Gamma synchronization between the medial temporal lobe and medial frontal cortex for goal-directed visual attention in humans.

IF 6.9 1区生物学 Q1 CELL BIOLOGY

Cell reports Pub Date : 2025-07-22 Epub Date: 2025-06-25 DOI:10.1016/j.celrep.2025.115905

Jie Zhang, Jing Xia, Huihui Zhou, Shuo Wang

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引用次数: 0

Abstract

Goal-directed visual attention is a fundamental cognitive function that engages multiple brain regions, yet the neural circuit mechanisms in humans remain unclear. We addressed this question by simultaneously recording neural activity from the medial temporal lobe (MTL) and medial frontal cortex (MFC) during a goal-directed visual search task. We found that gamma-band synchronization between the MTL and MFC signaled target detection. Using two additional tasks, we dissociated the neural processes underlying working memory and search decision execution, revealing distinct patterns of synchronization. Further analyses showed that dorsal anterior cingulate cortex (dACC) spike-MTL LFP synchronization encoded search dynamics and contributed to guiding behavior. Importantly, MTL-MFC synchronization disproportionately modulated neural representational geometry, highlighting its impact on information encoding. Finally, we demonstrated directional gamma influences across brain areas and cross-frequency coupling. Together, these findings illuminate the circuit-level dynamics underlying visual attention and offer insights into how the human brain selectively processes information in complex visual environments.

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人类目标导向视觉注意的内侧颞叶和内侧额叶皮层之间的伽马同步。

目标导向的视觉注意是一种涉及多个大脑区域的基本认知功能，但人类的神经回路机制尚不清楚。我们通过在目标导向的视觉搜索任务中同时记录内侧颞叶（MTL）和内侧额叶皮层（MFC）的神经活动来解决这个问题。我们发现MTL和MFC之间的伽玛波段同步是目标检测的信号。通过两个额外的任务，我们分离了工作记忆和搜索决策执行背后的神经过程，揭示了不同的同步模式。进一步分析表明，背前扣带皮层（dACC） spike-MTL - LFP同步编码了搜索动态，并有助于指导行为。重要的是，MTL-MFC同步不成比例地调制神经表征几何，突出其对信息编码的影响。最后，我们展示了跨脑区和跨频率耦合的定向伽马影响。总之，这些发现阐明了视觉注意背后的回路级动力学，并为人类大脑如何在复杂的视觉环境中选择性地处理信息提供了见解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cell reports CELL BIOLOGY-

CiteScore

13.80

自引率

1.10%

发文量

1305

审稿时长

77 days

期刊介绍： Cell Reports publishes high-quality research across the life sciences and focuses on new biological insight as its primary criterion for publication. The journal offers three primary article types: Reports, which are shorter single-point articles, research articles, which are longer and provide deeper mechanistic insights, and resources, which highlight significant technical advances or major informational datasets that contribute to biological advances. Reviews covering recent literature in emerging and active fields are also accepted. The Cell Reports Portfolio includes gold open-access journals that cover life, medical, and physical sciences, and its mission is to make cutting-edge research and methodologies available to a wide readership. The journal's professional in-house editors work closely with authors, reviewers, and the scientific advisory board, which consists of current and future leaders in their respective fields. The advisory board guides the scope, content, and quality of the journal, but editorial decisions are independently made by the in-house scientific editors of Cell Reports.