Cerebral cortex最新文献_第10页

Exploring the neural mechanisms linking healthy aging and cognitive maintenance: insights from Mendelian randomization and mediation analyses. 探索健康衰老和认知维持之间的神经机制：来自孟德尔随机化和中介分析的见解。

IF 2.9 2区医学

Cerebral cortex Pub Date : 2025-03-06 DOI: 10.1093/cercor/bhaf006

Tianyuyi Feng, Weizhong Xiao, Yunfei Li, Xiaohu Zhao

{"title":"Exploring the neural mechanisms linking healthy aging and cognitive maintenance: insights from Mendelian randomization and mediation analyses.","authors":"Tianyuyi Feng, Weizhong Xiao, Yunfei Li, Xiaohu Zhao","doi":"10.1093/cercor/bhaf006","DOIUrl":"10.1093/cercor/bhaf006","url":null,"abstract":"As global population ages, maintaining cognitive health in elderly is crucial. Previous studies suggest a positive link between healthy aging and cognition, but the neural mechanisms remain unclear. This study used genome-wide association studydata to investigate neural mechanisms between healthy aging and cognition. We employed 2-sample Mendelian randomization to evaluate causal relationship between healthy aging (indexed by a multivariate genetic predictor, mvAge) and 6 cognitive measurements. We then used a 2-step Mendelian randomization approach and mediation analysis to identify brain imaging-derived phenotypes potentially mediating this relationship. Mendelian randomization analysis indicated that healthy aging had a positive causal relationship with various cognitive functions (common executive function, intelligence, cognitive performance, and fluid intelligence score). Two-step Mendelian randomization analysis identified 27 brain imaging-derived phenotypes having robust causal relationships with healthy aging and various cognitive measurements. Mediation analysis suggested that volume of subcallosal cortex might mediate effects of healthy aging on all 4 cognitive functions. Volume of cerebellum's VIIb could mediate effects on common executive functions, while fractional anisotropy in the anterior thalamic radiation might mediate effects on intelligence and cognitive performance. These findings suggest that specific brain regions may play a potential mediating role in the relationship between healthy aging and cognitive maintenance.","PeriodicalId":9715,"journal":{"name":"Cerebral cortex","volume":"35 3","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143633712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Normative modeling of brain morphometry in self-limited epilepsy with centrotemporal spikes. 自限性癫痫伴中央颞叶尖峰的脑形态计量学规范建模。

IF 2.9 2区医学

Cerebral cortex Pub Date : 2025-03-06 DOI: 10.1093/cercor/bhaf064

Siqi Yang, Wei Liao, Yimin Zhou, Chengzong Peng, Juan Wang, Zhiqiang Zhang

{"title":"Normative modeling of brain morphometry in self-limited epilepsy with centrotemporal spikes.","authors":"Siqi Yang, Wei Liao, Yimin Zhou, Chengzong Peng, Juan Wang, Zhiqiang Zhang","doi":"10.1093/cercor/bhaf064","DOIUrl":"10.1093/cercor/bhaf064","url":null,"abstract":"Self-limited epilepsy with centrotemporal spikes is the most common pediatric epilepsy, characterized by an age-dependent onset that typically arises during childhood brain development and is followed by remission at puberty. However, the heterogeneity in children's brain development at the individual level complicates the challenge of personalized treatment. Our goal is to quantify individual deviations from the normative range of brain morphometric variation in children with Self-limited epilepsy with centrotemporal spikes and to assess their associations with clinical manifestations and cognitive functions. We have developed sex-specific normative models on regional subcortical volume, cortical thickness, and surface area data from 457 healthy children sourced from two datasets. These models were then utilized to map the brain morphometric deviations of children with Self-limited epilepsy with centrotemporal spikes (n = 187) and sex- and age-matched healthy controls (n = 108) from another dataset. In the Self-limited epilepsy with centrotemporal spikes group, children exhibited a higher proportion of regions with infra-normal deviations in subcortical volumes, the number of regions with normative deviations correlated with disease duration, seizure frequency, and Raven's total score. Our findings suggest that a few extreme distributions of heterogeneous brain morphometric deviations are present in a minority of individuals, emphasizing the need to monitor brain abnormalities throughout the course of the disease.","PeriodicalId":9715,"journal":{"name":"Cerebral cortex","volume":"35 3","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143699736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The hippocampus-IPL connectivity links to ADHD traits through sensory processing sensitivity. 海马体- ipl连接通过感觉处理敏感性与ADHD特征联系起来。

IF 2.9 2区医学

Cerebral cortex Pub Date : 2025-03-06 DOI: 10.1093/cercor/bhaf063

Liyu Zhou, Ting Xu, Tingyong Feng

{"title":"The hippocampus-IPL connectivity links to ADHD traits through sensory processing sensitivity.","authors":"Liyu Zhou, Ting Xu, Tingyong Feng","doi":"10.1093/cercor/bhaf063","DOIUrl":"10.1093/cercor/bhaf063","url":null,"abstract":"Accumulating evidence suggests that individuals with high sensory processing sensitivity often experience sensory overload and have difficulty sustaining attention, which can particularly resemble attention deficit symptoms of attention-deficit/hyperactivity disorder. However, due to the lack of understanding about the potential neural pathways involved in those processes, a comprehensive view of how sensory processing sensitivity and attention deficit are related is generally limited. Here, we quantified the sensory processing sensitivity and attention deficit using the Highly Sensitive Person Scale and the Adult Attention-deficit/Hyperactivity Disorder Self-Report Scale, respectively, to investigate the association between sensory processing sensitivity and attention deficit and further identify the corresponding neural substrates via the use of resting-state functional Magnetic Resonance Imaging (fMRI) analyses. On the behavioral level, the results indicated a significantly positive correlation between sensory processing sensitivity and attention deficit traits, while on the neural level, the sensory processing sensitivity score was positively correlated with functional connectivity between the rostral hippocampus and inferior parietal lobule, which is the core regions of the attention network. Mediation analysis revealed that hippocampus-Inferior Parietal Lobule (IPL) connectivity can further influence attention deficit through a mediating role of sensory processing sensitivity. Overall, these findings suggest that enhanced functional coupling between the hippocampus and attention network regions may heighten sensitivity to environmental stimuli, leading to increased distractibility and potentially contributing to attention deficit.","PeriodicalId":9715,"journal":{"name":"Cerebral cortex","volume":"35 3","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143656077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Decoding the impact of negative physical self-perception on inhibitory control ability from theta and beta rhythms. 从θ和β节律解读消极身体自我知觉对抑制控制能力的影响。

IF 2.9 2区医学

Cerebral cortex Pub Date : 2025-03-06 DOI: 10.1093/cercor/bhaf056

Junwei Lian, Jiaqi Guo, Xu Dai, Xia Deng, Yong Liu, Jia Zhao, Xu Lei

{"title":"Decoding the impact of negative physical self-perception on inhibitory control ability from theta and beta rhythms.","authors":"Junwei Lian, Jiaqi Guo, Xu Dai, Xia Deng, Yong Liu, Jia Zhao, Xu Lei","doi":"10.1093/cercor/bhaf056","DOIUrl":"10.1093/cercor/bhaf056","url":null,"abstract":"Previous studies have found inhibitory control differences between obese individuals and those of normal weight. However, some normal-weight individuals with high negative physical self-perception on the fatness subscale show restrictive eating behaviors and attentional bias toward high-calorie food, potentially influencing these differences. We collected behavioral and electroencephalography data using a novel inhibitory control task. Results showed that individuals with high negative physical self-perception on the fatness subscale exhibited significantly greater restraint eating behavior compared to controls. Both theta and beta power differed between groups, with higher theta power in the high negative physical self-perception on the fatness subscale group than in the obese group and more negative beta power in the high negative physical self-perception on the fatness subscale group compared to both other groups. Theta power was greater in no-go than go conditions, while beta power was more negative in response to high-calorie versus low-calorie food stimuli. Importantly, theta power successfully decoded go/no-go conditions across all groups using multivariate pattern analysis, while beta power distinguished these conditions only in the negative physical self-perception on the fatness subscale and control groups. These findings suggest that theta and beta power, along with multivariate pattern analysis, can reliably distinguish inhibitory control ability among the three groups, highlighting the importance of considering negative physical self-perception on the fatness subscale when assessing inhibitory control differences between normal-weight and obese individuals.","PeriodicalId":9715,"journal":{"name":"Cerebral cortex","volume":"35 3","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143656022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A deep learning model for characterizing altered gyro-sulcal functional connectivity in abstinent males with methamphetamine use disorder and associated emotional symptoms. 表征甲基苯丙胺使用障碍和相关情绪症状的戒断男性陀螺-沟功能连通性改变的深度学习模型。

IF 2.9 2区医学

Cerebral cortex Pub Date : 2025-03-06 DOI: 10.1093/cercor/bhaf062

Ping Jiang, Zhenxiang Xiao, Tao Geng, Jiayu Sun, Jiajun Xu, Xiaoqi Huang, Jing Li, Keith M Kendrick, Xi Jiang, Qiyong Gong

{"title":"A deep learning model for characterizing altered gyro-sulcal functional connectivity in abstinent males with methamphetamine use disorder and associated emotional symptoms.","authors":"Ping Jiang, Zhenxiang Xiao, Tao Geng, Jiayu Sun, Jiajun Xu, Xiaoqi Huang, Jing Li, Keith M Kendrick, Xi Jiang, Qiyong Gong","doi":"10.1093/cercor/bhaf062","DOIUrl":"10.1093/cercor/bhaf062","url":null,"abstract":"Failure to manage emotional withdrawal symptoms can exacerbate relapse to methamphetamine use. Understanding the neuro-mechanisms underlying methamphetamine overuse and the associated emotional withdrawal symptoms is crucial for developing effective clinical strategies. This study aimed to investigate the distinct functional contributions of fine-scale gyro-sulcal signaling in the psychopathology of patients with methamphetamine use disorder and its associations with emotional symptoms. We recruited 48 male abstinent methamphetamine use disorders and 48 age- and gender-matched healthy controls, obtaining their resting-state functional magnetic resonance imaging data along with scores on anxiety and depressive symptoms. The proposed deep learning model, a spatio-temporal graph convolutional network utilizing gyro-sulcal subdivisions, achieved the highest average classification accuracy in distinguishing resting-state functional magnetic resonance imaging data of methamphetamine use disorders from healthy controls. Within this model, nodes in the lateral orbitofrontal cortex, and the habitual and executive control networks, contributed most significantly to the classification. Additionally, emotional symptom scores were negatively correlated with the sum of negative functional connectivity in the right caudal anterior cingulate sulcus and the functional connectivity between the left putamen and pallidum in methamphetamine use disorders. These findings provide novel insights into the differential functions of gyral and sulcal regions, enhancing our understanding of the neuro-mechanisms underlying methamphetamine use disorders.","PeriodicalId":9715,"journal":{"name":"Cerebral cortex","volume":"35 3","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143691300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A role for the insula in establishing social dominance: structural and functional MRI studies in nonhuman primates. 脑岛在建立社会支配地位中的作用：非人类灵长类动物的结构和功能MRI研究。

IF 2.9 2区医学

Cerebral cortex Pub Date : 2025-03-06 DOI: 10.1093/cercor/bhaf043

Paul W Czoty, Mohammad Kawas, Kedar Madi, Richard Barcus, Jeongchul Kim, Jeremy P Hudson, Lindsey K Galbo-Thomma, Hongyu Yuan, James B Daunais, Christopher T Whitlow

{"title":"A role for the insula in establishing social dominance: structural and functional MRI studies in nonhuman primates.","authors":"Paul W Czoty, Mohammad Kawas, Kedar Madi, Richard Barcus, Jeongchul Kim, Jeremy P Hudson, Lindsey K Galbo-Thomma, Hongyu Yuan, James B Daunais, Christopher T Whitlow","doi":"10.1093/cercor/bhaf043","DOIUrl":"10.1093/cercor/bhaf043","url":null,"abstract":"Awareness of one's position in the social hierarchy is essential for survival. Conversely, poor social cognition is associated with several neuropsychiatric diseases. Although brain regions that mediate understanding of the social hierarchy are poorly understood, recent evidence implicates the insula. Magnetic resonance imaging (MRI) scans were acquired in twelve individually housed male cynomolgus monkeys to determine whether structural and functional characteristics of the insular cortex predicted the social rank that monkeys would attain once they formed stable social hierarchies. Structural MRI revealed that left insular volume was significantly larger in monkeys that would become dominant vs. subordinate. No differences were observed in other areas including amygdala, caudate nucleus, or prefrontal cortex. Volumetric differences were localized to dorsal anterior regions of both left and right insulae. Functional MRI revealed that global correlation, a measure of connectedness to the rest of the brain, was significantly lower in the left insula of monkeys who would become dominant vs. subordinate. Moreover, the fractional amplitude of low-frequency fluctuations, a reflection of spontaneous brain activity, trended lower in bilateral insula in the future dominant monkeys. This prospective study provides evidence for a role of the insula in the establishment and maintenance of social dominance relationships.","PeriodicalId":9715,"journal":{"name":"Cerebral cortex","volume":"35 3","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11915092/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143655778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Left-hemispheric atypicalities in the primary auditory cortex are associated with language comprehension and social skills in children with Autism Spectrum Disorder. 自闭症谱系障碍儿童初级听觉皮层左半球非典型与语言理解和社交技能有关。

IF 2.9 2区医学

Cerebral cortex Pub Date : 2025-03-06 DOI: 10.1093/cercor/bhaf055

Vardan Arutiunian, Irina Buyanova, Alina Minnigulova, Elizaveta Davydova, Darya Pereverzeva, Alexander Sorokin, Svetlana Tyushkevich, Uliana Mamokhina, Kamilla Danilina, Olga Dragoy

{"title":"Left-hemispheric atypicalities in the primary auditory cortex are associated with language comprehension and social skills in children with Autism Spectrum Disorder.","authors":"Vardan Arutiunian, Irina Buyanova, Alina Minnigulova, Elizaveta Davydova, Darya Pereverzeva, Alexander Sorokin, Svetlana Tyushkevich, Uliana Mamokhina, Kamilla Danilina, Olga Dragoy","doi":"10.1093/cercor/bhaf055","DOIUrl":"10.1093/cercor/bhaf055","url":null,"abstract":"Low-level auditory processing difficulties have been previously reported in children with Autism Spectrum Disorder (ASD), and some studies showed the relationship between these difficulties in the primary auditory cortex and language impairment in ASD. However, there is still a limited number of studies that comprehensively assess (i) amplitudes, latencies, and sensory gating effects in all early components of auditory processing (M50-M100-M200 complex) at the source level in magnetoencephalography with their relation to structural anatomy (gray matter volume, thickness, gyrification) (ii) and the association between brain metrics and clinical phenotype in the same group of children. To address this question, we used a standard paired-clicks paradigm in magnetoencephalography and brain morphometry analysis in children with and without ASD (NASD = 20, NTD = 20). First, the results revealed a reduction of M200 and altered M200 sensory gating effect in the left auditory cortex in children with ASD. Second, these alterations were related to lower language comprehension skills and higher autistic symptom severity. Finally, altered MEG responses were associated with gray matter thickness reduction as well as abnormal gyrification in the primary auditory cortex in ASD. The study revealed low-level functional and structural atypicalities in children with ASD and their relation to clinical phenotype.","PeriodicalId":9715,"journal":{"name":"Cerebral cortex","volume":"35 3","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143623745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neurofunctional aberrations associated with social cognition across clinical and genetic risk groups for schizophrenia: a meta-analysis of fMRI studies. 精神分裂症临床和遗传风险群体中与社会认知相关的神经功能畸变：fMRI 研究的荟萃分析。

IF 2.9 2区医学

Cerebral cortex Pub Date : 2025-03-06 DOI: 10.1093/cercor/bhaf052

Xi Fu, Yuhao Yao, Siyao An, Nanfang Pan, Xiaoyong Lin, Qiyong Gong, Hong Deng, Ying Chen

{"title":"Neurofunctional aberrations associated with social cognition across clinical and genetic risk groups for schizophrenia: a meta-analysis of fMRI studies.","authors":"Xi Fu, Yuhao Yao, Siyao An, Nanfang Pan, Xiaoyong Lin, Qiyong Gong, Hong Deng, Ying Chen","doi":"10.1093/cercor/bhaf052","DOIUrl":"10.1093/cercor/bhaf052","url":null,"abstract":"Aberrant social cognition is a core feature of schizophrenia, persisting from clinical high-risk and genetic high-risk states to the first episode of psychosis. This study aimed to identify shared and distinct social cognition-related functional alterations across clinical high-risk, genetic high-risk, and first episode of psychosis groups, shedding light on varying risk levels for first episode of psychosis development. Meta-analyses were performed on 38 whole-brain task-based functional magnetic resonance imaging studies (12 clinical high risk, 15 genetic high risk, 11 first episode of psychosis) using Seed-based d Mapping. Function abnormalities were assessed within each patient group, with quantitative comparisons made against controls. Clinical high-risk and genetic high-risk individuals showed neither shared nor distinct abnormal brain activation during social cognition tasks. A shared cluster of increased activation in the right anterior cingulate cortex was observed between genetic high-risk and first episode of psychosis groups. However, no conjunction or disjunction results were found between clinical high-risk and first episode of psychosis groups. Meta-regression analyses revealed accelerated age-related greater activation decline in the left insula in individuals with clinical high risk. In conclusion, the absence of shared social cognition-related brain activation between clinical high risk and genetic high risk may signify differences in neural correlates underlying social cognition deficits between these groups and they follow distinct neural pathways toward first episode of psychosis. The shared abnormal anterior cingulate cortex activation in genetic high risk and first episode of psychosis may represent an endophenotype of schizophrenia.","PeriodicalId":9715,"journal":{"name":"Cerebral cortex","volume":"35 3","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143728886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Structural pathways related to the subventricular zone are decreased in volume with altered microstructure in young adult males with autism spectrum disorder. 在年轻成年男性自闭症谱系障碍患者中，与室下区相关的结构通路体积减少，微结构改变。

IF 2.9 2区医学

Cerebral cortex Pub Date : 2025-03-06 DOI: 10.1093/cercor/bhaf041

Keita Tsujimura, Alpen Ortug, José Luis Alatorre Warren, Tadashi Shiohama, Christopher J McDougle, Rachel E Marcus, Chieh-En Jane Tseng, Nicole R Zürcher, Nathaniel D Mercaldo, Susan Faja, Alika Maunakea, Jacob Hooker, Emi Takahashi

{"title":"Structural pathways related to the subventricular zone are decreased in volume with altered microstructure in young adult males with autism spectrum disorder.","authors":"Keita Tsujimura, Alpen Ortug, José Luis Alatorre Warren, Tadashi Shiohama, Christopher J McDougle, Rachel E Marcus, Chieh-En Jane Tseng, Nicole R Zürcher, Nathaniel D Mercaldo, Susan Faja, Alika Maunakea, Jacob Hooker, Emi Takahashi","doi":"10.1093/cercor/bhaf041","DOIUrl":"10.1093/cercor/bhaf041","url":null,"abstract":"Autism spectrum disorder is a neurodevelopmental condition characterized by reduced social communication and repetitive behaviors. Altered neurogenesis, including disturbed neuronal migration, has been implicated in autism spectrum disorder. Using diffusion MRI, we previously identified neuronal migration pathways in the human fetal brain and hypothesized that similar pathways persist into adulthood, with differences in volume and microstructural characteristics between individuals with autism spectrum disorder and controls. We analyzed diffusion MRI-based tractography of subventricular zone-related pathways in 15 young adult men with autism spectrum disorder and 18 controls at Massachusetts General Hospital, with validation through the Autism Imaging Data Exchange II dataset. Participants with autism spectrum disorder had reduced subventricular zone pathway volumes and fractional anisotropy compared to controls. Furthermore, subventricular zone pathway volume was positively correlated (r: 0.68; 95% CI: 0.25 to 0.88) with symptom severity, suggesting that individuals with more severe symptoms tended to have larger subventricular zone pathway volumes, normalized by brain size. Analysis of the Autism Imaging Data Exchange cohort confirmed these findings of reduced subventricular zone pathway volumes in autism spectrum disorder. While some of these pathways may potentially include inaccurately disconnected pathways that go through the subventricular zone, our results suggest that diffusion MRI-based tractography pathways anatomically linked to the periventricular region are associated with certain symptom types in adult males with autism spectrum disorder.","PeriodicalId":9715,"journal":{"name":"Cerebral cortex","volume":"35 3","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143584765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neural correlates of the sense of agency in free and coerced moral decision-making among civilians and military personnel. 平民和军事人员在自由和强制道德决策中的代理感的神经关联。

IF 2.9 2区医学

Cerebral cortex Pub Date : 2025-03-06 DOI: 10.1093/cercor/bhaf049

Emilie A Caspar, Antonin Rovai, Salvatore Lo Bue, Axel Cleeremans

{"title":"Neural correlates of the sense of agency in free and coerced moral decision-making among civilians and military personnel.","authors":"Emilie A Caspar, Antonin Rovai, Salvatore Lo Bue, Axel Cleeremans","doi":"10.1093/cercor/bhaf049","DOIUrl":"10.1093/cercor/bhaf049","url":null,"abstract":"The sense of agency, the feeling of being the author of one's actions and outcomes, is critical for decision-making. While prior research has explored its neural correlates, most studies have focused on neutral tasks, overlooking moral decision-making. In addition, previous studies mainly used convenience samples, ignoring that some social environments may influence how authorship in moral decision-making is processed. This study investigated the neural correlates of sense of agency in civilians and military officer cadets, examining free and coerced choices in both agent and commander roles. Using a functional magnetic resonance imaging paradigm where participants could either freely choose or follow orders to inflict a mild shock on a victim, we assessed sense of agency through temporal binding-a temporal distortion between voluntary and less voluntary decisions. Our findings suggested that sense of agency is reduced when following orders compared to acting freely in both roles. Several brain regions correlated with temporal binding, notably the occipital lobe, superior/middle/inferior frontal gyrus, precuneus, and lateral occipital cortex. Importantly, no differences emerged between military and civilians at corrected thresholds, suggesting that daily environments have minimal influence on the neural basis of moral decision-making, enhancing the generalizability of the findings.","PeriodicalId":9715,"journal":{"name":"Cerebral cortex","volume":"35 3","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143603563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0