhesion disassembly, actin dynamics, and cell movement. CLMN-depleted cells display decreased polarization of ER-plasma membrane contacts and calcium signaling factor STIM1 and altered calcium signaling near ER-actin interfaces, suggesting that CLMN influences calcium signaling to facilitate F-actin/adhesion dynamics. Collectively, we map the sub-organelle proteome landscape of the ER, identify CLMN as an ER-actin tether, and describe a non-canonical mechanism by which ER tubules engage actin to regulate cell migration.</p>","PeriodicalId":9798,"journal":{"name":"Cell reports","volume":"44 4","pages":"115502"},"PeriodicalIF":7.5,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143784565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Cell reportsPub Date : 2025-04-03DOI: 10.1016/j.celrep.2025.115505
Zhengwei Zhong, Kun Wang, Ting Zhong, Jingwen Wang
{"title":"Mitochondrial fission regulates midgut muscle assembly and tick feeding capacity.","authors":"Zhengwei Zhong, Kun Wang, Ting Zhong, Jingwen Wang","doi":"10.1016/j.celrep.2025.115505","DOIUrl":"https://doi.org/10.1016/j.celrep.2025.115505","url":null,"abstract":"<p><p>Ticks ingest over 100 times their body weight in blood. As the primary tissue for blood storage and digestion, the tick midgut's regulation in response to this substantial blood volume remains unclear. Here, we show that blood intake triggers stem cell proliferation and mitochondrial fission in the midgut of Haemaphysalis longicornis. While inhibiting stem cell proliferation does not impact feeding behavior, disruption of mitochondrial fission impairs tick feeding capacity. Mitochondrial fission mediated by dynamin 2 (DNM2) regulates ATP generation, which in turn influences the expression of the tropomyosin-anchoring subunit troponin T (TNT). Knockdown of TNT disrupts muscle fiber assembly, hindering midgut enlargement and contraction, thereby preventing blood ingestion. These findings underscore the indispensable role of musculature in facilitating midgut expansion during feeding in ticks.</p>","PeriodicalId":9798,"journal":{"name":"Cell reports","volume":"44 4","pages":"115505"},"PeriodicalIF":7.5,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143784561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Cell reportsPub Date : 2025-04-03DOI: 10.1016/j.celrep.2025.115518
Joshua J Hamey, Manan Shah, John D Wade, Tara K Bartolec, Richard E H Wettenhall, Kate G R Quinlan, Nicholas A Williamson, Marc R Wilkins
{"title":"SMYD5 is a ribosomal methyltransferase that trimethylates RPL40 lysine 22 through recognition of a KXY motif.","authors":"Joshua J Hamey, Manan Shah, John D Wade, Tara K Bartolec, Richard E H Wettenhall, Kate G R Quinlan, Nicholas A Williamson, Marc R Wilkins","doi":"10.1016/j.celrep.2025.115518","DOIUrl":"https://doi.org/10.1016/j.celrep.2025.115518","url":null,"abstract":"<p><p>The eukaryotic ribosome is highly modified by protein methylation, yet many of the responsible methyltransferases remain unknown. Here, we identify SET and MYND domain-containing protein 5 (SMYD5) as a ribosomal protein methyltransferase that catalyzes trimethylation of RPL40/eL40 at lysine 22. Through a systematic mass spectrometry-based approach, we identify 12 primary sites of protein methylation in ribosomes from K562 cells, including at RPL40 K22. Through in vitro methylation of synthetic RPL40 using fractionated lysate, we then identify SMYD5 as a candidate RPL40 K22 methyltransferase. We show that recombinant SMYD5 has robust activity toward RPL40 K22 in vitro and that active site mutations ablate this activity. Knockouts of SMYD5 in K562 cells show a complete loss of RPL40 K22 methylation and decreased polysome levels. We show that SMYD5 does not methylate histones in vitro, and by systematic analysis of its recognition motif, we find that SMYD5 requires a KXY motif for methylation, explaining its lack of activity toward histones.</p>","PeriodicalId":9798,"journal":{"name":"Cell reports","volume":"44 4","pages":"115518"},"PeriodicalIF":7.5,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143784564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Cell reportsPub Date : 2025-04-02DOI: 10.1016/j.celrep.2025.115499
Sharon L Schendel, Xiaoying Yu, Peter J Halfmann, Jarjapu Mahita, Brendan Ha, Kathryn M Hastie, Haoyang Li, Daniel Bedinger, Camille Troup, Kan Li, Natalia Kuzmina, Jordi B Torrelles, Jennifer E Munt, Melissa Maddocks, Mary Osei-Twum, Heather M Callaway, Stephen Reece, Anne Palser, Paul Kellam, S Moses Dennison, Richard H C Huntwork, Gillian Q Horn, Milite Abraha, Elizabeth Feeney, Luis Martinez-Sobrido, Paula A Pino, Amberlee Hicks, Chengjin Ye, Jun-Gyu Park, Billie Maingot, Sivakumar Periasamy, Michael Mallory, Trevor Scobey, Marie-Noelle Lepage, Natalie St-Amant, Sarwat Khan, Anaïs Gambiez, Ralph S Baric, Alexander Bukreyev, Luc Gagnon, Timothy Germann, Yoshihiro Kawaoka, Georgia D Tomaras, Bjoern Peters, Erica Ollmann Saphire
{"title":"A global collaboration for systematic analysis of broad-ranging antibodies against the SARS-CoV-2 spike protein.","authors":"Sharon L Schendel, Xiaoying Yu, Peter J Halfmann, Jarjapu Mahita, Brendan Ha, Kathryn M Hastie, Haoyang Li, Daniel Bedinger, Camille Troup, Kan Li, Natalia Kuzmina, Jordi B Torrelles, Jennifer E Munt, Melissa Maddocks, Mary Osei-Twum, Heather M Callaway, Stephen Reece, Anne Palser, Paul Kellam, S Moses Dennison, Richard H C Huntwork, Gillian Q Horn, Milite Abraha, Elizabeth Feeney, Luis Martinez-Sobrido, Paula A Pino, Amberlee Hicks, Chengjin Ye, Jun-Gyu Park, Billie Maingot, Sivakumar Periasamy, Michael Mallory, Trevor Scobey, Marie-Noelle Lepage, Natalie St-Amant, Sarwat Khan, Anaïs Gambiez, Ralph S Baric, Alexander Bukreyev, Luc Gagnon, Timothy Germann, Yoshihiro Kawaoka, Georgia D Tomaras, Bjoern Peters, Erica Ollmann Saphire","doi":"10.1016/j.celrep.2025.115499","DOIUrl":"https://doi.org/10.1016/j.celrep.2025.115499","url":null,"abstract":"<p><p>The Coronavirus Immunotherapeutic Consortium (CoVIC) conducted side-by-side comparisons of over 400 anti-SARS-CoV-2 spike therapeutic antibody candidates contributed by large and small companies as well as academic groups on multiple continents. Nine reference labs analyzed antibody features, including in vivo protection in a mouse model of infection, spike protein affinity, high-resolution epitope binning, ACE-2 binding blockage, structures, and neutralization of pseudovirus and authentic virus infection, to build a publicly accessible dataset in the database CoVIC-DB. High-throughput, high-resolution binning of CoVIC antibodies defines a broad and predictive landscape of antibody epitopes on the SARS-CoV-2 spike protein and identifies features associated with durable potency against multiple SARS-CoV-2 variants of concern and high in vivo efficacy. Results of the CoVIC studies provide a guide for selecting effective and durable antibody therapeutics and for immunogen design as well as providing a framework for rapid response to future viral disease outbreaks.</p>","PeriodicalId":9798,"journal":{"name":"Cell reports","volume":"44 4","pages":"115499"},"PeriodicalIF":7.5,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143784559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Cell reportsPub Date : 2025-04-02DOI: 10.1016/j.celrep.2025.115510
Michael Herbst, Hakan Köksal, Silvan Brunn, Dominik Zanetti, Ioana Domocos, Viola De Stefani, Marco Gatti, Francesca Vivalda, Paulo Pereira, Marc Nater, Virginia Cecconi, Alessandro A Sartori, Maries van den Broek
{"title":"Cancer-cell-derived cGAMP limits the activity of tumor-associated CD8<sup>+</sup> T cells.","authors":"Michael Herbst, Hakan Köksal, Silvan Brunn, Dominik Zanetti, Ioana Domocos, Viola De Stefani, Marco Gatti, Francesca Vivalda, Paulo Pereira, Marc Nater, Virginia Cecconi, Alessandro A Sartori, Maries van den Broek","doi":"10.1016/j.celrep.2025.115510","DOIUrl":"https://doi.org/10.1016/j.celrep.2025.115510","url":null,"abstract":"<p><p>Using a mouse tumor model with inducible cancer-cell-intrinsic cyclic GMP-AMP (cGAMP) synthase (cGAS) expression, we show that cancer-cell-derived cGAMP is essential and sufficient to trigger a sustained type I interferon response within the tumor microenvironment. This leads to improved CD8<sup>+</sup> T cell-dependent tumor restriction. However, cGAMP limits the proliferation, survival, and function of stimulator of IFN genes (STING)-expressing, but not of STING-deficient, CD8<sup>+</sup> T cells. In vivo, STING deficiency in CD8<sup>+</sup> T cells enhances tumor restriction. Consequently, cancer-cell-derived cGAMP both drives and limits the anti-tumor potential of CD8<sup>+</sup> T cells. Mechanistically, T cell-intrinsic STING is associated with pro-apoptotic and antiproliferative gene signatures. Our findings suggest that STING signaling acts as a checkpoint in CD8<sup>+</sup> T cells that balances tumor immunity.</p>","PeriodicalId":9798,"journal":{"name":"Cell reports","volume":"44 4","pages":"115510"},"PeriodicalIF":7.5,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143779259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Cell reportsPub Date : 2025-04-02DOI: 10.1016/j.celrep.2025.115585
Lavanya Choppavarapu, Kun Fang, Tianxiang Liu, Aigbe G Ohihoin, Victor X Jin
{"title":"Hi-C profiling in tissues reveals 3D chromatin-regulated breast tumor heterogeneity informing a looping-mediated therapeutic avenue.","authors":"Lavanya Choppavarapu, Kun Fang, Tianxiang Liu, Aigbe G Ohihoin, Victor X Jin","doi":"10.1016/j.celrep.2025.115585","DOIUrl":"https://doi.org/10.1016/j.celrep.2025.115585","url":null,"abstract":"","PeriodicalId":9798,"journal":{"name":"Cell reports","volume":"44 4","pages":"115585"},"PeriodicalIF":7.5,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143779263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Cell reportsPub Date : 2025-04-02DOI: 10.1016/j.celrep.2025.115494
Julia Stomper, Abhishek Niroula, Roger Belizaire, Marie McConkey, Tagore Sanketh Bandaru, Benjamin L Ebert
{"title":"Sex differences in DNMT3A-mutant clonal hematopoiesis and the effects of estrogen.","authors":"Julia Stomper, Abhishek Niroula, Roger Belizaire, Marie McConkey, Tagore Sanketh Bandaru, Benjamin L Ebert","doi":"10.1016/j.celrep.2025.115494","DOIUrl":"https://doi.org/10.1016/j.celrep.2025.115494","url":null,"abstract":"<p><p>Blood cancers are generally more common in males, and the prevalence of most mutations that drive clonal hematopoiesis and myeloid malignancies is higher in males. In contrast, hematopoietic DNMT3A mutations are more common in females. Among ∼450,000 participants in the UK Biobank, the prevalence of DNMT3A mutations and copy-number abnormalities is higher in females than males. In a murine model, Dnmt3a-mutant hematopoietic stem cells (HSCs) from unperturbed female mice had increased stemness gene expression compared to male and wild-type (WT) mice. Estrogen regulates HSCs, and we found that Dnmt3a mutations maintain stemness in the setting of estrogen-induced proliferative stress. Dnmt3a-mutant myeloid cells outcompeted WT cells under chronic estrogen treatment, an effect that was dependent on cell-intrinsic estrogen receptor alpha activity. Our studies indicate that estrogen might contribute to the female predominance of DNMT3A-mutant clonal hematopoiesis.</p>","PeriodicalId":9798,"journal":{"name":"Cell reports","volume":"44 4","pages":"115494"},"PeriodicalIF":7.5,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143779271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Cell reportsPub Date : 2025-04-02DOI: 10.1016/j.celrep.2025.115503
Giacomo Potente, Yukiko Yasui, Eita Shimokawa, Jerry Jenkins, Rachel N Walstead, Jane Grimwood, Jeremy Schmutz, Jim Leebens-Mack, Tomas Bruna, Navneet Kaur, Raymond Lee, Sumaira Zama, Tomoha Tanaka, Yuka Umeya, Shogo Kawamura, Katsuyuki T Yamato, Katsushi Yamaguchi, Shuji Shigenobu, Masaki Shimamura, Takayuki Kohchi, Péter Szövényi
{"title":"Insights into convergent evolution of cosexuality in liverworts from the Marchantia quadrata genome.","authors":"Giacomo Potente, Yukiko Yasui, Eita Shimokawa, Jerry Jenkins, Rachel N Walstead, Jane Grimwood, Jeremy Schmutz, Jim Leebens-Mack, Tomas Bruna, Navneet Kaur, Raymond Lee, Sumaira Zama, Tomoha Tanaka, Yuka Umeya, Shogo Kawamura, Katsuyuki T Yamato, Katsushi Yamaguchi, Shuji Shigenobu, Masaki Shimamura, Takayuki Kohchi, Péter Szövényi","doi":"10.1016/j.celrep.2025.115503","DOIUrl":"https://doi.org/10.1016/j.celrep.2025.115503","url":null,"abstract":"<p><p>Sex chromosomes are expected to coevolve with their respective sex, potentially disfavoring their co-occurrence as cosexuality evolves. This effect is expected to be stronger where sex chromosomes are restricted to one sex, such as in plants expressing sex in their haploid stage. We assess this hypothesis in liverworts with U/V sex chromosomes, ancestral dioicy, and several independent transitions to monoicy (cosexuality). We report the chromosome-level genome assembly of Marchantia quadrata, which recently evolved monoicy, and perform comparative genomic analyses with its dioicous relative M. polymorpha. We find that monoicy evolved via retention of the V chromosome as a small ninth chromosome, complete loss of the U chromosome, and translocation of key U-linked genes to autosomes, among which the major sex-determining gene (Feminizer) acquired environmental/developmental regulation. Our findings parallel recent observations on Ricciocarpos natans, which evolved monoicy independently, suggesting genetic constraints that may make transitions to monoicy predictable in liverworts.</p>","PeriodicalId":9798,"journal":{"name":"Cell reports","volume":"44 4","pages":"115503"},"PeriodicalIF":7.5,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143779266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Cell reportsPub Date : 2025-04-02DOI: 10.1016/j.celrep.2025.115485
Ken Kirio, Ines Lucia Patop, Ane Martin Anduaga, Jenna Harris, Nagarjuna Pamudurti, The Nandar Su, Claire Martel, Sebastian Kadener
{"title":"Circular RNAs exhibit exceptional stability in the aging brain and serve as reliable age and experience indicators.","authors":"Ken Kirio, Ines Lucia Patop, Ane Martin Anduaga, Jenna Harris, Nagarjuna Pamudurti, The Nandar Su, Claire Martel, Sebastian Kadener","doi":"10.1016/j.celrep.2025.115485","DOIUrl":"https://doi.org/10.1016/j.celrep.2025.115485","url":null,"abstract":"<p><p>Circular RNAs (circRNAs) increase in the brain with age across various animal systems. To elucidate the reasons behind this phenomenon, we profile circRNAs from fly heads at six time points throughout their lifespan. Our results reveal a linear increase in circRNA levels with age, independent of changes in mRNA levels, overall transcription, intron retention, or host gene splicing, demonstrating that the age-related accumulation is due to high stability rather than increased biogenesis. This remarkable stability suggests that circRNAs can serve as markers of environmental experience. Indeed, flies exposed to a 10-day regimen at 29°C exhibit higher levels of specific circRNAs even 6 weeks after returning to standard conditions, indicating that circRNAs can reveal past environmental stimuli. Moreover, half-life measurements show circRNA stability exceeding 20 days, with some displaying virtually no degradation. These findings underscore the remarkable stability of circRNAs in vivo and their potential as markers for stress and life experiences.</p>","PeriodicalId":9798,"journal":{"name":"Cell reports","volume":"44 4","pages":"115485"},"PeriodicalIF":7.5,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143784560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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