犬尿酸诱导正常食欲的肠脑轴机制。

IF 7.5 1区 生物学 Q1 CELL BIOLOGY
Linghui Pan, Ruihua Li, Qiqi Li, Qin Zhu, Qian Zhou, Aru Su, Renli Qi, Zuohua Liu, Ruifan Wu, Songbo Wang, Lina Wang, Gang Shu, Qingyan Jiang, Canjun Zhu
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引用次数: 0

摘要

饲养对于宿主生物的生存和肠道微生物群的维持都是必不可少的。我们的研究重点是肠微生物代谢产物KYNA如何在禁食期间调节食欲。我们发现禁食显著提高了肠道内的KYNA水平,从而通过抑制结节神经节(NG)的迷走传入神经和激活弓形核(ARCAgRP)的AgRP神经元来增加短期食物摄入。通过膈下迷走神经切断(sdVx)、谷氨酸能NG/ARCAgRP神经元的化学激活/抑制、孤立束核(NTS)对ARCAgRP输入的抑制或肠迷走传入神经GPR35(一种KYNA受体)的敲低,KYNA的增氧作用被消除。我们的数据支持KYNA通过GPR35受体抑制迷走神经传入信号并随后激活ARCAgRP神经元的模型,从而导致食物摄入量增加。这些发现揭示了肠道微生物群在禁食期间控制食欲的机制,突出了微生物和宿主摄食行为之间的复杂关系。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The gut-brain axis mechanism of normal appetite induced by kynurenic acid.

Feeding is essential for both host-organism survival and gut-microbiota maintenance. Our research focuses on how kynurenic acid (KYNA), a gut-microbiota metabolite, regulates appetite during fasting. We find that fasting significantly raises KYNA levels in the intestine, which increases short-term food intake by inhibiting vagal afferent nerve in the nodose ganglion (NG) and activating AgRP neurons in arcuate nucleus (ARCAgRP). The orexigenic effects of KYNA are abolished by subdiaphragmatic vagotomy (sdVx), chemogenetic activation/inhibition of glutamatergic NG/ARCAgRP neurons, inhibiting the nucleus of the solitary tract (NTS) to ARCAgRP inputs, or knockdown of GPR35 (a KYNA receptor) in the intestinal vagal afferent nerve. Our data support a model in which KYNA acts through the GPR35 receptor to inhibit vagal afferent signaling and subsequently activate ARCAgRP neurons, which leads to increased food intake. These findings reveal a mechanism by which gut microbiota controls appetite during fasting, highlighting the complex relationship between microbial and host feeding behavior.

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来源期刊
Cell reports
Cell reports CELL BIOLOGY-
CiteScore
13.80
自引率
1.10%
发文量
1305
审稿时长
77 days
期刊介绍: Cell Reports publishes high-quality research across the life sciences and focuses on new biological insight as its primary criterion for publication. The journal offers three primary article types: Reports, which are shorter single-point articles, research articles, which are longer and provide deeper mechanistic insights, and resources, which highlight significant technical advances or major informational datasets that contribute to biological advances. Reviews covering recent literature in emerging and active fields are also accepted. The Cell Reports Portfolio includes gold open-access journals that cover life, medical, and physical sciences, and its mission is to make cutting-edge research and methodologies available to a wide readership. The journal's professional in-house editors work closely with authors, reviewers, and the scientific advisory board, which consists of current and future leaders in their respective fields. The advisory board guides the scope, content, and quality of the journal, but editorial decisions are independently made by the in-house scientific editors of Cell Reports.
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