Cerebral cortex最新文献_第8页

Local organization of spatial and shape information in the primate prefrontal cortex. 灵长类前额叶皮层空间和形状信息的局部组织。

IF 2.9 2区医学

Cerebral cortex Pub Date : 2024-09-03 DOI: 10.1093/cercor/bhae384

Yunyi Sun, Wenhao Dang, Rye G Jaffe, Christos Constantinidis

{"title":"Local organization of spatial and shape information in the primate prefrontal cortex.","authors":"Yunyi Sun, Wenhao Dang, Rye G Jaffe, Christos Constantinidis","doi":"10.1093/cercor/bhae384","DOIUrl":"10.1093/cercor/bhae384","url":null,"abstract":"The current understanding of sensory and motor cortical areas has been defined by the existence of topographical maps across the brain surface, however, higher cortical areas, such as the prefrontal cortex, seem to lack an equivalent organization, and only limited evidence of functional clustering of neurons with similar stimulus properties is evident in them. We thus sought to examine whether neurons that represent similar spatial and object information are clustered in the monkey prefrontal cortex and whether such an organization only emerges as a result of training. To this end, we analyzed neurophysiological recordings from male macaque monkeys before and after training in spatial and shape working memory tasks. Neurons with similar spatial or shape selectivity were more likely than chance to be encountered at short distances from each other. Some aspects of organization were present even in naïve animals, however other changes appeared after cognitive training. Our results reveal that prefrontal microstructure automatically supports orderly representations of spatial and object information.","PeriodicalId":9715,"journal":{"name":"Cerebral cortex","volume":"34 9","pages":""},"PeriodicalIF":2.9,"publicationDate":"2024-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11422719/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142342447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Transdiagnostic depression severity and its relationship to global and prefrontal-amygdala structural properties in people with major depression and post-traumatic stress disorder. 重度抑郁症和创伤后应激障碍患者的跨诊断抑郁症严重程度及其与整体和前额叶-杏仁核结构特性的关系。

IF 2.9 2区医学

Cerebral cortex Pub Date : 2024-09-03 DOI: 10.1093/cercor/bhae381

Lei Li, Jing Jiang, Shitong Zhong, Jinping Lin, Yuhao Yao, Graham J Kemp, Ying Chen, Qiyong Gong

{"title":"Transdiagnostic depression severity and its relationship to global and prefrontal-amygdala structural properties in people with major depression and post-traumatic stress disorder.","authors":"Lei Li, Jing Jiang, Shitong Zhong, Jinping Lin, Yuhao Yao, Graham J Kemp, Ying Chen, Qiyong Gong","doi":"10.1093/cercor/bhae381","DOIUrl":"10.1093/cercor/bhae381","url":null,"abstract":"While some studies have used a transdiagnostic approach to relate depression to metabolic or functional brain alterations, the structural substrate of depression across clinical diagnostic categories is underexplored. In a cross-sectional study of 52 patients with major depressive disorder and 51 with post-traumatic stress disorder, drug-naïve, and spanning mild to severe depression severity, we examined transdiagnostic depressive correlates with regional gray matter volume and the topological properties of gray matter-based networks. Locally, transdiagnostic depression severity correlated positively with gray matter volume in the right middle frontal gyrus and negatively with nodal topological properties of gray matter-based networks in the right amygdala. Globally, transdiagnostic depression severity correlated positively with normalized characteristic path length, a measure implying brain integration ability. Compared with 62 healthy control participants, both major depressive disorder and post-traumatic stress disorder patients showed altered nodal properties in regions of the fronto-limbic-striatal circuit, and global topological organization in major depressive disorder in particular was characterized by decreased integration and segregation. These findings provide evidence for a gray matter-based structural substrate underpinning depression, with the prefrontal-amygdala circuit a potential predictive marker for depressive symptoms across clinical diagnostic categories.","PeriodicalId":9715,"journal":{"name":"Cerebral cortex","volume":"34 9","pages":""},"PeriodicalIF":2.9,"publicationDate":"2024-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11420672/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142307183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Graspable foods and tools elicit similar responses in visual cortex. 可抓握的食物和工具会在视觉皮层引起类似的反应。

IF 2.9 2区医学

Cerebral cortex Pub Date : 2024-09-03 DOI: 10.1093/cercor/bhae383

John Brendan Ritchie, Spencer T Andrews, Maryam Vaziri-Pashkam, Chris I Baker

{"title":"Graspable foods and tools elicit similar responses in visual cortex.","authors":"John Brendan Ritchie, Spencer T Andrews, Maryam Vaziri-Pashkam, Chris I Baker","doi":"10.1093/cercor/bhae383","DOIUrl":"10.1093/cercor/bhae383","url":null,"abstract":"The extrastriatal visual cortex is known to exhibit distinct response profiles to complex stimuli of varying ecological importance (e.g. faces, scenes, and tools). Although food is primarily distinguished from other objects by its edibility, not its appearance, recent evidence suggests that there is also food selectivity in human visual cortex. Food is also associated with a common behavior, eating, and food consumption typically also involves the manipulation of food, often with hands. In this context, food items share many properties with tools: they are graspable objects that we manipulate in self-directed and stereotyped forms of action. Thus, food items may be preferentially represented in extrastriatal visual cortex in part because of these shared affordance properties, rather than because they reflect a wholly distinct kind of category. We conducted functional MRI and behavioral experiments to test this hypothesis. We found that graspable food items and tools were judged to be similar in their action-related properties and that the location, magnitude, and patterns of neural responses for images of graspable food items were similar in profile to the responses for tool stimuli. Our findings suggest that food selectivity may reflect the behavioral affordances of food items rather than a distinct form of category selectivity.","PeriodicalId":9715,"journal":{"name":"Cerebral cortex","volume":"34 9","pages":""},"PeriodicalIF":2.9,"publicationDate":"2024-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142342445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Left motor cortex contributes to auditory phonological discrimination. 左侧运动皮层有助于听觉语音辨别。

IF 2.9 2区医学

Cerebral cortex Pub Date : 2024-09-03 DOI: 10.1093/cercor/bhae369

Maxime Perron, Bernhard Ross, Claude Alain

{"title":"Left motor cortex contributes to auditory phonological discrimination.","authors":"Maxime Perron, Bernhard Ross, Claude Alain","doi":"10.1093/cercor/bhae369","DOIUrl":"https://doi.org/10.1093/cercor/bhae369","url":null,"abstract":"Evidence suggests that the articulatory motor system contributes to speech perception in a context-dependent manner. This study tested 2 hypotheses using magnetoencephalography: (i) the motor cortex is involved in phonological processing, and (ii) it aids in compensating for speech-in-noise challenges. A total of 32 young adults performed a phonological discrimination task under 3 noise conditions while their brain activity was recorded using magnetoencephalography. We observed simultaneous activation in the left ventral primary motor cortex and bilateral posterior-superior temporal gyrus when participants correctly identified pairs of syllables. This activation was significantly more pronounced for phonologically different than identical syllable pairs. Notably, phonological differences were resolved more quickly in the left ventral primary motor cortex than in the left posterior-superior temporal gyrus. Conversely, the noise level did not modulate the activity in frontal motor regions and the involvement of the left ventral primary motor cortex in phonological discrimination was comparable across all noise conditions. Our results show that the ventral primary motor cortex is crucial for phonological processing but not for compensation in challenging listening conditions. Simultaneous activation of left ventral primary motor cortex and bilateral posterior-superior temporal gyrus supports an interactive model of speech perception, where auditory and motor regions shape perception. The ventral primary motor cortex may be involved in a predictive coding mechanism that influences auditory-phonetic processing.","PeriodicalId":9715,"journal":{"name":"Cerebral cortex","volume":"34 9","pages":""},"PeriodicalIF":2.9,"publicationDate":"2024-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11427950/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142342446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Metabolic network connectivity disturbances in Parkinson's disease: a novel imaging biomarker. 帕金森病的代谢网络连接紊乱：一种新的成像生物标记。

IF 2.9 2区医学

Cerebral cortex Pub Date : 2024-09-03 DOI: 10.1093/cercor/bhae355

Bei Chen, Xiran Chen, Liling Peng, Shiqi Liu, Yongxiang Tang, Xin Gao

{"title":"Metabolic network connectivity disturbances in Parkinson's disease: a novel imaging biomarker.","authors":"Bei Chen, Xiran Chen, Liling Peng, Shiqi Liu, Yongxiang Tang, Xin Gao","doi":"10.1093/cercor/bhae355","DOIUrl":"https://doi.org/10.1093/cercor/bhae355","url":null,"abstract":"The diagnosis of Parkinson's Disease (PD) presents ongoing challenges. Advances in imaging techniques like 18F-fluorodeoxyglucose positron emission tomography (18F-FDG PET) have highlighted metabolic alterations in PD, yet the dynamic network interactions within the metabolic connectome remain elusive. To this end, we examined a dataset comprising 49 PD patients and 49 healthy controls. By employing a personalized metabolic connectome approach, we assessed both within- and between-network connectivities using Standard Uptake Value (SUV) and Jensen-Shannon Divergence Similarity Estimation (JSSE). A random forest algorithm was utilized to pinpoint key neuroimaging features differentiating PD from healthy states. Specifically, the results revealed heightened internetwork connectivity in PD, specifically within the somatomotor (SMN) and frontoparietal (FPN) networks, persisting after multiple comparison corrections (P < 0.05, Bonferroni adjusted for 10% and 20% sparsity). This altered connectivity effectively distinguished PD patients from healthy individuals. Notably, this study utilizes 18F-FDG PET imaging to map individual metabolic networks, revealing enhanced connectivity in the SMN and FPN among PD patients. This enhanced connectivity may serve as a promising imaging biomarker, offering a valuable asset for early PD detection.","PeriodicalId":9715,"journal":{"name":"Cerebral cortex","volume":"34 9","pages":""},"PeriodicalIF":2.9,"publicationDate":"2024-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142342448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Age and visual cortex inhibition: a TMS-MRS study. 年龄与视觉皮层抑制：TMS-MRS 研究。

IF 2.9 2区医学

Cerebral cortex Pub Date : 2024-09-03 DOI: 10.1093/cercor/bhae352

Molly Simmonite, Dalia Khammash, Katherine J Michon, Abbey Hamlin, Stephan F Taylor, Michael Vesia, Thad A Polk

{"title":"Age and visual cortex inhibition: a TMS-MRS study.","authors":"Molly Simmonite, Dalia Khammash, Katherine J Michon, Abbey Hamlin, Stephan F Taylor, Michael Vesia, Thad A Polk","doi":"10.1093/cercor/bhae352","DOIUrl":"https://doi.org/10.1093/cercor/bhae352","url":null,"abstract":"Paired-pulse transcranial magnetic stimulation is a valuable tool for investigating inhibitory mechanisms in motor cortex. We recently demonstrated its use in measuring cortical inhibition in visual cortex, using an approach in which participants trace the size of phosphenes elicited by stimulation to occipital cortex. Here, we investigate age-related differences in primary visual cortical inhibition and the relationship between primary visual cortical inhibition and local GABA+ in the same region, estimated using magnetic resonance spectroscopy. GABA+ was estimated in 28 young (18 to 28 years) and 47 older adults (65 to 84 years); a subset (19 young, 18 older) also completed a paired-pulse transcranial magnetic stimulation session, which assessed visual cortical inhibition. The paired-pulse transcranial magnetic stimulation measure of inhibition was significantly lower in older adults. Uncorrected GABA+ in primary visual cortex was also significantly lower in older adults, while measures of GABA+ that were corrected for the tissue composition of the magnetic resonance spectroscopy voxel were unchanged with age. Furthermore, paired-pulse transcranial magnetic stimulation-measured inhibition and magnetic resonance spectroscopy-measured tissue-corrected GABA+ were significantly positively correlated. These findings are consistent with an age-related decline in cortical inhibition in visual cortex and suggest paired-pulse transcranial magnetic stimulation effects in visual cortex are driven by GABAergic mechanisms, as has been demonstrated in motor cortex.","PeriodicalId":9715,"journal":{"name":"Cerebral cortex","volume":"34 9","pages":""},"PeriodicalIF":2.9,"publicationDate":"2024-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142124946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lower entorhinal cortex thickness is associated with greater financial exploitation vulnerability in cognitively unimpaired older adults. 认知能力未受损的老年人内侧皮层厚度较低与更易遭受经济剥削有关。

IF 2.9 2区医学

Cerebral cortex Pub Date : 2024-09-03 DOI: 10.1093/cercor/bhae360

Laura Fenton, Lauren E Salminen, Aaron C Lim, Gali H Weissberger, Annie L Nguyen, Jenna Axelrod, Daisy Noriega-Makarskyy, Hussein Yassine, Laura Mosqueda, S Duke Han

{"title":"Lower entorhinal cortex thickness is associated with greater financial exploitation vulnerability in cognitively unimpaired older adults.","authors":"Laura Fenton, Lauren E Salminen, Aaron C Lim, Gali H Weissberger, Annie L Nguyen, Jenna Axelrod, Daisy Noriega-Makarskyy, Hussein Yassine, Laura Mosqueda, S Duke Han","doi":"10.1093/cercor/bhae360","DOIUrl":"10.1093/cercor/bhae360","url":null,"abstract":"Research suggests that increased financial exploitation vulnerability due to declining decision making may be an early behavioral manifestation of brain changes occurring in preclinical Alzheimer's disease. One of the earliest documented brain changes during the preclinical phase is neurodegeneration in the entorhinal cortex. The objective of the current study was to examine the association between a measure of financial exploitation vulnerability and thickness in the entorhinal cortex in 97 cognitively unimpaired older adults. We also investigated financial exploitation vulnerability associations with frontal regions typically associated with decision making (e.g. dorsolateral and ventromedial prefrontal cortices), and additionally examined the interactive effect of age and cortical thickness on financial exploitation vulnerability. Results showed that greater financial exploitation vulnerability was associated with significantly lower entorhinal cortex thickness. There was a significant interaction between age and entorhinal cortex thickness on financial exploitation vulnerability, whereby lower entorhinal cortex thickness was associated with greater financial exploitation vulnerability in older participants. When the group was divided by age using a median split (70+ and <70 years old), lower entorhinal cortex thickness was associated with greater vulnerability only in the older group. Collectively, these findings suggest that financial exploitation vulnerability may serve as a behavioral manifestation of entorhinal cortex thinning, a phenomenon observed in suboptimal brain aging and preclinical Alzheimer's disease.","PeriodicalId":9715,"journal":{"name":"Cerebral cortex","volume":"34 9","pages":""},"PeriodicalIF":2.9,"publicationDate":"2024-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11371417/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142124949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neural substrate for the engagement of the ventral visual stream in motor control in the macaque monkey. 猕猴腹侧视觉流参与运动控制的神经基础

IF 2.9 2区医学

Cerebral cortex Pub Date : 2024-09-03 DOI: 10.1093/cercor/bhae354

Elena Borra, Marzio Gerbella, Stefano Rozzi, Giuseppe Luppino

{"title":"Neural substrate for the engagement of the ventral visual stream in motor control in the macaque monkey.","authors":"Elena Borra, Marzio Gerbella, Stefano Rozzi, Giuseppe Luppino","doi":"10.1093/cercor/bhae354","DOIUrl":"https://doi.org/10.1093/cercor/bhae354","url":null,"abstract":"The present study aimed to describe the cortical connectivity of a sector located in the ventral bank of the superior temporal sulcus in the macaque (intermediate area TEa and TEm [TEa/m]), which appears to represent the major source of output of the ventral visual stream outside the temporal lobe. The retrograde tracer wheat germ agglutinin was injected in the intermediate TEa/m in four macaque monkeys. The results showed that 58-78% of labeled cells were located within ventral visual stream areas other than the TE complex. Outside the ventral visual stream, there were connections with the memory-related medial temporal area 36 and the parahippocampal cortex, orbitofrontal areas involved in encoding subjective values of stimuli for action selection, and eye- or hand-movement related parietal (LIP, AIP, and SII), prefrontal (12r, 45A, and 45B) areas, and a hand-related dysgranular insula field. Altogether these data provide a solid substrate for the engagement of the ventral visual stream in large scale cortical networks for skeletomotor or oculomotor control. Accordingly, the role of the ventral visual stream could go beyond pure perceptual processes and could be also finalized to the neural mechanisms underlying the control of voluntary motor behavior.","PeriodicalId":9715,"journal":{"name":"Cerebral cortex","volume":"34 9","pages":""},"PeriodicalIF":2.9,"publicationDate":"2024-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142124950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Alpha oscillations during visual selective attention are aberrant in youth and adults with cerebral palsy. 患有脑瘫的青少年和成年人在视觉选择性注意过程中的α振荡出现异常。

IF 2.9 2区医学

Cerebral cortex Pub Date : 2024-09-03 DOI: 10.1093/cercor/bhae365

Rashelle M Hoffman, Michael P Trevarrow, Brandon J Lew, Tony W Wilson, Max J Kurz

{"title":"Alpha oscillations during visual selective attention are aberrant in youth and adults with cerebral palsy.","authors":"Rashelle M Hoffman, Michael P Trevarrow, Brandon J Lew, Tony W Wilson, Max J Kurz","doi":"10.1093/cercor/bhae365","DOIUrl":"10.1093/cercor/bhae365","url":null,"abstract":"Our understanding of the neurobiology underlying cognitive dysfunction in persons with cerebral palsy is very limited, especially in the neurocognitive domain of visual selective attention. This investigation utilized magnetoencephalography and an Eriksen arrow-based flanker task to quantify the dynamics underlying selective attention in a cohort of youth and adults with cerebral palsy (n = 31; age range = 9 to 47 yr) and neurotypical controls (n = 38; age range = 11 to 49 yr). The magnetoencephalography data were transformed into the time-frequency domain to identify neural oscillatory responses and imaged using a beamforming approach. The behavioral results indicated that all participants exhibited a flanker effect (greater response time for the incongruent compared to congruent condition) and that individuals with cerebral palsy were slower and less accurate during task performance. We computed interference maps to focus on the attentional component and found aberrant alpha (8 to 14 Hz) oscillations in the right primary visual cortices in the group with cerebral palsy. Alpha and theta (4 to 7 Hz) oscillations were also seen in the left and right insula, and these oscillations varied with age across all participants. Overall, persons with cerebral palsy exhibit deficiencies in the cortical dynamics serving visual selective attention, but these aberrations do not appear to be uniquely affected by age.","PeriodicalId":9715,"journal":{"name":"Cerebral cortex","volume":"34 9","pages":""},"PeriodicalIF":2.9,"publicationDate":"2024-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11374708/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142131909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Methylphenidate reduces spatial attentional bias by modulating fronto-striatal connectivity. 哌醋甲酯通过调节前额纹状体连接减少空间注意偏差

IF 2.9 2区医学

Cerebral cortex Pub Date : 2024-09-03 DOI: 10.1093/cercor/bhae379

Leehe Peled-Avron, Maryana Daood, Rachel Ben-Hayun, Michael Nevat, Judith Aharon-Peretz, Roee Admon, Rachel Tomer

{"title":"Methylphenidate reduces spatial attentional bias by modulating fronto-striatal connectivity.","authors":"Leehe Peled-Avron, Maryana Daood, Rachel Ben-Hayun, Michael Nevat, Judith Aharon-Peretz, Roee Admon, Rachel Tomer","doi":"10.1093/cercor/bhae379","DOIUrl":"10.1093/cercor/bhae379","url":null,"abstract":"Spatial attention bias reflects tendency to direct attention to specific side in space. This bias reflects asymmetric dopamine (DA) signaling in the striatum. Administration of DA agonists reduces spatial bias, yet the underlying mechanism is not yet clear. To address this, the current study tested whether methylphenidate (MPH; an indirect DA agonist) reduces orienting bias by modulating fronto-striatal connectivity. 54 adults with consistent bias completed the greyscales task which detects subtle biases during fMRI scanning under MPH (20 mg) or placebo, in a double-blind design. As hypothesized, MPH reduced bias by increasing orienting towards non-preferred hemispace, regardless of whether the initial bias was left or right. MPH-induced increases were found in activation of the medial superior frontal gyrus (mSFG: F[1;53] = 4.632, cluster-defining threshold of P < 0.05, minimal cluster size = 0, p_FWE = 0.036, η2 = 0.08) and its functional connectivity with the caudate (left caudate: F[1;53] = 12.664, p_FWE = 0.001, η2 = 0.192; right caudate: F[1;53] = 11.069, p_FWE = 0.002, η2 = 0.172), when orienting towards the non-preferred hemispace. MPH also reduced mSFG activation and fronto-striatal connectivity for the preferred hemispace. Results suggest modulation of frontal excitability due to increased caudate-mSFG functional connectivity. This mechanism may underlie the positive effect of dopaminergic agonists on abnormal patterns of directing attention in space.","PeriodicalId":9715,"journal":{"name":"Cerebral cortex","volume":"34 9","pages":""},"PeriodicalIF":2.9,"publicationDate":"2024-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142342449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0