Cerebral cortex最新文献

Sensorimotor expertise effects extend from dance to face perception. 感觉运动专长效应从舞蹈延伸到面部感知。

IF 3 2区医学

Cerebral cortex Pub Date : 2026-11-04 DOI: 10.1093/cercor/bhag186

Vasiliki Meletaki, Bettina Forster, Beatriz Calvo-Merino

{"title":"Sensorimotor expertise effects extend from dance to face perception.","authors":"Vasiliki Meletaki, Bettina Forster, Beatriz Calvo-Merino","doi":"10.1093/cercor/bhag186","DOIUrl":"10.1093/cercor/bhag186","url":null,"abstract":"Domain specific expertise affects neural and behavioral processes of perception and memory. We explore if sensorimotor expertise extends to other relevant social mechanisms, such as the neural processing of emotional faces. We recorded brain activity of 26 dancers and 26 non-dancers using visual and somatosensory evoked potentials (VEPs, SEPs) during an emotion and sex discrimination task on happy, afraid, and neutral faces. We predicted expertise-related modulation of visual facial emotion processing in visual and somatosensory areas. EEG results revealed distinct visual and somatosensory ERP patterns in the two groups. VEP findings showed that dancers distinguished between neutral and emotional faces at N170 and P200. Non-dancers differentiated between the three emotions with more lateralized processing. For SEPs, dancers uniquely showed early emotion effects (P50) in central somatosensory regions and task-modulated somatosensory engagement at later stages (N80, P100). Non-dancers showed later, localized somatosensory effects. In summary, dance expertise shapes both visual and somatosensory processing of facial emotion, indicating a broader neural representation of emotions. These findings provide novel evidence for a differential facial emotion processing in dancers, extending the dance expertise modulation beyond perception of dance-specific stimuli, to face emotion perception. Overall, this work highlights the strong influence of sensorimotor training on emotion perception.","PeriodicalId":9715,"journal":{"name":"Cerebral cortex","volume":"36 11","pages":""},"PeriodicalIF":3.0,"publicationDate":"2026-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13744284/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149370018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cannabidiol and fronto-parietal EEG connectivity in autistic children. 大麻二酚与自闭症儿童额顶叶脑电图连通性的关系。

IF 3 2区医学

Cerebral cortex Pub Date : 2026-11-04 DOI: 10.1093/cercor/bhag188

Nina-Francesca Parrella, Aron T Hill, Peter G Enticott, Luke A Downey, Sarah Catchlove, Talitha C Ford

{"title":"Cannabidiol and fronto-parietal EEG connectivity in autistic children.","authors":"Nina-Francesca Parrella, Aron T Hill, Peter G Enticott, Luke A Downey, Sarah Catchlove, Talitha C Ford","doi":"10.1093/cercor/bhag188","DOIUrl":"10.1093/cercor/bhag188","url":null,"abstract":"Autistic children often show altered brain network connectivity, including circuitry implicated in social cognition. Cannabidiol (CBD) has emerged as a potential therapy for autism, but its neural mechanisms remain under-researched. Here, we analyze resting-state data collected as part of a double-blind, placebo-controlled crossover trial, to explore whether 12 weeks of oral CBD oil could modulate functional connectivity in autistic children. Twenty-nine autistic children (5 to 12 years) completed two 12-week intervention periods (CBD and placebo, randomized) separated by an 8-week washout. Before and after each period, 5 min of eyes-open resting-state electroencephalography (EEG) were obtained from a subset of 18 participants (8 female). Functional connectivity was calculated across 16 electrode-pairs in the delta, theta, alpha, beta, and gamma bands. Beta-band connectivity between the right frontal and right inferior-parietal electrodes increased following CBD (P = 0.001, false discovery rate [FDR]-corrected P [pFDR] = 0.022), and alpha connectivity showed an increase that did not remain following FDR correction (P = 0.036, pFDR = 0.428). No significant differences were observed following placebo for any frequency band (pFDR > 0.69). This study provides preliminary evidence that 12 weeks of cannabidiol is associated with an increase in right fronto-parietal (F4-P8) functional connectivity in autistic children, most pronounced in the beta-band. Replication in larger samples is needed to confirm generalizability and clinical relevance.","PeriodicalId":9715,"journal":{"name":"Cerebral cortex","volume":"36 11","pages":""},"PeriodicalIF":3.0,"publicationDate":"2026-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13733498/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149332677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neurobehavioral correlates of changing one's mind in ADHD and OCD. ADHD和OCD患者改变想法的神经行为关联。

IF 3 2区医学

Cerebral cortex Pub Date : 2026-11-04 DOI: 10.1093/cercor/bhag187

Katharina Zühlsdorff, Jeffrey W Dalley, Trevor W Robbins, Sharon Morein-Zamir

{"title":"Neurobehavioral correlates of changing one's mind in ADHD and OCD.","authors":"Katharina Zühlsdorff, Jeffrey W Dalley, Trevor W Robbins, Sharon Morein-Zamir","doi":"10.1093/cercor/bhag187","DOIUrl":"https://doi.org/10.1093/cercor/bhag187","url":null,"abstract":"Cognitive flexibility is an executive function that allows individuals to adjust behavior in response to changing environmental demands. We assessed volitional switching under uncertainty, without rule-based learning, in the \"Change Your Mind\" task. Nineteen patients with obsessive-compulsive disorder (OCD), 19 patients with attention-deficit hyperactivity disorder (ADHD) and matched control participants (20 per group) completed the task while undergoing a functional MRI scan. The task was a two-alternative forced choice paradigm where each stimulus was presented twice successively, with spurious feedback following the first presentation. This allowed participants the opportunity to repeat or change their response. Participants with ADHD changed their response more frequently than controls following a previously correct response, associated with reduced accuracy on the second trial. This was accompanied with smaller differences between change and repeat trials in the superior frontal gyrus, paracingulate gyrus, and frontal pole compared to controls. Participants with OCD did not differ from healthy controls in their performance but exhibited greater activity on both change and repeat trials in the pre- and postcentral gyri than controls. These results point to distinct neurobehavioral differences in patients with ADHD and OCD underlying what is often termed more broadly inflexible behavior.","PeriodicalId":9715,"journal":{"name":"Cerebral cortex","volume":"36 11","pages":""},"PeriodicalIF":3.0,"publicationDate":"2026-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149377559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dissociable contributions of cortical thickness and surface area to cognitive aging: evidence from multiple longitudinal cohorts. 皮质厚度和表面积对认知衰老的可分离贡献：来自多个纵向队列的证据。

IF 3 2区医学

Cerebral cortex Pub Date : 2026-10-06 DOI: 10.1093/cercor/bhag181

Ina Demetriou, Marta Correia, Didac Vidal-Piñeiro, Simon E Fisher, Else Eising, Valentina Escott-Price, Matthew Bracher-Smith, Dace Apšvalka, Adam Attaheri, Tina Emery, Richard N Henson

{"title":"Dissociable contributions of cortical thickness and surface area to cognitive aging: evidence from multiple longitudinal cohorts.","authors":"Ina Demetriou, Marta Correia, Didac Vidal-Piñeiro, Simon E Fisher, Else Eising, Valentina Escott-Price, Matthew Bracher-Smith, Dace Apšvalka, Adam Attaheri, Tina Emery, Richard N Henson","doi":"10.1093/cercor/bhag181","DOIUrl":"10.1093/cercor/bhag181","url":null,"abstract":"Cortical volume, a widely-used marker of brain aging, is the product of two genetically and developmentally dissociable morphometric features: thickness and area. However, it remains unclear whether these two features have dissociable consequences for cognitive aging. To address this, we analyze cross-sectional and longitudinal neuroimaging and cognitive data from one discovery cohort (Cam-CAN) and two independent, pre-registered replication cohorts (OASIS-3 and HABS-HD), leveraging wide age ranges across adulthood, different follow-up intervals and diverse population backgrounds. We show that thickness declines more steeply with age than does area, and shows stronger associations with longitudinal change in fluid cognitive abilities, fairly uniformly across the cortex. Cognitive change is also dependent on baseline thickness, independent of thickness change and independent of baseline cognitive ability. In contrast, area is comparatively stable across adulthood, at least until old age, and shows weaker and more heterogeneous associations with cognitive change. Together, these findings help to reconcile inconsistencies in the literature, and indicate that thickness provides a more sensitive marker of dynamic neurobiological processes underlying cognitive aging, whereas area seems to reflect primarily stable, trait-like variation in cognitive ability.","PeriodicalId":9715,"journal":{"name":"Cerebral cortex","volume":"36 10","pages":""},"PeriodicalIF":3.0,"publicationDate":"2026-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13704776/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149263356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reduced social brain coupling to others' face threats in narcissism. 在自恋中，减少了社会大脑对他人面部威胁的耦合。

IF 3 2区医学

Cerebral cortex Pub Date : 2026-10-06 DOI: 10.1093/cercor/bhag175

Matias Piispanen, Jarno Tuominen, Mariel Wuolio, Pentti Henttonen, Ville J Harjunen, Emmi Koskinen, Elizabeth Krusemark, Enrico Glerean, Pärttyli Rinne, Mikko Sams, Anssi Peräkylä, Juha Salmi

{"title":"Reduced social brain coupling to others' face threats in narcissism.","authors":"Matias Piispanen, Jarno Tuominen, Mariel Wuolio, Pentti Henttonen, Ville J Harjunen, Emmi Koskinen, Elizabeth Krusemark, Enrico Glerean, Pärttyli Rinne, Mikko Sams, Anssi Peräkylä, Juha Salmi","doi":"10.1093/cercor/bhag175","DOIUrl":"10.1093/cercor/bhag175","url":null,"abstract":"Although several studies have linked narcissism to reduced empathy, the neural mechanisms underlying narcissistic behavior in socially complex, naturalistic contexts remain poorly understood. This study investigated how grandiose narcissistic traits are associated with neural dynamics in empathy-related areas of the \"social brain\" when participants observed another person receiving face-threatening feedback. We hypothesized that individuals with high narcissistic traits would exhibit lower intersubject correlation (ISC), indicating less synchronized neural responses across participants, in the anterior insula (aINS), dorsolateral prefrontal cortex (dlPFC), and posterior cingulate cortex (PCC) in response to face threats directed at others. Participants with high (n = 28) and low (n = 30) scores in grandiose narcissism watched videos during functional magnetic resonance imaging in which another person received face-threatening feedback to a personal story. Consistent with our hypothesis, highly narcissistic individuals exhibited reduced ISC in the dlPFC and PCC. In aINS, the effect did not reach statistical significance. The present findings suggest that trait narcissism reduces convergence in empathic responses particularly in areas related to cognitive empathy when witnessing social threats targeted at others. These findings further indicate that ecologically relevant experimental designs may help clarify how personality traits are expressed in neural responses to socially meaningful events.","PeriodicalId":9715,"journal":{"name":"Cerebral cortex","volume":"36 10","pages":""},"PeriodicalIF":3.0,"publicationDate":"2026-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13709960/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149263311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Laplace-based cortical thickness without volumetric discretisation. 无体积离散的拉普拉斯皮质厚度。

IF 3 2区医学

Cerebral cortex Pub Date : 2026-10-06 DOI: 10.1093/cercor/bhag179

Alastair Snell, David Reutens, Jiaxin Du, Viktor Vegh

{"title":"Laplace-based cortical thickness without volumetric discretisation.","authors":"Alastair Snell, David Reutens, Jiaxin Du, Viktor Vegh","doi":"10.1093/cercor/bhag179","DOIUrl":"https://doi.org/10.1093/cercor/bhag179","url":null,"abstract":"Laplace-based methods define cortical thickness as the length of a streamline connecting the pial and white surfaces, but existing implementations discretize the volume and lose accuracy in tight folds. Surface-based methods use Euclidean inter-surface distances that cannot enforce orthogonal, non-crossing correspondences. We solve Laplace's equation on the cortical surface itself using a boundary element method, with pial and white surfaces as Dirichlet boundaries and the surrounding edge Neumann boundaries; thickness is the length of a streamline traced along the analytic gradient field. We tested 8044 streamlines across analytical shapes, synthetic gyral patches, and real cortices; reciprocal paths returned within 0.05 mm of their origin, with 95th-percentile asymmetry below 0.68%. On folded patches with known ground truth, length-normalized bias was 0.0003 mm/mm independent of curvature. Streamline validity remained near-complete above a mean triangle shape quality of 0.90 and degraded sharply below 0.80, defining a practical mesh threshold. In three focal cortical dysplasia patients, each imaged at 3 T and 7 T, the method resolved focal thickening at the lesion site, with contralateral cortex mapped alongside as a visual reference. Vertex-wise comparison against FreeSurfer on identical surfaces showed differences scaling with local curvature. The observed bias is over an order of magnitude below preclinical Alzheimer's thinning rates.","PeriodicalId":9715,"journal":{"name":"Cerebral cortex","volume":"36 10","pages":""},"PeriodicalIF":3.0,"publicationDate":"2026-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149263270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Global feature-based suppression without local target competition. 无局部目标竞争的全局特征抑制。

IF 3 2区医学

Cerebral cortex Pub Date : 2026-10-06 DOI: 10.1093/cercor/bhag182

Gundlach Christopher, Müller Matthias M

{"title":"Global feature-based suppression without local target competition.","authors":"Gundlach Christopher, Müller Matthias M","doi":"10.1093/cercor/bhag182","DOIUrl":"https://doi.org/10.1093/cercor/bhag182","url":null,"abstract":"Feature-based attention (FBA) enables the prioritization of behaviorally relevant stimulus features across the visual field by enhancing processing of attended and suppressing unattended information. While global amplification of attended features is well established, it remains unclear whether suppression of unattended features reflects a global mechanism or depends on local spatial competition with attended stimuli. Here, we tested whether suppression of unattended colors requires direct local competition with the attended color. Participants performed a feature-based attentional shifting task while viewing centrally task-relevant and peripherally task-irrelevant, frequency-tagged random-dot kinematograms. By systematically varying the combination of attended and unattended colors in the periphery, we isolated the conditions under which suppression emerges. Steady-state visual evoked potentials were used to track neural modulations in early sensory processing. As expected, cueing a particular color led to robust global amplification of the attended color. Critically, unattended colors were suppressed globally irrespective of whether they were presented together with the attended color. These findings demonstrate that suppression of unattended features does not require direct competition with the attended feature. FBA operates via global allocation of attentional resources that enhances attended features while suppressing non-attended features, consistent with accounts combining feature-similarity gain and biased competition.","PeriodicalId":9715,"journal":{"name":"Cerebral cortex","volume":"36 10","pages":""},"PeriodicalIF":3.0,"publicationDate":"2026-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149263282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The functional lateralization of white matter with sex differences. 脑白质功能侧化与性别差异。

IF 3 2区医学

Cerebral cortex Pub Date : 2026-10-06 DOI: 10.1093/cercor/bhag178

Zhuo-Yan Cai, Kang Hu, Ze-Qiang Linli

{"title":"The functional lateralization of white matter with sex differences.","authors":"Zhuo-Yan Cai, Kang Hu, Ze-Qiang Linli","doi":"10.1093/cercor/bhag178","DOIUrl":"https://doi.org/10.1093/cercor/bhag178","url":null,"abstract":"Numerous studies indicate that the brain demonstrates functional lateralization with distinct patterns between males and females, but they primarily have focused on gray matter, with only a handful considering white matter (WM) and sex differences. Utilizing rs-fMRI from the Southwest University Longitudinal Imaging Multimodal (SLIM) dataset, we quantified lateralization of WM as the difference in each region's synchronization with the left versus right hemisphere, and examined its temporal fluctuations and sex differences. Then, the Louvain community detection algorithm clustered lateralization patterns, and sex differences within each cluster were analyzed. We established the functional connectivity network, assessed its properties, and utilized correlation analysis to examine the relationship between lateralization and network. Our analyses revealed that WM demonstrated a left-lateralized trend in the left hemisphere and a right-lateralized trend in the right hemisphere. Moreover, functional lateralization was more pronounced in males than females. We also categorized the regions into three spatial clusters, revealing sex differences in the lateralization patterns within each cluster. Additionally, lateralization patterns are intricately associated with the functional connectivity network. These findings provide insights into functional lateralization and sex differences, and may inform future investigations of the neural mechanisms associated with functional specialization, cognition, behavior, and neurological disorders.","PeriodicalId":9715,"journal":{"name":"Cerebral cortex","volume":"36 10","pages":""},"PeriodicalIF":3.0,"publicationDate":"2026-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149263268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Temporal brain dynamics and fluid reasoning after extreme prematurity. 极度早产后的颞脑动力学和流体推理。

IF 3 2区医学

Cerebral cortex Pub Date : 2026-10-06 DOI: 10.1093/cercor/bhag174

Nelly Padilla, Anira Escrichs, Elvira Del Agua, Morten Kringelbach, Antonio Donaire, Gustavo Deco, Ulrika Åden

{"title":"Temporal brain dynamics and fluid reasoning after extreme prematurity.","authors":"Nelly Padilla, Anira Escrichs, Elvira Del Agua, Morten Kringelbach, Antonio Donaire, Gustavo Deco, Ulrika Åden","doi":"10.1093/cercor/bhag174","DOIUrl":"10.1093/cercor/bhag174","url":null,"abstract":"Extremely preterm (EPT) birth (<28 weeks' gestation) disrupts brain maturation and increases later neurodevelopmental and mental health vulnerability. Temporal irreversibility quantifies directional brain dynamics, capturing the temporal organization of brain function. We examined whether EPT birth alters temporal irreversibility at 10 years and its association with cognition at 12 years. Resting-state functional MRI was acquired at 10 years of age in 33 children born EPT and 26 term-born controls. At 12 years of age, 29 children born EPT and 21 term-born controls underwent cognitive assessment using the Wechsler Intelligence Scale for Children-Fifth edition (WISC-V). Temporal irreversibility was quantified globally, across large-scale functional networks (visual, somatomotor, dorsal attention, salience, limbic, control, and default mode [DMN]), and at the node level using the INSIDEOUT framework. Children born EPT showed reduced temporal irreversibility globally and in higher-order association networks (control and DMN, P < 0.01; dorsal attention and salience, P < 0.05). Node-level analyses identified two association-network parcels that remained significant after false discovery rate correction (left precuneus and right dorsomedial frontal cortices). Within the EPT group, fluid reasoning was the only WISC-V domain significantly associated with temporal irreversibility, with higher global irreversibility associated with poorer fluid reasoning. These findings may inform future neurodevelopmental monitoring and intervention strategies after prematurity.","PeriodicalId":9715,"journal":{"name":"Cerebral cortex","volume":"36 10","pages":""},"PeriodicalIF":3.0,"publicationDate":"2026-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13677789/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149219771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

IF 3 2区医学

Cerebral cortex Pub Date : 2026-10-06 DOI: 10.1093/cercor/bhag171

James P Lister, Alison E Comrie, Carol A Barnes

{"title":"Age-related differences in behavior-driven activity in LEC but not MEC.","authors":"James P Lister, Alison E Comrie, Carol A Barnes","doi":"10.1093/cercor/bhag171","DOIUrl":"10.1093/cercor/bhag171","url":null,"abstract":"The hippocampus integrates spatial information from medial entorhinal cortex (MEC) with non-spatial sensory information from lateral entorhinal cortex (LEC) to form episodic memories. While age-related memory dysfunction is linked to several changes in neuronal function within hippocampal subfields, the effects of aging on MEC and LEC cellular activity patterns are less well-characterized. Here, we investigated MEC and LEC population activity in adult versus aged rats by monitoring the expression of the immediate early gene Arc across two behavioral task sessions with olfactory stimuli separated by a rest period. Aging did not affect the percentage of activated neurons in MEC or their consistent Arc expression patterns across sessions, consistent with stably coding repeated spatial experiences. In contrast, fewer LEC neurons were activated during behavior in aged than adult rats, indicating a specific age-associated hypoactivity in LEC. Additionally, regardless of group, more LEC neurons were activated during the second session compared to the first, which may reflect temporally sensitive LEC neuronal activity increasingly engaged across episodes of experience. These results indicate that aging affects input to the hippocampus in a region-specific manner and are also consistent with observations that suggest that some LEC neurons may provide a temporal tag for episodic memories.","PeriodicalId":9715,"journal":{"name":"Cerebral cortex","volume":"36 10","pages":""},"PeriodicalIF":3.0,"publicationDate":"2026-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13677780/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149219758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0