Cell reports最新文献_第2页

A direct interaction between the RNA-binding proteins Staufen and Tm1-I/C in the oskar mRNA transport complex. oskar mRNA转运复合体中rna结合蛋白Staufen和Tm1-I/C之间的直接相互作用。

IF 7.5 1区生物学

Cell reports Pub Date : 2025-06-25 DOI: 10.1016/j.celrep.2025.115906

Thomas Gaber, Thomas Monecke, Julia Grabowski, Bernd Simon, Tobias Williams, Vera Roman, Jeffrey Chao, Janosch Hennig, Anne Ephrussi, Dierk Niessing, Simone Heber

引用次数: 0

Gamma synchronization between the medial temporal lobe and medial frontal cortex for goal-directed visual attention in humans. 人类目标导向视觉注意的内侧颞叶和内侧额叶皮层之间的伽马同步。

IF 7.5 1区生物学

Cell reports Pub Date : 2025-06-25 DOI: 10.1016/j.celrep.2025.115905

Jie Zhang, Jing Xia, Huihui Zhou, Shuo Wang

{"title":"Gamma synchronization between the medial temporal lobe and medial frontal cortex for goal-directed visual attention in humans.","authors":"Jie Zhang, Jing Xia, Huihui Zhou, Shuo Wang","doi":"10.1016/j.celrep.2025.115905","DOIUrl":"https://doi.org/10.1016/j.celrep.2025.115905","url":null,"abstract":"Goal-directed visual attention is a fundamental cognitive function that engages multiple brain regions, yet the neural circuit mechanisms in humans remain unclear. We addressed this question by simultaneously recording neural activity from the medial temporal lobe (MTL) and medial frontal cortex (MFC) during a goal-directed visual search task. We found that gamma-band synchronization between the MTL and MFC signaled target detection. Using two additional tasks, we dissociated the neural processes underlying working memory and search decision execution, revealing distinct patterns of synchronization. Further analyses showed that dorsal anterior cingulate cortex (dACC) spike-MTL LFP synchronization encoded search dynamics and contributed to guiding behavior. Importantly, MTL-MFC synchronization disproportionately modulated neural representational geometry, highlighting its impact on information encoding. Finally, we demonstrated directional gamma influences across brain areas and cross-frequency coupling. Together, these findings illuminate the circuit-level dynamics underlying visual attention and offer insights into how the human brain selectively processes information in complex visual environments.","PeriodicalId":9798,"journal":{"name":"Cell reports","volume":"44 7","pages":"115905"},"PeriodicalIF":7.5,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144504873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gut commensal bacteria-derived methionine is required for host reproduction by modulating RNA m6A methylation of the insulin receptor. 肠道共生细菌衍生的蛋氨酸是通过调节胰岛素受体的RNA m6A甲基化来实现宿主繁殖所必需的。

IF 7.5 1区生物学

Cell reports Pub Date : 2025-06-24 DOI: 10.1016/j.celrep.2025.115911

Qiuyuan Zhang, ZhuRong Deng, Xiaoxue Li, Jiao Qiao, Ziniu Li, Peipei Liu, Alfred M Handler, Bruno Lemaitre, Weiwei Zheng, Hongyu Zhang

{"title":"Gut commensal bacteria-derived methionine is required for host reproduction by modulating RNA m6A methylation of the insulin receptor.","authors":"Qiuyuan Zhang, ZhuRong Deng, Xiaoxue Li, Jiao Qiao, Ziniu Li, Peipei Liu, Alfred M Handler, Bruno Lemaitre, Weiwei Zheng, Hongyu Zhang","doi":"10.1016/j.celrep.2025.115911","DOIUrl":"https://doi.org/10.1016/j.celrep.2025.115911","url":null,"abstract":"Gut commensal bacteria promote host reproduction by modulating metabolism and nutrition, but the molecular mechanisms by which microbes regulate reproduction remain unclear. Here, we show that gut commensal bacteria promote host reproduction by providing the amino acid methionine, which controls the RNA m6A modification level of insulin receptor (InR) in the ovary of the invasive insect Bactrocera dorsalis. Antibiotic-treated B. dorsalis shows reduced RNA m6A methylation levels and methionine content, resulting in arrested ovarian development and decreased fecundity. The gut commensal bacterium Enterobacter hormaechei-derived metabolite methionine restores the decreased RNA m6A level and the reproductive defects. Notably, the knockdown of METTL3 and METTL14, two genes encoding the RNA m6A methyltransferases, reduces InR mRNA and protein levels and impairs ovarian development in B. dorsalis. Our findings further expand the functional landscape of RNA m6A modification to include nutrient-dependent control of ovarian development and highlight the essential role of epigenetic regulation in microbe-host interactions.","PeriodicalId":9798,"journal":{"name":"Cell reports","volume":"44 7","pages":"115911"},"PeriodicalIF":7.5,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144494903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Division of labor among H3K4 methyltransferases defines distinct facets of homeostatic plasticity. H3K4甲基转移酶之间的分工定义了稳态可塑性的不同方面。

IF 7.5 1区生物学

Cell reports Pub Date : 2025-06-24 Epub Date: 2025-05-21 DOI: 10.1016/j.celrep.2025.115746

Takao Tsukahara, Saini Kethireddy, Katherine M Bonefas, Alex Chen, Brendan L M Sutton, Kenjiro Bandow, Yali Dou, Shigeki Iwase, Michael A Sutton

{"title":"Division of labor among H3K4 methyltransferases defines distinct facets of homeostatic plasticity.","authors":"Takao Tsukahara, Saini Kethireddy, Katherine M Bonefas, Alex Chen, Brendan L M Sutton, Kenjiro Bandow, Yali Dou, Shigeki Iwase, Michael A Sutton","doi":"10.1016/j.celrep.2025.115746","DOIUrl":"10.1016/j.celrep.2025.115746","url":null,"abstract":"Heterozygous mutations in any of the six H3K4 methyltransferases (KMT2s) result in monogenic neurodevelopmental disorders, indicating non-redundant yet poorly understood roles of this enzyme family in neurodevelopment. However, the specific cellular role of KMT2 enzymes in the brain remains poorly understood, owing to the clear non-catalytic functions of each family member and the potential for functional redundancy in installing H3K4 methylation (H3K4me). Here, we identify an instructive role for H3K4me in controlling synapse function and a division of labor among the six KMT2 enzymes in regulating homeostatic synaptic scaling. Using RNAi screening, conditional genetics, small-molecule inhibitors, and transcriptional profiling, our data reveal that individual KMT2 enzymes have unique roles and operate in specific phases to control distinct facets of homeostatic scaling. Together, our results suggest that the expansion of this enzyme family in mammals is key to coupling fine-tuned gene expression changes to adaptive modifications of synaptic function.","PeriodicalId":9798,"journal":{"name":"Cell reports","volume":"44 6","pages":"115746"},"PeriodicalIF":7.5,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144126942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Early-life development of the gut virome and plasmidome: A longitudinal study in cesarean-born infants. 肠道病毒和质粒的早期发育：对剖宫产婴儿的纵向研究。

IF 7.5 1区生物学

Cell reports Pub Date : 2025-06-24 Epub Date: 2025-05-23 DOI: 10.1016/j.celrep.2025.115731

Asier Fernández-Pato, Trishla Sinha, Sanzhima Garmaeva, Anastasia Gulyaeva, Nataliia Kuzub, Simon Roux, Jingyuan Fu, Alexander Kurilshikov, Alexandra Zhernakova

{"title":"Early-life development of the gut virome and plasmidome: A longitudinal study in cesarean-born infants.","authors":"Asier Fernández-Pato, Trishla Sinha, Sanzhima Garmaeva, Anastasia Gulyaeva, Nataliia Kuzub, Simon Roux, Jingyuan Fu, Alexander Kurilshikov, Alexandra Zhernakova","doi":"10.1016/j.celrep.2025.115731","DOIUrl":"10.1016/j.celrep.2025.115731","url":null,"abstract":"Mobile genetic elements (MGE) are critical yet understudied determinants of gut microbiome composition. In this secondary analysis of a randomized controlled trial (NCT06030713), we characterized the gut virome and plasmidome in 195 samples from 28 mother-infant dyads delivered by cesarean section. Infant mobilome increases in richness over the first 6 postnatal weeks, demonstrating high individual-specificity and temporal stability, establishing a personal persistent mobilome. Formula-fed infants exhibit greater mobilome richness than breastfed infants, with plasmid composition being influenced by antibiotic exposure and birth weight. Plasmids constitute a reservoir of antibiotic resistance genes (ARG), with around 5% of infant gut plasmid taxonomic units carrying ARG. Notably, ARG profiles do not differ with antibiotic exposure at birth. Mother-infant sharing of viral and plasmid strains primarily occurs after 6 months of age. Overall, our integrative analysis offers insights into the dynamics, modulation, and origin of MGE in the developing gut microbiome.","PeriodicalId":9798,"journal":{"name":"Cell reports","volume":"44 6","pages":"115731"},"PeriodicalIF":7.5,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144141464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dissecting pre- to post-implantation transition of DNA methylome-transcriptome dynamics in early mammalian development. 解剖早期哺乳动物发育中DNA甲基组-转录组动力学的植入前到植入后转变。

IF 7.5 1区生物学

Cell reports Pub Date : 2025-06-24 Epub Date: 2025-06-03 DOI: 10.1016/j.celrep.2025.115790

Qingyuan Zhu, Ying Liu, Xin Hao, Shengyi Yan, Jitao Ge, Changqing Zheng, Xianwen Ren, Fan Zhou

{"title":"Dissecting pre- to post-implantation transition of DNA methylome-transcriptome dynamics in early mammalian development.","authors":"Qingyuan Zhu, Ying Liu, Xin Hao, Shengyi Yan, Jitao Ge, Changqing Zheng, Xianwen Ren, Fan Zhou","doi":"10.1016/j.celrep.2025.115790","DOIUrl":"10.1016/j.celrep.2025.115790","url":null,"abstract":"Pre- to post-implantation transition is an essential step for early mammalian development. The epigenome dynamics such as DNA methylome and transcriptome of embryos have been analyzed, while the coordination between these two molecular layers controlling lineage fate remained elusive. Here, with a multidimensional profiling of peri-implantation embryos, we present the emerging lineage-specific DNA methylation (DNAme) patterns across species. The maternal and paternal DNA methylation levels exhibit differential dynamics in transposon elements. Genes with lineage-specific unmethylated promoters early in development retain this state and are expressed later, suggesting a role in lineage fate determination. By measuring both molecular dimensions simultaneously in individual developing cells, we identified a group of gene promoters with positive correlation between DNAme and RNAex along epiblast development. Functional validation suggested DNAme at these promoters contributes to non-canonical DNAme-RNAex dynamics, potentially via complex TF-mediated or epigenetic regulation. This study provides clues for understanding molecular regulation of peri-implantation embryogenesis.","PeriodicalId":9798,"journal":{"name":"Cell reports","volume":"44 6","pages":"115790"},"PeriodicalIF":7.5,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144233335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The glycolytic reaction PGAM restrains Th17 pathogenicity and Th17-dependent autoimmunity. 糖酵解反应PGAM抑制Th17致病性和Th17依赖性自身免疫。

IF 7.5 1区生物学

Cell reports Pub Date : 2025-06-24 Epub Date: 2025-06-05 DOI: 10.1016/j.celrep.2025.115799

Chao Wang, Allon Wagner, Johannes Fessler, David DeTomaso, Sarah Zaghouani, Yulin Zhou, Kerry Pierce, Raymond A Sobel, Clary Clish, Nir Yosef, Vijay K Kuchroo

{"title":"The glycolytic reaction PGAM restrains Th17 pathogenicity and Th17-dependent autoimmunity.","authors":"Chao Wang, Allon Wagner, Johannes Fessler, David DeTomaso, Sarah Zaghouani, Yulin Zhou, Kerry Pierce, Raymond A Sobel, Clary Clish, Nir Yosef, Vijay K Kuchroo","doi":"10.1016/j.celrep.2025.115799","DOIUrl":"10.1016/j.celrep.2025.115799","url":null,"abstract":"Glucose metabolism is a critical regulator of T cell function, largely thought to support their activation and effector differentiation. Here, we investigate how individual glycolytic reactions determine the pathogenicity of T helper 17 (Th17) cells using Compass, an algorithm we previously developed for inferring metabolic states from single-cell RNA sequencing. Surprisingly, Compass predicted that the metabolic shunt between 3-phosphoglycerate (3PG) and 2-phosphoglycerate (2PG) is inversely correlated with pathogenicity in Th17 cells. Indeed, perturbation of phosphoglycerate mutase (PGAM), the enzyme catalyzing 3PG to 2PG conversion, induces a pathogenic gene expression program by suppressing a gene module associated with the least pathogenic state of Th17 cells. Finally, PGAM inhibition in Th17 cells exacerbates neuroinflammation in the adoptive transfer model of experimental autoimmune encephalomyelitis, consistently with PGAM promoting the non-pathogenic phenotype of Th17 cells. Overall, our study identifies PGAM, contrary to other glycolytic enzymes, as a negative regulator of pathogenic Th17 cell differentiation.","PeriodicalId":9798,"journal":{"name":"Cell reports","volume":"44 6","pages":"115799"},"PeriodicalIF":7.5,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144246597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Combinatorial transcriptional regulation establishes subtype-appropriate synaptic properties in auditory neurons. 组合转录调节在听觉神经元中建立适合亚型的突触特性。

IF 7.5 1区生物学

Cell reports Pub Date : 2025-06-24 Epub Date: 2025-06-06 DOI: 10.1016/j.celrep.2025.115796

Isle Bastille, Lucy Lee, Cynthia Moncada-Reid, Wei-Ming Yu, Austen Sitko, Andrea Yung, Mina Zamani, Nele Christophersen, Reza Maroofian, Hamid Galehdari, Norbert Babai, Barbara Vona, Tobias Moser, Lisa Goodrich

{"title":"Combinatorial transcriptional regulation establishes subtype-appropriate synaptic properties in auditory neurons.","authors":"Isle Bastille, Lucy Lee, Cynthia Moncada-Reid, Wei-Ming Yu, Austen Sitko, Andrea Yung, Mina Zamani, Nele Christophersen, Reza Maroofian, Hamid Galehdari, Norbert Babai, Barbara Vona, Tobias Moser, Lisa Goodrich","doi":"10.1016/j.celrep.2025.115796","DOIUrl":"10.1016/j.celrep.2025.115796","url":null,"abstract":"Neurons develop diverse synapses that vary in content, morphology, and size. Although transcriptional regulators of neurotransmitter identity are known, it remains unclear how synaptic features are patterned among neuronal subtypes. In the auditory system, glutamatergic synaptic properties vary across three spiral ganglion neuron (SGN) subtypes that collectively encode sound. Here, we demonstrate that Maf transcription factors combinatorially shape synaptic properties in SGNs. SGN subtypes express different ratios of c-Maf and Mafb, which act redundantly to impart subtype identities and individually to shape subtype-appropriate gene expression programs. On their own, c-Maf and Mafb have independent and opposing effects on synaptic features and hearing. A mutation in the MAFB leucine zipper domain causes deafness in humans, underscoring the importance of regulated Maf activity for hearing. Thus, functional diversity and coordinated action of Maf family members enable flexible and robust control of gene expression needed to generate synaptic heterogeneity across neuronal subtypes.","PeriodicalId":9798,"journal":{"name":"Cell reports","volume":"44 6","pages":"115796"},"PeriodicalIF":7.5,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144246665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

RNA m⁶A dynamics promote transcription and RNA stability of bivalent genes during iPSC-induced generation of human lung progenitors. 在ipsc诱导的人肺祖细胞生成过程中，RNA m6A动态促进了二价基因的转录和RNA稳定性。

IF 7.5 1区生物学

Cell reports Pub Date : 2025-06-24 Epub Date: 2025-06-06 DOI: 10.1016/j.celrep.2025.115802

Shenghua Dong, Junjie Pang, Yushuai Wang, Le Han, Xiaoxiao Zhou, Feng Huang, Subo Zhang, Ning Ma, Huilin Huang, Hengyou Weng

{"title":"RNA m6A dynamics promote transcription and RNA stability of bivalent genes during iPSC-induced generation of human lung progenitors.","authors":"Shenghua Dong, Junjie Pang, Yushuai Wang, Le Han, Xiaoxiao Zhou, Feng Huang, Subo Zhang, Ning Ma, Huilin Huang, Hengyou Weng","doi":"10.1016/j.celrep.2025.115802","DOIUrl":"10.1016/j.celrep.2025.115802","url":null,"abstract":"RNA N6-methyladenosine (m6A) modifications play a crucial role in the control of RNA synthesis and metabolism during embryonic development. However, the m6A landscape and its impact on early embryonic lung development remain elusive. In this study, we uncover the dynamic and stage-specific patterns of the m6A methylome that correlate with gene expression changes during the differentiation of human induced pluripotent stem cells (iPSCs) into lung progenitors (LPs). Mechanistically, RNA binding motif protein 15B (RBM15B) is upregulated and enhances m6A modification in differentiated cells. Concurrently, the loss of the m6A reader YTH domain-containing protein 1 (YTHDC1) alleviates Polycomb repressive complex 2 (PRC2)-mediated transcriptional silencing of bivalent genes such as GATA4, GATA6, and EOMES. Moreover, the upregulation of another m6A reader, insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2), further stabilizes these messenger RNA (mRNA) transcripts. The switch of m6A readers coordinates chromatin remodeling and post-transcriptional regulation to drive lung endoderm specification. This study highlights the delicate m6A-centered regulatory mechanisms and the indispensable role of m6A modification in the early stages of embryonic lung development.","PeriodicalId":9798,"journal":{"name":"Cell reports","volume":"44 6","pages":"115802"},"PeriodicalIF":7.5,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144246673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Physiological role and mechanisms of action for a long noncoding haplotype region. 长非编码单倍型区域的生理作用和作用机制。

IF 7.5 1区生物学

Cell reports Pub Date : 2025-06-24 Epub Date: 2025-06-09 DOI: 10.1016/j.celrep.2025.115805

Hong Xue, Manoj K Mishra, Yong Liu, Pengyuan Liu, Michael Grzybowski, Rajan Pandey, Kristie Usa, Mark A Vanden Avond, Niharika Bala, Abdel A Alli, Allen W Cowley, Qiongzi Qiu, Andrew S Greene, Sridhar Rao, Caitlin C O'Meara, Aron M Geurts, Mingyu Liang

{"title":"Physiological role and mechanisms of action for a long noncoding haplotype region.","authors":"Hong Xue, Manoj K Mishra, Yong Liu, Pengyuan Liu, Michael Grzybowski, Rajan Pandey, Kristie Usa, Mark A Vanden Avond, Niharika Bala, Abdel A Alli, Allen W Cowley, Qiongzi Qiu, Andrew S Greene, Sridhar Rao, Caitlin C O'Meara, Aron M Geurts, Mingyu Liang","doi":"10.1016/j.celrep.2025.115805","DOIUrl":"10.1016/j.celrep.2025.115805","url":null,"abstract":"Direct targeting of noncoding genomic regions harboring common sequence variants associated with human traits through in vivo animal model studies and precise genome editing in human cells is essential for closing the critical gap between genetic discoveries and physiological understanding. However, such investigation has been impractical for many of these variants as they are in haplotypes containing multiple single-nucleotide polymorphisms (SNPs) spanning thousands of base pairs and have small effect sizes. We developed an integrated approach to address this challenge, combining an efficient two-step technique to precisely edit large haplotypes in human induced pluripotent stem cells and orthologous region deletion in phenotypically permissive animal models. As proof of principle, we applied this approach to examine a blood pressure-associated locus with a noncoding haplotype containing 11 SNPs spanning 17.4 kbp. We found a robust blood pressure effect of nearly 10 mmHg and identified the physiological and molecular mechanisms involved.","PeriodicalId":9798,"journal":{"name":"Cell reports","volume":"44 6","pages":"115805"},"PeriodicalIF":7.5,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144265439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0