Association of Emotional Stress and Adaptive Behavior with Stroke Risk: A Mendelian Randomization Study.

IF 3.6 4区 医学 Q3 CELL BIOLOGY
Jianyu Liu, Chunlan Pu, Cao Liu, Qiang Zhou, Da Liu, Tianqi Lu, Zhouyang Liu, Xing Guo, Hua Liu
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引用次数: 0

Abstract

Although emotional stress and adaptive behavior are known to influence cardiovascular health, direct evidence linking them to stroke remains limited. This study aims to clarify the associations between emotional stress, adaptive behaviors, and the risk of stroke. We conducted a two-sample Mendelian randomization analysis using data from the UK Biobank, the European Bioinformatics Institute, the Integrative Epidemiology Unit, and the FinnGen project. Indirect effects were estimated using the product of coefficients method. Low satisfaction with family relationships was associated with increased risks of all stroke and ischemic stroke. Mood swings were linked to higher risks of all stroke, ischemic stroke, and large-artery stroke, while feelings of tension were associated with large-artery stroke and small vessel stroke. Interestingly, nervousness was inversely associated with intracerebral hemorrhage risk. Participation in group leisure activities was associated with reduced risks of all stroke, ischemic stroke, and small vessel stroke. In contrast, several adaptive behaviors were linked to increased stroke risk, including vigorous physical activity (all stroke), summer outdoor activities (all stroke and ischemic stroke), winter outdoor activities (all stroke), and prolonged television watching (all stroke, ischemic stroke, and large-artery stroke). Mediation analyses suggested that hypertension, type 2 diabetes, atherosclerotic heart disease, and chronic ischemic heart disease may partially mediate these associations. The study provides genetic evidence supporting a potential causal relationship between emotional stress, adaptive behaviors, and stroke subtypes. Individuals can easily modify adaptive behaviors and manage emotional stress in their daily routines. Understanding these associations may inform future strategies for stroke prevention; however, due to limitations inherent in the current study design, our findings require further validation in large-scale prospective cohort studies.

情绪压力和适应性行为与中风风险的关联:一项孟德尔随机研究。
虽然已知情绪压力和适应性行为会影响心血管健康,但将它们与中风联系起来的直接证据仍然有限。本研究旨在阐明情绪压力、适应性行为和中风风险之间的关系。我们使用来自英国生物银行、欧洲生物信息学研究所、综合流行病学单位和FinnGen项目的数据进行了双样本孟德尔随机化分析。采用系数积法估计间接效应。对家庭关系的低满意度与所有中风和缺血性中风的风险增加有关。情绪波动与所有中风、缺血性中风和大动脉中风的高风险有关,而紧张感与大动脉中风和小血管中风有关。有趣的是,紧张与脑出血风险呈负相关。参加集体休闲活动与所有中风、缺血性中风和小血管中风的风险降低有关。相比之下,一些适应性行为与中风风险增加有关,包括剧烈运动(所有中风)、夏季户外活动(所有中风和缺血性中风)、冬季户外活动(所有中风)和长时间看电视(所有中风、缺血性中风和大动脉中风)。中介分析表明,高血压、2型糖尿病、动脉粥样硬化性心脏病和慢性缺血性心脏病可能部分介导这些关联。该研究提供了支持情绪压力、适应性行为和中风亚型之间潜在因果关系的遗传证据。个人可以很容易地在日常生活中调整适应性行为和管理情绪压力。了解这些关联可以为未来卒中预防策略提供信息;然而,由于当前研究设计固有的局限性,我们的发现需要在大规模前瞻性队列研究中进一步验证。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
7.70
自引率
0.00%
发文量
137
审稿时长
4-8 weeks
期刊介绍: Cellular and Molecular Neurobiology publishes original research concerned with the analysis of neuronal and brain function at the cellular and subcellular levels. The journal offers timely, peer-reviewed articles that describe anatomic, genetic, physiologic, pharmacologic, and biochemical approaches to the study of neuronal function and the analysis of elementary mechanisms. Studies are presented on isolated mammalian tissues and intact animals, with investigations aimed at the molecular mechanisms or neuronal responses at the level of single cells. Cellular and Molecular Neurobiology also presents studies of the effects of neurons on other organ systems, such as analysis of the electrical or biochemical response to neurotransmitters or neurohormones on smooth muscle or gland cells.
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