Cerebral cortex最新文献

Exploring common and distinct neural basis of procrastination and impulsivity through elastic net regression.

IF 2.9 2区医学

Cerebral cortex Pub Date : 2025-01-14 DOI: 10.1093/cercor/bhae503

Yao Yin, Ti Su, Xueke Wang, Bowen Hu, Rong Zhang, Feng Zhou, Tingyong Feng

{"title":"Exploring common and distinct neural basis of procrastination and impulsivity through elastic net regression.","authors":"Yao Yin, Ti Su, Xueke Wang, Bowen Hu, Rong Zhang, Feng Zhou, Tingyong Feng","doi":"10.1093/cercor/bhae503","DOIUrl":"https://doi.org/10.1093/cercor/bhae503","url":null,"abstract":"Prior work highlighted that procrastination and impulsivity shared a common neuroanatomical basis in the dorsolateral prefrontal cortex, implying a tight relationship between these traits. However, theorists hold that procrastination is motivated by avoiding aversiveness, while impulsivity is driven by approaching immediate pleasure. Hence, exploring the common and distinct neural basis underlying procrastination and impulsivity through functional neuroimaging becomes imperative. To address this, we employed elastic net regression to examine the links between whole-brain resting-state functional connectivity and these traits in 822 university students from China. Results showed that the functional connections between the default network and the visual network were positively associated with both traits, indicating that the dysfunction of higher-order cognition (eg self-control) may account for their tight relationship. A distinct neural basis was also identified: Procrastination was negatively associated with functional connections between the frontal-parietal network and the ventral-attention network and between the cingular-opercular network and the subcortical network. In contrast, connections between the default network and the somato-motor network were negatively associated with impulsivity. These findings suggest that procrastination may be rooted in emotion-regulation deficits, while impulsivity may be rooted in reward-processing deficits. This deeper understanding of their neural basis provides insights for developing targeted interventions.","PeriodicalId":9715,"journal":{"name":"Cerebral cortex","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142977620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Contributions of short- and long-range white matter tracts in dynamic compensation with aging.

IF 2.9 2区医学

Cerebral cortex Pub Date : 2025-01-13 DOI: 10.1093/cercor/bhae496

Priyanka Chakraborty, Suman Saha, Gustavo Deco, Arpan Banerjee, Dipanjan Roy

{"title":"Contributions of short- and long-range white matter tracts in dynamic compensation with aging.","authors":"Priyanka Chakraborty, Suman Saha, Gustavo Deco, Arpan Banerjee, Dipanjan Roy","doi":"10.1093/cercor/bhae496","DOIUrl":"https://doi.org/10.1093/cercor/bhae496","url":null,"abstract":"Optimal brain function is shaped by a combination of global information integration, facilitated by long-range connections, and local processing, which relies on short-range connections and underlying biological factors. With aging, anatomical connectivity undergoes significant deterioration, which affects the brain's overall function. Despite the structural loss, previous research has shown that normative patterns of functions remain intact across the lifespan, defined as the compensatory mechanism of the aging brain. However, the crucial components in guiding the compensatory preservation of the dynamical complexity and the underlying mechanisms remain uncovered. Moreover, it remains largely unknown how the brain readjusts its biological parameters to maintain optimal brain dynamics with age; in this work, we provide a parsimonious mechanism using a whole-brain generative model to uncover the role of sub-communities comprised of short-range and long-range connectivity in driving the dynamic compensation process in the aging brain. We utilize two neuroimaging datasets to demonstrate how short- and long-range white matter tracts affect compensatory mechanisms. We unveil their modulation of intrinsic global scaling parameters, such as global coupling strength and conduction delay, via a personalized large-scale brain model. Our key finding suggests that short-range tracts predominantly amplify global coupling strength with age, potentially representing an epiphenomenon of the compensatory mechanism. This mechanistically explains the significance of short-range connections in compensating for the major loss of long-range connections during aging. This insight could help identify alternative avenues to address aging-related diseases where long-range connections are significantly deteriorated.","PeriodicalId":9715,"journal":{"name":"Cerebral cortex","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142977616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Can guilt enhance sensitivity to other's suffering? An EEG investigation into moral emotions and pain empathy.

IF 2.9 2区医学

Cerebral cortex Pub Date : 2025-01-09 DOI: 10.1093/cercor/bhae501

He Wang, Ye Zhang, Lihong Ao, Rui Huang, Yujia Meng, Shuyu Jia, XiuJun Zhang, Yingjie Liu

{"title":"Can guilt enhance sensitivity to other's suffering? An EEG investigation into moral emotions and pain empathy.","authors":"He Wang, Ye Zhang, Lihong Ao, Rui Huang, Yujia Meng, Shuyu Jia, XiuJun Zhang, Yingjie Liu","doi":"10.1093/cercor/bhae501","DOIUrl":"https://doi.org/10.1093/cercor/bhae501","url":null,"abstract":"As a unique form of empathy, pain empathy often has a close relationship with society and morality. Research has revealed that moral emotions can influence pain empathy. The underlying physiological mechanism still needs to be further examined to understand how moral emotions affect pain empathy. This study employs EEG and Machine Learning techniques, using a painful image induction paradigm to explore the impact of moral emotion (guilt)-on pain empathy and its neural mechanisms. Participants without pain sensation were instructed to observe and evaluate pictures of an anonymous hand in painful or non-painful pictures under feelings of guilt or neutral emotion. Results found slower reaction times and higher pain ratings for painful pictures. Furthermore, guilt led to higher pain ratings. Under conditions of painful pictures, guilt-induced greater P3(350-450ms) amplitudes and higher α oscillations and enhanced the functional connectivity between the prefrontal cortex, the central frontal region, and the parieto-occipital lobe. K-nearest neighbor can effectively classify high and low-pain empathy under guilt emotion. The result showed that guilt promotes the brain's processing of painful picture, causing individuals to pay high attention and engage in deep cognitive processing. This study provides insights into enhancing empathy and fostering interpersonal relationships.","PeriodicalId":9715,"journal":{"name":"Cerebral cortex","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142945265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Extending insights from LeDoux: using movies to study subjective, clinically meaningful experiences in neuroscience. 扩展勒杜的见解：利用电影研究神经科学中具有临床意义的主观体验。

IF 2.9 2区医学

Cerebral cortex Pub Date : 2025-01-08 DOI: 10.1093/cercor/bhae422

Peter A Kirk, Daniel S Pine, Katharina Kircanski

{"title":"Extending insights from LeDoux: using movies to study subjective, clinically meaningful experiences in neuroscience.","authors":"Peter A Kirk, Daniel S Pine, Katharina Kircanski","doi":"10.1093/cercor/bhae422","DOIUrl":"10.1093/cercor/bhae422","url":null,"abstract":"Neuroscience research with public health relevance to emotional disorders examines brain-behavior relations. Joe LeDoux's legacy advances these efforts in ways that remain truly unique. While recognized for his basic science research, he also inspires applied researchers, guiding an agenda for clinical scientists: understanding the pathophysiology of altered subjective experiences in emotional disorders. For brain imaging, movie-watching approaches help clinicians realize this agenda due to movies' relative strength in evoking rich, meaningful subjective experiences. Here, we describe methodological advances in movie-watching paradigms that might sustain LeDoux's impact by facilitating the discovery of neural mechanisms generating complex emotional responses. Of note, while linking subjective emotion to pathophysiology is a first step, innovations in movie-watching designs, especially involving therapeutic techniques for emotional disorders, can boost clinical application. Leveraging research on pathophysiology to generate novel therapy reflects the clinical legacy sustained through Joe LeDoux's rousing career.","PeriodicalId":9715,"journal":{"name":"Cerebral cortex","volume":" ","pages":"58-64"},"PeriodicalIF":2.9,"publicationDate":"2025-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11712263/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142459029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fear, learning, and the amygdala: a personal reflection in honor of Joseph LeDoux. 恐惧、学习和杏仁核：纪念约瑟夫-勒杜的个人思考。

IF 2.9 2区医学

Cerebral cortex Pub Date : 2025-01-08 DOI: 10.1093/cercor/bhae394

Kevin S LaBar

引用次数: 0

Honoring the legacy of Joseph E. LeDoux: introduction to the Special Issue. 纪念约瑟夫-E-勒杜的遗产：特刊导言。

IF 2.9 2区医学

Cerebral cortex Pub Date : 2025-01-08 DOI: 10.1093/cercor/bhae463

Daniela Schiller, Joshua Johansen, Linnaea Ostroff

引用次数: 0

When emotion and time meet from human and rodent perspectives: a central role for the amygdala? 从人类和啮齿动物的角度看情感与时间的交汇：杏仁核的核心作用？

IF 2.9 2区医学

Cerebral cortex Pub Date : 2025-01-08 DOI: 10.1093/cercor/bhae454

Valérie Doyère, Sylvie Droit-Volet

{"title":"When emotion and time meet from human and rodent perspectives: a central role for the amygdala?","authors":"Valérie Doyère, Sylvie Droit-Volet","doi":"10.1093/cercor/bhae454","DOIUrl":"10.1093/cercor/bhae454","url":null,"abstract":"Initiated by a long stay of Valérie Doyère in the laboratory of Joseph LeDoux, a Franco-American collaborative group was formed around the topic of emotion and time perception in a comparative perspective between humans and non-human animals. Here, we discuss results from our studies on the mechanisms underlying time distortion under 2 conditions, timing of a threatening stimulus and timing of a neutral stimulus in the context of fear, with insights from neurodevelopment. Although the type of temporal distortion depends on the experimental situations, in both humans and rodents a high-arousal emotion automatically triggers acceleration of an \"internal clock\" system, an effect that may rely on the early maturing amygdala. Our studies, particularly in humans, also point to the role of attention and self-awareness in regulating the effect of fear on timing, relying on the prefrontal cortex, a late maturing structure. Thus, in line with LeDoux, while the amygdala may process all characteristics of events (including time) necessary to quickly trigger appropriate survival behaviors, some type of time distortions may rely on higher-order processing, some specific to humans. The extent of the network underlying threat-related time distortions remains to be explored, with species comparisons being a promising means of investigation.","PeriodicalId":9715,"journal":{"name":"Cerebral cortex","volume":" ","pages":"34-41"},"PeriodicalIF":2.9,"publicationDate":"2025-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142692784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

How to interpret LeDoux's multistate hierarchical theory of consciousness. 如何解读勒杜的意识多态层次理论。

IF 2.9 2区医学

Cerebral cortex Pub Date : 2025-01-08 DOI: 10.1093/cercor/bhae389

Richard Brown

引用次数: 0

On role models and Joe LeDoux. 关于榜样和乔-勒杜。

IF 2.9 2区医学

Cerebral cortex Pub Date : 2025-01-08 DOI: 10.1093/cercor/bhae417

Sheena A Josselyn

{"title":"On role models and Joe LeDoux.","authors":"Sheena A Josselyn","doi":"10.1093/cercor/bhae417","DOIUrl":"10.1093/cercor/bhae417","url":null,"abstract":"Joseph LeDoux is a pioneering neuroscientist who has made profound discoveries that continue to impact our understanding of the neural basis of emotion and memory, particularly the role of the amygdala in threat conditioning. LeDoux's trailblazing and elegant studies were some of the first to examine the circuit basis of behavior. His work combined techniques to trace pathways into and out of the amygdala important for threat conditioning and related behaviors. Since that time, these types of circuit tracing studies have exploded in popularity across neuroscience, and I would argue, we all owe a debt to LeDoux for this. LeDoux has made numerous additional contributions to neuroscience and, by bringing emotion back to neuroscience, has helped unite neuroscience with psychology. A gifted writer with a knack for communicating complicated scientific ideas in an accessible manner, LeDoux has become an ambassador of science who uses his love of music to help educate and inspire. Perhaps more important than these laudable scientific achievements, LeDoux is also a true \"gentleman\" of science, showing that science need not be a contact sport. Here, I give a personal account on why Joseph LeDoux is one of my scientific role models.","PeriodicalId":9715,"journal":{"name":"Cerebral cortex","volume":" ","pages":"15-18"},"PeriodicalIF":2.9,"publicationDate":"2025-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11712266/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142459030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

My science and career with Joseph E. LeDoux. 我与约瑟夫-E-勒杜的科学和职业生涯

IF 2.9 2区医学

Cerebral cortex Pub Date : 2025-01-08 DOI: 10.1093/cercor/bhae466

Elizabeth A Phelps

引用次数: 0