Anti-dengue virus antibodies that elicit complement-mediated lysis of Zika virion correlate with protection from severe dengue disease.

IF 7.5 1区生物学 Q1 CELL BIOLOGY

Cell reports Pub Date : 2025-05-05 DOI:10.1016/j.celrep.2025.115613

Antonio G Dias, Elias M Duarte, Jose Victor Zambrana, Jaime A Cardona-Ospina, Sandra Bos, Vicky Roy, Julia Huffaker, Guillermina Kuan, Angel Balmaseda, Galit Alter, Eva Harris

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引用次数: 0

Abstract

Antibodies from primary dengue (DENV1-4) or Zika (ZIKV) virus infections can influence subsequent heterotypic infections, but their protective characteristics are not well defined. We analyzed pre-infection plasma samples from children in our Nicaraguan cohort study who later developed either dengue fever (DF; n = 31) or dengue hemorrhagic fever/dengue shock syndrome (DHF/DSS; n = 33) upon secondary heterotypic DENV infection. Various antibody properties, notably antibody-dependent complement deposition, correlated with protection against DHF/DSS. Interestingly, this association was strongest when using recombinant ZIKV antigens despite participants being ZIKV naive. Additionally, complement-mediated virion lysis (virolysis) with ZIKV virions was strongly associated with protection, a finding replicated in an independent sample set. ZIKV virolysis emerged as the only antibody property linked to reduced risk of DHF/DSS and severe symptoms such as thrombocytopenia and plasma leakage. These results suggest that ZIKV-cross-reactive anti-DENV antibodies that mediate complement-dependent virolysis may lower the risk of severe disease, informing the development of effective dengue vaccines and therapeutics.

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引发补体介导的寨卡病毒粒子裂解的抗登革热病毒抗体与预防严重登革热疾病相关。

来自原发性登革热（DENV1-4）或寨卡病毒（ZIKV）感染的抗体可影响随后的异型感染，但其保护特性尚不明确。我们分析了尼加拉瓜队列研究中感染前儿童的血浆样本，这些儿童后来发展为登革热(DF；n = 31)或登革出血热/登革休克综合征(DHF/DSS；n = 33)继发异型DENV感染。各种抗体特性，特别是抗体依赖性补体沉积，与DHF/DSS的保护相关。有趣的是，当使用重组寨卡病毒抗原时，这种关联是最强的，尽管参与者是寨卡病毒幼稚型。此外，补体介导的病毒粒子裂解（病毒裂解）与ZIKV病毒粒子的保护密切相关，这一发现在一个独立的样本集中得到了重复。寨卡病毒解毒是与降低DHF/DSS风险和血小板减少症和血浆渗漏等严重症状相关的唯一抗体特性。这些结果表明，介导补体依赖性病毒溶解的zikv交叉反应性抗denv抗体可能降低严重疾病的风险，为开发有效的登革热疫苗和治疗方法提供信息。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cell reports CELL BIOLOGY-

CiteScore

13.80

自引率

1.10%

发文量

1305

审稿时长

77 days

期刊介绍： Cell Reports publishes high-quality research across the life sciences and focuses on new biological insight as its primary criterion for publication. The journal offers three primary article types: Reports, which are shorter single-point articles, research articles, which are longer and provide deeper mechanistic insights, and resources, which highlight significant technical advances or major informational datasets that contribute to biological advances. Reviews covering recent literature in emerging and active fields are also accepted. The Cell Reports Portfolio includes gold open-access journals that cover life, medical, and physical sciences, and its mission is to make cutting-edge research and methodologies available to a wide readership. The journal's professional in-house editors work closely with authors, reviewers, and the scientific advisory board, which consists of current and future leaders in their respective fields. The advisory board guides the scope, content, and quality of the journal, but editorial decisions are independently made by the in-house scientific editors of Cell Reports.