Cerebral cortex最新文献_第10页

Structural mediation of the default-mode network in children with callosal agenesis. 胼胝体发育不全儿童默认模式网络的结构调节。

IF 2.9 2区医学

Cerebral cortex Pub Date : 2025-07-01 DOI: 10.1093/cercor/bhaf190

Céline Provins, Anjali Tarun Nahalka, Léa Schmidt, Vicki Anderson, Alissandra McIlroy, Amanda Wood, Oscar Esteban, Richard Leventer, Megan Spencer-Smith, Dimitri Van De Ville, Vanessa Siffredi

{"title":"Structural mediation of the default-mode network in children with callosal agenesis.","authors":"Céline Provins, Anjali Tarun Nahalka, Léa Schmidt, Vicki Anderson, Alissandra McIlroy, Amanda Wood, Oscar Esteban, Richard Leventer, Megan Spencer-Smith, Dimitri Van De Ville, Vanessa Siffredi","doi":"10.1093/cercor/bhaf190","DOIUrl":"https://doi.org/10.1093/cercor/bhaf190","url":null,"abstract":"Agenesis of the corpus callosum is a neurodevelopmental condition characterized by the partial or complete absence of the corpus callosum, the largest white matter bundle connecting the cerebral hemispheres. The default-mode network comprises bilateral frontal, temporal, and parietal regions that exhibit correlated activity at rest. Previous studies show that individuals with agenesis of the corpus callosum show overall preserved default-mode network functional connectivity, suggesting compensatory mechanisms for maintaining bilaterally correlated activity. In this study, we aimed to explore white matter pathways that support default-mode network-related networks in 15 children with agenesis of the corpus callosum and 27 typically developing controls, using combined diffusion and functional magnetic resonance imaging. A seed-based and dynamic functional connectivity approach enabled us to examine default-mode network spatial and temporal properties and their white matter substrates. While spatial default-mode network patterns were similar across groups, we found differences in temporal dynamics of 1 network and in white matter-default-mode network correspondence. These differences were either observed in white matter tracts directly associated with complete or partial absence of the corpus callosum or in white matter tracts such as the fornix and the anterior and posterior commissures, which have been previously implicated in neuroplasticity in agenesis of the corpus callosum. Our findings show that default-mode network dynamics can remain functionally preserved despite significant white matter alterations.","PeriodicalId":9715,"journal":{"name":"Cerebral cortex","volume":"35 7","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144717646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prefrontal activity to negative emotions moderates the longitudinal links between parents and youth's internalizing symptoms. 对负面情绪的前额叶活动调节了父母和青少年内化症状之间的纵向联系。

IF 2.9 2区医学

Cerebral cortex Pub Date : 2025-07-01 DOI: 10.1093/cercor/bhaf170

Zeyi Shi, Beiming Yang, Zexi Zhou, Claudia M Haase, Yang Qu

{"title":"Prefrontal activity to negative emotions moderates the longitudinal links between parents and youth's internalizing symptoms.","authors":"Zeyi Shi, Beiming Yang, Zexi Zhou, Claudia M Haase, Yang Qu","doi":"10.1093/cercor/bhaf170","DOIUrl":"https://doi.org/10.1093/cercor/bhaf170","url":null,"abstract":"Parents' internalizing symptoms, such as anxiety and depression, may contribute to similar symptoms in their youth. However, these associations vary, as youth with better emotion regulation may be more protected from negative parental influence. Yet, it remains unclear how youth's neural correlates of emotion regulation, particularly in prefrontal regions-such as dorsolateral prefrontal cortex (dlPFC), lateral orbitofrontal cortex (lOFC), and medial orbitofrontal cortex (mOFC)-play a role in these associations. To address this gap, this study used two-wave longitudinal data that spanned 2 yr from the nationwide Adolescent Brain Cognitive Development study including 7,932 youth (Mage = 9.96 yr, SD = 7.52; 49% females) and their parents. Results revealed significant longitudinal associations between parents' and youth's internalizing symptoms over 2 yr. Moreover, youth's dlPFC, lOFC, and mOFC activity to negative emotions moderated these links. Youth with higher activity in these regions showed weaker parent-youth associations in internalizing symptoms over time. This study provides robust evidence that dlPFC, lOFC, and mOFC serve as neurobiological protective factors in the longitudinal links between parents and youth's internalizing symptoms. Findings inform interventions targeting youth's neural development in emotion regulation to promote emotional adjustment in families where parents face mental health challenges.","PeriodicalId":9715,"journal":{"name":"Cerebral cortex","volume":"35 7","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144641914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Alterations in cortical 40-Hz auditory steady-state response dynamics in children with mild-to-severe hearing loss are related to hearing aid use. 轻度至重度听力损失儿童皮质40-Hz听觉稳态反应动力学的改变与助听器的使用有关。

IF 2.9 2区医学

Cerebral cortex Pub Date : 2025-07-01 DOI: 10.1093/cercor/bhaf178

Zhiying Shen, Wai Hon Lee, Jacob A Eastman, Michaela R Frenzel, Alex I Wiesman, Tony W Wilson, Elizabeth A Walker, Ryan W McCreery, Elizabeth Heinrichs-Graham

{"title":"Alterations in cortical 40-Hz auditory steady-state response dynamics in children with mild-to-severe hearing loss are related to hearing aid use.","authors":"Zhiying Shen, Wai Hon Lee, Jacob A Eastman, Michaela R Frenzel, Alex I Wiesman, Tony W Wilson, Elizabeth A Walker, Ryan W McCreery, Elizabeth Heinrichs-Graham","doi":"10.1093/cercor/bhaf178","DOIUrl":"10.1093/cercor/bhaf178","url":null,"abstract":"Children who are hard-of-hearing (CHH) show greater variability in language and academic outcomes than children with normal hearing (CNH) throughout development, despite early detection and intervention. Nonetheless, our understanding of the neural mechanisms underlying sensory and cognitive processing in CHH remains incomplete. The 40-Hz cortical auditory steady-state response (ASSR) has been widely used as a marker of auditory system integrity and shown to relate to cognition. Thus, the current study sought to determine the impact of mild-to-severe hearing loss on cortical ASSR dynamics. Thirty-seven participants ages 7-15 years old heard a broadband click train stimulus presented at 40 Hz binaurally during magnetoencephalography (MEG). Peak sources in the bilateral primary auditory cortices were identified, and the power envelope of the 40 Hz ASSR was extracted as a function of time and submitted to linear mixed modeling. We found a significant three-way interaction, suggesting that CHH exhibit altered ASSR dynamics between hemispheres compared to CNH. Moreover, hearing aid use was significantly correlated with left hemisphere ASSR power in CHH. These data underscore the importance of consistent auditory access in CHH and provide preliminary evidence that neuroimaging may hold promise in determining the mechanisms underlying behavioral variability in this population.","PeriodicalId":9715,"journal":{"name":"Cerebral cortex","volume":"35 7","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12265889/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144641907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Structural and functional attention network connectivity in relation to visual selective attention dysfunction in cerebral visual impairment. 脑视觉障碍患者视觉选择性注意功能障碍的结构和功能注意网络连接。

IF 2.9 2区医学

Cerebral cortex Pub Date : 2025-07-01 DOI: 10.1093/cercor/bhaf173

Marie Drottar, Claire E Manley, Negin Nadvar, Howard J Cabral, Peter J Bex, Lotfi B Merabet, Corinna M Bauer

{"title":"Structural and functional attention network connectivity in relation to visual selective attention dysfunction in cerebral visual impairment.","authors":"Marie Drottar, Claire E Manley, Negin Nadvar, Howard J Cabral, Peter J Bex, Lotfi B Merabet, Corinna M Bauer","doi":"10.1093/cercor/bhaf173","DOIUrl":"10.1093/cercor/bhaf173","url":null,"abstract":"Individuals with cerebral visual impairment (CVI) often demonstrate difficulties with visual selective attention; however, the underlying neural mechanisms remain unclear. In this study, we investigated whether structural and functional connectivity between and within the attention networks, thalamus, and early visual areas is differentially associated with performance on a conjunction search task in participants with CVI as compared to controls. Data from 26 participants was collected and analyzed (10 CVI, four female, 17.4 years, 5.38 s.d., 16 control, 10 female, 22.25 years, 4.25 s.d.). White matter tracts associated with the dorsal and ventral attention networks as well as structural and functional connectivity matrices of the dorsal and ventral attention networks were generated for each participant. Group differences in conjunction search outcomes, tract volume, and network connectivity strength were evaluated. General linear models were used to investigate the relationship between neuroimaging predictor variables and each of the four conjunction search primary outcomes. All analyses were adjusted for age and verbal cognition. In the CVI group impaired visual search was associated with weaker structural and stronger functional connectivity, while in the control group the opposite effect was observed. Together, these results suggest that functional over-recruitment may be a maladaptive compensatory mechanism.","PeriodicalId":9715,"journal":{"name":"Cerebral cortex","volume":"35 7","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12336986/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144559315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Linking gray matter structure to trust in mild cognitive impairment: a voxel-based morphometry study. 连接灰质结构与轻度认知障碍的信任：基于体素的形态测量学研究。

IF 2.9 2区医学

Cerebral cortex Pub Date : 2025-07-01 DOI: 10.1093/cercor/bhaf140

Yiqi Chen, Hao He, Yiyang Ding, Wuhai Tao, Qing Guan, Frank Krueger

{"title":"Linking gray matter structure to trust in mild cognitive impairment: a voxel-based morphometry study.","authors":"Yiqi Chen, Hao He, Yiyang Ding, Wuhai Tao, Qing Guan, Frank Krueger","doi":"10.1093/cercor/bhaf140","DOIUrl":"https://doi.org/10.1093/cercor/bhaf140","url":null,"abstract":"Older adults with mild cognitive impairment (MCI) exhibit a reduction in trust propensity (TP), which is correlated with heightened affective sensitivity to betrayal. However, the mediating role of this affective component in declining TP in MCI and the influence of structural brain alterations on reduced TP via affect warrant further investigation. We conducted multiple mediation analyses to assess whether differences in TP between MCI and normal healthy controls (NHCs) were mediated by affect, motivation, executive function, and social cognition. Whole-brain mediation analyses identified neural substrates and moderated mediation analyses examined whether structural brain changes influenced TP via affect differently between the two groups. Our results revealed a significant mediating effect of affect on the group difference in TP. Atrophy within the thalamus and anterior insula (AI) in the MCI group was found to contribute to their diminished TP. Furthermore, moderated mediation analysis showed that the influence of the thalamus and AI on TP was mediated by affect within the MCI group but not NHCs. These findings suggest that reduced TP in MCI is primarily driven by the increased sensitivity to betrayal, which is underpinned by structural alterations within salience network regions rather than alterations in other trust-related cognitive domains.","PeriodicalId":9715,"journal":{"name":"Cerebral cortex","volume":"35 7","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144552442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neural correlates of negative aesthetic evaluations in visual art: a neuroimaging meta-analysis. 视觉艺术中负面审美评价的神经相关性：神经影像学荟萃分析。

IF 2.9 2区医学

Cerebral cortex Pub Date : 2025-07-01 DOI: 10.1093/cercor/bhaf156

Ryan Joseph Slaby, Maria Arioli, Marco Tettamanti, Zaira Cattaneo

{"title":"Neural correlates of negative aesthetic evaluations in visual art: a neuroimaging meta-analysis.","authors":"Ryan Joseph Slaby, Maria Arioli, Marco Tettamanti, Zaira Cattaneo","doi":"10.1093/cercor/bhaf156","DOIUrl":"10.1093/cercor/bhaf156","url":null,"abstract":"Neuroaesthetics has focused on investigating positive aesthetic evaluations while neglecting negative aesthetic evaluations. The employment of domain-general neural systems may engender hedonic valuation across an affective space of (dis)pleasure towards artistic and non-artistic stimuli. Hence, we conducted a meta-analysis assessing neural correlates associated with negative aesthetic evaluations towards visual artwork (NAE) and with viewing or evaluating negative non-artistic images from the International Affective Picture System (N-IAPS). Literature search screenings found 16 studies and 16 experiments for the NAE and 46 studies and 47 experiments for the N-IAPS. GingerALE software employed activation likelihood estimation analyses to specify neural correlates within and between NAE and N-IAPS. Meta-analytic results from the NAE solely revealed the right fusiform gyrus encroaching the anterior cerebellum, while activations across frontal, occipital, temporal and subcortical areas were revealed for the N-IAPS. A commonality between the NAE and N-IAPS was revealed within the right fusiform gyrus. These results suggest that the domain-general neural systems are at play across negative visual affective experiences, yet the context of stimulus engagement, such as aesthetic, may modulate how these neural systems are employed. Given the scarcity of results, future research in neuroaesthetics must expand from positive aesthetic evaluations to ascertain neural correlates within negative aesthetic evaluations.","PeriodicalId":9715,"journal":{"name":"Cerebral cortex","volume":"35 7","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12235005/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144583204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The influence of moral characteristics on social pain empathy: evidence from event-related potential and eye-tracking techniques. 道德特征对社会痛苦共情的影响：来自事件相关电位和眼动追踪技术的证据。

IF 2.9 2区医学

Cerebral cortex Pub Date : 2025-07-01 DOI: 10.1093/cercor/bhaf177

Mingxue Zhan, Huibin Jia

{"title":"The influence of moral characteristics on social pain empathy: evidence from event-related potential and eye-tracking techniques.","authors":"Mingxue Zhan, Huibin Jia","doi":"10.1093/cercor/bhaf177","DOIUrl":"https://doi.org/10.1093/cercor/bhaf177","url":null,"abstract":"Previous studies have revealed that the moral level of targets can influence individuals' empathic responses toward them. Here, we investigated the visual attention patterns and neural mechanisms related to how moral characteristics modulate individuals' empathic responses to social pain via a word-priming social exclusion empathy task in which participants needed to judge whether the target persons with a high or low moral level were excluded or not in social situations. We found that for ERPs, when participants viewed neutral images, a significantly more negative N1 component was evoked in low-moral priming condition and a significantly more positive P3 component was evoked in high-moral priming condition. Regarding eye-tracking metrics, when participants viewed social exclusion images, the fixation time-related metrics under high-moral priming condition were significantly longer than those under low-moral priming condition. We speculate that this may be related to the expected conflict experienced by the participants when they saw high-moral individuals being socially excluded. This expected conflict may have caused attentional avoidance in that situation, which may be related to the relatively lower emotional arousal. This attentional avoidance during the early stage of visual processing resulted in significantly more cognitive resources being invested and longer fixation time-related metrics.","PeriodicalId":9715,"journal":{"name":"Cerebral cortex","volume":"35 7","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144583206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Learn from your competitor or cooperator? A hyperscanning functional near-infrared spectroscopy study of gender-specific neural dynamics during interactive learning. 向你的竞争对手或合作者学习？互动学习过程中性别特异性神经动力学的超扫描功能近红外光谱研究。

IF 2.9 2区医学

Cerebral cortex Pub Date : 2025-07-01 DOI: 10.1093/cercor/bhaf196

Ming Peng, Xiaoying Yang, Honghui Cai, Mengfei Cai, Xu Li, Mingming Zhang

{"title":"Learn from your competitor or cooperator? A hyperscanning functional near-infrared spectroscopy study of gender-specific neural dynamics during interactive learning.","authors":"Ming Peng, Xiaoying Yang, Honghui Cai, Mengfei Cai, Xu Li, Mingming Zhang","doi":"10.1093/cercor/bhaf196","DOIUrl":"https://doi.org/10.1093/cercor/bhaf196","url":null,"abstract":"Social learning, a critical mechanism for human adaptation to complex societal environments, hinges not only on learners' cognitive and emotional processes but also on modes and contexts of social interaction. However, the exact mechanisms by which these factors impact social learning, and how gender differences modulate this process, remain unclear. This study employed a dual-player version of the Iowa Gambling Task, where participants alternated selecting decks under cooperative or competitive conditions. Neural signals from the right prefrontal cortex and right temporoparietal junction were captured using functional near-infrared spectroscopy equipment. Results indicated more safe decks but less frequent switching between decks in the cooperative than the competitive context. Participants reported more positive learning experiences in cooperation condition. We found higher intra-brain activation during observation than during direct reaction. Additionally, as an observer, the loss of a competitor triggered greater activation. Stage changes were observed in intra-brain activation and inter-brain synchronization (IBS), revealing gender differences in the stage effect on activation, and opposite effects on time-aligned and time-lagged IBS. Furthermore, gender-specific trends emerged, with males exhibiting higher IBS in competition and females showing higher IBS in cooperation. This study reveals dynamic neuroadaptive reconfigurations in cross-brain connectivity throughout the learning trajectory.","PeriodicalId":9715,"journal":{"name":"Cerebral cortex","volume":"35 7","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144673936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Asymmetric access to social vs. economic resources during development calibrates socio-cognitive pathways to risk-taking in emerging adults. 在发展过程中对社会和经济资源的不对称获取校准了新兴成年人冒险的社会认知途径。

IF 2.9 2区医学

Cerebral cortex Pub Date : 2025-07-01 DOI: 10.1093/cercor/bhaf169

Minwoo Lee, Marlen Z Gonzalez

{"title":"Asymmetric access to social vs. economic resources during development calibrates socio-cognitive pathways to risk-taking in emerging adults.","authors":"Minwoo Lee, Marlen Z Gonzalez","doi":"10.1093/cercor/bhaf169","DOIUrl":"https://doi.org/10.1093/cercor/bhaf169","url":null,"abstract":"Developmental plasticity enables organisms to adapt to early-life environments by tailoring neurocognitive and behavioral strategies to local risks and resources. However, existing research often reduces this dynamic calibration to aggregate exposure to adversity, leaving the effect of distinct early-life environments on adult behaviors and brain functions poorly understood. We investigated how differential childhood socio-economic contexts influence adult risk-taking and associated mechanisms. Forty-eight adults were recruited, and grouped based on their relative access to social (socially-rich) or economic (economically-rich) resources during childhood and completed a balloon analog risk task during functional magnetic resonance imaging scanning. Risk-taking tendencies were estimated via computational modeling and analyzed relative to developmental and current socio-economic contexts. While groups showed similar average risk-taking tendencies, for socially-rich participants only, greater current social support correlated with lower risk-taking. Similarly, risk-taking in both groups coincided with activation in the supramarginal gyrus. However, socially-rich participants uniquely recruited occipito-parietal cortices during risk-taking, a pattern attenuated by higher current social support. Across groups, supramarginal gyrus-prefrontal cortex connectivity tracked mismatches between childhood- and current resource environments, potentially reflecting \"sensitized-specialization\" of neural systems. Our findings highlight how exposure to distinct early-life environments shapes divergent neurocognitive mechanisms underlying adult risk-taking, offering insights for developing context-sensitive interventions.","PeriodicalId":9715,"journal":{"name":"Cerebral cortex","volume":"35 7","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144559312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Brain mechanisms of (dis)agreement: ERP evidence from binary choice responses. （不）一致的脑机制：来自二元选择反应的ERP证据。

IF 2.9 2区医学

Cerebral cortex Pub Date : 2025-07-01 DOI: 10.1093/cercor/bhaf167

Timofei Ponomarev, Anatoly Vasilyev, Eva Novikova, Alexandra Pokidko, Natalia Zaitseva, Dmitry Zaitsev, Alexander Kaplan

{"title":"Brain mechanisms of (dis)agreement: ERP evidence from binary choice responses.","authors":"Timofei Ponomarev, Anatoly Vasilyev, Eva Novikova, Alexandra Pokidko, Natalia Zaitseva, Dmitry Zaitsev, Alexander Kaplan","doi":"10.1093/cercor/bhaf167","DOIUrl":"https://doi.org/10.1093/cercor/bhaf167","url":null,"abstract":"Agreement and disagreement are essential brain processes that enable effective communication and decision-making. However, a clear neurophysiological framework explaining their organization is still lacking. The present study aimed to identify EEG correlates of implicit agreement and disagreement, developing a novel experimental paradigm to model these internal responses. Participants were tasked with mentally responding to binary (\"yes\" or \"no\") questions and evaluating the accuracy of a computer system's attempts to \"guess\" their responses. Event-related potentials (ERP) revealed distinct patterns associated with agreement and disagreement in two key contexts: when participants read the final word of a question and when they observed the computer's \"guess.\" Disagreement, compared to agreement, elicited larger ERP amplitudes, specifically an enhanced N400 component in the first context and increased feedback-related negativity in the second. Considering the associations of these ERP components with cognitive processes, this research offers robust evidence linking agreement and disagreement to the brain's effort in reconciling personal beliefs and expectations with new information. Furthermore, the experimental framework and findings provide a foundation for the development of brain-computer interfaces (BCIs) capable of detecting \"yes\" and \"no\" commands based on their intrinsic EEG predictors, offering promising applications in assistive technologies and neural communication systems.","PeriodicalId":9715,"journal":{"name":"Cerebral cortex","volume":"35 7","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144559313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0