Cerebral cortex最新文献

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Microglial regulation of white matter development and its disruption in autism spectrum disorder. 自闭症谱系障碍中小胶质细胞对白质发育的调控及其中断。
IF 2.9 2区 医学
Cerebral cortex Pub Date : 2025-04-01 DOI: 10.1093/cercor/bhaf109
Katherine Canada, Tanya M Evans, Kevin A Pelphrey
{"title":"Microglial regulation of white matter development and its disruption in autism spectrum disorder.","authors":"Katherine Canada, Tanya M Evans, Kevin A Pelphrey","doi":"10.1093/cercor/bhaf109","DOIUrl":"https://doi.org/10.1093/cercor/bhaf109","url":null,"abstract":"<p><p>White matter, comprising approximately 50% of the human brain, is crucial for efficient neuronal signaling and a wide range of brain functions, including social cognition, sensation, memory, motor control, and information integration across cortical brain regions in the service of perception and cognition. White matter, composed of myelinated axons, results from complex interactions between different cell types, with oligodendrocytes (OLs) and microglia playing integral roles. Microglia, the brain's resident immune cells, regulate oligodendrogenesis through phagocytosis and molecular signaling, for example through cytokines, which promote and inhibit maturation stages of OL lineage cells. Maternal immune activation (MIA) is a recognized risk factor for neurodevelopmental disorders, especially autism spectrum disorder (ASD). The physiological presentation of ASD includes white matter abnormalities and immune dysregulation. Emerging evidence indicates that MIA may reduce microglial reactivity and alter cytokine release in offspring, potentially disrupting the delicate balance required for proper white matter development. Understanding the intricate interplay between oligodendrocytes, microglia, inflammation, and white matter development in the context of MIA provides valuable insights into the etiology of and core symptoms of ASD and possible therapeutic targets.</p>","PeriodicalId":9715,"journal":{"name":"Cerebral cortex","volume":"35 4","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143976579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effects of gaming content from social media on individuals with internet gaming disorder: an fMRI study. 社交媒体游戏内容对网络游戏障碍患者的影响:一项功能磁共振成像研究。
IF 2.9 2区 医学
Cerebral cortex Pub Date : 2025-04-01 DOI: 10.1093/cercor/bhaf096
Yuka Fujimoto, Junya Fujino, Daisuke Matsuyoshi, Daisuke Jitoku, Nanase Kobayashi, Chenyu Qian, Shoko Okuzumi, Shisei Tei, Takehiro Tamura, Takefumi Ueno, Makiko Yamada, Hidehiko Takahashi
{"title":"Effects of gaming content from social media on individuals with internet gaming disorder: an fMRI study.","authors":"Yuka Fujimoto, Junya Fujino, Daisuke Matsuyoshi, Daisuke Jitoku, Nanase Kobayashi, Chenyu Qian, Shoko Okuzumi, Shisei Tei, Takehiro Tamura, Takefumi Ueno, Makiko Yamada, Hidehiko Takahashi","doi":"10.1093/cercor/bhaf096","DOIUrl":"https://doi.org/10.1093/cercor/bhaf096","url":null,"abstract":"<p><p>Internet gaming disorder is an increasing public health problem due to the widespread availability of online gaming. Social media platforms drive this trend by enabling gameplay sharing and increasing user engagement, potentially reinforcing addictive gaming behaviors. Understanding how gaming content exposure on social media affects brain activity in individuals with internet gaming disorder is crucial. This study aimed to investigate gaming content neural responses on social media in individuals with internet gaming disorder using functional magnetic resonance imaging. We aimed to determine differences in activation patterns that contribute to understanding the neurobiological underpinnings of internet gaming disorder by examining brain activity in these individuals and comparing it to healthy controls. Additionally, we investigated the association of brain activity with clinical characteristics (internet gaming disorder severity and illness duration). The participants with internet gaming disorder demonstrated increased bilateral orbitofrontal cortex, bilateral hippocampus, left precuneus, and right superior temporal gyrus activation in response to gaming-related cues on social media compared to healthy controls. Additionally, internet gaming disorder severity and illness duration correlated with left hippocampus activation levels. These results improve our understanding of how gaming-related content on social media affects individuals with internet gaming disorder. Our findings provide valuable information into the neurobiological features of internet gaming disorder and help develop effective treatment interventions.</p>","PeriodicalId":9715,"journal":{"name":"Cerebral cortex","volume":"35 4","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143960445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Can microglia negatively impact myelin development in autism? 小胶质细胞会对自闭症患者的髓磷脂发育产生负面影响吗?
IF 2.9 2区 医学
Cerebral cortex Pub Date : 2025-04-01 DOI: 10.1093/cercor/bhaf100
Gustavo Della-Flora Nunes
{"title":"Can microglia negatively impact myelin development in autism?","authors":"Gustavo Della-Flora Nunes","doi":"10.1093/cercor/bhaf100","DOIUrl":"https://doi.org/10.1093/cercor/bhaf100","url":null,"abstract":"<p><p>There is emerging evidence for the involvement of microglia and oligodendrocytes in the pathophysiology of autism. The accompanying review article summarize this evidence and explore potential ways microglia can modulate oligodendrocyte function in autism. Further investigation of the role of microglia and oligodendrocytes in autism may help clarify autism pathogenesis and holds promise to ameliorate autism phenotypes.</p>","PeriodicalId":9715,"journal":{"name":"Cerebral cortex","volume":"35 4","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143967017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Impact of visual and auditory deprivation on speech perception: an EEG study. 视觉和听觉剥夺对言语感知的影响:一项脑电图研究。
IF 2.9 2区 医学
Cerebral cortex Pub Date : 2025-04-01 DOI: 10.1093/cercor/bhaf086
Christine Turgeon, Vanessa Hadid, Paméla Trudeau-Fisette, Inga Knoth, Franco Lepore, Sarah Lippé, Lucie Ménard
{"title":"Impact of visual and auditory deprivation on speech perception: an EEG study.","authors":"Christine Turgeon, Vanessa Hadid, Paméla Trudeau-Fisette, Inga Knoth, Franco Lepore, Sarah Lippé, Lucie Ménard","doi":"10.1093/cercor/bhaf086","DOIUrl":"https://doi.org/10.1093/cercor/bhaf086","url":null,"abstract":"<p><p>This study investigated the impact of auditory and visual deprivation on speech processing by analyzing auditory evoked potentials (MMN, P3a, P2, N2b) in congenitally blind individuals, cochlear implant (CI) users, and normal-hearing controls. Using a passive oddball paradigm with /u/ as the standard stimulus and /i/ and /y/ as deviants, we recorded and analyzed auditory evoked potentials in fronto-central and centro-parietal regions. Blind participants exhibited significantly faster MMN and N2b latencies than controls and CI users, reflecting enhanced auditory temporal resolution due to cross-modal plasticity. CI users showed reduced P2 and N2b amplitudes, indicating challenges in early sensory processing and conflict monitoring, particularly for the /i/-/u/ contrast. Notably, blind participants had larger P3a amplitudes, emphasizing superior attentional engagement in response to deviant stimuli. Postlingually deafened CI users exhibited greater P3a amplitudes than prelingually deafened users, underscoring the impact of early auditory experiences on cortical responses. These findings demonstrate distinct effects of sensory deprivation on speech processing, with blind individuals showing compensatory neural mechanisms and CI users experiencing sensory and cognitive challenges. The results underscore the need for personalized rehabilitation strategies to enhance outcomes for populations with sensory deprivation and highlight the potential of cross-modal plasticity in auditory rehabilitation.</p>","PeriodicalId":9715,"journal":{"name":"Cerebral cortex","volume":"35 4","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12038810/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143983834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Unraveling white matter alterations in autism: the role of oligodendrocytes, microglia, and neuroinflammation. 解开自闭症中的白质改变:少突胶质细胞、小胶质细胞和神经炎症的作用。
IF 2.9 2区 医学
Cerebral cortex Pub Date : 2025-04-01 DOI: 10.1093/cercor/bhaf094
Yuri Bozzi
{"title":"Unraveling white matter alterations in autism: the role of oligodendrocytes, microglia, and neuroinflammation.","authors":"Yuri Bozzi","doi":"10.1093/cercor/bhaf094","DOIUrl":"https://doi.org/10.1093/cercor/bhaf094","url":null,"abstract":"<p><p>Researchers are increasingly investigating the developmental origins of white matter alterations in autism spectrum disorder (ASD). A recent review by Canada, Evans, and Pelphrey highlights the roles of oligodendrocytes and microglia in ASD-related white matter abnormalities. Evidence suggests that ASD risk genes impact oligodendrocyte development and myelination, while microglia dysfunction due to immune challenges may further disrupt white matter formation. Emerging studies link neuroinflammation to altered white matter trajectories, supporting early intervention strategies. Future research integrating neuroimaging, genetics, and immune profiling may enhance our understanding and facilitate the development of targeted neuroimmune therapies for ASD.</p>","PeriodicalId":9715,"journal":{"name":"Cerebral cortex","volume":"35 4","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143981238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The laminar pattern of proprioceptive activation in human primary motor cortex. 人初级运动皮层本体感觉激活的层流模式。
IF 2.9 2区 医学
Cerebral cortex Pub Date : 2025-04-01 DOI: 10.1093/cercor/bhaf076
Lasse Knudsen, Fanhua Guo, Daniel Sharoh, Jiepin Huang, Jakob U Blicher, Torben E Lund, Yan Zhou, Peng Zhang, Yan Yang
{"title":"The laminar pattern of proprioceptive activation in human primary motor cortex.","authors":"Lasse Knudsen, Fanhua Guo, Daniel Sharoh, Jiepin Huang, Jakob U Blicher, Torben E Lund, Yan Zhou, Peng Zhang, Yan Yang","doi":"10.1093/cercor/bhaf076","DOIUrl":"https://doi.org/10.1093/cercor/bhaf076","url":null,"abstract":"<p><p>The primary motor cortex (M1) is increasingly being recognized for its vital role in proprioceptive somatosensation. However, our current understanding of proprioceptive processing at the laminar scale is limited. Empirical findings in primates and rodents suggest a pronounced role of superficial cortical layers, but the involvement of deep layers has yet to be examined in humans. Submillimeter resolution functional magnetic resonance imaging (fMRI) has emerged in recent years, paving the way for studying layer-dependent activity in humans (laminar fMRI). In the present study, laminar fMRI was employed to investigate the influence of proprioceptive somatosensation on M1 deep layer activation using passive finger movements. Significant M1 deep layer activation was observed in response to proprioceptive stimulation across 10 healthy subjects using a vascular space occupancy (VASO)-sequence at 7 T. For further validation, two additional datasets were included which were obtained using a balanced steady-state free precession sequence with ultrahigh (0.3 mm) in-plane resolution, yielding converging results. These results were interpreted in the light of previous laminar fMRI studies and the active inference account of motor control. We propose that a considerable proportion of M1 deep layer activation is due to proprioceptive influence and that deep layers of M1 constitute a key component in proprioceptive circuits.</p>","PeriodicalId":9715,"journal":{"name":"Cerebral cortex","volume":"35 4","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11998912/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143978173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The prediction of auditory consequences of own and observed actions: a brain decoding multivariate pattern study. 预测自己和观察到的行为的听觉后果:一个大脑解码多变量模式研究。
IF 2.9 2区 医学
Cerebral cortex Pub Date : 2025-04-01 DOI: 10.1093/cercor/bhaf091
Marta Ghio, Karolin Haegert, Alexander Seidel, Boris Suchan, Patrizia Thoma, Christian Bellebaum
{"title":"The prediction of auditory consequences of own and observed actions: a brain decoding multivariate pattern study.","authors":"Marta Ghio, Karolin Haegert, Alexander Seidel, Boris Suchan, Patrizia Thoma, Christian Bellebaum","doi":"10.1093/cercor/bhaf091","DOIUrl":"https://doi.org/10.1093/cercor/bhaf091","url":null,"abstract":"<p><p>Evidence from the auditory domain suggests that sounds generated by self-performed as well as observed actions are processed differently compared to external sounds. This study aimed to investigate which brain regions are involved in the processing of auditory stimuli generated by actions, addressing the question of whether cerebellar forward models, which are supposed to predict the sensory consequences of self-performed actions, similarly underlie predictions for action observation. We measured brain activity with functional magnetic resonance imaging (fMRI) while participants elicited a sound via button press, observed another person performing this action, or listened to external sounds. By applying multivariate pattern analysis (MVPA), we found evidence for altered processing in the right auditory cortex for sounds following both self-performed and observed actions relative to external sounds. Evidence for the prediction of auditory action consequences was found in the bilateral cerebellum and the right supplementary motor area, but only for self-performed actions. Our results suggest that cerebellar forward models contribute to predictions of sensory consequences only for action performance. While predictions are also generated for action observation, the underlying mechanisms remain to be elucidated.</p>","PeriodicalId":9715,"journal":{"name":"Cerebral cortex","volume":"35 4","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12038811/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143981579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Regional, but not brain-wide, graph theoretic measures are robustly and reproducibly linked to general cognitive ability. 局部的,而不是全脑的,图论测量与一般的认知能力有可靠的和可重复的联系。
IF 2.9 2区 医学
Cerebral cortex Pub Date : 2025-04-01 DOI: 10.1093/cercor/bhaf074
M Fiona Molloy, Aman Taxali, Mike Angstadt, Tristan Greathouse, Katherine Toda-Thorne, Katherine L McCurry, Alexander Weigard, Omid Kardan, Lily Burchell, Maria Dziubinski, Jason Choi, Melanie Vandersluis, Cleanthis Michael, Mary M Heitzeg, Chandra Sripada
{"title":"Regional, but not brain-wide, graph theoretic measures are robustly and reproducibly linked to general cognitive ability.","authors":"M Fiona Molloy, Aman Taxali, Mike Angstadt, Tristan Greathouse, Katherine Toda-Thorne, Katherine L McCurry, Alexander Weigard, Omid Kardan, Lily Burchell, Maria Dziubinski, Jason Choi, Melanie Vandersluis, Cleanthis Michael, Mary M Heitzeg, Chandra Sripada","doi":"10.1093/cercor/bhaf074","DOIUrl":"https://doi.org/10.1093/cercor/bhaf074","url":null,"abstract":"<p><p>General cognitive ability (GCA), also called \"general intelligence,\" is thought to depend on network properties of the brain, which can be quantified through graph theoretic measures such as small worldness and module degree. An extensive set of studies examined links between GCA and graphical properties of resting state connectomes. However, these studies often involved small samples, applied just a few graph theory measures in each study, and yielded inconsistent results, making it challenging to identify the architectural underpinnings of GCA. Here, we address these limitations by systematically investigating univariate and multivariate relationships between GCA and 17 whole-brain and node-level graph theory measures in individuals from the Adolescent Brain Cognitive Development Study (n = 5937). We demonstrate that whole-brain graph theory measures, including small worldness and global efficiency, fail to exhibit meaningful relationships with GCA. In contrast, multiple node-level graphical measures, especially module degree (within-network connectivity), exhibit strong associations with GCA. We establish the robustness of these results by replicating them in a second large sample, the Human Connectome Project (n = 847), and across a variety of modeling choices. This study provides the most comprehensive and definitive account to date of complex interrelationships between GCA and graphical properties of the brain's intrinsic functional architecture.</p>","PeriodicalId":9715,"journal":{"name":"Cerebral cortex","volume":"35 4","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143991191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Enhancing creativity with covert neurofeedback: causal evidence for default-executive network coupling in creative thinking. 用隐蔽神经反馈增强创造力:创造性思维中默认-执行网络耦合的因果证据。
IF 2.9 2区 医学
Cerebral cortex Pub Date : 2025-04-01 DOI: 10.1093/cercor/bhaf065
Simone A Luchini, Xinbing Zhang, Ryan T White, Michael Lührs, Michal Ramot, Roger E Beaty
{"title":"Enhancing creativity with covert neurofeedback: causal evidence for default-executive network coupling in creative thinking.","authors":"Simone A Luchini, Xinbing Zhang, Ryan T White, Michael Lührs, Michal Ramot, Roger E Beaty","doi":"10.1093/cercor/bhaf065","DOIUrl":"10.1093/cercor/bhaf065","url":null,"abstract":"<p><p>Creativity neuroscience has consistently reported increased functional connectivity between the default mode network and the executive control network supports creative cognition, potentially reflecting coordination of generative and evaluative cognitive processes. However, evidence has been purely correlational-no causal demonstrations show that default mode network-executive control network interaction specifically drives creative performance. We sought causal evidence for default mode network-executive control network coupling in creative thinking using functional near-infrared spectroscopy-brain connectivity neurofeedback, which can endogenously modify functional connectivity through reinforcement learning. Importantly, we employed covert neurofeedback, where participants were unaware of the specific brain activity being trained, allowing for unbiased evaluation of cognitive and neural impacts. In a default-executive neurofeedback condition (n = 15), we entrained coupling between the medial prefrontal cortex and the dorsolateral prefrontal cortex, hubs of the default mode network and executive control network, respectively. We compared this with a default-motor condition (n = 15), entraining coupling between the medial prefrontal cortex and the supplementary motor area. Approximately 24 h later, default-executive neurofeedback led to increased coupling between the default mode network and the executive control network during a creative thinking task (generating creative object uses), extending to broader default mode network regions. Behaviorally, we observed a double dissociation: The default-executive condition increased idea originality, while the default-motor condition improved go/no-go reaction times. We thus provide the first evidence that default mode network-executive control network coupling causally enhances creative performance.</p>","PeriodicalId":9715,"journal":{"name":"Cerebral cortex","volume":"35 4","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143802611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correction to: Brain activation patterns reflecting differences in music training: listening by ear vs. reading sheet music for the recognition of contexts and structures in a composition. 更正:反映音乐训练差异的大脑激活模式:通过耳朵听与阅读乐谱来识别作品中的背景和结构。
IF 2.9 2区 医学
Cerebral cortex Pub Date : 2025-04-01 DOI: 10.1093/cercor/bhaf095
{"title":"Correction to: Brain activation patterns reflecting differences in music training: listening by ear vs. reading sheet music for the recognition of contexts and structures in a composition.","authors":"","doi":"10.1093/cercor/bhaf095","DOIUrl":"10.1093/cercor/bhaf095","url":null,"abstract":"","PeriodicalId":9715,"journal":{"name":"Cerebral cortex","volume":"35 4","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11998910/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143978567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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