Cellular and Molecular Neurobiology最新文献

{"title":"Interplay Between Autophagy, Cellular Senescence, and Brain Aging: Neuroprotective Implications of Intermittent Fasting.","authors":"Ishika Singh, Shreya Bhat, Rajesh Tamatta, Abhishek Kumar Singh","doi":"10.1007/s10571-026-01709-7","DOIUrl":"10.1007/s10571-026-01709-7","url":null,"abstract":"","PeriodicalId":9742,"journal":{"name":"Cellular and Molecular Neurobiology","volume":" ","pages":""},"PeriodicalIF":4.8,"publicationDate":"2026-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13018527/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147431171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Peripheral Inflammatory Biomarkers in Parkinson's Disease: Clinical Correlations and Stratification.","authors":"Guo-Yun Jiang, Fan Li, Jin-Hui Yin, Ling-Xiao Cao","doi":"10.1007/s10571-026-01708-8","DOIUrl":"10.1007/s10571-026-01708-8","url":null,"abstract":"<p><p>Growing evidence underscores neuroinflammation's role in Parkinson's disease (PD), with accumulating evidence suggesting a potential role for peripheral inflammation. The clinical applicability and mechanistic relevance of peripheral inflammatory biomarkers in PD remain to be fully elucidated. We analyzed data from the Parkinson's Progression Markers Initiative (PPMI), including longitudinal clinical assessments, blood counts, cerebrospinal fluid (CSF) biomarkers, and genetic data. Six peripheral inflammatory indices were derived: neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR), platelet-to-lymphocyte ratio (PLR), systemic immune-inflammation index (SII), systemic inflammation response index (SIRI), and aggregate index of systemic inflammation (AISI). Spearman correlation, multiple linear regression, and generalized estimating equations were employed to examine associations. Unsupervised k-means clustering was performed to identify distinct inflammatory clusters, with differences assessed using ANCOVA analysis. NLR and SII were significantly elevated in PD, with NLR showing the strongest association. Peripheral inflammatory biomarkers showed distinct clinical correlations, with NLR demonstrating associations with both non-motor (cognitive decline, olfactory impairment, and depression, p < 0.001) and motor symptoms (p < 0.001). SII, and SIRI showed correlations with motor progression (p < 0.001), while SII additionally associated with sleepiness disorders (p < 0.001). Cluster analysis identified two distinct inflammatory clusters: a high-inflammation cluster demonstrating significantly worse cognitive function (p = 0.008), olfactory impairment (p < 0.001), and autonomic dysfunction (p < 0.001) at baseline, along with accelerated motor (p = 0.038) and cognitive decline (p < 0.001) during follow-up. This high-inflammation cluster also showed elevated CSF neurodegeneration markers including pTau, tTau, NfL, and GFAP (p < 0.05). Peripheral inflammatory biomarkers show robust associations with clinical features in PD, highlighting their potential as markers associated with disease features and progression, and suggesting a basis for inflammatory-based subgrouping.</p>","PeriodicalId":9742,"journal":{"name":"Cellular and Molecular Neurobiology","volume":" ","pages":""},"PeriodicalIF":4.8,"publicationDate":"2026-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13009453/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147372185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nitric Oxide Donor Alleviates Cardiac Arrest Induced Blood Brain Barrier Injury by Inhibiting HMGB1-ATG5 Mediated Endothelial Autophagy.","authors":"Pengyu Duan, Yonghong Bi, Weiyu Feng, Zhehao Jin, Yao Meng, Hangbing Li, Xiaoyan Li, Lan Luo, Xiangcheng Zhao, Bing Zhang","doi":"10.1007/s10571-026-01706-w","DOIUrl":"10.1007/s10571-026-01706-w","url":null,"abstract":"","PeriodicalId":9742,"journal":{"name":"Cellular and Molecular Neurobiology","volume":" ","pages":""},"PeriodicalIF":4.8,"publicationDate":"2026-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13018516/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147369378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigating the Regulatory Mechanisms and Prognostic Significance of miR-941 Targeting the Nrf2/Keap1 Pathway in Elderly Ischemic Stroke Patients.","authors":"Xixia Huang, Jianpeng Gao, Rongbin Zhu, Yifei Sun, Lina Zhang, Xinhai Gao","doi":"10.1007/s10571-025-01639-w","DOIUrl":"10.1007/s10571-025-01639-w","url":null,"abstract":"<p><p>This study aims to explore the role and underlying correlation of miR-941 in the targeted regulation of the Keap1/Nrf2 signaling pathway in the prognosis of senile ischemic stroke (IS), providing new targets and strategies for clinical treatment. Totally 102 elderly IS patients admitted from July 2022 to June 2023 in Jing'an District Shibei hospital were enrolled and divided into hyperacute, acute, subacute, and chronic phases by disease course and imaging results. Peripheral blood samples were collected. RT-PCR was used to detect miR-941, Nrf2 mRNA and Keap1 mRNA expression levels, and ELISA for HO-1, NQO-1, SOD, and GSH-Px1 expression. The modified Rankin scale (mRS) evaluated patients' prognosis, and logistic regression analyzed influencing factors. The receiver operating characteristic (ROC) and Kaplan-Meier curves analyzed the predictive value of miR-941 and the Nrf2/Keap1 signaling pathway in IS prognosis and their correlation with patients' survival periods. The expression levels of miR-941 and Nrf2 mRNA gradually decreased in different stages of IS, while the expression of Keap1 mRNA gradually increased, and the expression levels of antioxidant factors HO-1, NQO-1, SOD, and GSH-Px1 also decreased significantly (all P < 0.001). The relative abundances of miR-941 and Nrf2 mRNA were significantly negatively correlated with the NIHSS score (P < 0.001), while Keap1 mRNA was positively correlated with the NIHSS score (P < 0.001). Logistic regression analysis showed that miR-941 and Nrf2 mRNA were protective factors for a good prognosis of IS (P < 0.001), while Keap1 mRNA was a risk factor for a poor prognosis (P < 0.01). ROC curve analysis showed that miR-941 had high predictive efficacy in the prognosis of IS (the AUCs were 0.801). Kaplan-Meier survival analysis showed that the survival periods of patients in the high-expression groups of miR-941 and Nrf2 were significantly longer than those in the low-expression groups (P < 0.001), while the survival period of patients in the high-expression group of Keap1 mRNA was significantly shortened (P < 0.001). The correlation between miR-941 and Keap1/Nrf2 signaling pathway is crucial in the course and prognosis of senile ischemic cerebral infarction. High miR-941 and Nrf2 mRNA levels correlate with good prognosis, while high Keap1 mRNA levels link to poor prognosis. These molecules probably serve as potential biomarkers for clinical prognosis and new treatment targets.</p>","PeriodicalId":9742,"journal":{"name":"Cellular and Molecular Neurobiology","volume":" ","pages":""},"PeriodicalIF":4.8,"publicationDate":"2026-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13005787/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147364371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Decoding the Glioblastoma Microenvironment: AI-Driven Analysis of Cellular MRI Signatures for Targeted Therapy.","authors":"Yao Sun, Kai Wang, Tiantao Ye","doi":"10.1007/s10571-026-01705-x","DOIUrl":"10.1007/s10571-026-01705-x","url":null,"abstract":"<p><p>Glioblastoma (GB), the most aggressive primary brain tumor, is characterized by profound inter- and intratumoral heterogeneity and a highly immunosuppressive tumor microenvironment (TME), both of which contribute to its poor prognosis and resistance to conventional therapies. The dynamic interplay between malignant cells and diverse TME constituents including immune cells, neural elements, and extracellular matrix components drives tumor progression, clonal evolution, and therapeutic failure. Traditional treatment modalities such as surgery, radiotherapy, and chemotherapy often fall short due to their inability to address the spatial and temporal complexity of the TME. Recent advances in artificial intelligence (AI) and cellular MRI profiling offer promising avenues for decoding the GB microenvironment at unprecedented resolution. By integrating AI-driven analysis of cellular MRI signatures, researchers can identify distinct microenvironmental niches and resistant subclones, enabling the development of targeted therapies that simultaneously disrupt tumor cells and their supportive ecosystems. This approach holds potential to overcome current therapeutic limitations and pave the way for personalized, microenvironment-informed interventions in GB management.</p>","PeriodicalId":9742,"journal":{"name":"Cellular and Molecular Neurobiology","volume":" ","pages":""},"PeriodicalIF":4.8,"publicationDate":"2026-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13005796/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147353675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex-Dependent Dynamics of Behavioural and Neuropathological Changes in an A53T Alpha-Synuclein Mouse Model of Parkinson's Disease.","authors":"Maider Zubelzu, Raphaelle Bidgood, Ane Murueta-Goyena, José Ángel Ruiz-Ortega, José Vicente Lafuente, Teresa Morera-Herreras","doi":"10.1007/s10571-026-01707-9","DOIUrl":"10.1007/s10571-026-01707-9","url":null,"abstract":"","PeriodicalId":9742,"journal":{"name":"Cellular and Molecular Neurobiology","volume":" ","pages":""},"PeriodicalIF":4.8,"publicationDate":"2026-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13003041/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147353736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Dopamine D1-Like Receptor Agonist Ameliorates Traumatic Brain Injury Through its Immunosuppressive Effects.","authors":"Mohammed E Choudhury, Ayane Takenaga, Haruto Yamamoto, Hiroto Yamauchi, Emiri Koga, Naoki Abe, Noriyuki Miyaue, Shirabe Matsumoto, Keisuke Sekiya, Akari Kusakawa, Naohito Tokunaga, Koichi Tanaka, Takeharu Kunieda, Masahiro Nagai, Junya Tanaka, Tasuku Nishihara","doi":"10.1007/s10571-026-01690-1","DOIUrl":"10.1007/s10571-026-01690-1","url":null,"abstract":"<p><p>Traumatic brain injury (TBI) causes progressive nervous tissue degeneration long after the initial injury due to secondary neuroinflammatory reactions. G protein-coupled dopamine D1-like receptors, which elevate intracellular cAMP levels, have been shown to mediate the suppressive effects on lipopolysaccharide (LPS)-induced proinflammatory activation of microglia and macrophages. The present study investigated whether or not the D1-like receptor-specific agonist SKF-81297 (SKF) administered intraperitoneally once daily for 3days starting 1 h after TBI could ameliorate TBI in a rat model of stab wounds in the forebrain. SKF reduced the volume of TBI-induced brain tissue loss, increased mobile activity, and ameliorated cognitive dysfunction two months after TBI. A single dose of SKF suppressed the expression of IL-1β and TNFα in brain tissue by reducing oxidative injury at 24 h post-TBI. SKF decreased the energy metabolism of microglia, macrophages, and neutrophils in TBI brain. SKF prevented LPS-induced translocation of NFκB into the nuclei of primary cultured microglia. The agonist clenbuterol (CLB) for adrenergic β2 receptor, another Gs-linked GPCR, exerted comparable ameliorative effects in TBI model rats by suppressing neuroinflammation. In summary, SKF may exert anti-inflammatory effects by suppressing the NFkB pathway through increasing cAMP similarly to CLB and also by decreasing energy metabolism of inflammatory cells, leading to amelioration of TBI-induced brain degeneration.</p>","PeriodicalId":9742,"journal":{"name":"Cellular and Molecular Neurobiology","volume":" ","pages":""},"PeriodicalIF":4.8,"publicationDate":"2026-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12988141/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147316588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Double-Edged Sword Effect of the Fibrinolytic System in Alzheimer's Disease.","authors":"Mingqing Tang, Meimei Liang, Xianying Zhang, Chunzhan Hong, Lichao Ye","doi":"10.1007/s10571-026-01699-6","DOIUrl":"10.1007/s10571-026-01699-6","url":null,"abstract":"<p><p>Alzheimer's disease (AD), the most prevalent neurodegenerative disorder, is fundamentally driven by dysregulation between amyloid-β (Aβ) production and clearance. Although multiple Aβ clearance pathways have been reported, the fibrinolytic system remains the only enzymatically validated degradation route. Notably, a striking paradox is emerging: fibrinolytic agents exhibit both neuroprotective and AD-promoting effects in clinical observations. This duality necessitates urgent investigation into the fibrinolytic system's double-edged sword mechanism in AD pathogenesis. This review provides the first comprehensive analysis of the fibrinolytic system's dichotomous regulatory functions in AD progression, summarizes current advancements in the pathogenesis and therapeutic interventions, and proposes novel research directions. By resolving this molecular paradox, we aim to accelerate transformative breakthroughs in AD prevention and precision medicine strategies. Fibrinolytic System: Neuroprotection vs. Pathogenesis. The fibrinolytic system alleviates AD by directly degrading Aβ and indirectly improving the microenvironment of the central nervous system and cerebrovascular system. Meanwhile, this system also accelerates AD by promoting neuroinflammation and tau hyperphosphorylation.</p>","PeriodicalId":9742,"journal":{"name":"Cellular and Molecular Neurobiology","volume":" ","pages":""},"PeriodicalIF":4.8,"publicationDate":"2026-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12992866/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147302822","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neuroradiological Phenotype Expansion of the Siddiqi Syndrome: A Case Report.","authors":"Paula Trilla, Laia Rodriguez-Revenga, Aurora Sanchez, Irene Madrigal, Jose Cesar Milisenda, Esteban Muñoz, Maria Isabel Alvarez-Mora","doi":"10.1007/s10571-026-01672-3","DOIUrl":"10.1007/s10571-026-01672-3","url":null,"abstract":"","PeriodicalId":9742,"journal":{"name":"Cellular and Molecular Neurobiology","volume":"46 1","pages":""},"PeriodicalIF":4.8,"publicationDate":"2026-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12948736/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147302825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"D-serine: A Multitalented Neuromodulator in Brain Function, Systemic Homeostasis, and Disease.","authors":"Jing Wang, Yujin Guo, Wenxiu Han, Hailiang Zhang, Pei Jiang","doi":"10.1007/s10571-026-01696-9","DOIUrl":"10.1007/s10571-026-01696-9","url":null,"abstract":"","PeriodicalId":9742,"journal":{"name":"Cellular and Molecular Neurobiology","volume":" ","pages":""},"PeriodicalIF":4.8,"publicationDate":"2026-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12992856/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147282487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}