Cerebral cortex最新文献_第10页

Test-retest reliability of resting-state EEG intrinsic neural timescales. 静息状态脑电图固有神经时间标的重测信度。

IF 2.9 2区医学

Cerebral cortex Pub Date : 2025-02-05 DOI: 10.1093/cercor/bhaf034

Xiaoling Tang, Shan Wang, Xinye Xu, Wenbo Luo, Mingming Zhang

{"title":"Test-retest reliability of resting-state EEG intrinsic neural timescales.","authors":"Xiaoling Tang, Shan Wang, Xinye Xu, Wenbo Luo, Mingming Zhang","doi":"10.1093/cercor/bhaf034","DOIUrl":"10.1093/cercor/bhaf034","url":null,"abstract":"Intrinsic neural timescales, which reflect the duration of neural information storage within local brain regions and capacity for information integration, are typically measured using autocorrelation windows (ACWs). Extraction of intrinsic neural timescales from resting-state brain activity has been extensively applied in psychiatric disease research. Given the potential of intrinsic neural timescales as a neural marker for psychiatric disorders, investigating their reliability is crucial. This study, using an open-source database, aimed to evaluate the test-retest reliability of ACW-0 and ACW-50 under both eyes-open and eyes-closed conditions across three sessions. The intraclass correlation coefficients (ICCs) were employed to quantify the reliability of the intrinsic neural timescales. Our results showed that intrinsic neural timescales exhibited good reliability (ICC > 0.6) at the whole-brain level across different index types and eye states. Spatially, except for the right temporal region in the eyes-open condition, all other regions showed moderate-to-high ICCs. Over 60% of the electrodes demonstrated moderate-to-high intrinsic neural timescale ICCs under both eyes-open and eyes-closed conditions, with ACW-0 being more stable than ACW-50. Moreover, in the new dataset, the above results were consistently reproduced. The present study comprehensively assessed the reliability of intrinsic neural timescale under various conditions, providing robust evidence for their stability in neuroscience and psychiatry.","PeriodicalId":9715,"journal":{"name":"Cerebral cortex","volume":"35 2","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143490908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sequence-dependent predictive coding during the learning and rewiring of skills. 在技能学习和重新布线过程中依赖序列的预测编码。

IF 2.9 2区医学

Cerebral cortex Pub Date : 2025-02-05 DOI: 10.1093/cercor/bhaf025

Ádám Takács, Teodóra Vékony, Felipe Pedraza, Frederic Haesebaert, Barbara Tillmann, Christian Beste, Dezső Németh

{"title":"Sequence-dependent predictive coding during the learning and rewiring of skills.","authors":"Ádám Takács, Teodóra Vékony, Felipe Pedraza, Frederic Haesebaert, Barbara Tillmann, Christian Beste, Dezső Németh","doi":"10.1093/cercor/bhaf025","DOIUrl":"10.1093/cercor/bhaf025","url":null,"abstract":"In the constantly changing environment that characterizes our daily lives, the ability to predict and adapt to new circumstances is crucial. This study examines the influence of sequence and knowledge adaptiveness on predictive coding in skill learning and rewiring. Participants were exposed to two different visuomotor sequences with overlapping probabilities. By applying temporal decomposition and multivariate pattern analysis, we dissected the neural underpinnings across different levels of signal coding. The study provides neurophysiological evidence for the influence of knowledge adaptiveness on shaping predictive coding, revealing that these are intricately linked and predominantly manifest at the abstract and motor coding levels. These findings challenge the traditional view of a competitive relationship between learning context and knowledge, suggesting instead a hierarchical integration where their properties are processed simultaneously. This integration facilitates the adaptive reuse of existing knowledge in the face of new learning. By shedding light on the mechanisms of predictive coding in visuomotor sequences, this research contributes to a deeper understanding of how the brain navigates and adapts to environmental changes, offering insights into the foundational processes that underlie learning and adaptation in dynamic contexts.","PeriodicalId":9715,"journal":{"name":"Cerebral cortex","volume":"35 2","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143482131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Contributions of short- and long-range white matter tracts in dynamic compensation with aging. 短、长程白质束在衰老动态补偿中的作用。

IF 2.9 2区医学

Cerebral cortex Pub Date : 2025-02-05 DOI: 10.1093/cercor/bhae496

Priyanka Chakraborty, Suman Saha, Gustavo Deco, Arpan Banerjee, Dipanjan Roy

{"title":"Contributions of short- and long-range white matter tracts in dynamic compensation with aging.","authors":"Priyanka Chakraborty, Suman Saha, Gustavo Deco, Arpan Banerjee, Dipanjan Roy","doi":"10.1093/cercor/bhae496","DOIUrl":"10.1093/cercor/bhae496","url":null,"abstract":"Optimal brain function is shaped by a combination of global information integration, facilitated by long-range connections, and local processing, which relies on short-range connections and underlying biological factors. With aging, anatomical connectivity undergoes significant deterioration, which affects the brain's overall function. Despite the structural loss, previous research has shown that normative patterns of functions remain intact across the lifespan, defined as the compensatory mechanism of the aging brain. However, the crucial components in guiding the compensatory preservation of the dynamical complexity and the underlying mechanisms remain uncovered. Moreover, it remains largely unknown how the brain readjusts its biological parameters to maintain optimal brain dynamics with age; in this work, we provide a parsimonious mechanism using a whole-brain generative model to uncover the role of sub-communities comprised of short-range and long-range connectivity in driving the dynamic compensation process in the aging brain. We utilize two neuroimaging datasets to demonstrate how short- and long-range white matter tracts affect compensatory mechanisms. We unveil their modulation of intrinsic global scaling parameters, such as global coupling strength and conduction delay, via a personalized large-scale brain model. Our key finding suggests that short-range tracts predominantly amplify global coupling strength with age, potentially representing an epiphenomenon of the compensatory mechanism. This mechanistically explains the significance of short-range connections in compensating for the major loss of long-range connections during aging. This insight could help identify alternative avenues to address aging-related diseases where long-range connections are significantly deteriorated.","PeriodicalId":9715,"journal":{"name":"Cerebral cortex","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142977616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Modulation by serotonin reveals preferred recurrent excitatory connectivity in layer II of rat neocortex. 5 -羟色胺的调节揭示了大鼠新皮层第二层的周期性兴奋性连接。

IF 2.9 2区医学

Cerebral cortex Pub Date : 2025-02-05 DOI: 10.1093/cercor/bhaf008

Fransiscus Adrian Agahari, Christian Stricker

{"title":"Modulation by serotonin reveals preferred recurrent excitatory connectivity in layer II of rat neocortex.","authors":"Fransiscus Adrian Agahari, Christian Stricker","doi":"10.1093/cercor/bhaf008","DOIUrl":"10.1093/cercor/bhaf008","url":null,"abstract":"We reported that in layer II pyramidal cells of rat somatosensory cortex, 10 μM serotonin (5-HT) alters miniature excitatory postsynaptic current frequency in a subset of cells (47%, \"responders\", RC; \"non-responders\", NC otherwise) via 5-HT2 receptors (5-HT2R) but in all pairs reduced evoked excitatory postsynaptic current amplitude by ~50% (Agahari FA, Stricker C. 2021. Serotonergic modulation of spontaneous and evoked transmitter release in layer II pyramidal cells of rat somatosensory cortex. Cereb Cortex. 31:1182-1200. https://doi.org/10.1093/cercor/bhaa285.) suggestive of preferential connectivity. We provide different lines of evidence that distinguish these subsets. First, after 5-HT exposure, changes in miniature excitatory postsynaptic current, spontaneous EPSC frequency, or whole-cell noise (σw) were restricted to postsynaptic cells in pairs (PO) and RC but absent in presynaptic (PR) and NC. Second, exposure caused a large change in holding current with a small variability in NC, but a small one with a large variability in PO/RC. In addition, ΔRin in PO/RC was larger than in PR/NC, with a negative correlation between ΔIhold and ΔRin in NC, a positive in PO, but none in RC. Third, an unbiased classifier identified most PO as RC and all PR as NC. Our data establish two distinct sets of pyramidal cells having a preferred connectivity from NC → RC. 5-HT2R-mediated modulation of transmitter release may likely reduce the signal-to-noise ratio in the ipsilateral but leave the output to the contralateral side unaffected.","PeriodicalId":9715,"journal":{"name":"Cerebral cortex","volume":"35 2","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143398386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Brain functional differences during irony comprehension in adolescents with ASD. 青少年ASD反语理解的脑功能差异。

IF 2.9 2区医学

Cerebral cortex Pub Date : 2025-02-05 DOI: 10.1093/cercor/bhaf003

Shilin Xu, Xin Wang, Linling Shen, Xiaohui Yan, Guoyan Feng, Fan Cao

{"title":"Brain functional differences during irony comprehension in adolescents with ASD.","authors":"Shilin Xu, Xin Wang, Linling Shen, Xiaohui Yan, Guoyan Feng, Fan Cao","doi":"10.1093/cercor/bhaf003","DOIUrl":"10.1093/cercor/bhaf003","url":null,"abstract":"Irony comprehension is challenging for both individuals with ASD and poor comprehenders (PCs). We aimed to examine the common and specific mechanisms underlying irony comprehension difficulty in the two populations. Both adolescents with ASD and PC showed lower performance in irony comprehension than an age-matched typical control group (TD). The ASD group also showed deficits in theory of mind (ToM), while the PC group showed impairments in structural language skills. In the brain, the ASD group showed reduced brain activation in the left inferior frontal gyrus (IFG) compared to both the TD and the PC group, suggesting ASD-specific differences, which was further found to be correlated with ToM deficits in ASD. Both the TD and the PC group showed greater activation for the ironic than the literal condition in the bilateral medial prefrontal cortex (mPFC), but the ASD group did not, suggesting ASD-specific difference in irony comprehension. The PC group showed reduced activation in the right cuneus compared to the TD, which was correlated with the language comprehension score, suggesting different mechanisms than ASD. Our findings provide insights about the neurocognitive mechanisms underlying impaired irony comprehension in ASD and PC.","PeriodicalId":9715,"journal":{"name":"Cerebral cortex","volume":"35 2","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143381705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Conceptual obstacles to the existence of an innate sense of number in the brain. 大脑中存在先天数字感的概念障碍。

IF 2.9 2区医学

Cerebral cortex Pub Date : 2025-02-05 DOI: 10.1093/cercor/bhaf017

César Frederico Dos Santos

引用次数: 0

Cell-type-specific expression of Nav1.6 in the developing brain of mice and its involvement in glial activation in Alzheimer's disease. 小鼠脑发育过程中Nav1.6的细胞型特异性表达及其参与阿尔茨海默病的神经胶质激活

IF 2.9 2区医学

Cerebral cortex Pub Date : 2025-02-05 DOI: 10.1093/cercor/bhaf038

Kabir Ahmad, Bakhtawar Khan, Khizar Khan, Muhammad Khalid Iqbal, Xin Wang, Salman Shaikh, Ao-Ran Sui, Yue Lin Huang, Michael Ntim, Yue Kong, Jia Shu, Qiong Wu, Qi-Fa Li, Shao Li, Guang Yang

{"title":"Cell-type-specific expression of Nav1.6 in the developing brain of mice and its involvement in glial activation in Alzheimer's disease.","authors":"Kabir Ahmad, Bakhtawar Khan, Khizar Khan, Muhammad Khalid Iqbal, Xin Wang, Salman Shaikh, Ao-Ran Sui, Yue Lin Huang, Michael Ntim, Yue Kong, Jia Shu, Qiong Wu, Qi-Fa Li, Shao Li, Guang Yang","doi":"10.1093/cercor/bhaf038","DOIUrl":"10.1093/cercor/bhaf038","url":null,"abstract":"Voltage-gated sodium channels (Nav's), particularly Nav1.6, are crucial for action potential generation in neurons and are linked to brain disorders. This study explores the cell-type-specific expression of Nav1.6 in C57BL/6 mice brains at various developmental stages. Coronal sections from embryonic day 14 to postnatal day 30 were examined. Nav1.6 expression increased at both protein and messenger RNA (mRNA) levels during this period. Immunofluorescence double staining revealed that Nav1.6 is primarily localized on neurons. Astrocytes show increasing expression from prenatal to postnatal stages, correlating with maturation. Microglia exhibit low-intensity expression throughout the development. Co-expression of Nav1.6 with oligodendrocyte precursor cell marker NG2 is observed from E14 through postnatal stages, with prominent co-expression on day 21 and day 30. Consistent co-expression with olig2 is observed from E16 to day 30. In primary cultures, astrocytes had higher Nav1.6 levels compared to microglia and oligodendrocyte precursor cells. Nav1.6 expression was upregulated in astrocytes and microglia in APP/amyloid beta precursor protein/presenilin 1 (PS1) transgenic mice. Down-regulating Nav1.6 in vitro reduced amyloid beta-induced microglial activation and cytokine levels (IL-1β, TNF-α). These findings highlight Nav1.6 as a potential target for therapeutic interventions against neurodegenerative diseases.","PeriodicalId":9715,"journal":{"name":"Cerebral cortex","volume":"35 2","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143556004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The hemispheric differences in prefrontal function of Internet game disorder and non-Internet game disorder: an activation likelihood estimation meta-analysis. 网络游戏障碍与非网络游戏障碍前额叶功能半球差异：激活似然估计meta分析。

IF 2.9 2区医学

Cerebral cortex Pub Date : 2025-02-05 DOI: 10.1093/cercor/bhae493

Rui Xue, Jiaqi Li, Haibo Yang

引用次数: 0

Exploring common and distinct neural basis of procrastination and impulsivity through elastic net regression. 通过弹性网络回归探讨拖延症和冲动性的共同和独特的神经基础。

IF 2.9 2区医学

Cerebral cortex Pub Date : 2025-02-05 DOI: 10.1093/cercor/bhae503

Yao Yin, Ti Su, Xueke Wang, Bowen Hu, Rong Zhang, Feng Zhou, Tingyong Feng

{"title":"Exploring common and distinct neural basis of procrastination and impulsivity through elastic net regression.","authors":"Yao Yin, Ti Su, Xueke Wang, Bowen Hu, Rong Zhang, Feng Zhou, Tingyong Feng","doi":"10.1093/cercor/bhae503","DOIUrl":"10.1093/cercor/bhae503","url":null,"abstract":"Prior work highlighted that procrastination and impulsivity shared a common neuroanatomical basis in the dorsolateral prefrontal cortex, implying a tight relationship between these traits. However, theorists hold that procrastination is motivated by avoiding aversiveness, while impulsivity is driven by approaching immediate pleasure. Hence, exploring the common and distinct neural basis underlying procrastination and impulsivity through functional neuroimaging becomes imperative. To address this, we employed elastic net regression to examine the links between whole-brain resting-state functional connectivity and these traits in 822 university students from China. Results showed that the functional connections between the default network and the visual network were positively associated with both traits, indicating that the dysfunction of higher-order cognition (eg self-control) may account for their tight relationship. A distinct neural basis was also identified: Procrastination was negatively associated with functional connections between the frontal-parietal network and the ventral-attention network and between the cingular-opercular network and the subcortical network. In contrast, connections between the default network and the somato-motor network were negatively associated with impulsivity. These findings suggest that procrastination may be rooted in emotion-regulation deficits, while impulsivity may be rooted in reward-processing deficits. This deeper understanding of their neural basis provides insights for developing targeted interventions.","PeriodicalId":9715,"journal":{"name":"Cerebral cortex","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142977620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neuronal mechanisms enhancing selectivity of the innate number sense via learning. 通过学习增强先天数感选择性的神经元机制。

IF 2.9 2区医学

Cerebral cortex Pub Date : 2025-02-05 DOI: 10.1093/cercor/bhaf019

Andreas Nieder

引用次数: 0