{"title":"RABC1-ABI1模块在拟南芥中协调脂滴动员和发芽后生长停止。","authors":"Yifei Wang, Min Zhang, Pengyue Sun, Xin Zhao, Ruo-Xi Zhang, Yun-Kuan Liang","doi":"10.1016/j.celrep.2025.115655","DOIUrl":null,"url":null,"abstract":"<p><p>Abscisic acid (ABA) promotes post-germination growth arrest (PGGA), thereby enhancing plant survival under adverse conditions such as high salinity. Lipid droplets (LDs) are universally conserved dynamic organelles that can store and mobilize neutral lipids for their multiple cellular roles. The molecular mechanism whereby a plant coordinates LD mobilization and PGGA in response to environmental stresses remains poorly understood. Here, we report that RABC1 deficiency enhances PGGA, which could be efficiently mitigated by either inhibiting ABA biosynthesis or promoting LD breakdown. ABI1 interacts with and dephosphorylates RABC1 and promotes the interactions between RABC1 and its effectors SEIPIN2 and SEIPIN3, consequently enhancing LD mobilization. Taken together, these results report a regulatory mechanism of LD mobilization for plant stress tolerance and highlight a concerted interplay between lipid metabolism and hormonal signaling.</p>","PeriodicalId":9798,"journal":{"name":"Cell reports","volume":"44 5","pages":"115655"},"PeriodicalIF":7.5000,"publicationDate":"2025-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"RABC1-ABI1 module coordinates lipid droplet mobilization and post-germination growth arrest in Arabidopsis.\",\"authors\":\"Yifei Wang, Min Zhang, Pengyue Sun, Xin Zhao, Ruo-Xi Zhang, Yun-Kuan Liang\",\"doi\":\"10.1016/j.celrep.2025.115655\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Abscisic acid (ABA) promotes post-germination growth arrest (PGGA), thereby enhancing plant survival under adverse conditions such as high salinity. Lipid droplets (LDs) are universally conserved dynamic organelles that can store and mobilize neutral lipids for their multiple cellular roles. The molecular mechanism whereby a plant coordinates LD mobilization and PGGA in response to environmental stresses remains poorly understood. Here, we report that RABC1 deficiency enhances PGGA, which could be efficiently mitigated by either inhibiting ABA biosynthesis or promoting LD breakdown. ABI1 interacts with and dephosphorylates RABC1 and promotes the interactions between RABC1 and its effectors SEIPIN2 and SEIPIN3, consequently enhancing LD mobilization. Taken together, these results report a regulatory mechanism of LD mobilization for plant stress tolerance and highlight a concerted interplay between lipid metabolism and hormonal signaling.</p>\",\"PeriodicalId\":9798,\"journal\":{\"name\":\"Cell reports\",\"volume\":\"44 5\",\"pages\":\"115655\"},\"PeriodicalIF\":7.5000,\"publicationDate\":\"2025-05-03\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Cell reports\",\"FirstCategoryId\":\"99\",\"ListUrlMain\":\"https://doi.org/10.1016/j.celrep.2025.115655\",\"RegionNum\":1,\"RegionCategory\":\"生物学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CELL BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Cell reports","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1016/j.celrep.2025.115655","RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CELL BIOLOGY","Score":null,"Total":0}
RABC1-ABI1 module coordinates lipid droplet mobilization and post-germination growth arrest in Arabidopsis.
Abscisic acid (ABA) promotes post-germination growth arrest (PGGA), thereby enhancing plant survival under adverse conditions such as high salinity. Lipid droplets (LDs) are universally conserved dynamic organelles that can store and mobilize neutral lipids for their multiple cellular roles. The molecular mechanism whereby a plant coordinates LD mobilization and PGGA in response to environmental stresses remains poorly understood. Here, we report that RABC1 deficiency enhances PGGA, which could be efficiently mitigated by either inhibiting ABA biosynthesis or promoting LD breakdown. ABI1 interacts with and dephosphorylates RABC1 and promotes the interactions between RABC1 and its effectors SEIPIN2 and SEIPIN3, consequently enhancing LD mobilization. Taken together, these results report a regulatory mechanism of LD mobilization for plant stress tolerance and highlight a concerted interplay between lipid metabolism and hormonal signaling.
期刊介绍：
Cell Reports publishes high-quality research across the life sciences and focuses on new biological insight as its primary criterion for publication. The journal offers three primary article types: Reports, which are shorter single-point articles, research articles, which are longer and provide deeper mechanistic insights, and resources, which highlight significant technical advances or major informational datasets that contribute to biological advances. Reviews covering recent literature in emerging and active fields are also accepted.
The Cell Reports Portfolio includes gold open-access journals that cover life, medical, and physical sciences, and its mission is to make cutting-edge research and methodologies available to a wide readership.
The journal's professional in-house editors work closely with authors, reviewers, and the scientific advisory board, which consists of current and future leaders in their respective fields. The advisory board guides the scope, content, and quality of the journal, but editorial decisions are independently made by the in-house scientific editors of Cell Reports.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
