Cell reports最新文献_第9页

Blocking apoptosis promotes survival and alters developmental dynamics of human retinal ganglion cells in retinal organoids. 阻断细胞凋亡可促进视网膜类器官中视网膜神经节细胞的存活并改变其发育动态。

IF 6.9 1区生物学

Cell reports Pub Date : 2026-04-16 DOI: 10.1016/j.celrep.2026.117270

Jingliang Simon Zhang, Brian Guy, Clayton P Santiago, Caterina Tiozzo, Meghana Sreenath, Ya-Wen Chen, Seth Blackshaw, Robert J Johnston

{"title":"Blocking apoptosis promotes survival and alters developmental dynamics of human retinal ganglion cells in retinal organoids.","authors":"Jingliang Simon Zhang, Brian Guy, Clayton P Santiago, Caterina Tiozzo, Meghana Sreenath, Ya-Wen Chen, Seth Blackshaw, Robert J Johnston","doi":"10.1016/j.celrep.2026.117270","DOIUrl":"10.1016/j.celrep.2026.117270","url":null,"abstract":"Retinal ganglion cells (RGCs) are the projection neurons connecting the retina to the brain. In many species, a substantial proportion of RGCs are eliminated by programmed cell death during development to regulate their final number, but how cell death impacts human RGC development remains poorly understood. Here, we characterized cell death in human fetal retinas and retinal organoids. Both retinas and organoids exhibited two waves of apoptosis: an early wave targeting neurogenic retinal progenitor cells and neuronal precursors and a late wave affecting RGCs and other neurons. Additionally, organoids displayed a distinct wave of necrosis. Blocking apoptosis in organoids via BAX/BAK double knockout improved RGC survival but delayed RGC neurogenesis and maturation. Our results highlight the roles of apoptosis in human RGC development and the challenges in retinal organoid design. Addressing these limitations will improve the utility of organoids for studying human retinal development and modeling optic neuropathies such as glaucoma.","PeriodicalId":9798,"journal":{"name":"Cell reports","volume":"45 4","pages":"117270"},"PeriodicalIF":6.9,"publicationDate":"2026-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147715809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mechanical memory primes cells for confined migration. 机械记忆为细胞的有限迁移做好准备。

IF 6.9 1区生物学

Cell reports Pub Date : 2026-04-16 DOI: 10.1016/j.celrep.2026.117267

Jia Wen Nicole Lee, Yeji Chang, Malhar S Chitnis, Yixuan Li, Xu Gao, Avery Rui Sun, Jin Zhu, Jennifer L Young, Andrew W Holle

{"title":"Mechanical memory primes cells for confined migration.","authors":"Jia Wen Nicole Lee, Yeji Chang, Malhar S Chitnis, Yixuan Li, Xu Gao, Avery Rui Sun, Jin Zhu, Jennifer L Young, Andrew W Holle","doi":"10.1016/j.celrep.2026.117267","DOIUrl":"https://doi.org/10.1016/j.celrep.2026.117267","url":null,"abstract":"When migratory cells move between stiffness niches in vivo, they encounter confined spaces imposed by extracellular matrix (ECM) networks. Cells from one niche possess mechanosensitive adaptations that influence their response to new environments, a concept known as mechanical memory. How this memory is acquired and how it influences migratory potential in confinement remain poorly understood. Here, we combine stiffness priming using polyacrylamide hydrogels with a confinement platform to screen memory across healthy and transformed cells. Using a dose-and-passage approach, we find that cells primed on soft substrates navigate confinement more efficiently. Bulk RNA sequencing identifies NFATC2 as a transcription factor mediating mechanical memory through genetic reprogramming. Inhibition of NFATC2 confirms that it is required for memory acquisition and enhanced confined migration. Highly invasive cancer cells fail to retain mechanically induced phenotypes following cue removal, suggesting differential adaptation strategies. These findings establish mechanical memory as a cell-intrinsic regulator of confined migration.","PeriodicalId":9798,"journal":{"name":"Cell reports","volume":"45 4","pages":"117267"},"PeriodicalIF":6.9,"publicationDate":"2026-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147715858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gene-culture coevolution shapes olfactory receptor gene diversity in Orang Asli populations. 基因文化共同进化塑造了猩猩群体嗅觉受体基因的多样性。

IF 6.9 1区生物学

Cell reports Pub Date : 2026-04-16 DOI: 10.1016/j.celrep.2026.117181

Yueyang Ma, Boon-Peng Hoh, Shuhua Xu, Lian Deng

{"title":"Gene-culture coevolution shapes olfactory receptor gene diversity in Orang Asli populations.","authors":"Yueyang Ma, Boon-Peng Hoh, Shuhua Xu, Lian Deng","doi":"10.1016/j.celrep.2026.117181","DOIUrl":"https://doi.org/10.1016/j.celrep.2026.117181","url":null,"abstract":"The genetic and evolutionary basis of human olfaction remains understudied. We examined olfactory receptor (OR) gene evolution in Malaysian Orang Asli with distinct subsistence modes: Negrito hunter-gatherers, Senoi swidden-agriculturalists, and Jakun horticulturalists. Global populations generally display elevated OR diversity relative to genome-wide levels, whereas Negritos exhibit conserved OR gene profiles featured by lower mutation load, accelerated ancestral allele retention, and depleted archaic introgression. Subsistence-related divergence revealed adaptive signals at the ancestral haplotypes in OR12D2 (geosmin) and OR52J3-OR52E2 (butter) and enriched archaic introgression in musk/fruity receptors (e.g., OR5A1/2 and OR4D6) in Negritos, whereas agriculturalists showed diversification involving pleiotropic targets, including OR12D3 (insulin regulation) and receptors tied to lung function. These findings suggest that directional selections preserve ancestral olfactory repertoires in hunter-gatherers, while agricultural transitions drive diversification through direct chemosensory adaptation and indirect pleiotropic pressures. Our analysis demonstrated how subsistence strategies shape sensory evolution via intertwined genetic, cultural, and environmental pathways.","PeriodicalId":9798,"journal":{"name":"Cell reports","volume":" ","pages":"117181"},"PeriodicalIF":6.9,"publicationDate":"2026-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147716349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Amygdala stress-responsive ensembles mediate distinct susceptibility to negative stress-induced remote depression in adolescent and adult mice. 杏仁核应激反应系统介导青少年和成年小鼠对负应激诱导的远端抑郁的不同易感性。

IF 6.9 1区生物学

Cell reports Pub Date : 2026-04-16 DOI: 10.1016/j.celrep.2026.117281

Yue You, Chang-Ting Lv, Peng-Tao Ni, Shi-Jie Wang, Le Liu, Yu-Tong Song, Ze Hui, Yao Huang, Yao Liu, Kun Tong, Jing-Ru Hao, Nan Sun, Jun-Li Cao, Can Gao

{"title":"Amygdala stress-responsive ensembles mediate distinct susceptibility to negative stress-induced remote depression in adolescent and adult mice.","authors":"Yue You, Chang-Ting Lv, Peng-Tao Ni, Shi-Jie Wang, Le Liu, Yu-Tong Song, Ze Hui, Yao Huang, Yao Liu, Kun Tong, Jing-Ru Hao, Nan Sun, Jun-Li Cao, Can Gao","doi":"10.1016/j.celrep.2026.117281","DOIUrl":"https://doi.org/10.1016/j.celrep.2026.117281","url":null,"abstract":"Adolescent stress increases susceptibility to adult depression, potentially by encoding negative memories in stress-responsive neuronal ensembles, though the mechanisms remain unclear. In this study, we use a social defeat stress model with Tet-off labeling to examine the effects of short-term stress during adolescence and adulthood on behavior and cellular changes. Adolescent stress generates denser, more excitable stress-responsive neuronal ensembles in the basolateral amygdala (BLA) compared to adult stress, suggesting persistent traces of early-life stress that heighten remote depression risk. Adolescent mice display underdeveloped, hypoactive parvalbumin (PV) interneurons in the BLA, further suppressed by microglial phagocytic activity. Bidirectional modulation of BLA stress-responsive neuronal ensembles or PV neurons significantly alters depression-like behaviors. Overall, our findings indicate that BLA stress-responsive neuronal ensembles mediate differences in depression susceptibility between adolescent and adult stressed mice, with microglial dysfunction impairing PV neuron inhibitory control. These insights offer potential targets for early intervention in adult depression.","PeriodicalId":9798,"journal":{"name":"Cell reports","volume":"45 4","pages":"117281"},"PeriodicalIF":6.9,"publicationDate":"2026-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147715598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dose-dependent mitochondrial H₂O₂ signaling drives toxicity or stress adaptation and longevity in fission yeast. 剂量依赖的线粒体H2O2信号驱动裂变酵母的毒性或应激适应和寿命。

IF 6.9 1区生物学

Cell reports Pub Date : 2026-04-16 DOI: 10.1016/j.celrep.2026.117277

Laura de Cubas, María Florencia Crevatin, Montserrat Vega, Susanna Boronat, José Ayté, Elena Hidalgo

{"title":"Dose-dependent mitochondrial H2O2 signaling drives toxicity or stress adaptation and longevity in fission yeast.","authors":"Laura de Cubas, María Florencia Crevatin, Montserrat Vega, Susanna Boronat, José Ayté, Elena Hidalgo","doi":"10.1016/j.celrep.2026.117277","DOIUrl":"https://doi.org/10.1016/j.celrep.2026.117277","url":null,"abstract":"The spatiotemporal dynamics of hydrogen peroxide (H2O2) signaling and its effects on gene expression and cell fitness remain unclear. Using fission yeast, we applied genetic tools to control and monitor intracellular H2O2 levels. We expressed the H2O2 biosensor HyPer7 in four subcellular compartments, overexpressed D-amino acid oxidase (Dao1) in specific locations to induce localized H2O2 production, and modulated H2O2 detoxification or sensing. H2O2 concentrations showed 2- to 5-fold reductions across membranes, and D-amino acid treatments generated nanomolar H2O2 levels in Dao1-expressing cells. Mitochondrial-targeted Dao1 produced H2O2 fluxes capable of reaching the nucleus. While high mitochondrial H2O2 disrupted mitochondrial morphology and respiration, lower levels triggered antioxidant defenses, enhancing stress resistance and longevity. These findings establish a quantitative framework for mitochondrial H2O2 signaling and demonstrate that localized redox signals from mitochondria can either promote or impair cellular fitness depending on their intensity.","PeriodicalId":9798,"journal":{"name":"Cell reports","volume":"45 4","pages":"117277"},"PeriodicalIF":6.9,"publicationDate":"2026-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147715848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

RNA virus polymerase-helicase coupling enables rapid elongation through duplex RNA. RNA病毒聚合酶解旋酶偶联使双链RNA快速伸长。

IF 6.9 1区生物学

Cell reports Pub Date : 2026-04-16 DOI: 10.1016/j.celrep.2026.117273

Pim P B America, Subhas C Bera, Arnab Das, Thomas K Anderson, John C Marecki, Flávia S Papini, Jamie J Arnold, Robert N Kirchdoerfer, Craig E Cameron, Kevin D Raney, Martin Depken, David Dulin

{"title":"RNA virus polymerase-helicase coupling enables rapid elongation through duplex RNA.","authors":"Pim P B America, Subhas C Bera, Arnab Das, Thomas K Anderson, John C Marecki, Flávia S Papini, Jamie J Arnold, Robert N Kirchdoerfer, Craig E Cameron, Kevin D Raney, Martin Depken, David Dulin","doi":"10.1016/j.celrep.2026.117273","DOIUrl":"10.1016/j.celrep.2026.117273","url":null,"abstract":"Positive-sense RNA ((+)RNA) viruses often encode helicases presumed to support replication. Their precise role remains unresolved, though, especially in coronaviruses (CoVs), where the helicase translocates in the opposite direction to the polymerase. Using high-throughput single-molecule magnetic tweezers, we show that the coronavirus helicase enhances RNA synthesis through duplex RNA by 10-fold, forming a directional complex with the viral polymerase. Despite opposing polarity, the helicase coordinates elongation by engaging with the non-template strand. A detailed kinetic model derived from large datasets reveals distinct dynamic states, including fast-bursting and slow, backtracking-prone modes, which are governed by helicase engagement. These results uncover an active coupling mechanism that modulates replication dynamics and provide a mechanistic basis for continuous versus discontinuous RNA synthesis in coronaviruses. Our findings establish the viral helicase as a central regulator of RNA replication.","PeriodicalId":9798,"journal":{"name":"Cell reports","volume":"45 4","pages":"117273"},"PeriodicalIF":6.9,"publicationDate":"2026-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147716095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mapping immune imprinting zones enables predictive vaccination optimization. 绘制免疫印迹区使预测疫苗接种优化成为可能。

IF 6.9 1区生物学

Cell reports Pub Date : 2026-04-16 DOI: 10.1016/j.celrep.2026.117271

Wei Yang, Kaichun Jin, Wei Li, Zhixing Ding, Houze Yu, Zumi Zhou, Wei Su, Xiao Zhu, Xupu Ma, Na Wan, Lei Xing, Yanli Chen, Xuanjing Yu, Xiaolu Tang, Taicheng Zhou, Jinzhong Lin, Hao Li, Jian Lu, Zijie Scott Zhang

{"title":"Mapping immune imprinting zones enables predictive vaccination optimization.","authors":"Wei Yang, Kaichun Jin, Wei Li, Zhixing Ding, Houze Yu, Zumi Zhou, Wei Su, Xiao Zhu, Xupu Ma, Na Wan, Lei Xing, Yanli Chen, Xuanjing Yu, Xiaolu Tang, Taicheng Zhou, Jinzhong Lin, Hao Li, Jian Lu, Zijie Scott Zhang","doi":"10.1016/j.celrep.2026.117271","DOIUrl":"https://doi.org/10.1016/j.celrep.2026.117271","url":null,"abstract":"Immune imprinting, where prior exposures shape antibody responses to variant antigens, remains a central obstacle to optimizing vaccination against evolving viruses. Here, we present DynaVac, a mathematical framework that models antigen-specific B cell dynamics, particularly the competition between memory and naive compartments across antigenic distances. Calibrated on neutralization titers from murine and human studies spanning diverse SARS-CoV-2 vaccine platforms, DynaVac accurately predicts antibody responses across complex heterologous and multivalent regimens. In silico simulations reveal three imprinting zones-protection, pitfall, and breakthrough-that determine when updated vaccinations amplify, are suppressed by, or bypass preexisting immunity. Unlike prior models limited to qualitative or single-exposure settings, DynaVac integrates empirical cross-neutralization matrices and enables prospective simulation of continuous booster responses across antigenic variants, dosages, and intervals. DynaVac also provides an actionable strategy for guiding real-time vaccine updates and strain selection. While DynaVac is calibrated on SARS-CoV-2, its structure is generalizable to other fast-evolving pathogens.","PeriodicalId":9798,"journal":{"name":"Cell reports","volume":"45 4","pages":"117271"},"PeriodicalIF":6.9,"publicationDate":"2026-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147715831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Low expression levels of the conserved nuclear histone acetyltransferase 1 restrict virus infection in plants. 保守的核组蛋白乙酰转移酶1的低表达水平限制了病毒在植物中的感染。

IF 6.9 1区生物学

Cell reports Pub Date : 2026-04-16 DOI: 10.1016/j.celrep.2026.117282

Laihua Dong, Hao Wang, Weihong Lin, Zhikang Ye, Jieyu Liu, Junxia Hu, Xifeng Chen, Dezhi Peng, Jipeng Xie, Pei Wang, Lianyi Zang, Qin Yan, Qibin Wu, Xiangdong Li, Caifu Jiang, Zaifeng Fan, Youxiong Que, Kaitong Du, Tao Zhou

{"title":"Low expression levels of the conserved nuclear histone acetyltransferase 1 restrict virus infection in plants.","authors":"Laihua Dong, Hao Wang, Weihong Lin, Zhikang Ye, Jieyu Liu, Junxia Hu, Xifeng Chen, Dezhi Peng, Jipeng Xie, Pei Wang, Lianyi Zang, Qin Yan, Qibin Wu, Xiangdong Li, Caifu Jiang, Zaifeng Fan, Youxiong Que, Kaitong Du, Tao Zhou","doi":"10.1016/j.celrep.2026.117282","DOIUrl":"https://doi.org/10.1016/j.celrep.2026.117282","url":null,"abstract":"Potyviruses constitute the largest genus of plant-infecting RNA viruses and cause global economic losses in numerous crops. Understanding host modulation of viral pathogenicity is crucial for durable control strategy design, yet this remains poorly understood for most viruses. Here, we illustrate that the conserved host factor histone acetyltransferase 1 (HAT1) modulates viral protein acetylation, contributing to potyvirus infection in plants. By working with a prevalent potyvirus, sugarcane mosaic virus (SCMV), we uncovered that ZmHAT1 directly acetylates lysine190 of the SCMV-encoded helper-component proteinase (HC-Pro; the main pathogenicity determinant). This acetylation is essential to sustain the double-stranded RNA affinity of HC-Pro and to maintain its stability via inhibiting ubiquitination-mediated degradation. Furthermore, the expression genome-wide association study (eGWAS) coupled with functional analysis revealed a strong association of the expression levels of ZmHAT1 with SCMV infection. Together, these findings identify a conserved pro-viral factor and a potential engineering target for broad-spectrum antiviral crops.","PeriodicalId":9798,"journal":{"name":"Cell reports","volume":"45 4","pages":"117282"},"PeriodicalIF":6.9,"publicationDate":"2026-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147715890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Microbial damper: Rhizosphere microbiome mitigates stress-induced plant growth-defense conflicts. 微生物阻尼器：根际微生物群减轻胁迫诱导的植物生长-防御冲突。

IF 6.9 1区生物学

Cell reports Pub Date : 2026-04-16 DOI: 10.1016/j.celrep.2026.117278

Xiaoyu Liu, Jianguo Zeng, Penghao Xie, Qirong Shen, Jun Yuan

引用次数: 0

Tolerance to extracellular acidic pH facilitates tumor plasticity. 对细胞外酸性pH值的耐受性促进了肿瘤的可塑性。

IF 6.9 1区生物学

Cell reports Pub Date : 2026-04-16 DOI: 10.1016/j.celrep.2026.117226

Manami Hasegawa, Bo Xu, Keisuke Maeda, Motoaki Seki, FeiFei Cai, Runmei Cui, Ritsuko Ando, Suzuka Nakagawa, Ayana Sakamoto, Cayla Boycott, Hiroyuki Yatabe, Miyuki Nishida, Ken Matsumoto, Chisato Iwabuchi-Yoshida, Sho Aki, Kazuyuki Yamagata, Rika Tsuchida, Mami Takahashi, Futoshi Kuribayashi, Hiroyasu Kidoya, Hiroshi Hirata, Shingo Matsumoto, Shinsuke Sando, Hideyuki Yanai, Nozomu Yachie, Tsuyoshi Osawa

{"title":"Tolerance to extracellular acidic pH facilitates tumor plasticity.","authors":"Manami Hasegawa, Bo Xu, Keisuke Maeda, Motoaki Seki, FeiFei Cai, Runmei Cui, Ritsuko Ando, Suzuka Nakagawa, Ayana Sakamoto, Cayla Boycott, Hiroyuki Yatabe, Miyuki Nishida, Ken Matsumoto, Chisato Iwabuchi-Yoshida, Sho Aki, Kazuyuki Yamagata, Rika Tsuchida, Mami Takahashi, Futoshi Kuribayashi, Hiroyasu Kidoya, Hiroshi Hirata, Shingo Matsumoto, Shinsuke Sando, Hideyuki Yanai, Nozomu Yachie, Tsuyoshi Osawa","doi":"10.1016/j.celrep.2026.117226","DOIUrl":"https://doi.org/10.1016/j.celrep.2026.117226","url":null,"abstract":"Cancer cells sustain glycolysis despite oxygen availability, creating an acidic microenvironment via proton and lactate export, but how they survive acid stress is unclear. We show that severe acidification (pH 5.6) induces necroptosis, whereas moderate acidity (pH 6.8) prevents death and enables anchorage-independent survival and tumor initiation. RNA sequencing of suspended cells at pH 6.8 revealed activation of respiratory chain complex and complement pathways, consistent with adaptation to this pH. A genome-wide CRISPR-Cas9 knockout screen in PANC1 cells under chronic acidity identified FAM129C as a regulator of acid tolerance and survival. In xenografts, FAM129C overexpression reduced PIGR expression, implicating this axis in tumor growth and immune infiltration. Anti-PD-L1 plus a complement inhibitor showed synergistic anti-tumor activity in PIGR-overexpressing tumors. Thus, acidic stress engages a pathway that allows cancer cells to evade necroptosis and promote tumor plasticity, providing potential avenues for therapeutic intervention targeting pH-dependent cell-death pathways.","PeriodicalId":9798,"journal":{"name":"Cell reports","volume":" ","pages":"117226"},"PeriodicalIF":6.9,"publicationDate":"2026-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147716347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0