Cell reports最新文献_第6页

Transcriptomic profiling of day 3 human embryos of poor quality reveals molecular links to divergent developmental trajectories. 第 3 天人类劣质胚胎的转录组分析揭示了与不同发育轨迹的分子联系。

IF 7.5 1区生物学

Cell reports Pub Date : 2024-10-31 DOI: 10.1016/j.celrep.2024.114888

Yan Li, Wencheng Zhu, Yuchen Qian, Haiyan Yang, Yonggen Wu, Juan Meng, Xuefeng Huang, Zhen Liu, Liangshan Mu

引用次数: 0

Genomic convergence in terrestrial root plants through tandem duplication in response to soil microbial pressures. 陆生根系植物在土壤微生物压力下通过串联复制实现基因组趋同。

IF 7.5 1区生物学

Cell reports Pub Date : 2024-10-30 DOI: 10.1016/j.celrep.2024.114961

Wenwu Wu, Liangyu Guo, Liufan Yin, Bijun Cai, Jing Li, Xiaoxiao Li, Jian Yang, Haichao Zhou, Zeng Tao, Yan Li

引用次数: 0

The dynamic TaRACK1B-TaSGT1-TaHSP90 complex modulates NLR-protein-mediated antiviral immunity in wheat. 动态的 TaRACK1B-TaSGT1-TaHSP90 复合物调节小麦中 NLR 蛋白介导的抗病毒免疫。

IF 7.5 1区生物学

Cell reports Pub Date : 2024-10-30 DOI: 10.1016/j.celrep.2024.114959

Haichao Hu, Tianye Zhang, Jinnan Wang, Jun Guo, Yaoyao Jiang, Qiansheng Liao, Lu Chen, Qisen Lu, Peng Liu, Kaili Zhong, Jiaqian Liu, Jianping Chen, Jian Yang

引用次数: 0

TMEM106B-mediated SARS-CoV-2 infection allows for robust ACE2-independent infection in vitro but not in vivo. 由 TMEM106B 介导的 SARS-CoV-2 感染可在体外但不在体内实现强大的 ACE2 依赖性感染。

IF 7.5 1区生物学

Cell reports Pub Date : 2024-10-30 DOI: 10.1016/j.celrep.2024.114921

Kexin Yan, Troy Dumenil, Romal Stewart, Cameron R Bishop, Bing Tang, Wilson Nguyen, Andreas Suhrbier, Daniel J Rawle

{"title":"TMEM106B-mediated SARS-CoV-2 infection allows for robust ACE2-independent infection in vitro but not in vivo.","authors":"Kexin Yan, Troy Dumenil, Romal Stewart, Cameron R Bishop, Bing Tang, Wilson Nguyen, Andreas Suhrbier, Daniel J Rawle","doi":"10.1016/j.celrep.2024.114921","DOIUrl":"10.1016/j.celrep.2024.114921","url":null,"abstract":"Angiotensin-converting enzyme 2 (ACE2) is the primary entry receptor for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), but ACE2-independent entry has been observed in vitro for strains with the spike-E484D substitution. Here, we conduct a whole-genome CRISPR-Cas9 knockout screen using SARS-CoV-2 mouse adapted 1 (SARS-CoV-2MA1), which carries spike-E484D, to identify the ACE2-independent entry mechanisms. SARS-CoV-2MA1 infection in HEK293T cells relies on heparan sulfate and endocytic pathways, with TMEM106B, a transmembrane lysosomal protein, the most significant contributor. While SARS-CoV-2MA1 productively infects human brain organoids and K18-hACE2 mouse brains, it does not infect C57BL/6J or Ifnar-/- mouse brains. This suggests that ACE2-independent entry via TMEM106B, which is predominantly expressed in the brain, does not overtly increase the risk of SARS-CoV-2 neuroinvasiveness in mice with endogenous Ace2 expression. Importantly, SARS-CoV-2MA1 does not replicate in the Ace2-/- mouse respiratory tract. Overall, this suggests that robust ACE2-independent infection by SARS-CoV-2MA1 is likely an in vitro phenomenon with no apparent implications for infection in vivo.","PeriodicalId":9798,"journal":{"name":"Cell reports","volume":"43 11","pages":"114921"},"PeriodicalIF":7.5,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142557269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A brain-to-text framework for decoding natural tonal sentences. 用于解码自然音调句子的 "从大脑到文本 "框架。

IF 7.5 1区生物学

Cell reports Pub Date : 2024-10-30 DOI: 10.1016/j.celrep.2024.114924

Daohan Zhang, Zhenjie Wang, Youkun Qian, Zehao Zhao, Yan Liu, Xiaotao Hao, Wanxin Li, Shuo Lu, Honglin Zhu, Luyao Chen, Kunyu Xu, Yuanning Li, Junfeng Lu

{"title":"A brain-to-text framework for decoding natural tonal sentences.","authors":"Daohan Zhang, Zhenjie Wang, Youkun Qian, Zehao Zhao, Yan Liu, Xiaotao Hao, Wanxin Li, Shuo Lu, Honglin Zhu, Luyao Chen, Kunyu Xu, Yuanning Li, Junfeng Lu","doi":"10.1016/j.celrep.2024.114924","DOIUrl":"https://doi.org/10.1016/j.celrep.2024.114924","url":null,"abstract":"Speech brain-computer interfaces (BCIs) directly translate brain activity into speech sound and text. Despite successful applications in non-tonal languages, the distinct syllabic structures and pivotal lexical information conveyed through tonal nuances present challenges in BCI decoding for tonal languages like Mandarin Chinese. Here, we designed a brain-to-text framework to decode Mandarin sentences from invasive neural recordings. Our framework dissects speech onset, base syllables, and lexical tones, integrating them with contextual information through Bayesian likelihood and a Viterbi decoder. The results demonstrate accurate tone and syllable decoding during naturalistic speech production. The overall word error rate (WER) for 10 offline-decoded tonal sentences with a vocabulary of 40 high-frequency Chinese characters is 21% (chance: 95.3%) averaged across five participants, and tone decoding accuracy reaches 93% (chance: 25%), surpassing previous intracranial Mandarin tonal syllable decoders. This study provides a robust and generalizable approach for brain-to-text decoding of continuous tonal speech sentences.","PeriodicalId":9798,"journal":{"name":"Cell reports","volume":"43 11","pages":"114924"},"PeriodicalIF":7.5,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142562658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Molecularly Distinct Clathrin-Coated Pits Differentially Impact EGFR Fate and Signaling. 分子上不同的凝集素包被坑对表皮生长因子受体的命运和信号传导有不同的影响。

IF 7.5 1区生物学

Cell reports Pub Date : 2024-10-30 DOI: 10.1016/j.celrep.2024.114970

Roberta Pascolutti, Veronica Algisi, Alexia Conte, Andrea Raimondi, Mithun Pasham, Srigokul Upadhyayula, Raphael Gaudin, Tanja Maritzen, Elisa Barbieri, Giusi Caldieri, Chiara Tordonato, Stefano Confalonieri, Stefano Freddi, Maria Grazia Malabarba, Elena Maspero, Simona Polo, Carlo Tacchetti, Volker Haucke, Tom Kirchhausen, Pier Paolo Di Fiore, Sara Sigismund

引用次数: 0

H3K9 lactylation in malignant cells facilitates CD8⁺ T cell dysfunction and poor immunotherapy response. 恶性细胞中的 H3K9 乳化促进 CD8+ T 细胞功能障碍和免疫疗法反应不良。

IF 7.5 1区生物学

Cell reports Pub Date : 2024-10-29 DOI: 10.1016/j.celrep.2024.114957

Ruijie Wang, Chuwen Li, Zhongyi Cheng, Mingyu Li, Jianbo Shi, Zhiyuan Zhang, Shufang Jin, Hailong Ma

引用次数: 0

Deciphering the regulatory mechanisms and biological implications of ARID1A missense mutations in cancer. 破译 ARID1A 错义突变在癌症中的调控机制和生物学意义。

IF 7.5 1区生物学

Cell reports Pub Date : 2024-10-29 DOI: 10.1016/j.celrep.2024.114916

Fang Liu, Jun Ying, Kai Yang, Xinyuan Xiong, Nan Yang, Shu Wang, Wenzhen Zhao, Huiqin Zhu, Ming Yu, Jun Wu, Jie Yang, Xiaonan Wang, Xuxu Sun

{"title":"Deciphering the regulatory mechanisms and biological implications of ARID1A missense mutations in cancer.","authors":"Fang Liu, Jun Ying, Kai Yang, Xinyuan Xiong, Nan Yang, Shu Wang, Wenzhen Zhao, Huiqin Zhu, Ming Yu, Jun Wu, Jie Yang, Xiaonan Wang, Xuxu Sun","doi":"10.1016/j.celrep.2024.114916","DOIUrl":"https://doi.org/10.1016/j.celrep.2024.114916","url":null,"abstract":"ARID1A is a key component of the switch/sucrose non-fermentable (SWI/SNF) chromatin remodeling complex and functions as a critical tumor suppressor in various cancers. In this study, we find that tumor cells with hotspot missense mutations in ARID1A (AT-rich interactive domain-containing protein 1A) exhibit a malignant phenotype. Mechanistically, these mutations facilitate the translocation of ARID1A mutant proteins to the cytoplasm by the nucleocytoplasmic shuttler XPO1 (exportin 1). Subsequently, the E3 ubiquitin ligase STUB1 ubiquitinates the ARID1A mutant protein, marking it for degradation. Knocking down STUB1 or inhibiting XPO1 stabilizes the ARID1A mutant protein, retaining it in the nucleus, which restores the assembly of the cBAF complex, the chromatin remodeling function, and the normal expression of genes related to the MAPK and anti-apoptotic pathways, thereby decreasing the tumor burden. Our research shows that nuclear-localized mutated ARID1A proteins retain tumor-suppressive function. We identify promising strategies to treat cancers harboring missense mutations in the BAF complex.","PeriodicalId":9798,"journal":{"name":"Cell reports","volume":"43 11","pages":"114916"},"PeriodicalIF":7.5,"publicationDate":"2024-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142543941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Automated live-cell single-molecule tracking in enteroid monolayers reveals transcription factor dynamics probing lineage-determining function. 肠道单层细胞中的自动活细胞单分子追踪技术揭示了转录因子的动态变化，可探测决定血统的功能。

IF 7.5 1区生物学

Cell reports Pub Date : 2024-10-29 DOI: 10.1016/j.celrep.2024.114914

Nike Walther, Sathvik Anantakrishnan, Thomas G W Graham, Gina M Dailey, Robert Tjian, Xavier Darzacq

{"title":"Automated live-cell single-molecule tracking in enteroid monolayers reveals transcription factor dynamics probing lineage-determining function.","authors":"Nike Walther, Sathvik Anantakrishnan, Thomas G W Graham, Gina M Dailey, Robert Tjian, Xavier Darzacq","doi":"10.1016/j.celrep.2024.114914","DOIUrl":"10.1016/j.celrep.2024.114914","url":null,"abstract":"Lineage transcription factors (TFs) provide one regulatory level of differentiation crucial for the generation and maintenance of healthy tissues. To probe TF function by measuring their dynamics during adult intestinal homeostasis, we established HILO-illumination-based live-cell single-molecule tracking (SMT) in mouse small intestinal enteroid monolayers recapitulating tissue differentiation hierarchies in vitro. To increase the throughput, capture cellular features, and correlate morphological characteristics with diffusion parameters, we developed an automated imaging and analysis pipeline, broadly applicable to two-dimensional culture systems. Studying two absorptive lineage-determining TFs, we found an expression level-independent contrasting diffusive behavior: while Hes1, key determinant of absorptive lineage commitment, displays a large cell-to-cell variability and an average fraction of DNA-bound molecules of ∼32%, Hnf4g, conferring enterocyte identity, exhibits more uniform dynamics and a bound fraction of ∼56%. Our results suggest that TF diffusive behavior could indicate the progression of differentiation and modulate early versus late differentiation within a lineage.","PeriodicalId":9798,"journal":{"name":"Cell reports","volume":"43 11","pages":"114914"},"PeriodicalIF":7.5,"publicationDate":"2024-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142557265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Muscle inflammation is regulated by NF-κB from multiple cells to control distinct states of wasting in cancer cachexia. 肌肉炎症受多种细胞的 NF-κB 调节，从而控制癌症恶病质中不同的消瘦状态。

IF 7.5 1区生物学

Cell reports Pub Date : 2024-10-29 DOI: 10.1016/j.celrep.2024.114925

Benjamin R Pryce, Alexander Oles, Erin E Talbert, Martin J Romeo, Silvia Vaena, Sudarshana Sharma, Victoria Spadafora, Lauren Tolliver, David A Mahvi, Katherine A Morgan, William P Lancaster, Eryn Beal, Natlie Koren, Bailey Watts, Morgan Overstreet, Stefano Berto, Suganya Subramanian, Kubra Calisir, Anna Crawford, Brian Neelon, Michael C Ostrowski, Teresa A Zimmers, James G Tidball, David J Wang, Denis C Guttridge

{"title":"Muscle inflammation is regulated by NF-κB from multiple cells to control distinct states of wasting in cancer cachexia.","authors":"Benjamin R Pryce, Alexander Oles, Erin E Talbert, Martin J Romeo, Silvia Vaena, Sudarshana Sharma, Victoria Spadafora, Lauren Tolliver, David A Mahvi, Katherine A Morgan, William P Lancaster, Eryn Beal, Natlie Koren, Bailey Watts, Morgan Overstreet, Stefano Berto, Suganya Subramanian, Kubra Calisir, Anna Crawford, Brian Neelon, Michael C Ostrowski, Teresa A Zimmers, James G Tidball, David J Wang, Denis C Guttridge","doi":"10.1016/j.celrep.2024.114925","DOIUrl":"https://doi.org/10.1016/j.celrep.2024.114925","url":null,"abstract":"Although cancer cachexia is classically characterized as a systemic inflammatory disorder, emerging evidence indicates that weight loss also associates with local tissue inflammation. We queried the regulation of this inflammation and its causality to cachexia by exploring skeletal muscle, whose atrophy strongly associates with poor outcomes. Using multiple mouse models and patient samples, we show that cachectic muscle is marked by enhanced innate immunity. Nuclear factor κB (NF-κB) activity in multiple cells, including satellite cells, myofibers, and fibro-adipogenic progenitors, promotes macrophage expansion equally derived from infiltrating monocytes and resident cells. Moreover, NF-κB-activated cells and macrophages undergo crosstalk; NF-κB+ cells recruit macrophages to inhibit regeneration and promote atrophy but, interestingly, also protect myofibers, while macrophages stimulate NF-κB+ cells to sustain an inflammatory feedforward loop. Together, we propose that NF-κB functions in multiple cells in the muscle microenvironment to stimulate macrophages that both promote and protect against muscle wasting in cancer.","PeriodicalId":9798,"journal":{"name":"Cell reports","volume":"43 11","pages":"114925"},"PeriodicalIF":7.5,"publicationDate":"2024-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142543944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0