Cell reports最新文献_第3页

Single-molecule imaging prefusion intermediate conformations of MERS-CoV spike trimers in membrane during entry. MERS-CoV刺突三聚体进入膜时的单分子成像预融合中间构象。

IF 7.5 1区生物学

Cell reports Pub Date : 2025-06-25 DOI: 10.1016/j.celrep.2025.115916

Shuvankar Dey, Purba Pahari, Mridul Shukla, Raiees Andrabi, Dibyendu Kumar Das

{"title":"Single-molecule imaging prefusion intermediate conformations of MERS-CoV spike trimers in membrane during entry.","authors":"Shuvankar Dey, Purba Pahari, Mridul Shukla, Raiees Andrabi, Dibyendu Kumar Das","doi":"10.1016/j.celrep.2025.115916","DOIUrl":"https://doi.org/10.1016/j.celrep.2025.115916","url":null,"abstract":"Middle East respiratory syndrome coronavirus (MERS-CoV) entry into host cells is mediated by the spike (S) glycoprotein trimer. The S2 domain of spike promotes membrane fusion for MERS entry, but its mechanism of action is currently elusive. Here, we applied real-time single-molecule fluorescence resonance energy transfer (smFRET) imaging to MERS-CoV S virions to identify the prefusion intermediate states of the S2 domain on the pathway to membrane fusion and understand their role in S neutralization by S2 stem-helix-targeted neutralizing antibodies. Our observations revealed the S2 domain of unliganded MERS-CoV S to be intrinsically dynamic, with the prefusion conformation transitioning between three distinct prefusion intermediate conformations, whose relative occupancies were remodeled by receptor dipeptidylpeptidase 4 (DPP4), protease TMPRSS2, and antibody binding. Acidic pH dramatically shifts the conformational equilibrium of S2 in favor of the fusion-competent intermediate conformation. Broadly neutralizing antibodies targeting the S2 stem-helix limit the conformational transitions of S2 and inhibit the refolding of spike to the post-fusion state.","PeriodicalId":9798,"journal":{"name":"Cell reports","volume":"44 7","pages":"115916"},"PeriodicalIF":7.5,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144511616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Identifying the target, mechanism, and agonist of α-ketoglutaric acid in delaying mesenchymal stem cell senescence. α-酮戊二酸延缓间充质干细胞衰老的靶点、机制及激动剂的鉴定。

IF 7.5 1区生物学

Cell reports Pub Date : 2025-06-25 DOI: 10.1016/j.celrep.2025.115917

Zhao Cui, Jiameng Li, Caifeng Li, Shiwen Deng, Wei Liu, Tong Lei, Junxian Cao, Ziyi Wang, Xiaoxu Wang, Shuhua Ma, Yinhua Zhu, Hongjun Yang, Peng Chen

{"title":"Identifying the target, mechanism, and agonist of α-ketoglutaric acid in delaying mesenchymal stem cell senescence.","authors":"Zhao Cui, Jiameng Li, Caifeng Li, Shiwen Deng, Wei Liu, Tong Lei, Junxian Cao, Ziyi Wang, Xiaoxu Wang, Shuhua Ma, Yinhua Zhu, Hongjun Yang, Peng Chen","doi":"10.1016/j.celrep.2025.115917","DOIUrl":"https://doi.org/10.1016/j.celrep.2025.115917","url":null,"abstract":"α-ketoglutaric acid (AKG), a tricarboxylic acid cycle metabolite central to aerobic metabolism and longevity, retains unresolved anti-aging protein targets. Here, we demonstrate that reduced isocitrate dehydrogenase 1 (IDH1) expression during senescence lowers AKG production, accelerating the aging of mesenchymal stem cells (MSCs). Exogenous AKG or IDH1 overexpression restores AKG levels, enabling 2-oxoglutarate and Fe(II)-dependent oxygenase domain-containing protein 1 (OGFOD1)-catalyzed hydroxylation of ribosomal protein S23 (RPS23) at proline 62. Mechanistically, AKG stabilizes the OGFOD1-RPS23 complex, enhancing translation accuracy to limit misfolded protein accumulation while sustaining synthesis rates, thereby balancing proteostasis. The natural flavonoid scutellarin (Scu), identified as an IDH1 agonist, elevates AKG to delay MSC senescence. In aged mice, Scu improves cognitive function, reduces osteoporosis and skin aging, and suppresses senescence-associated secretory phenotype. Our findings identify the AKG-IDH1-RPS23 axis as a regulator of stem cell senescence and we propose metabolic reprogramming strategies for anti-aging therapies.","PeriodicalId":9798,"journal":{"name":"Cell reports","volume":"44 7","pages":"115917"},"PeriodicalIF":7.5,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144504875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cytokine-induced reprogramming of human macrophages toward Alzheimer's disease-relevant molecular and cellular phenotypes in vitro. 细胞因子诱导的巨噬细胞重编程对阿尔茨海默病相关分子和细胞表型的影响

IF 7.5 1区生物学

Cell reports Pub Date : 2025-06-25 DOI: 10.1016/j.celrep.2025.115909

Anna Podleśny-Drabiniok, Carmen Romero-Molina, Tulsi Patel, Wen Yi See, Yiyuan Liu, Edoardo Marcora, Alison M Goate

{"title":"Cytokine-induced reprogramming of human macrophages toward Alzheimer's disease-relevant molecular and cellular phenotypes in vitro.","authors":"Anna Podleśny-Drabiniok, Carmen Romero-Molina, Tulsi Patel, Wen Yi See, Yiyuan Liu, Edoardo Marcora, Alison M Goate","doi":"10.1016/j.celrep.2025.115909","DOIUrl":"10.1016/j.celrep.2025.115909","url":null,"abstract":"Myeloid cells, including brain-resident microglia and peripheral macrophages, play key roles in neurodegenerative diseases such as Alzheimer's disease (AD). Studying their disease-associated states is limited by the lack of robust in vitro models. Here, we test whether a cytokine mix (interleukin [IL]-4, CSF1, IL-34, and transforming growth factor-β) reprograms human THP-1 macrophages toward AD-relevant phenotypes. This treatment induces significant transcriptomic changes, driving THP-1 macrophages toward a transcriptional state reminiscent of disease-associated microglia and lipid-associated macrophages (LAM), collectively referred to as DLAM. Transcriptome profiling reveals gene expression changes related to oxidative phosphorylation, lysosome function, and lipid metabolism. Single-cell RNA sequencing shows an increased proportion of DLAM clusters in cytokine mix-treated THP-1 macrophages. Functional assays demonstrate alterations in cell motility, phagocytosis, lysosomal activity, and metabolic profiles. These findings provide insights into cytokine-mediated reprogramming of macrophages toward disease-relevant states, highlighting their role in neurodegenerative diseases and potential for therapeutic development.","PeriodicalId":9798,"journal":{"name":"Cell reports","volume":"44 7","pages":"115909"},"PeriodicalIF":7.5,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144504872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A direct interaction between the RNA-binding proteins Staufen and Tm1-I/C in the oskar mRNA transport complex. oskar mRNA转运复合体中rna结合蛋白Staufen和Tm1-I/C之间的直接相互作用。

IF 7.5 1区生物学

Cell reports Pub Date : 2025-06-25 DOI: 10.1016/j.celrep.2025.115906

Thomas Gaber, Thomas Monecke, Julia Grabowski, Bernd Simon, Tobias Williams, Vera Roman, Jeffrey Chao, Janosch Hennig, Anne Ephrussi, Dierk Niessing, Simone Heber

引用次数: 0

Gamma synchronization between the medial temporal lobe and medial frontal cortex for goal-directed visual attention in humans. 人类目标导向视觉注意的内侧颞叶和内侧额叶皮层之间的伽马同步。

IF 7.5 1区生物学

Cell reports Pub Date : 2025-06-25 DOI: 10.1016/j.celrep.2025.115905

Jie Zhang, Jing Xia, Huihui Zhou, Shuo Wang

{"title":"Gamma synchronization between the medial temporal lobe and medial frontal cortex for goal-directed visual attention in humans.","authors":"Jie Zhang, Jing Xia, Huihui Zhou, Shuo Wang","doi":"10.1016/j.celrep.2025.115905","DOIUrl":"https://doi.org/10.1016/j.celrep.2025.115905","url":null,"abstract":"Goal-directed visual attention is a fundamental cognitive function that engages multiple brain regions, yet the neural circuit mechanisms in humans remain unclear. We addressed this question by simultaneously recording neural activity from the medial temporal lobe (MTL) and medial frontal cortex (MFC) during a goal-directed visual search task. We found that gamma-band synchronization between the MTL and MFC signaled target detection. Using two additional tasks, we dissociated the neural processes underlying working memory and search decision execution, revealing distinct patterns of synchronization. Further analyses showed that dorsal anterior cingulate cortex (dACC) spike-MTL LFP synchronization encoded search dynamics and contributed to guiding behavior. Importantly, MTL-MFC synchronization disproportionately modulated neural representational geometry, highlighting its impact on information encoding. Finally, we demonstrated directional gamma influences across brain areas and cross-frequency coupling. Together, these findings illuminate the circuit-level dynamics underlying visual attention and offer insights into how the human brain selectively processes information in complex visual environments.","PeriodicalId":9798,"journal":{"name":"Cell reports","volume":"44 7","pages":"115905"},"PeriodicalIF":7.5,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144504873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gut commensal bacteria-derived methionine is required for host reproduction by modulating RNA m6A methylation of the insulin receptor. 肠道共生细菌衍生的蛋氨酸是通过调节胰岛素受体的RNA m6A甲基化来实现宿主繁殖所必需的。

IF 7.5 1区生物学

Cell reports Pub Date : 2025-06-24 DOI: 10.1016/j.celrep.2025.115911

Qiuyuan Zhang, ZhuRong Deng, Xiaoxue Li, Jiao Qiao, Ziniu Li, Peipei Liu, Alfred M Handler, Bruno Lemaitre, Weiwei Zheng, Hongyu Zhang

{"title":"Gut commensal bacteria-derived methionine is required for host reproduction by modulating RNA m6A methylation of the insulin receptor.","authors":"Qiuyuan Zhang, ZhuRong Deng, Xiaoxue Li, Jiao Qiao, Ziniu Li, Peipei Liu, Alfred M Handler, Bruno Lemaitre, Weiwei Zheng, Hongyu Zhang","doi":"10.1016/j.celrep.2025.115911","DOIUrl":"https://doi.org/10.1016/j.celrep.2025.115911","url":null,"abstract":"Gut commensal bacteria promote host reproduction by modulating metabolism and nutrition, but the molecular mechanisms by which microbes regulate reproduction remain unclear. Here, we show that gut commensal bacteria promote host reproduction by providing the amino acid methionine, which controls the RNA m6A modification level of insulin receptor (InR) in the ovary of the invasive insect Bactrocera dorsalis. Antibiotic-treated B. dorsalis shows reduced RNA m6A methylation levels and methionine content, resulting in arrested ovarian development and decreased fecundity. The gut commensal bacterium Enterobacter hormaechei-derived metabolite methionine restores the decreased RNA m6A level and the reproductive defects. Notably, the knockdown of METTL3 and METTL14, two genes encoding the RNA m6A methyltransferases, reduces InR mRNA and protein levels and impairs ovarian development in B. dorsalis. Our findings further expand the functional landscape of RNA m6A modification to include nutrient-dependent control of ovarian development and highlight the essential role of epigenetic regulation in microbe-host interactions.","PeriodicalId":9798,"journal":{"name":"Cell reports","volume":"44 7","pages":"115911"},"PeriodicalIF":7.5,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144494903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Division of labor among H3K4 methyltransferases defines distinct facets of homeostatic plasticity. H3K4甲基转移酶之间的分工定义了稳态可塑性的不同方面。

IF 7.5 1区生物学

Cell reports Pub Date : 2025-06-24 Epub Date: 2025-05-21 DOI: 10.1016/j.celrep.2025.115746

Takao Tsukahara, Saini Kethireddy, Katherine M Bonefas, Alex Chen, Brendan L M Sutton, Kenjiro Bandow, Yali Dou, Shigeki Iwase, Michael A Sutton

{"title":"Division of labor among H3K4 methyltransferases defines distinct facets of homeostatic plasticity.","authors":"Takao Tsukahara, Saini Kethireddy, Katherine M Bonefas, Alex Chen, Brendan L M Sutton, Kenjiro Bandow, Yali Dou, Shigeki Iwase, Michael A Sutton","doi":"10.1016/j.celrep.2025.115746","DOIUrl":"10.1016/j.celrep.2025.115746","url":null,"abstract":"Heterozygous mutations in any of the six H3K4 methyltransferases (KMT2s) result in monogenic neurodevelopmental disorders, indicating non-redundant yet poorly understood roles of this enzyme family in neurodevelopment. However, the specific cellular role of KMT2 enzymes in the brain remains poorly understood, owing to the clear non-catalytic functions of each family member and the potential for functional redundancy in installing H3K4 methylation (H3K4me). Here, we identify an instructive role for H3K4me in controlling synapse function and a division of labor among the six KMT2 enzymes in regulating homeostatic synaptic scaling. Using RNAi screening, conditional genetics, small-molecule inhibitors, and transcriptional profiling, our data reveal that individual KMT2 enzymes have unique roles and operate in specific phases to control distinct facets of homeostatic scaling. Together, our results suggest that the expansion of this enzyme family in mammals is key to coupling fine-tuned gene expression changes to adaptive modifications of synaptic function.","PeriodicalId":9798,"journal":{"name":"Cell reports","volume":"44 6","pages":"115746"},"PeriodicalIF":7.5,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144126942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Early-life development of the gut virome and plasmidome: A longitudinal study in cesarean-born infants. 肠道病毒和质粒的早期发育：对剖宫产婴儿的纵向研究。

IF 7.5 1区生物学

Cell reports Pub Date : 2025-06-24 Epub Date: 2025-05-23 DOI: 10.1016/j.celrep.2025.115731

Asier Fernández-Pato, Trishla Sinha, Sanzhima Garmaeva, Anastasia Gulyaeva, Nataliia Kuzub, Simon Roux, Jingyuan Fu, Alexander Kurilshikov, Alexandra Zhernakova

{"title":"Early-life development of the gut virome and plasmidome: A longitudinal study in cesarean-born infants.","authors":"Asier Fernández-Pato, Trishla Sinha, Sanzhima Garmaeva, Anastasia Gulyaeva, Nataliia Kuzub, Simon Roux, Jingyuan Fu, Alexander Kurilshikov, Alexandra Zhernakova","doi":"10.1016/j.celrep.2025.115731","DOIUrl":"10.1016/j.celrep.2025.115731","url":null,"abstract":"Mobile genetic elements (MGE) are critical yet understudied determinants of gut microbiome composition. In this secondary analysis of a randomized controlled trial (NCT06030713), we characterized the gut virome and plasmidome in 195 samples from 28 mother-infant dyads delivered by cesarean section. Infant mobilome increases in richness over the first 6 postnatal weeks, demonstrating high individual-specificity and temporal stability, establishing a personal persistent mobilome. Formula-fed infants exhibit greater mobilome richness than breastfed infants, with plasmid composition being influenced by antibiotic exposure and birth weight. Plasmids constitute a reservoir of antibiotic resistance genes (ARG), with around 5% of infant gut plasmid taxonomic units carrying ARG. Notably, ARG profiles do not differ with antibiotic exposure at birth. Mother-infant sharing of viral and plasmid strains primarily occurs after 6 months of age. Overall, our integrative analysis offers insights into the dynamics, modulation, and origin of MGE in the developing gut microbiome.","PeriodicalId":9798,"journal":{"name":"Cell reports","volume":"44 6","pages":"115731"},"PeriodicalIF":7.5,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144141464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dissecting pre- to post-implantation transition of DNA methylome-transcriptome dynamics in early mammalian development. 解剖早期哺乳动物发育中DNA甲基组-转录组动力学的植入前到植入后转变。

IF 7.5 1区生物学

Cell reports Pub Date : 2025-06-24 Epub Date: 2025-06-03 DOI: 10.1016/j.celrep.2025.115790

Qingyuan Zhu, Ying Liu, Xin Hao, Shengyi Yan, Jitao Ge, Changqing Zheng, Xianwen Ren, Fan Zhou

{"title":"Dissecting pre- to post-implantation transition of DNA methylome-transcriptome dynamics in early mammalian development.","authors":"Qingyuan Zhu, Ying Liu, Xin Hao, Shengyi Yan, Jitao Ge, Changqing Zheng, Xianwen Ren, Fan Zhou","doi":"10.1016/j.celrep.2025.115790","DOIUrl":"10.1016/j.celrep.2025.115790","url":null,"abstract":"Pre- to post-implantation transition is an essential step for early mammalian development. The epigenome dynamics such as DNA methylome and transcriptome of embryos have been analyzed, while the coordination between these two molecular layers controlling lineage fate remained elusive. Here, with a multidimensional profiling of peri-implantation embryos, we present the emerging lineage-specific DNA methylation (DNAme) patterns across species. The maternal and paternal DNA methylation levels exhibit differential dynamics in transposon elements. Genes with lineage-specific unmethylated promoters early in development retain this state and are expressed later, suggesting a role in lineage fate determination. By measuring both molecular dimensions simultaneously in individual developing cells, we identified a group of gene promoters with positive correlation between DNAme and RNAex along epiblast development. Functional validation suggested DNAme at these promoters contributes to non-canonical DNAme-RNAex dynamics, potentially via complex TF-mediated or epigenetic regulation. This study provides clues for understanding molecular regulation of peri-implantation embryogenesis.","PeriodicalId":9798,"journal":{"name":"Cell reports","volume":"44 6","pages":"115790"},"PeriodicalIF":7.5,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144233335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The glycolytic reaction PGAM restrains Th17 pathogenicity and Th17-dependent autoimmunity. 糖酵解反应PGAM抑制Th17致病性和Th17依赖性自身免疫。

IF 7.5 1区生物学

Cell reports Pub Date : 2025-06-24 Epub Date: 2025-06-05 DOI: 10.1016/j.celrep.2025.115799

Chao Wang, Allon Wagner, Johannes Fessler, David DeTomaso, Sarah Zaghouani, Yulin Zhou, Kerry Pierce, Raymond A Sobel, Clary Clish, Nir Yosef, Vijay K Kuchroo

{"title":"The glycolytic reaction PGAM restrains Th17 pathogenicity and Th17-dependent autoimmunity.","authors":"Chao Wang, Allon Wagner, Johannes Fessler, David DeTomaso, Sarah Zaghouani, Yulin Zhou, Kerry Pierce, Raymond A Sobel, Clary Clish, Nir Yosef, Vijay K Kuchroo","doi":"10.1016/j.celrep.2025.115799","DOIUrl":"10.1016/j.celrep.2025.115799","url":null,"abstract":"Glucose metabolism is a critical regulator of T cell function, largely thought to support their activation and effector differentiation. Here, we investigate how individual glycolytic reactions determine the pathogenicity of T helper 17 (Th17) cells using Compass, an algorithm we previously developed for inferring metabolic states from single-cell RNA sequencing. Surprisingly, Compass predicted that the metabolic shunt between 3-phosphoglycerate (3PG) and 2-phosphoglycerate (2PG) is inversely correlated with pathogenicity in Th17 cells. Indeed, perturbation of phosphoglycerate mutase (PGAM), the enzyme catalyzing 3PG to 2PG conversion, induces a pathogenic gene expression program by suppressing a gene module associated with the least pathogenic state of Th17 cells. Finally, PGAM inhibition in Th17 cells exacerbates neuroinflammation in the adoptive transfer model of experimental autoimmune encephalomyelitis, consistently with PGAM promoting the non-pathogenic phenotype of Th17 cells. Overall, our study identifies PGAM, contrary to other glycolytic enzymes, as a negative regulator of pathogenic Th17 cell differentiation.","PeriodicalId":9798,"journal":{"name":"Cell reports","volume":"44 6","pages":"115799"},"PeriodicalIF":7.5,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144246597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0