能量代谢和脑老化：延缓神经元退化的策略。

IF 3.6 4区医学 Q3 CELL BIOLOGY

Cellular and Molecular Neurobiology Pub Date : 2025-04-21 DOI:10.1007/s10571-025-01555-z

Donghui Na, Zechen Zhang, Meng Meng, Meiyu Li, Junyan Gao, Jiming Kong, Guohui Zhang, Ying Guo

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引用次数: 0

摘要

衰老的特征是生理功能的逐渐下降，脑老化是许多神经退行性疾病的主要危险因素。鉴于大脑的高能量需求，维持充足的ATP供应对其正常功能至关重要。然而，随着年龄的增长，线粒体功能障碍和能量代谢恶化导致总能量产生减少和线粒体质量控制（MQC）受损。因此，促进健康老龄化已成为当代研究的重点。本文综述了能量代谢与脑衰老的关系，强调了MQC与能量代谢的关系，并提出了以能量代谢为目标延缓脑衰老的策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Energy Metabolism and Brain Aging: Strategies to Delay Neuronal Degeneration.

Aging is characterized by a gradual decline in physiological functions, with brain aging being a major risk factor for numerous neurodegenerative diseases. Given the brain's high energy demands, maintaining an adequate ATP supply is crucial for its proper function. However, with advancing age, mitochondria dysfunction and a deteriorating energy metabolism lead to reduced overall energy production and impaired mitochondrial quality control (MQC). As a result, promoting healthy aging has become a key focus in contemporary research. This review examines the relationship between energy metabolism and brain aging, highlighting the connection between MQC and energy metabolism, and proposes strategies to delay brain aging by targeting energy metabolism.

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来源期刊

Cellular and Molecular Neurobiology 生物-神经科学

CiteScore

7.70

自引率

0.00%

发文量

137

审稿时长

4-8 weeks

期刊介绍： Cellular and Molecular Neurobiology publishes original research concerned with the analysis of neuronal and brain function at the cellular and subcellular levels. The journal offers timely, peer-reviewed articles that describe anatomic, genetic, physiologic, pharmacologic, and biochemical approaches to the study of neuronal function and the analysis of elementary mechanisms. Studies are presented on isolated mammalian tissues and intact animals, with investigations aimed at the molecular mechanisms or neuronal responses at the level of single cells. Cellular and Molecular Neurobiology also presents studies of the effects of neurons on other organ systems, such as analysis of the electrical or biochemical response to neurotransmitters or neurohormones on smooth muscle or gland cells.