Cellular and Molecular Neurobiology最新文献_第3页

Metabolic Symbiosis and Vulnerability in the CNS Axon-Myelin Unit. 中枢神经系统轴突-髓鞘单元的代谢共生和脆弱性。

IF 4.8 4区医学

Cellular and Molecular Neurobiology Pub Date : 2026-04-11 DOI: 10.1007/s10571-026-01729-3

Kun Miao, Meng Meng, Liangjing Liu, Meiyu Li, Yuanyuan Bai, Ying Guo, Guohui Zhang, Jiming Kong, Jiao Mu

引用次数: 0

Exploring the Association of Genetic Determinants of SIRT1, MTHFR, and MIR146A Gene Polymorphism with the Ischemic Stroke Predisposition: A Case Control Study. 探讨SIRT1、MTHFR和MIR146A基因多态性的遗传决定因素与缺血性卒中易感性的关系：一项病例对照研究

IF 4.8 4区医学

Cellular and Molecular Neurobiology Pub Date : 2026-04-09 DOI: 10.1007/s10571-026-01688-9

Abdullah Hamadi, Rashid Mir, Osama M Al-Amer, Mohammed Alasseiri, Mamdoh S Moawadh, Jameel Barnawi, Mohammad A Alanazi, Atif Abdulwahab A Oyouni, Abeer Al-Tuwaijri, Fawzyah Obeedallah Albaldi, Hassan A Madkhali

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Correction: Mitochondrial Transplantation Therapy for Ischemic Stroke: Progress and Challenges. 线粒体移植治疗缺血性中风：进展和挑战。

IF 4.8 4区医学

Cellular and Molecular Neurobiology Pub Date : 2026-04-06 DOI: 10.1007/s10571-026-01721-x

Zhi-Hong Zhao, Xue-Ling Yang, Zi-Wei Lu, Tao Li, Li-Li Zhao, Ye Li, Mei-Juan Dang, Gui-Lian Zhang, Kun Chen, Hong Fan

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Narrative Review "Dual Frontiers in Neurodegeneration: Pharmacological Synergies and Divergences in Parkinson's Disease and Type 2 Diabetes Mellitus". 《神经退行性疾病的双重前沿：帕金森病和2型糖尿病的药理协同作用和分歧》。

IF 4.8 4区医学

Cellular and Molecular Neurobiology Pub Date : 2026-04-03 DOI: 10.1007/s10571-026-01702-0

Omnya A Sharallah, Vishnu Malakar, Ahmed E Salama, Salma M Elmaaz, Salma A Daba, Nitesh Kumar Poddar

引用次数: 0

A Hypothesis-Generating Pharmacologic Profile for Sargramostim Treatment of Parkinson's Disease. Sargramostim治疗帕金森病的药理学假说

IF 4.8 4区医学

Cellular and Molecular Neurobiology Pub Date : 2026-04-01 DOI: 10.1007/s10571-026-01717-7

Susmita Sil, Xiaoqing Du, Samia Akter, Mohit Kumar, Davina B Oludipe, Arnab Saha, Guoku Hu, Katie R Ostlund, Gleb R Haynatzki, Pamela Santamaria, R Lee Mosley, Howard E Gendelman

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Epigenetic Mechanisms Regulating Ferroptosis in Ischemic Stroke: From Pathogenesis to Therapeutic Targets. 调控缺血性脑卒中铁下垂的表观遗传机制：从发病机制到治疗靶点。

IF 4.8 4区医学

Cellular and Molecular Neurobiology Pub Date : 2026-03-25 DOI: 10.1007/s10571-026-01718-6

Jiale Gan, Xinyi Yang, Jianan Wu, Ziyan Cai, Xianglong Zhai, Yang Wu, Wenlei Li, Minghua Wu

{"title":"Epigenetic Mechanisms Regulating Ferroptosis in Ischemic Stroke: From Pathogenesis to Therapeutic Targets.","authors":"Jiale Gan, Xinyi Yang, Jianan Wu, Ziyan Cai, Xianglong Zhai, Yang Wu, Wenlei Li, Minghua Wu","doi":"10.1007/s10571-026-01718-6","DOIUrl":"10.1007/s10571-026-01718-6","url":null,"abstract":"Ischemic stroke (IS) remains a leading cause of death and disability worldwide; however, effective neuroprotective therapies are lacking. Ferroptosis, an iron-dependent form of regulated cell death driven by lipid peroxidation, has emerged as a key contributor to neuronal injury following cerebral ischemia. Epigenetic mechanisms, including DNA methylation, histone modification, and microRNA (miRNA) regulation, critically modulate ferroptosis-related gene expression. This review systematically examines how epigenetic modifications regulate ferroptosis in IS by influencing iron homeostasis, antioxidant defense systems, and lipid metabolism. We highlighted key regulatory axes, such as DNMT-mediated GPX4 and PINK1 methylation, HDAC-regulated iron uptake and antioxidant defense, ubiquitination-dependent SLC7A11 and ACSL4 regulation, and miRNA/ferroptosis-related targets. Furthermore, we discuss the therapeutic potential of targeting these epigenetic-ferroptosis interactions for IS treatment. Understanding these mechanistic links may facilitate the development of novel epigenetic-based strategies to inhibit ferroptosis and improve the outcomes of patients with IS.","PeriodicalId":9742,"journal":{"name":"Cellular and Molecular Neurobiology","volume":" ","pages":""},"PeriodicalIF":4.8,"publicationDate":"2026-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13062076/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147509720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Research Progress on Spinal Cord Repair Based on Regulation of the Neuroregenerative Microenvironment. 基于神经再生微环境调控的脊髓修复研究进展。

IF 4.8 4区医学

Cellular and Molecular Neurobiology Pub Date : 2026-03-24 DOI: 10.1007/s10571-026-01711-z

Zixiang Deng, Huijie Zhang, Xiaoyu Li, Yongbin Feng, Yang Liu, Hanfei Shang, Ming Li, Xiaoyi Zhou, Xianzhao Wei

引用次数: 0

Recent Advances in the Non-viral Delivery of Genes to Central Nervous System Disorders. 中枢神经系统疾病非病毒基因传递的最新进展。

IF 4.8 4区医学

Cellular and Molecular Neurobiology Pub Date : 2026-03-21 DOI: 10.1007/s10571-026-01703-z

Hany E Marei

{"title":"Recent Advances in the Non-viral Delivery of Genes to Central Nervous System Disorders.","authors":"Hany E Marei","doi":"10.1007/s10571-026-01703-z","DOIUrl":"10.1007/s10571-026-01703-z","url":null,"abstract":"Disorders of the central nervous system (CNS), neurological disorders, neurodegenerative disorders, genetic disorders) constitute a significant burden on global health, and current treatment options remain challenging. As treatment for CNS disorders is primarily palliative, the underlying causes of disease progression are not addressed through conventional pharmacologic therapies. Gene therapy has the potential to address these root causes of disease progression; however, many of the vectors used in gene therapy (e.g., adeno-associated viruses (AAVs)) have limitations such as immunogenicity, low cargo capacity, and crossing the blood-brain barrier (BBB). These limitations have led to significant progress in the development of non-viral gene delivery systems. Compared with viral vectors, non-viral platforms offer improved safety profiles, greater design flexibility, lower production costs, and superior suitability for repeated administration. This review reports recent advancements in the development of non-viral platforms for CNS gene delivery and focuses on lipid-based nanoparticles, polymeric nanoparticles, exosome-based techniques, and new hybrid technologies. Particular emphasis is placed on nanoparticle modification approaches to enhance BBB penetration and enable delivery of genome-editing technologies (CRISPR/Cas systems). The review provides explanations of clinical trials, regulatory considerations, and manufacturing issues that result from the recent developments noted above. It also explores the emerging role of artificial intelligence in supporting carrier design and enhancing delivery efficiency. Both artificial intelligence and non-viral platforms have the potential to facilitate the advancement of safe, effective, and repeatably administered gene therapies for patients with CNS disorders.","PeriodicalId":9742,"journal":{"name":"Cellular and Molecular Neurobiology","volume":" ","pages":""},"PeriodicalIF":4.8,"publicationDate":"2026-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13049138/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147493340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mitochondrial DNA Damage in Substantia Nigra Pars Compacta Astrocytes Exacerbates Dopaminergic Neuron Loss in a 6-Hydroxydopamine Mouse Model of Parkinsonism. 在6-羟多巴胺小鼠帕金森模型中，黑质致密部星形胶质细胞线粒体DNA损伤加剧了多巴胺能神经元的丢失。

IF 4.8 4区医学

Cellular and Molecular Neurobiology Pub Date : 2026-03-19 DOI: 10.1007/s10571-026-01713-x

Daniela A Ayala, Grace M Hall, Debanjana Das, Eliana Tijerina, Luisa Lopez Villagran, Zaid Khan, Devanshi Paliwal, Anu Anand, Mendell Rimer, Rahul Srinivasan

引用次数: 0

The Interaction of Neutrophil Extracellular Traps and Complement in Intracerebral Hemorrhage. 中性粒细胞胞外陷阱与补体在脑出血中的相互作用。

IF 4.8 4区医学

Cellular and Molecular Neurobiology Pub Date : 2026-03-19 DOI: 10.1007/s10571-026-01675-0

Yaxin Shang, Binglin Kuang, Jia Zheng, Yunpeng Du, Tong Shang, Baochun Luo, Yue Sun, Lei Zheng, Baiwen Zhang, Li Liu, Wei Zou

{"title":"The Interaction of Neutrophil Extracellular Traps and Complement in Intracerebral Hemorrhage.","authors":"Yaxin Shang, Binglin Kuang, Jia Zheng, Yunpeng Du, Tong Shang, Baochun Luo, Yue Sun, Lei Zheng, Baiwen Zhang, Li Liu, Wei Zou","doi":"10.1007/s10571-026-01675-0","DOIUrl":"10.1007/s10571-026-01675-0","url":null,"abstract":"Intracerebral hemorrhage (ICH) is a prevalent cerebrovascular disease, which is an important cause of death and disability. Accumulating evidence indicates that the neutrophil extracellular traps (NETs) and complement cascade play an important role in the injury after ICH. Neutrophils, the first leukocyte subset recruited to the cerebral parenchyma following ICH, exacerbate cerebral tissue damage via the release of NETs. As a core component of the innate immune system, the complement system aggravates cerebral edema and pathological injury after ICH through a variety of complex pathological processes. Some complement molecules, such as C5a, C3a, and C1q, are associated with increased neutrophil recruitment and NETs release. Therefore, this review summarized the formation of NETs and activation of complement, the role of NETs and complement in ICH, the interaction between NETs and complement, and related treatment methods, providing new therapeutic strategies for clinical treatment.","PeriodicalId":9742,"journal":{"name":"Cellular and Molecular Neurobiology","volume":" ","pages":""},"PeriodicalIF":4.8,"publicationDate":"2026-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13038820/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147484807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0