Cerebral cortex最新文献_第10页

Fear, learning, and the amygdala: a personal reflection in honor of Joseph LeDoux. 恐惧、学习和杏仁核：纪念约瑟夫-勒杜的个人思考。

IF 2.9 2区医学

Cerebral cortex Pub Date : 2025-01-08 DOI: 10.1093/cercor/bhae394

Kevin S LaBar

引用次数: 0

Honoring the legacy of Joseph E. LeDoux: introduction to the Special Issue. 纪念约瑟夫-E-勒杜的遗产：特刊导言。

IF 2.9 2区医学

Cerebral cortex Pub Date : 2025-01-08 DOI: 10.1093/cercor/bhae463

Daniela Schiller, Joshua Johansen, Linnaea Ostroff

引用次数: 0

When emotion and time meet from human and rodent perspectives: a central role for the amygdala? 从人类和啮齿动物的角度看情感与时间的交汇：杏仁核的核心作用？

IF 2.9 2区医学

Cerebral cortex Pub Date : 2025-01-08 DOI: 10.1093/cercor/bhae454

Valérie Doyère, Sylvie Droit-Volet

{"title":"When emotion and time meet from human and rodent perspectives: a central role for the amygdala?","authors":"Valérie Doyère, Sylvie Droit-Volet","doi":"10.1093/cercor/bhae454","DOIUrl":"10.1093/cercor/bhae454","url":null,"abstract":"Initiated by a long stay of Valérie Doyère in the laboratory of Joseph LeDoux, a Franco-American collaborative group was formed around the topic of emotion and time perception in a comparative perspective between humans and non-human animals. Here, we discuss results from our studies on the mechanisms underlying time distortion under 2 conditions, timing of a threatening stimulus and timing of a neutral stimulus in the context of fear, with insights from neurodevelopment. Although the type of temporal distortion depends on the experimental situations, in both humans and rodents a high-arousal emotion automatically triggers acceleration of an \"internal clock\" system, an effect that may rely on the early maturing amygdala. Our studies, particularly in humans, also point to the role of attention and self-awareness in regulating the effect of fear on timing, relying on the prefrontal cortex, a late maturing structure. Thus, in line with LeDoux, while the amygdala may process all characteristics of events (including time) necessary to quickly trigger appropriate survival behaviors, some type of time distortions may rely on higher-order processing, some specific to humans. The extent of the network underlying threat-related time distortions remains to be explored, with species comparisons being a promising means of investigation.","PeriodicalId":9715,"journal":{"name":"Cerebral cortex","volume":" ","pages":"34-41"},"PeriodicalIF":2.9,"publicationDate":"2025-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142692784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

How to interpret LeDoux's multistate hierarchical theory of consciousness. 如何解读勒杜的意识多态层次理论。

IF 2.9 2区医学

Cerebral cortex Pub Date : 2025-01-08 DOI: 10.1093/cercor/bhae389

Richard Brown

引用次数: 0

On role models and Joe LeDoux. 关于榜样和乔-勒杜。

IF 2.9 2区医学

Cerebral cortex Pub Date : 2025-01-08 DOI: 10.1093/cercor/bhae417

Sheena A Josselyn

{"title":"On role models and Joe LeDoux.","authors":"Sheena A Josselyn","doi":"10.1093/cercor/bhae417","DOIUrl":"10.1093/cercor/bhae417","url":null,"abstract":"Joseph LeDoux is a pioneering neuroscientist who has made profound discoveries that continue to impact our understanding of the neural basis of emotion and memory, particularly the role of the amygdala in threat conditioning. LeDoux's trailblazing and elegant studies were some of the first to examine the circuit basis of behavior. His work combined techniques to trace pathways into and out of the amygdala important for threat conditioning and related behaviors. Since that time, these types of circuit tracing studies have exploded in popularity across neuroscience, and I would argue, we all owe a debt to LeDoux for this. LeDoux has made numerous additional contributions to neuroscience and, by bringing emotion back to neuroscience, has helped unite neuroscience with psychology. A gifted writer with a knack for communicating complicated scientific ideas in an accessible manner, LeDoux has become an ambassador of science who uses his love of music to help educate and inspire. Perhaps more important than these laudable scientific achievements, LeDoux is also a true \"gentleman\" of science, showing that science need not be a contact sport. Here, I give a personal account on why Joseph LeDoux is one of my scientific role models.","PeriodicalId":9715,"journal":{"name":"Cerebral cortex","volume":" ","pages":"15-18"},"PeriodicalIF":2.9,"publicationDate":"2025-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11712266/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142459030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

My science and career with Joseph E. LeDoux. 我与约瑟夫-E-勒杜的科学和职业生涯

IF 2.9 2区医学

Cerebral cortex Pub Date : 2025-01-08 DOI: 10.1093/cercor/bhae466

Elizabeth A Phelps

引用次数: 0

Emotional future simulations: neural and cognitive perspectives. 情感未来模拟：神经和认知视角。

IF 2.9 2区医学

Cerebral cortex Pub Date : 2025-01-08 DOI: 10.1093/cercor/bhae388

Daniel L Schacter, Sarah E Kalinowski, Jenna M Wilson

引用次数: 0

On the bright side of blindsight. Considerations from new observations of awareness in a blindsight patient. 盲视的光明面。从对盲视患者意识的新观察中得出的思考。

IF 2.9 2区医学

Cerebral cortex Pub Date : 2025-01-08 DOI: 10.1093/cercor/bhae456

Beatrice de Gelder, Nicholas Humphrey, Alan J Pegna

引用次数: 0

Introspective psychophysics for the study of subjective experience. 研究主观体验的内省心理物理学。

IF 2.9 2区医学

Cerebral cortex Pub Date : 2025-01-08 DOI: 10.1093/cercor/bhae455

Megan A K Peters

{"title":"Introspective psychophysics for the study of subjective experience.","authors":"Megan A K Peters","doi":"10.1093/cercor/bhae455","DOIUrl":"10.1093/cercor/bhae455","url":null,"abstract":"Studying subjective experience is hard. We believe that pain is not identical to nociception, nor pleasure a computational reward signal, nor fear the activation of \"threat circuitry\". Unfortunately, introspective self-reports offer our best bet for accessing subjective experience, but many still believe that introspection is \"unreliable\" and \"unverifiable\". But which of introspection's faults do we find most damning? Is it that introspection provides imperfect access to brain processes (e.g. perception, memory)? That subjective experience is not objectively verifiable? That it is hard to isolate from non-subjective processing capacity? Here, I argue none of these prevents us from building a meaningful, impactful psychophysical research program that treats subjective experience as a valid empirical target through precisely characterizing relationships among environmental variables, brain processes and behavior, and self-reported phenomenology. Following recent similar calls by Peters (Towards characterizing the canonical computations generating phenomenal experience. 2022. Neurosci Biobehav Rev: 142, 104903), Kammerer and Frankish (What forms could introspective systems take? A research programme. 2023. J Conscious Stud 30:13-48), and Fleming (Metacognitive psychophysics in humans, animals, and AI. 2023. J Conscious Stud 30:113-128), \"introspective psychophysics\" thus treats introspection's apparent faults as features, not bugs-just as the noise and distortions linking environment to behavior inspired Fechner's psychophysics over 150 years ago. This next generation of psychophysics will establish a powerful tool for building and testing precise explanatory models of phenomenology across many dimensions-urgency, emotion, clarity, vividness, confidence, and more.","PeriodicalId":9715,"journal":{"name":"Cerebral cortex","volume":" ","pages":"49-57"},"PeriodicalIF":2.9,"publicationDate":"2025-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142680885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Examining threat responses through a developmental lens. 从发展的角度审视威胁反应。

IF 2.9 2区医学

Cerebral cortex Pub Date : 2025-01-08 DOI: 10.1093/cercor/bhae449

B J Casey, Yen-Chu Lin, Heidi C Meyer

{"title":"Examining threat responses through a developmental lens.","authors":"B J Casey, Yen-Chu Lin, Heidi C Meyer","doi":"10.1093/cercor/bhae449","DOIUrl":"10.1093/cercor/bhae449","url":null,"abstract":"Adolescence has been characterized by risk taking and fearlessness. Yet, the emergence of anxiety disorders that are associated with fear peaks during this developmental period. Moreover, adolescents show heightened sensitivity to stress relative to children and adults. To address inconsistencies between the common characterization of adolescents as fearless and the evidence of heightened anxiety and stress during this time, we build upon foundational discoveries of threat-related circuitry and behavior in adult rodents by Joseph LeDoux and colleagues. Specifically, the conservation of this circuitry across species has provided opportunities for identifying mechanisms underlying threat responses that we have extended to developing humans and rodents. We elucidate situations in which adolescents show heightened threat responses and others where they appear fearless and link them to developmental changes of threat circuitry during this period. We discuss the potential adaptiveness of these threat responses for survival of the individual and species but also the potential risks for anxiety and stress. We end by offering potential new ways in which behavioral treatments for youth with anxiety and stress-related disorders may be optimized to target the developing vs developed brain.","PeriodicalId":9715,"journal":{"name":"Cerebral cortex","volume":" ","pages":"19-33"},"PeriodicalIF":2.9,"publicationDate":"2025-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142675292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0