Cerebral cortex最新文献

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Goal-directed learning is multidimensional and accompanied by diverse and widespread changes in neocortical signaling. 目标导向学习是多维的,并伴随着新皮层信号的多样化和广泛变化。
IF 2.9 2区 医学
Cerebral cortex Pub Date : 2024-08-01 DOI: 10.1093/cercor/bhae328
Krista Marrero, Krithiga Aruljothi, Christian Delgadillo, Sarah Kabbara, Lovleen Swatch, Edward Zagha
{"title":"Goal-directed learning is multidimensional and accompanied by diverse and widespread changes in neocortical signaling.","authors":"Krista Marrero, Krithiga Aruljothi, Christian Delgadillo, Sarah Kabbara, Lovleen Swatch, Edward Zagha","doi":"10.1093/cercor/bhae328","DOIUrl":"10.1093/cercor/bhae328","url":null,"abstract":"<p><p>New tasks are often learned in stages with each stage reflecting a different learning challenge. Accordingly, each learning stage is likely mediated by distinct neuronal processes. And yet, most rodent studies of the neuronal correlates of goal-directed learning focus on individual outcome measures and individual brain regions. Here, we longitudinally studied mice from naïve to expert performance in a head-fixed, operant conditioning whisker discrimination task. In addition to tracking the primary behavioral outcome of stimulus discrimination, we tracked and compared an array of object-based and temporal-based behavioral measures. These behavioral analyses identify multiple, partially overlapping learning stages in this task, consistent with initial response implementation, early stimulus-response generalization, and late response inhibition. To begin to understand the neuronal foundations of these learning processes, we performed widefield Ca2+ imaging of dorsal neocortex throughout learning and correlated behavioral measures with neuronal activity. We found distinct and widespread correlations between neocortical activation patterns and various behavioral measures. For example, improvements in sensory discrimination correlated with target stimulus evoked activations of response-related cortices along with distractor stimulus evoked global cortical suppression. Our study reveals multidimensional learning for a simple goal-directed learning task and generates hypotheses for the neuronal modulations underlying these various learning processes.</p>","PeriodicalId":9715,"journal":{"name":"Cerebral cortex","volume":null,"pages":null},"PeriodicalIF":2.9,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11304966/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141896893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Medial to lateral frontal functional connectivity mapping reveals the organization of cingulate cortex. 从内侧到外侧的额叶功能连接图揭示了扣带皮层的组织结构。
IF 2.9 2区 医学
Cerebral cortex Pub Date : 2024-08-01 DOI: 10.1093/cercor/bhae322
Marion Ducret, Camille Giacometti, Manon Dirheimer, Audrey Dureux, Delphine Autran-Clavagnier, Fadila Hadj-Bouziane, Charles Verstraete, Franck Lamberton, Charles R E Wilson, Céline Amiez, Emmanuel Procyk
{"title":"Medial to lateral frontal functional connectivity mapping reveals the organization of cingulate cortex.","authors":"Marion Ducret, Camille Giacometti, Manon Dirheimer, Audrey Dureux, Delphine Autran-Clavagnier, Fadila Hadj-Bouziane, Charles Verstraete, Franck Lamberton, Charles R E Wilson, Céline Amiez, Emmanuel Procyk","doi":"10.1093/cercor/bhae322","DOIUrl":"https://doi.org/10.1093/cercor/bhae322","url":null,"abstract":"<p><p>The functional organization of the frontal lobe is a source of debate, focusing on broad functional subdivisions, large-scale networks, or local refined specificities. Multiple neurocognitive models have tried to explain how functional interactions between cingulate and lateral frontal regions contribute to decision making and cognitive control, but their neuroanatomical bases remain unclear. We provide a detailed description of the functional connectivity between cingulate and lateral frontal regions using resting-state functional MRI in rhesus macaques. The analysis focuses on the functional connectivity of the rostral part of the cingulate sulcus with the lateral frontal cortex. Data-driven and seed-based analysis revealed three clusters within the cingulate sulcus organized along the rostro-caudal axis: the anterior, mid, and posterior clusters display increased functional connectivity with, respectively, the anterior lateral prefrontal regions, face-eye lateral frontal motor cortical areas, and hand lateral frontal motor cortex. The location of these clusters can be predicted in individual subjects based on morphological landmarks. These results suggest that the anterior cluster corresponds to the anterior cingulate cortex, whereas the posterior clusters correspond to the face-eye and hand cingulate motor areas within the anterior midcingulate cortex. These data provide a comprehensive framework to identify cingulate subregions based on functional connectivity and local organization.</p>","PeriodicalId":9715,"journal":{"name":"Cerebral cortex","volume":null,"pages":null},"PeriodicalIF":2.9,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141916124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Spatiotemporal whole-brain activity and functional connectivity of melodies recognition. 旋律识别的时空全脑活动和功能连接。
IF 2.9 2区 医学
Cerebral cortex Pub Date : 2024-08-01 DOI: 10.1093/cercor/bhae320
Leonardo Bonetti, Elvira Brattico, Francesco Carlomagno, Joana Cabral, Angus Stevner, Gustavo Deco, Peter C Whybrow, Marcus Pearce, Dimitrios Pantazis, Peter Vuust, Morten L Kringelbach
{"title":"Spatiotemporal whole-brain activity and functional connectivity of melodies recognition.","authors":"Leonardo Bonetti, Elvira Brattico, Francesco Carlomagno, Joana Cabral, Angus Stevner, Gustavo Deco, Peter C Whybrow, Marcus Pearce, Dimitrios Pantazis, Peter Vuust, Morten L Kringelbach","doi":"10.1093/cercor/bhae320","DOIUrl":"10.1093/cercor/bhae320","url":null,"abstract":"<p><p>Music is a non-verbal human language, built on logical, hierarchical structures, that offers excellent opportunities to explore how the brain processes complex spatiotemporal auditory sequences. Using the high temporal resolution of magnetoencephalography, we investigated the unfolding brain dynamics of 70 participants during the recognition of previously memorized musical sequences compared to novel sequences matched in terms of entropy and information content. Measures of both whole-brain activity and functional connectivity revealed a widespread brain network underlying the recognition of the memorized auditory sequences, which comprised primary auditory cortex, superior temporal gyrus, insula, frontal operculum, cingulate gyrus, orbitofrontal cortex, basal ganglia, thalamus, and hippocampus. Furthermore, while the auditory cortex responded mainly to the first tones of the sequences, the activity of higher-order brain areas such as the cingulate gyrus, frontal operculum, hippocampus, and orbitofrontal cortex largely increased over time during the recognition of the memorized versus novel musical sequences. In conclusion, using a wide range of analytical techniques spanning from decoding to functional connectivity and building on previous works, our study provided new insights into the spatiotemporal whole-brain mechanisms for conscious recognition of auditory sequences.</p>","PeriodicalId":9715,"journal":{"name":"Cerebral cortex","volume":null,"pages":null},"PeriodicalIF":2.9,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11304985/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141896897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Exploring functional connectivity in large-scale brain networks in obsessive-compulsive disorder: a systematic review of EEG and fMRI studies. 探索强迫症大规模大脑网络的功能连接:脑电图和 fMRI 研究的系统回顾。
IF 2.9 2区 医学
Cerebral cortex Pub Date : 2024-08-01 DOI: 10.1093/cercor/bhae327
M Prabhavi N Perera, Efstathia S Gotsis, Neil W Bailey, Bernadette M Fitzgibbon, Paul B Fitzgerald
{"title":"Exploring functional connectivity in large-scale brain networks in obsessive-compulsive disorder: a systematic review of EEG and fMRI studies.","authors":"M Prabhavi N Perera, Efstathia S Gotsis, Neil W Bailey, Bernadette M Fitzgibbon, Paul B Fitzgerald","doi":"10.1093/cercor/bhae327","DOIUrl":"10.1093/cercor/bhae327","url":null,"abstract":"<p><p>Obsessive-compulsive disorder (OCD) is a debilitating psychiatric condition that is difficult to treat due to our limited understanding of its pathophysiology. Functional connectivity in brain networks, as evaluated through neuroimaging studies, plays a pivotal role in understanding OCD. While both electroencephalography (EEG) and functional magnetic resonance imaging (fMRI) have been extensively employed in OCD research, few have fully synthesized their findings. To bridge this gap, we reviewed 166 studies (10 EEG, 156 fMRI) published up to December 2023. In EEG studies, OCD exhibited lower connectivity in delta and alpha bands, with inconsistent findings in other frequency bands. Resting-state fMRI studies reported conflicting connectivity patterns within the default mode network (DMN) and sensorimotor cortico-striato-thalamo-cortical (CSTC) circuitry. Many studies observed decreased resting-state connectivity between the DMN and salience network (SN), implicating the 'triple network model' in OCD. Task-related hyperconnectivity within the DMN-SN and hypoconnectivity between the SN and frontoparietal network suggest OCD-related cognitive inflexibility, potentially due to triple network dysfunction. In conclusion, our review highlights diverse connectivity differences in OCD, revealing complex brain network interplay that contributes to symptom manifestation. However, the presence of conflicting findings underscores the necessity for targeted research to achieve a comprehensive understanding of the pathophysiology of OCD.</p>","PeriodicalId":9715,"journal":{"name":"Cerebral cortex","volume":null,"pages":null},"PeriodicalIF":2.9,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11329673/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141995376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The impact of bilateral versus unilateral anterior temporal lobe damage on face recognition, person knowledge and semantic memory. 双侧与单侧前颞叶损伤对人脸识别、人物知识和语义记忆的影响。
IF 2.9 2区 医学
Cerebral cortex Pub Date : 2024-08-01 DOI: 10.1093/cercor/bhae336
Matthew A Rouse, Siddharth Ramanan, Ajay D Halai, Angélique Volfart, Peter Garrard, Karalyn Patterson, James B Rowe, Matthew A Lambon Ralph
{"title":"The impact of bilateral versus unilateral anterior temporal lobe damage on face recognition, person knowledge and semantic memory.","authors":"Matthew A Rouse, Siddharth Ramanan, Ajay D Halai, Angélique Volfart, Peter Garrard, Karalyn Patterson, James B Rowe, Matthew A Lambon Ralph","doi":"10.1093/cercor/bhae336","DOIUrl":"10.1093/cercor/bhae336","url":null,"abstract":"<p><p>The functional importance of the anterior temporal lobes (ATLs) has come to prominence in two active, albeit unconnected literatures-(i) face recognition and (ii) semantic memory. To generate a unified account of the ATLs, we tested the predictions from each literature and examined the effects of bilateral versus unilateral ATL damage on face recognition, person knowledge, and semantic memory. Sixteen people with bilateral ATL atrophy from semantic dementia (SD), 17 people with unilateral ATL resection for temporal lobe epilepsy (TLE; left = 10, right = 7), and 14 controls completed tasks assessing perceptual face matching, person knowledge and general semantic memory. People with SD were impaired across all semantic tasks, including person knowledge. Despite commensurate total ATL damage, unilateral resection generated mild impairments, with minimal differences between left- and right-ATL resection. Face matching performance was largely preserved but slightly reduced in SD and right TLE. All groups displayed the familiarity effect in face matching; however, it was reduced in SD and right TLE and was aligned with the level of item-specific semantic knowledge in all participants. We propose a neurocognitive framework whereby the ATLs underpin a resilient bilateral representation system that supports semantic memory, person knowledge and face recognition.</p>","PeriodicalId":9715,"journal":{"name":"Cerebral cortex","volume":null,"pages":null},"PeriodicalIF":2.9,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11315654/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141911976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
High segregation and diminished global integration in large-scale brain functional networks enhances the perceptual binding of cross-modal stimuli. 大尺度大脑功能网络中的高度分离和减弱的全局整合增强了跨模态刺激的感知结合。
IF 2.9 2区 医学
Cerebral cortex Pub Date : 2024-08-01 DOI: 10.1093/cercor/bhae323
Soibam Shyamchand Singh, Abhishek Mukherjee, Partha Raghunathan, Dipanjan Ray, Arpan Banerjee
{"title":"High segregation and diminished global integration in large-scale brain functional networks enhances the perceptual binding of cross-modal stimuli.","authors":"Soibam Shyamchand Singh, Abhishek Mukherjee, Partha Raghunathan, Dipanjan Ray, Arpan Banerjee","doi":"10.1093/cercor/bhae323","DOIUrl":"10.1093/cercor/bhae323","url":null,"abstract":"<p><p>Speech perception requires the binding of spatiotemporally disjoint auditory-visual cues. The corresponding brain network-level information processing can be characterized by two complementary mechanisms: functional segregation which refers to the localization of processing in either isolated or distributed modules across the brain, and integration which pertains to cooperation among relevant functional modules. Here, we demonstrate using functional magnetic resonance imaging recordings that subjective perceptual experience of multisensory speech stimuli, real and illusory, are represented in differential states of segregation-integration. We controlled the inter-subject variability of illusory/cross-modal perception parametrically, by introducing temporal lags in the incongruent auditory-visual articulations of speech sounds within the McGurk paradigm. The states of segregation-integration balance were captured using two alternative computational approaches. First, the module responsible for cross-modal binding of sensory signals defined as the perceptual binding network (PBN) was identified using standardized parametric statistical approaches and their temporal correlations with all other brain areas were computed. With increasing illusory perception, the majority of the nodes of PBN showed decreased cooperation with the rest of the brain, reflecting states of high segregation but reduced global integration. Second, using graph theoretic measures, the altered patterns of segregation-integration were cross-validated.</p>","PeriodicalId":9715,"journal":{"name":"Cerebral cortex","volume":null,"pages":null},"PeriodicalIF":2.9,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141896894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Interaction of the dorsolateral prefrontal cortex with the precuneal medial parietal cortex for the monitoring of information in working memory in the macaque monkey. 猕猴背外侧前额叶皮层与楔前内侧顶叶皮层在监控工作记忆信息方面的相互作用
IF 2.9 2区 医学
Cerebral cortex Pub Date : 2024-08-01 DOI: 10.1093/cercor/bhae315
Michael Petrides, Sarah Lefebvre, Jennifer Novek, Veronika Zlatkina
{"title":"Interaction of the dorsolateral prefrontal cortex with the precuneal medial parietal cortex for the monitoring of information in working memory in the macaque monkey.","authors":"Michael Petrides, Sarah Lefebvre, Jennifer Novek, Veronika Zlatkina","doi":"10.1093/cercor/bhae315","DOIUrl":"10.1093/cercor/bhae315","url":null,"abstract":"<p><p>The executive control process of monitoring information in working memory depends on the mid-dorsolateral prefrontal cortical region (cytoarchitectonic areas 46 and 9/46) in interaction with the hippocampal memory system. Anatomical studies demonstrated strong connectivity between the mid-dorsolateral prefrontal cortex and the medial parietal area PGm that lies on the precuneus. Area PGm is also strongly connected with the attentional system on the lateral inferior parietal lobule (area PG) and the limbic retrosplenial/posterior cingulate region that interacts with the hippocampal memory system. Thus, in terms of anatomical connectivity, area PGm appears to be a critical node for the integration of executive control processing from the prefrontal cortex with the online attentional and memory related processing. This hypothesis was tested in macaque monkeys with the crossed unilateral lesion methodology. A unilateral lesion in the mid-dorsolateral prefrontal cortex was combined with a unilateral lesion in area PGm in the opposite hemisphere. The results demonstrated an impairment on the externally ordered working memory task that assesses the monitoring of information in working memory. Thus, the medial parietal area PGm is a critical node in mediating the functional interaction between the prefrontal region for the executive control process of monitoring information and the memory system.</p>","PeriodicalId":9715,"journal":{"name":"Cerebral cortex","volume":null,"pages":null},"PeriodicalIF":2.9,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141896896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correction to: Obesogenic diet induces sex-specific alterations of contextual fear memory and associated hippocampal activity in mice. 更正:致肥饮食诱导小鼠性别特异性改变情境恐惧记忆和相关海马活动
IF 2.9 2区 医学
Cerebral cortex Pub Date : 2024-08-01 DOI: 10.1093/cercor/bhae367
{"title":"Correction to: Obesogenic diet induces sex-specific alterations of contextual fear memory and associated hippocampal activity in mice.","authors":"","doi":"10.1093/cercor/bhae367","DOIUrl":"https://doi.org/10.1093/cercor/bhae367","url":null,"abstract":"","PeriodicalId":9715,"journal":{"name":"Cerebral cortex","volume":null,"pages":null},"PeriodicalIF":2.9,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142079290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Six types of loves differentially recruit reward and social cognition brain areas. 六种类型的爱情会对大脑的奖赏和社会认知区域进行不同程度的调用。
IF 2.9 2区 医学
Cerebral cortex Pub Date : 2024-08-01 DOI: 10.1093/cercor/bhae331
Pärttyli Rinne, Juha M Lahnakoski, Heini Saarimäki, Mikke Tavast, Mikko Sams, Linda Henriksson
{"title":"Six types of loves differentially recruit reward and social cognition brain areas.","authors":"Pärttyli Rinne, Juha M Lahnakoski, Heini Saarimäki, Mikke Tavast, Mikko Sams, Linda Henriksson","doi":"10.1093/cercor/bhae331","DOIUrl":"10.1093/cercor/bhae331","url":null,"abstract":"<p><p>Feelings of love are among the most significant human phenomena. Love informs the formation and maintenance of pair bonds, parent-offspring attachments, and influences relationships with others and even nature. However, little is known about the neural mechanisms of love beyond romantic and maternal types. Here, we characterize the brain areas involved in love for six different objects: romantic partner, one's children, friends, strangers, pets, and nature. We used functional magnetic resonance imaging (fMRI) to measure brain activity, while we induced feelings of love using short stories. Our results show that neural activity during a feeling of love depends on its object. Interpersonal love recruited social cognition brain areas in the temporoparietal junction and midline structures significantly more than love for pets or nature. In pet owners, love for pets activated these same regions significantly more than in participants without pets. Love in closer affiliative bonds was associated with significantly stronger and more widespread activation in the brain's reward system than love for strangers, pets, or nature. We suggest that the experience of love is shaped by both biological and cultural factors, originating from fundamental neurobiological mechanisms of attachment.</p>","PeriodicalId":9715,"journal":{"name":"Cerebral cortex","volume":null,"pages":null},"PeriodicalIF":2.9,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11345515/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142055103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Temporal dynamics of white and gray matter plasticity during motor skill acquisition: a comparative diffusion tensor imaging and multiparametric mapping analysis. 运动技能习得过程中白质和灰质可塑性的时间动态:弥散张量成像和多参数绘图的比较分析。
IF 2.9 2区 医学
Cerebral cortex Pub Date : 2024-08-01 DOI: 10.1093/cercor/bhae344
Tim Emmenegger, Gergely David, Siawoosh Mohammadi, Gabriel Ziegler, Martina F Callaghan, Alan Thompson, Karl J Friston, Nikolaus Weiskopf, Tim Killeen, Patrick Freund
{"title":"Temporal dynamics of white and gray matter plasticity during motor skill acquisition: a comparative diffusion tensor imaging and multiparametric mapping analysis.","authors":"Tim Emmenegger, Gergely David, Siawoosh Mohammadi, Gabriel Ziegler, Martina F Callaghan, Alan Thompson, Karl J Friston, Nikolaus Weiskopf, Tim Killeen, Patrick Freund","doi":"10.1093/cercor/bhae344","DOIUrl":"https://doi.org/10.1093/cercor/bhae344","url":null,"abstract":"<p><p>Learning new motor skills relies on neural plasticity within motor and limbic systems. This study uniquely combined diffusion tensor imaging and multiparametric mapping MRI to detail these neuroplasticity processes. We recruited 18 healthy male participants who underwent 960 min of training on a computer-based motion game, while 14 were scanned without training. Diffusion tensor imaging, which quantifies tissue microstructure by measuring the capacity for, and directionality of, water diffusion, revealed mostly linear changes in white matter across the corticospinal-cerebellar-thalamo-hippocampal circuit. These changes related to performance and reflected different responses to upper- and lower-limb training in brain areas with known somatotopic representations. Conversely, quantitative MRI metrics, sensitive to myelination and iron content, demonstrated mostly quadratic changes in gray matter related to performance and reflecting somatotopic representations within the same brain areas. Furthermore, while myelin and iron-sensitive multiparametric mapping MRI was able to describe time lags between different cortical brain systems, diffusion tensor imaging detected time lags within the white matter of the motor systems. These findings suggest that motor skill learning involves distinct phases of white and gray matter plasticity across the sensorimotor network, with the unique combination of diffusion tensor imaging and multiparametric mapping MRI providing complementary insights into the underlying neuroplastic responses.</p>","PeriodicalId":9715,"journal":{"name":"Cerebral cortex","volume":null,"pages":null},"PeriodicalIF":2.9,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11364465/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142104687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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