Prefrontal ErbB4-positive interneurons for avoidance.

IF 7.5 1区生物学 Q1 CELL BIOLOGY

Cell reports Pub Date : 2025-04-29 DOI:10.1016/j.celrep.2025.115628

Wanpeng Cui, Chen Shen, Wen-Cheng Xiong, Lin Mei

引用次数: 0

Abstract

Avoidance is a major behavior for survival. The prefrontal cortex (PFC) is known to be involved in approach-avoidance decision-making, but how PFC interneurons (INs) collaborate with excitatory neurons in this process remains unclear. Our research reveals that ErbB4⁺ interneurons (B4INs) increased calcium transients in avoidance behaviors of freely moving mice. B4IN inhibition or activation is required for and sufficient to induce avoidance behaviors. B4INs receive monosynaptic inputs from glutamatergic neurons in the basal forebrain (BF), whose activation and suppression induce and inhibit avoidance, respectively. By registering target neurons of B4INs, we show that most avoidance-associated neurons are under the inhibitory control of B4INs, suggesting that B4INs act by suppressing excitatory neurons to mediate avoidance behaviors. Finally, pharmacological inhibition of ErbB4 reduces avoidance behaviors, suggesting that B4IN activity depends on ErbB4 kinase activity. These results reveal a causal role for B4INs in avoidance behaviors.

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前额叶erbb4阳性中间神经元。

逃避是生存的主要行为。众所周知，前额皮质（PFC）参与避近决策，但PFC中间神经元（INs）在这一过程中如何与兴奋性神经元合作尚不清楚。我们的研究表明，ErbB4+中间神经元（B4INs）增加了自由运动小鼠回避行为中的钙瞬态。B4IN的抑制或激活是诱导回避行为的必要条件和充分条件。B4INs接受基底前脑（BF）谷氨酸能神经元的单突触输入，其激活和抑制分别诱导和抑制回避。通过记录B4INs的靶神经元，我们发现大多数回避相关神经元受到B4INs的抑制控制，这表明B4INs通过抑制兴奋性神经元来介导回避行为。最后，ErbB4的药理抑制减少了回避行为，这表明B4IN的活性取决于ErbB4激酶的活性。这些结果揭示了B4INs在回避行为中的因果作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cell reports CELL BIOLOGY-

CiteScore

13.80

自引率

1.10%

发文量

1305

审稿时长

77 days

期刊介绍： Cell Reports publishes high-quality research across the life sciences and focuses on new biological insight as its primary criterion for publication. The journal offers three primary article types: Reports, which are shorter single-point articles, research articles, which are longer and provide deeper mechanistic insights, and resources, which highlight significant technical advances or major informational datasets that contribute to biological advances. Reviews covering recent literature in emerging and active fields are also accepted. The Cell Reports Portfolio includes gold open-access journals that cover life, medical, and physical sciences, and its mission is to make cutting-edge research and methodologies available to a wide readership. The journal's professional in-house editors work closely with authors, reviewers, and the scientific advisory board, which consists of current and future leaders in their respective fields. The advisory board guides the scope, content, and quality of the journal, but editorial decisions are independently made by the in-house scientific editors of Cell Reports.