小胶质细胞衰老的特征。

IF 3.6 4区 医学 Q3 CELL BIOLOGY
Laura Carr, Sanam Mustafa, Lyndsey E Collins-Praino
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引用次数: 0

摘要

由于衰老与神经退行性疾病(NDs)的发展有关,如阿尔茨海默病和帕金森病,因此将年龄相关变化的独立影响与疾病过程引起的变化区分开来是很重要的。要做到这一点,中枢神经系统(CNS)细胞作为老年功能的变化需要更好的表征。由于小胶质细胞通过控制中枢神经系统免疫反应与nd的发展和进展有关,因此引起了人们的特别关注。因此,了解小胶质细胞功能障碍在多大程度上与生理衰老有关,而不是疾病过程,是至关重要的。随着小胶质细胞年龄的增长,它们被认为呈现出具有明显营养不良形态的促炎表型。然而,尽管已经在一系列其他细胞类型(如巨噬细胞)中研究了衰老的特征,但对衰老小胶质细胞中发生的功能变化的详细考虑仍然难以捉摸。在这里,我们描述了小胶质细胞的动态表型,并评估了当前对小胶质细胞衰老的理解状态,重点是最近更新的12个衰老标志。了解这些特征如何出现在小胶质细胞中代表着朝着更好地表征小胶质细胞衰老迈出的一步,这对于开发更具代表性的NDs模型至关重要。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The Hallmarks of Ageing in Microglia.

As ageing is linked to the development of neurodegenerative diseases (NDs), such as Alzheimer's Disease and Parkinson's Disease, it is important to disentangle the independent effect of age-related changes from those due to disease processes. To do so, changes to central nervous system (CNS) cells as a function of advanced age need better characterisation. Microglia are of particular interest due to their proposed links with the development and progression of NDs through control of the CNS immune response. Therefore, understanding the extent to which microglial dysfunction is related to phyisological ageing, rather than a disease process, is critical. As microglia age, they are believed to take on a pro-inflammatory phenotype with a distinct dystrophic morphology. Nevertheless, while established hallmarks of ageing have been investigated across a range of other cell types, such as macrophages, a detailed consideration of functional changes that occur in aged microglia remains elusive. Here, we describe the dynamic phenotypes of microglia and evaluate the current state of understanding of microglial ageing, focusing on the recently updated twelve hallmarks of ageing. Understanding how these hallmarks present in microglia represents a step towards better characterisation of microglial ageing, which is essential in the development of more representative models of NDs.

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来源期刊
CiteScore
7.70
自引率
0.00%
发文量
137
审稿时长
4-8 weeks
期刊介绍: Cellular and Molecular Neurobiology publishes original research concerned with the analysis of neuronal and brain function at the cellular and subcellular levels. The journal offers timely, peer-reviewed articles that describe anatomic, genetic, physiologic, pharmacologic, and biochemical approaches to the study of neuronal function and the analysis of elementary mechanisms. Studies are presented on isolated mammalian tissues and intact animals, with investigations aimed at the molecular mechanisms or neuronal responses at the level of single cells. Cellular and Molecular Neurobiology also presents studies of the effects of neurons on other organ systems, such as analysis of the electrical or biochemical response to neurotransmitters or neurohormones on smooth muscle or gland cells.
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