Cerebral cortex最新文献_第8页

Effects of parental socioeconomic status on offspring's fetal neurodevelopment. 父母的社会经济地位对后代胎儿神经发育的影响。

IF 2.9 2区医学

Cerebral cortex Pub Date : 2024-11-05 DOI: 10.1093/cercor/bhae443

Julia Mathan, Mélanie Maximino-Pinheiro, Qin He, Gabriela Rezende, Iris Menu, Cloelia Tissier, Emilie Salvia, Katell Mevel, Lorna Le Stanc, Julie Vidal, Marine Moyon, Lisa Delalande, Francois Orliac, Nicolas Poirel, Catherine Oppenheim, Olivier Houdé, Boris Chaumette, Grégoire Borst, Arnaud Cachia

{"title":"Effects of parental socioeconomic status on offspring's fetal neurodevelopment.","authors":"Julia Mathan, Mélanie Maximino-Pinheiro, Qin He, Gabriela Rezende, Iris Menu, Cloelia Tissier, Emilie Salvia, Katell Mevel, Lorna Le Stanc, Julie Vidal, Marine Moyon, Lisa Delalande, Francois Orliac, Nicolas Poirel, Catherine Oppenheim, Olivier Houdé, Boris Chaumette, Grégoire Borst, Arnaud Cachia","doi":"10.1093/cercor/bhae443","DOIUrl":"https://doi.org/10.1093/cercor/bhae443","url":null,"abstract":"Emerging evidence underscores the prenatal period's critical role in shaping later cognition and health, influenced by an intricate interplay of parental genetic and environmental factors. Birth weight is commonly used as a retrospective indicator of fetal development, but recent focus has shifted to more specific proxies of neurodevelopment, like cortical sulcal patterns, which are established in utero and remain stable after birth. This study aimed to elucidate the interrelated effects of parental socioeconomic status, brain volume, birth weight, and sulcal patterns in the anterior cingulate cortex. Utilizing structural Magnetic Resonance Imaging (MRI), parental educational attainment, and related polygenic risk scores, the study analyzed 203 healthy right-handed participants aged 9 to 18. Structural equation modeling demonstrated that the anterior cingulate cortex sulcal pattern is influenced by parental socioeconomic status and global brain volume, with socioeconomic status correlating with a polygenic risk score. These findings suggest that prenatal neurodevelopmental processes may mediate the intergenerational transmission of inequalities.","PeriodicalId":9715,"journal":{"name":"Cerebral cortex","volume":"34 11","pages":""},"PeriodicalIF":2.9,"publicationDate":"2024-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142615453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neuroanatomical correlates of subjective tinnitus: insights from advanced cortical morphology analysis. 主观耳鸣的神经解剖相关性：高级皮层形态分析的启示。

IF 2.9 2区医学

Cerebral cortex Pub Date : 2024-11-05 DOI: 10.1093/cercor/bhae432

Himanshu R Pandey, Amit Keshri, Neeraj Sinha, Uttam Kumar

{"title":"Neuroanatomical correlates of subjective tinnitus: insights from advanced cortical morphology analysis.","authors":"Himanshu R Pandey, Amit Keshri, Neeraj Sinha, Uttam Kumar","doi":"10.1093/cercor/bhae432","DOIUrl":"https://doi.org/10.1093/cercor/bhae432","url":null,"abstract":"Subjective tinnitus, characterized by the perception of phantom sounds in the absence of external stimuli, presents significant challenges in both audiology and neurology. Once thought to primarily involve aberrant neural activity within auditory pathways, it is now understood to engage a broader array of neuroanatomical structures. This study investigated the connections between auditory, cognitive, and sensory processing regions, which are crucial for unraveling the complex neurobiological basis of tinnitus. Using high-resolution T1-weighted magnetic resonance imaging, we compared 52 individuals with subjective tinnitus with 52 age-matched healthy controls, focusing on cerebral cortex features, including fractal dimensionality, gyrification, and sulcal depth. Covariate analyses were conducted to explore the relationships between tinnitus duration, Tinnitus Handicap Inventory scores, anxiety score, and neuroanatomical changes. We found significant alterations in key brain regions involved in sensory processing, cognition, and emotional regulation, including the insula, lateral occipital cortex, middle frontal gyrus, and superior parietal lobule. These neuroanatomical changes were strongly correlated with the severity and chronicity of tinnitus symptoms. Our findings reveal profound structural changes in the brain associated with subjective tinnitus, offering valuable insights into the condition's underlying mechanisms and providing a potential framework for guiding future research and therapeutic interventions.","PeriodicalId":9715,"journal":{"name":"Cerebral cortex","volume":"34 11","pages":""},"PeriodicalIF":2.9,"publicationDate":"2024-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142589795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Global changes in the pattern of connectivity in developmental prosopagnosia. 发育性前视力障碍患者连通性模式的整体变化。

IF 2.9 2区医学

Cerebral cortex Pub Date : 2024-11-05 DOI: 10.1093/cercor/bhae435

Gabriela Epihova, Richard Cook, Timothy J Andrews

{"title":"Global changes in the pattern of connectivity in developmental prosopagnosia.","authors":"Gabriela Epihova, Richard Cook, Timothy J Andrews","doi":"10.1093/cercor/bhae435","DOIUrl":"10.1093/cercor/bhae435","url":null,"abstract":"Developmental prosopagnosia is a neurodevelopmental condition characterized by difficulties in recognizing the identity of a person from their face. While current theories of the neural basis of developmental prosopagnosia focus on the face processing network, successful recognition of face identities requires broader integration of neural signals across the whole brain. Here, we asked whether disruptions in global functional and structural connectivity contribute to the face recognition difficulties observed in developmental prosopagnosia. We found that the left temporal pole was less functionally connected to the rest of the brain in developmental prosopagnosia. This was driven by weaker contralateral connections to the middle and inferior temporal gyri, as well as to the medial prefrontal cortex. The pattern of global connectivity in the left temporal pole was also disrupted in developmental prosopagnosia. Critically, these changes in global functional connectivity were only evident when participants viewed faces. Structural connectivity analysis revealed localized reductions in connectivity between the left temporal pole and a number of regions, including the fusiform gyrus, inferior temporal gyrus, and orbitofrontal cortex. Our findings underscore the importance of whole-brain integration in supporting typical face recognition and provide evidence that disruptions in connectivity involving the left temporal pole may underlie the characteristic difficulties of developmental prosopagnosia.","PeriodicalId":9715,"journal":{"name":"Cerebral cortex","volume":"34 11","pages":""},"PeriodicalIF":2.9,"publicationDate":"2024-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11546179/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142602814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Oculomotor functional connectivity associated with motor sequence learning. 与运动序列学习相关的眼球运动功能连通性

IF 2.9 2区医学

Cerebral cortex Pub Date : 2024-11-05 DOI: 10.1093/cercor/bhae434

Cristina Rubino, Justin W Andrushko, Shie Rinat, Adam T Harrison, Lara A Boyd

{"title":"Oculomotor functional connectivity associated with motor sequence learning.","authors":"Cristina Rubino, Justin W Andrushko, Shie Rinat, Adam T Harrison, Lara A Boyd","doi":"10.1093/cercor/bhae434","DOIUrl":"10.1093/cercor/bhae434","url":null,"abstract":"Acquisition of learned motor sequences involves saccades directed toward the goal to gather visual information prior to reaching. While goal-directed actions involve both eye and hand movements, the role of brain areas controlling saccades during motor sequence learning is still unclear. This study aimed to determine whether resting-state functional connectivity of oculomotor regions is associated with behavioral changes resulting from motor sequence learning. We investigated connectivity between oculomotor control regions and candidate regions involved in oculomotor control and motor sequence learning. Twenty adults had brain scans before 3 days of motor task practice and after a 24-hour retention test, which was used to assess sequence-specific learning. During testing, both saccades and reaches were tracked. Stronger connectivity in multiple oculomotor regions prior to motor task practice correlated with greater sequence-specific learning for both saccades and reaches. A more negative connectivity change involving oculomotor regions from pre- to post-training correlated with greater sequence-specific learning for both saccades and reaches. Overall, oculomotor functional connectivity was associated with the magnitude of behavioral change resulting from motor sequence learning, providing insight into the function of the oculomotor system during motor sequence learning.","PeriodicalId":9715,"journal":{"name":"Cerebral cortex","volume":"34 11","pages":""},"PeriodicalIF":2.9,"publicationDate":"2024-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11546180/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142602815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Enhancing perceptual, attentional, and working memory demands through variable practice schedules: insights from high-density EEG multi-scale analyses. 通过不同的练习时间表提高知觉、注意力和工作记忆要求：高密度脑电图多尺度分析的启示。

IF 2.9 2区医学

Cerebral cortex Pub Date : 2024-11-05 DOI: 10.1093/cercor/bhae425

Alexandre Cretton, Kate Schipper, Mahmoud Hassan, Paolo Ruggeri, Jérôme Barral

{"title":"Enhancing perceptual, attentional, and working memory demands through variable practice schedules: insights from high-density EEG multi-scale analyses.","authors":"Alexandre Cretton, Kate Schipper, Mahmoud Hassan, Paolo Ruggeri, Jérôme Barral","doi":"10.1093/cercor/bhae425","DOIUrl":"10.1093/cercor/bhae425","url":null,"abstract":"Contextual interference (CI) enhances learning by practicing motor tasks in a random order rather than a blocked order. One hypothesis suggests that the benefits arise from enhanced early perceptual/attentional processes, while another posits that better learning is due to highly activated mnemonic processes. We used high-density electroencephalography in a multi-scale analysis approach, including topographic analyses, source estimations, and functional connectivity, to examine the intertwined dynamics of attentional and mnemonic processes within short time windows. We recorded scalp activity from 35 participants as they performed an aiming task at three different distances, under both random and blocked conditions using a crossover design. Our results showed that topographies associated with processes related to perception/attention (N1, P3a) and working memory (P3b) were more pronounced in the random condition. Source estimation analyses supported these findings, revealing greater involvement of the perceptual ventral pathway, anterior cingulate and parietal cortices, along with increased functional connectivity in ventral alpha and frontoparietal theta band networks during random practice. Our results suggest that CI is driven, in the random compared to the blocked condition, by enhanced specific processes such as perceptual, attentional, and working memory processes, as well as large-scale functional networks sustaining more general attentional and executive processes.","PeriodicalId":9715,"journal":{"name":"Cerebral cortex","volume":"34 11","pages":""},"PeriodicalIF":2.9,"publicationDate":"2024-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11538921/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142582206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The aging of emotional words processing in implicit and explicit emotion task: an ERP study. 内隐和外显情绪任务中情绪词处理的老化：一项ERP研究。

IF 2.9 2区医学

Cerebral cortex Pub Date : 2024-11-05 DOI: 10.1093/cercor/bhae424

Ling Bao, Qingfang Zhang

{"title":"The aging of emotional words processing in implicit and explicit emotion task: an ERP study.","authors":"Ling Bao, Qingfang Zhang","doi":"10.1093/cercor/bhae424","DOIUrl":"https://doi.org/10.1093/cercor/bhae424","url":null,"abstract":"This study examined how cognitive aging affects emotional word processing using event-related potential technique. Young and older adults completed both implicit lexical decision and explicit emotion categorization tasks involving positive, negative, and neutral words. Behaviorally, older adults displayed a negative emotion effect in the implicit task, which was absent in young adults. While both age groups exhibited both positive and negative emotion effects in the explicit task, older adults demonstrated a greater positivity bias compared to young adults. Event-related potential technique data revealed that young adults exhibited an early negative emotion effect on the P2 and a late emotion effect on the late positivity potentials in the implicit task. In contrast, older adults exhibited an early negativity bias effect on the P2, as well as both negative and positive emotion effects on the N400, and positive emotion effects on the late positivity potentials. In the explicit task, young adults showed both early and late negative emotion effects on the P2 and late positivity potentials, while older adults showed both negative and positive emotion effects on the late positivity potentials. The results suggest distinct processing mechanisms for emotion words in young and older adults, involving both bottom-up and top-down mechanisms, which support the socioemotional selectivity theory.","PeriodicalId":9715,"journal":{"name":"Cerebral cortex","volume":"34 11","pages":""},"PeriodicalIF":2.9,"publicationDate":"2024-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142602740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gestational and early postnatal protein malnutrition disrupts neurodevelopment in rhesus macaques. 妊娠期和产后早期蛋白质营养不良会破坏猕猴的神经发育。

IF 2.9 2区医学

Cerebral cortex Pub Date : 2024-11-05 DOI: 10.1093/cercor/bhae462

Joshua A Karpf, Elinor L Sullivan, Victoria H J Roberts, Colin Studholme, Charles T Roberts, Christopher D Kroenke

{"title":"Gestational and early postnatal protein malnutrition disrupts neurodevelopment in rhesus macaques.","authors":"Joshua A Karpf, Elinor L Sullivan, Victoria H J Roberts, Colin Studholme, Charles T Roberts, Christopher D Kroenke","doi":"10.1093/cercor/bhae462","DOIUrl":"10.1093/cercor/bhae462","url":null,"abstract":"Adequate nutrition during gestation is critical for fetal development, and deficits in protein are associated with neurological and behavioral impairments in offspring placing a significant burden on global health. Fetal and neonatal longitudinal magnetic resonance assessments of brain development spanning mid-gestation to 11 months of age were conducted in rhesus macaque (Macaca mulatta) (n = 22; 9 females) generated from an established nonhuman primate model of gestational protein reduction to ascertain the neurodevelopmental effects of reduced maternal protein intake. Structural abnormalities were identified in two reduced diet groups, in addition to age-dependent whole-brain volume deficits in the most severely reduced (50% vs. 33% reduction) protein cohort, primarily restricted to gray matter structures; i.e. cortical/subcortical gray matter and the cerebellum. Diffusion-weighted imaging revealed widespread postnatal reductions in white matter fractional anisotropy, concentrated in the corpus callosum for both reduced protein levels relative to control diet. Despite extensive neurodevelopmental alterations detectable by longitudinal imaging, early behavioral assessments conducted at 1 month revealed minor perturbations. These results highlight differential impacts of reduced maternal and infant protein intake on gray and white matter formation and organization, with potential implications for early motor development.","PeriodicalId":9715,"journal":{"name":"Cerebral cortex","volume":"34 11","pages":""},"PeriodicalIF":2.9,"publicationDate":"2024-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142715558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Enhancing motor skill learning through multiple sessions of online high-definition transcranial direct current stimulation in healthy adults: insights from EEG power spectrum. 通过多次在线高清经颅直流电刺激加强健康成年人的运动技能学习：脑电图功率谱的启示。

IF 2.9 2区医学

Cerebral cortex Pub Date : 2024-10-03 DOI: 10.1093/cercor/bhae395

Feng Guo, Maolin Niu, Nicholas J Hanson, Jianrui Guo, Kuo Zhou, Tan Zhao, Yinghui Ren

{"title":"Enhancing motor skill learning through multiple sessions of online high-definition transcranial direct current stimulation in healthy adults: insights from EEG power spectrum.","authors":"Feng Guo, Maolin Niu, Nicholas J Hanson, Jianrui Guo, Kuo Zhou, Tan Zhao, Yinghui Ren","doi":"10.1093/cercor/bhae395","DOIUrl":"https://doi.org/10.1093/cercor/bhae395","url":null,"abstract":"The purpose of this study was to evaluate the influence of high-definition transcranial direct current stimulation (HD-tDCS) on finger motor skill acquisition. Thirty-one healthy adult males were randomly assigned to one of three groups: online HD-tDCS (administered during motor skill learning), offline HD-tDCS (delivered before motor skill learning), and a sham group. Participants engaged in a visual isometric pinch task for three consecutive days. Overall motor skill learning and speed-accuracy tradeoff function were used to evaluate the efficacy of tDCS. Electroencephalography was recorded and power spectral density was calculated. Both online and offline HD-tDCS total motor skill acquisition was significantly higher than the sham group (P < 0.001 and P < 0.05, respectively). Motor skill acquisition in the online group was higher than offline (P = 0.132, Cohen's d = 1.46). Speed-accuracy tradeoff function in the online group was higher than both offline and sham groups in the post-test. The online group exhibited significantly lower electroencephalography activity in the frontal, fronto-central, and centro-parietal alpha band regions compared to the sham (P < 0.05). The findings suggest that HD-tDCS application can boost finger motor skill acquisition, with online HD-tDCS displaying superior facilitation. Furthermore, online HD-tDCS reduces the power of alpha rhythms during motor skill execution, enhancing information processing and skill learning efficiency.","PeriodicalId":9715,"journal":{"name":"Cerebral cortex","volume":"34 10","pages":""},"PeriodicalIF":2.9,"publicationDate":"2024-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142375195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Causal relationships between cerebral cortical structure and preeclampsia: insights from bidirectional Mendelian randomization and colocalization analysis. 大脑皮层结构与子痫前期之间的因果关系：双向孟德尔随机化和共聚焦分析的启示。

IF 2.9 2区医学

Cerebral cortex Pub Date : 2024-10-03 DOI: 10.1093/cercor/bhae400

Qiong Liu, Shaoqing Jiang, Yan Li, Aiyin Zhou, Hanfan Long, Weifen Zhong

{"title":"Causal relationships between cerebral cortical structure and preeclampsia: insights from bidirectional Mendelian randomization and colocalization analysis.","authors":"Qiong Liu, Shaoqing Jiang, Yan Li, Aiyin Zhou, Hanfan Long, Weifen Zhong","doi":"10.1093/cercor/bhae400","DOIUrl":"https://doi.org/10.1093/cercor/bhae400","url":null,"abstract":"Preeclampsia, a multifaceted condition characterized by high blood pressure during pregnancy, is linked to substantial health risks for both the mother and the fetus. Previous studies suggest potential neurological impacts, but the causal relationships between cortical structural changes and preeclampsia remain unclear. We utilized genome-wide association study data for cortical thickness (TH) and surface area (SA) across multiple brain regions and preeclampsia. Bidirectional Mendelian randomization (MR) analyses were conducted to assess causality, followed by co-localization analyses to confirm shared genetic architecture. Increased cortical TH in the inferior parietal and supramarginal regions, and an enlarged SA in the postcentral region, were significantly associated with higher preeclampsia risk. Conversely, preeclampsia was linked to increased SA in the supramarginal and middle temporal gyri, and decreased SA in the lingual gyrus. Co-localization analyses indicated distinct genetic determinants for cortical structures and preeclampsia. Our findings reveal bidirectional influences between cortical structural features and preeclampsia, suggesting neuroinflammatory and vascular mechanisms as potential pathways. These insights underscore the importance of considering brain structure in preeclampsia risk assessment and highlight the need for further research into neuroprotective strategies.","PeriodicalId":9715,"journal":{"name":"Cerebral cortex","volume":"34 10","pages":""},"PeriodicalIF":2.9,"publicationDate":"2024-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142399507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Uncovering neural substrates across Alzheimer's disease stages using contrastive variational autoencoder. 利用对比变异自动编码器揭示阿尔茨海默病各阶段的神经基质

IF 2.9 2区医学

Cerebral cortex Pub Date : 2024-10-03 DOI: 10.1093/cercor/bhae393

Yan Tang, Chao Yang, Yuqi Wang, Yunhao Zhang, Jiang Xin, Hao Zhang, Hua Xie

{"title":"Uncovering neural substrates across Alzheimer's disease stages using contrastive variational autoencoder.","authors":"Yan Tang, Chao Yang, Yuqi Wang, Yunhao Zhang, Jiang Xin, Hao Zhang, Hua Xie","doi":"10.1093/cercor/bhae393","DOIUrl":"https://doi.org/10.1093/cercor/bhae393","url":null,"abstract":"Alzheimer's disease is the most common major neurocognitive disorder. Although currently, no cure exists, understanding the neurobiological substrate underlying Alzheimer's disease progression will facilitate early diagnosis and treatment, slow disease progression, and improve prognosis. In this study, we aimed to understand the morphological changes underlying Alzheimer's disease progression using structural magnetic resonance imaging data from cognitively normal individuals, individuals with mild cognitive impairment, and Alzheimer's disease via a contrastive variational autoencoder model. We used contrastive variational autoencoder to generate synthetic data to boost the downstream classification performance. Due to the ability to parse out the nonclinical factors such as age and gender, contrastive variational autoencoder facilitated a purer comparison between different Alzheimer's disease stages to identify the pathological changes specific to Alzheimer's disease progression. We showed that brain morphological changes across Alzheimer's disease stages were significantly associated with individuals' neurofilament light chain concentration, a potential biomarker for Alzheimer's disease, highlighting the biological plausibility of our results.","PeriodicalId":9715,"journal":{"name":"Cerebral cortex","volume":"34 10","pages":""},"PeriodicalIF":2.9,"publicationDate":"2024-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142371066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0