Cellular and Molecular Neurobiology最新文献

{"title":"Neuro-Behavioral Improvement and Mechanistic Pathways of Bone Marrow-Derived Mesenchymal Stem Cells and Exosomes in Experimental Multiple Sclerosis: A Systematic Review and Meta-analysis.","authors":"Hadis Kariminejad-Farsangi, Haniyeh Kariminejad-Farsangi, Meraj Sharifi, Saman Azh, Zahra Ghadery Nasab, Marzie Dehghan-Kuroki, Sara Joushi","doi":"10.1007/s10571-026-01715-9","DOIUrl":"https://doi.org/10.1007/s10571-026-01715-9","url":null,"abstract":"","PeriodicalId":9742,"journal":{"name":"Cellular and Molecular Neurobiology","volume":" ","pages":""},"PeriodicalIF":4.8,"publicationDate":"2026-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147716361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Plasma Extracellular Vesicles (EVs)-Mediated Immune Dysregulation and Chronic Inflammation in Autism Spectrum Disorder.","authors":"Houda Yasmine Ali Moussa, Remy Thomas, Rawan Hussam Albatarni, Kyung Chul Shin, Wared Nour-Eldine, Fouad A Al-Shaban, Sara A Abdulla, Abeer R Al-Shammari, Julie Decock, Yongsoo Park","doi":"10.1007/s10571-026-01723-9","DOIUrl":"10.1007/s10571-026-01723-9","url":null,"abstract":"","PeriodicalId":9742,"journal":{"name":"Cellular and Molecular Neurobiology","volume":"46 1","pages":""},"PeriodicalIF":4.8,"publicationDate":"2026-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13090467/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147716325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mitochondrial-Immune Dysfunction in MS: Therapeutic Potential of EV-Mediated Transfer.","authors":"Parsa Navazi, Mohammad Fereidouni, Nafiseh Erfanian","doi":"10.1007/s10571-026-01716-8","DOIUrl":"https://doi.org/10.1007/s10571-026-01716-8","url":null,"abstract":"","PeriodicalId":9742,"journal":{"name":"Cellular and Molecular Neurobiology","volume":" ","pages":""},"PeriodicalIF":4.8,"publicationDate":"2026-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147716323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Role and Diagnostic Efficacy of the METTL14/GADD45B m⁶A Methylation/BDNF Regulatory Axis in Acute Ischemic Stroke.","authors":"Jin-Ying Lai, Jun-Hua Lu, Meng-Yue Li, Bei-Bei Li, Bao-Yun Jin, Jiang-Jie Hao, Ying Zhao, Ying Lin, Li-Qiu Ma, Ren Liu, Shu-Fan Zhang, Hong-Jun Guan","doi":"10.1007/s10571-026-01710-0","DOIUrl":"https://doi.org/10.1007/s10571-026-01710-0","url":null,"abstract":"<p><p>Despite advances in acute ischemic stroke (AIS) research, identifying reliable biomarkers and regulatory mechanisms remains challenging. We first identified AIS-related genes via extensive literature review, retrieved dataset GSE16561 from the Gene Expression Omnibus (GEO, https://ncbi.nlm.nih.gov/geo/), and performed differential/enrichment analyses. Bioinformatics verified N6-methyladenosine (m⁶A) sites in target genes, focusing on the methyltransferase-like protein 14 (METTL14)/growth arrest and DNA damage-inducible β (GADD45B) m⁶A methylation/brain-derived neurotrophic factor (BDNF) axis. Peripheral blood samples, biochemical indicators, and demographic data were collected from Hongqi Hospital Affiliated to Mudanjiang Medical University. Human umbilical vein endothelial cells (HUVECs) underwent transfection and oxygen-glucose deprivation (OGD). METTL14, GADD45B, and BDNF were detected by reverse transcription-quantitative polymerase chain reaction (RT-qPCR); BDNF protein by enzyme-linked immunosorbent assay (ELISA); global RNA m⁶A by Dot Blot; and GADD45B m⁶A by methylated RNA immunoprecipitation-quantitative polymerase chain reaction (MeRIP-RT-qPCR). Differential, diagnostic efficacy, logistic regression analyses, and nomogram validation were conducted. AIS patients showed increased METTL14, decreased GADD45B/BDNF, and increased levels of global m⁶A RNA and GADD45B m⁶A RNA (P < 0.05). Receiver operating characteristic (ROC) analysis confirmed the three genes' good diagnostic efficacy. The nomogram integrating these genes, globulin (GLOB), diabetes, high-density lipoprotein cholesterol (HDL-C), and hypertension performed excellently. This study highlights METTL14, GADD45B, and BDNF as key AIS biomarkers; METTL14 may indirectly regulate BDNF via GADD45B m⁶A methylation, providing potential therapeutic targets and novel mechanistic insights.</p>","PeriodicalId":9742,"journal":{"name":"Cellular and Molecular Neurobiology","volume":" ","pages":""},"PeriodicalIF":4.8,"publicationDate":"2026-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147697664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unknotting the Role of circRNAs and IGF2BP3 in Alzheimer's Disease.","authors":"Sayed Mohammad Firdous, Sinhapurage Navodi Sandamini Jayathilaka, Souvik Marick, Pratyush Porel","doi":"10.1007/s10571-026-01724-8","DOIUrl":"https://doi.org/10.1007/s10571-026-01724-8","url":null,"abstract":"<p><p>Alzheimer's disease (AD) is a complex neurological ailment that is associated with memory loss, confusion, and mood disturbances. Genetic, molecular, and cellular factors, including oxidative stress, inflammation, neurotransmitter alterations, and amyloid β (Aβ) plaques and neurofibrillary tangles (NFTs), are associated with the disease. These can be associated with protein and DNA damage, mitochondrial dysfunction, energy shortages, inflammation, and hippocampal neuron death. Circular non-coding RNAs (circRNAs) are covalently closed and essential to many physiological and pathological processes. CircRNA may be a molecular modulator of neurodegeneration, as it may influence protein transcription and interaction with essential RNA-binding proteins (RBP) in the cortical and hippocampal regions, particularly in photoreceptor neurons and white matter.Insulin-like Growth Factor 2 mRNA-Binding Protein 3. (IGF2BP3), which belongs totheinsulin-like growth factor 2 encoded mRNA-binding protein family, affects neuronal differentiation, synaptic plasticity, translation, localization, mRNA stability, and neurogenesis. Research indicates that IGF2BP3 has been reported to modulate neuron survival and function genes, as well as BACE1 translation, which creates Aβ. AD has a complex etiology; thus, understanding its molecular processes is crucial. Investigating circRNAs and IGF2BP3 activities may reveal new disease are associated with and therapy options. This review explores the emerging roles ofcircRNAs as diagnostic biomarkers and potential therapeutic targets inmanagingAD.</p>","PeriodicalId":9742,"journal":{"name":"Cellular and Molecular Neurobiology","volume":" ","pages":""},"PeriodicalIF":4.8,"publicationDate":"2026-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147697712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association Between CDH1 Downregulation and Lymphocyte Cell-Cycle Dysfunction in Alzheimer's Disease and Mild Cognitive Impairment.","authors":"Paloma Monllor, Begoña Lopez, Maria-Angeles Lloret, Jose-Luis Leon, Erika Lopez, Mari-Carmen Badia, Ana Lloret","doi":"10.1007/s10571-026-01725-7","DOIUrl":"https://doi.org/10.1007/s10571-026-01725-7","url":null,"abstract":"","PeriodicalId":9742,"journal":{"name":"Cellular and Molecular Neurobiology","volume":" ","pages":""},"PeriodicalIF":4.8,"publicationDate":"2026-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147688335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MELK is Required for G2/M Phase Progression in Cortical Progenitors: Insights from Rare ASD-Associated Variants.","authors":"Liyang Zhao, Xianjing Li, Kang Yang, Miaomiao Jiang, Zhonghe Chen, Yiqian Shao, Tianlan Lu, Dai Zhang, Lifang Wang, Jun Li","doi":"10.1007/s10571-026-01728-4","DOIUrl":"https://doi.org/10.1007/s10571-026-01728-4","url":null,"abstract":"<p><p>Maternal embryonic leucine zipper kinase (MELK) is a cell cycle regulator, yet its role in embryonic cortical development remains unclear. We identified ultra-rare, predicted loss-of-function MELK variants in ASD individuals, prompting this functional investigation. Published human single-cell transcriptomics showed that MELK expression is enriched in neural progenitors and correlates with the G2/M phase. Using in utero electroporation in mouse cortex, we found that Melk knockdown reduced the proportion of progenitors in G2/M phase. Knockdown also caused impaired multipolar-to-bipolar transition and shorter leading processes. Complementing these findings, transcriptomic analysis of FACS-sorted Melk-knockdown cortical cells revealed downregulation of G2/M-related genes and cytoskeletal regulators linked to neuronal morphogenesis. Together, these findings identify MELK as a critical regulator of both G2/M phase progression and neuronal morphogenesis during cortical development, providing a mechanistic link to neurodevelopmental conditions.</p>","PeriodicalId":9742,"journal":{"name":"Cellular and Molecular Neurobiology","volume":" ","pages":""},"PeriodicalIF":4.8,"publicationDate":"2026-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147670840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Inhibition of Ferroptosis Alleviates Early Brain Injury After Subarachnoid Hemorrhage In Vitro and In Vivo via Reduction of Lipid Peroxidation.","authors":"Yuchen Li, Yao Liu, Pei Wu, Yang Tian, Binbing Liu, Jinju Wang, Ji Bihl, Huaizhang Shi","doi":"10.1007/s10571-026-01727-5","DOIUrl":"10.1007/s10571-026-01727-5","url":null,"abstract":"","PeriodicalId":9742,"journal":{"name":"Cellular and Molecular Neurobiology","volume":"46 1","pages":""},"PeriodicalIF":4.8,"publicationDate":"2026-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13076813/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147670791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Does Enriched Environment Improve Chronic Immobilization Stress-Induced Cognitive and Behavioral Changes in Adult Male Rats?","authors":"Mona A Mohammed, Amira S Ahmed, Fatma M M Salem, Eman S H Abd Allah","doi":"10.1007/s10571-026-01712-y","DOIUrl":"10.1007/s10571-026-01712-y","url":null,"abstract":"","PeriodicalId":9742,"journal":{"name":"Cellular and Molecular Neurobiology","volume":" ","pages":""},"PeriodicalIF":4.8,"publicationDate":"2026-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13076856/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147662241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cell Therapy for Spinal Cord Injury: Mechanistic Insights and Translational Challenges.","authors":"Duc-Hiep Bach, Bui Van Giang, Thanh Liem Nguyen","doi":"10.1007/s10571-026-01720-y","DOIUrl":"https://doi.org/10.1007/s10571-026-01720-y","url":null,"abstract":"","PeriodicalId":9742,"journal":{"name":"Cellular and Molecular Neurobiology","volume":" ","pages":""},"PeriodicalIF":4.8,"publicationDate":"2026-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147662270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}