Cerebral cortex最新文献_第9页

State shyness enhances recruitment of social processing regions while reducing communication of prefrontal regulatory regions. 状态羞怯增强了社会处理区域的招募，同时减少了前额叶调节区域的交流。

IF 2.9 2区医学

Cerebral cortex Pub Date : 2025-07-01 DOI: 10.1093/cercor/bhaf142

Liang Li, Yujie Zhang, Benjamin Becker, Hong Li

{"title":"State shyness enhances recruitment of social processing regions while reducing communication of prefrontal regulatory regions.","authors":"Liang Li, Yujie Zhang, Benjamin Becker, Hong Li","doi":"10.1093/cercor/bhaf142","DOIUrl":"https://doi.org/10.1093/cercor/bhaf142","url":null,"abstract":"State shyness is characterized by a swift and intense emotional response to social stressors, playing a crucial role in shaping the dynamic neural processes in social interactions. However, its underlying neural mechanisms remain unclear. Using a novel shyness-induction paradigm and functional magnetic resonance imaging (fMRI), we investigated brain activation and connectivity patterns associated with state shyness in 41 healthy adults (25 females; Mage = 21.41 ± 2.56). State shyness elicited increased activity in social processing regions, including the bilateral superior temporal, left middle temporal, and medial superior frontal regions. On the network level state shyness decreased connectivity within a regulatory frontal network encompassing dorsomedial prefrontal, anterior cingulate, superior, and inferior frontal systems. No effect on amygdala activation or connectivity was observed. These findings highlight distinct neural correlates of state shyness, emphasizing its reliance on prefrontal and temporal regions for immediate emotion regulation and social cognitive control. Moreover, the results differentiate state shyness from trait shyness, with the latter more closely linked to sustained interactions between the prefrontal cortex and limbic system, especially the amygdala. By elucidating the neural underpinnings of state shyness, this study contributes to a deeper understanding of the situational and transient nature of shy responses in dynamic social contexts.","PeriodicalId":9715,"journal":{"name":"Cerebral cortex","volume":"35 7","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144552443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Molecular and cellular rhythms in excitatory and inhibitory neurons in the mouse prefrontal cortex. 小鼠前额皮质兴奋性和抑制性神经元的分子和细胞节律。

IF 2.9 2区医学

Cerebral cortex Pub Date : 2025-07-01 DOI: 10.1093/cercor/bhaf188

Jennifer N Burns, Aaron K Jenkins, RuoFei Yin, Wei Zong, Lauren M DePoy, Kaitlyn A Petersen, Mariya Kaminsky, Chelsea A Vadnie, Madeline R Scott, George C Tseng, Yanhua H Huang, Colleen A McClung

{"title":"Molecular and cellular rhythms in excitatory and inhibitory neurons in the mouse prefrontal cortex.","authors":"Jennifer N Burns, Aaron K Jenkins, RuoFei Yin, Wei Zong, Lauren M DePoy, Kaitlyn A Petersen, Mariya Kaminsky, Chelsea A Vadnie, Madeline R Scott, George C Tseng, Yanhua H Huang, Colleen A McClung","doi":"10.1093/cercor/bhaf188","DOIUrl":"10.1093/cercor/bhaf188","url":null,"abstract":"While previous studies have found rhythms in gene expression in the prefrontal cortex (PFC), the contribution of different cell types and potential variation by sex has not been determined. Of interest are excitatory pyramidal cells and inhibitory parvalbumin (PV) interneurons, as the interaction between these cells is thought to underlie gamma oscillations and play a role in schizophrenia. We identify cell-type-specific rhythms in ribosome-associated transcripts from PV and pyramidal cells in the mouse PFC and assess rhythms in PV cell electrophysiology. We find that while core molecular clock genes are synchronized between cell types, pyramidal cells have nearly twice as many rhythmic transcripts as PV cells (35% vs. 18%). Moreover, in contrast to PV cells, rhythmic transcripts in pyramidal cells show substantial overlap between sexes. Additionally, there is a sex-specific reduction in action potential amplitude and spike frequency adaptation during the dark phase in PV cells from females. This study demonstrates that rhythms in gene expression and electrophysiological properties in the PFC vary by cell type and by sex. Moreover, the biological processes associated with rhythmic transcripts may provide insight into the unique functions of rhythms in these cells, as well as their selective vulnerabilities to circadian disruption.","PeriodicalId":9715,"journal":{"name":"Cerebral cortex","volume":"35 7","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12276627/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144667271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

More generosity, less inequity aversion? Neural correlates of fairness perception under social distance and of its relation to generosity. 更多的慷慨，更少的不平等厌恶？社会距离下公平感知的神经关联及其与慷慨的关系。

IF 2.9 2区医学

Cerebral cortex Pub Date : 2025-07-01 DOI: 10.1093/cercor/bhaf152

Ailian Wang, Chenchen Lin, Wenhao Mao, Jia Jin

{"title":"More generosity, less inequity aversion? Neural correlates of fairness perception under social distance and of its relation to generosity.","authors":"Ailian Wang, Chenchen Lin, Wenhao Mao, Jia Jin","doi":"10.1093/cercor/bhaf152","DOIUrl":"https://doi.org/10.1093/cercor/bhaf152","url":null,"abstract":"Humans instinctively react negatively to inequity, while generosity counters this tendency. Previous studies show that both fairness perception and generosity involve balancing behaviors and motivations in social interactions. However, their relationship remains underexplored, limiting our understanding of the complex psychological processes underlying social behavior. Using a social discounting task, we assessed individual generosity, while an Ultimatum Game task with concurrent electroencephalogram recording allowed us to quantify inequity aversion and fairness perception by manipulating social distance and inequity levels. We found that both generosity and fairness perception decrease with increasing social distance, whereas inequity aversion increases. Modeling the decay of generosity across social distances, we found that decayed generosity was positively associated with inequity aversion in the friend condition and negatively correlated with the attenuation of fairness perception. These results suggest that the decay of generosity with social distance is linked to reduced sensitivity to inequity toward friends and heightened neural differences in fairness perception across social relationships. Our study provides electrophysiological evidence of individual variability in generosity and inequity aversion influenced by social distance, expanding inequity aversion theory.","PeriodicalId":9715,"journal":{"name":"Cerebral cortex","volume":"35 7","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144641911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neuromodulatory influences on propagation of traveling waves along the unimodal-transmodal gradient. 沿单峰-跨峰梯度的行波传播的神经调节影响。

IF 2.9 2区医学

Cerebral cortex Pub Date : 2025-07-01 DOI: 10.1093/cercor/bhaf183

Verónica Mäki-Marttunen, Sander Tjalling Nieuwenhuis

{"title":"Neuromodulatory influences on propagation of traveling waves along the unimodal-transmodal gradient.","authors":"Verónica Mäki-Marttunen, Sander Tjalling Nieuwenhuis","doi":"10.1093/cercor/bhaf183","DOIUrl":"10.1093/cercor/bhaf183","url":null,"abstract":"Understanding the factors underlying brain activity fluctuation is important to understand the flexible nature of the brain and cognition. Growing evidence indicates that functional magnetic resonance imaging (fMRI) activity travels as waves around global signal peaks following a unimodal-transmodal gradient. This may explain the organization of brain activity into functional networks, but why the strength of integration between networks fluctuates is uncertain. Given that arousal-related neuromodulatory systems affect network integration and that traveling waves are modulated by arousal, we aimed to assess the hypothesis that an increase in neuromodulatory tone can affect network integration by modulating the speed of propagation of traveling waves. We tested this hypothesis using pharmacological fMRI/pupil measurements during rest and tasks. Atomoxetine, which increases extracellular catecholamine levels, was associated with faster traveling waves, and faster traveling waves correlated with more network integration. We also examined temporal variations in pupil size, a signature of transient changes in neuromodulatory activity, and found that the periods of traveling waves were characterized by larger pupil size. Our results suggest that neuromodulatory tone affects traveling wave propagation, and that this arousal-modulated propagation shapes integrated functional connectivity features, highlighting specific effects of prolonged and transient neuromodulatory influences on slow brain dynamics.","PeriodicalId":9715,"journal":{"name":"Cerebral cortex","volume":"35 7","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12262121/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144641913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The neural underpinnings of aphantasia: a case study of identical twins. 幻觉症的神经基础：同卵双胞胎的案例研究。

IF 2.9 2区医学

Cerebral cortex Pub Date : 2025-07-01 DOI: 10.1093/cercor/bhaf192

Emma Megla, Deepasri Prasad, Wilma A Bainbridge

引用次数: 0

Neuroimaging correlates of genetics in patients with Wilson's disease. Wilson病患者的神经影像学与遗传学的相关性

IF 2.9 2区医学

Cerebral cortex Pub Date : 2025-07-01 DOI: 10.1093/cercor/bhaf186

Yang Yu, Rou-Min Wang, Yi Dong, Xi-Ze Jia, Zhi-Ying Wu

{"title":"Neuroimaging correlates of genetics in patients with Wilson's disease.","authors":"Yang Yu, Rou-Min Wang, Yi Dong, Xi-Ze Jia, Zhi-Ying Wu","doi":"10.1093/cercor/bhaf186","DOIUrl":"https://doi.org/10.1093/cercor/bhaf186","url":null,"abstract":"Wilson's disease is an inherited disorder of copper metabolism. Despite significant advancements in neuroimaging studies, prior research into the pathological mechanism of Wilson's disease has ignored the crucial impact of mutation on the disease. This study examined brain imaging in relation to mutation in patients with Wilson's disease. A total of 57 Wilson's disease patients and 25 healthy controls were recruited in the current research. Patients were classified as having either the p.R778L or the p.P992L mutation (N = 43) or other mutations (N = 14). Utilizing the amplitude of low-frequency fluctuations, fractional amplitude of low-frequency fluctuations, and voxel-based morphology, the brain function and structure of Wilson's disease were explored. Compared to healthy controls, Wilson's disease patients with the p.R778L or p.P992L mutation showed greater atrophy in the bilateral putamen, caudate, globus pallidus, thalamus, amygdala, insula, and hippocampus. And these patients showed altered spontaneous neural activity in many more brain regions than healthy controls in three frequency bands. Significant correlation was found between altered brain volume and Unified Wilson's Disease Rating Scale neurological subscale scores. These findings reveal the functional and structural characteristics of Wilson's disease and emphasize the importance of exploring the neuroimaging correlation of genetic mutations in Wilson's disease.","PeriodicalId":9715,"journal":{"name":"Cerebral cortex","volume":"35 7","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144697736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Preoptic area influences sleep-related seizures in a genetic epilepsy mouse model. 遗传性癫痫小鼠模型中视前区影响睡眠相关癫痫发作。

IF 2.9 2区医学

Cerebral cortex Pub Date : 2025-07-01 DOI: 10.1093/cercor/bhaf187

Cobie Victoria Potesta, Madeleine Sandra Cargile, Andrea Yan, Sarah Xiong, Robert L Macdonald, Martin J Gallagher, Chengwen Zhou

{"title":"Preoptic area influences sleep-related seizures in a genetic epilepsy mouse model.","authors":"Cobie Victoria Potesta, Madeleine Sandra Cargile, Andrea Yan, Sarah Xiong, Robert L Macdonald, Martin J Gallagher, Chengwen Zhou","doi":"10.1093/cercor/bhaf187","DOIUrl":"10.1093/cercor/bhaf187","url":null,"abstract":"In patients with refractory epilepsy, states of sleep and wakefulness affect the expression of seizures. However, the mechanism by which subcortical sleep circuitry affects seizures is unknown. Here, using Gabrg2Q390X knock-in (KI) genetic epileptic mouse model, we found that during sleep, subcortical preoptic area (POA) neurons were active in het Gabrg2Q390X KI mice and their activity preceded or/and coincided with epileptic (poly)spike-wave discharges. Optogenetic manipulating the POA activity altered sleep/wake periods in wild-type (wt) and the het Gabrg2Q390X KI mice. Most importantly, short-period optogenetic activation of epileptic cortical neurons alone did not effectively trigger seizures in the het Gabrg2Q390X KI mice, while optogenetic activation of the POA nucleus slightly influenced spontaneous epileptic activity in the het Gabrg2Q390X KI mice. In contrast, coordinated optogenetic activation/suppression of the subcortical POA nucleus with the optogenetic activation of epileptic cortical neurons effectively enhanced or suppressed epileptic activity in the het Gabrg2Q390X KI mice, indicating that the subcortical POA activation exacerbates seizures in the het Gabrg2Q390X KI mice. In addition, suppression of the subcortical POA nucleus decreased myoclonic jerks in the Gabrg2Q390X KI mice. Overall, this study reveals a circuit-based mechanism of sleep-preferential seizures in one genetic epilepsy model with implications for refractory epilepsy.","PeriodicalId":9715,"journal":{"name":"Cerebral cortex","volume":"35 7","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12281508/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144689023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Top-down attentional control resilience reveals time-sensitive transcranial magnetic stimulation effects. 自上而下的注意控制弹性揭示了经颅磁刺激的时间敏感性。

IF 2.9 2区医学

Cerebral cortex Pub Date : 2025-07-01 DOI: 10.1093/cercor/bhaf168

Stefano Gallotto, Teresa Schuhmann, Felix Duecker, Alexander T Sack

{"title":"Top-down attentional control resilience reveals time-sensitive transcranial magnetic stimulation effects.","authors":"Stefano Gallotto, Teresa Schuhmann, Felix Duecker, Alexander T Sack","doi":"10.1093/cercor/bhaf168","DOIUrl":"https://doi.org/10.1093/cercor/bhaf168","url":null,"abstract":"The frontal eye fields (FEFs) are critically involved in voluntary shifts of attention by sending top-down signals to posterior cortices to modulate local alpha-band activity. However, the exact temporo-spatial dynamics of this process are still unclear. Here, we investigated how covert shifts of attention and associated modulations of posterior alpha power are affected after FEF inhibition by transcranial magnetic stimulation (TMS). Neither right nor left FEF disruption impaired attention task performance. This absence of behavioral effects seems to be related to the here employed long cue-target intervals, giving the attention system sufficient time to compensate (across trials) for the TMS insult. Alpha power modulation was quantified both in the entire cue-target interval, and in two additional time windows: after cue presentation (early) and before target appearance (late). TMS effects on alpha power clearly differed across time windows, being strongest in the early time window. The reduced TMS effect in the late window might reflect recovery/compensation employed by the attention system, possibly explaining the lack of TMS-induced behavioral effects. These results are in line with a central role of the FEF in the control of visuospatial attention and support the notion of compensation mechanisms in cognitive brain systems in the temporal domain.","PeriodicalId":9715,"journal":{"name":"Cerebral cortex","volume":"35 7","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144717648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neurocomputational mechanisms underlying how social status affects learning of trust behavior. 社会地位如何影响信任行为学习的神经计算机制。

IF 2.9 2区医学

Cerebral cortex Pub Date : 2025-07-01 DOI: 10.1093/cercor/bhaf191

Siying Li, Jean-Claude Dreher, Edmund Derrington, Haoke Li, Chen Qu

{"title":"Neurocomputational mechanisms underlying how social status affects learning of trust behavior.","authors":"Siying Li, Jean-Claude Dreher, Edmund Derrington, Haoke Li, Chen Qu","doi":"10.1093/cercor/bhaf191","DOIUrl":"10.1093/cercor/bhaf191","url":null,"abstract":"Social status, as a prominent social characteristic, exerts a significant influence on various aspects of life. However, there is only limited behavioral and neural evidence regarding the relationship between social status and the construction of trust. In this study, we used computational modeling and functional magnetic resonance imaging to unveil the trajectory of trust-related processing by using a repeated trust game. Human participants assumed the role of trustor and engaged in interactions with fictitious partners (trustees) who varied in social status. Participants were more inclined to trust Superiors than Inferiors and gradually modified their trust decisions based on their partners' reciprocity. Furthermore, we unveiled the neurocomputational mechanisms of two cognitive processes: (i) prior-based static modulation supported by the ventromedial prefrontal cortex (vmPFC), amygdala, and their neural coupling, and (ii) the reward network engaged in feedback-based dynamic modulation. We also found that prior bias in the social value of social status can reduce the reliance on the feedback-based dynamic modulation rooted in the vmPFC and ventral striatum. The present findings enhance the understanding of the neural representations of how social status modulates trust-related processing and trustworthiness updating.","PeriodicalId":9715,"journal":{"name":"Cerebral cortex","volume":"35 7","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144673937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dynamic changes in electrical brain activity during passive learning of foreign speech sound discrimination. 外语语音识别被动学习过程中脑电活动的动态变化。

IF 2.9 2区医学

Cerebral cortex Pub Date : 2025-07-01 DOI: 10.1093/cercor/bhaf181

Qin Li, Jari L O Kurkela, Kaisa Lohvansuu, Jarmo A Hämäläinen, Xueqiao Li, Weiyong Xu, Piia Astikainen

{"title":"Dynamic changes in electrical brain activity during passive learning of foreign speech sound discrimination.","authors":"Qin Li, Jari L O Kurkela, Kaisa Lohvansuu, Jarmo A Hämäläinen, Xueqiao Li, Weiyong Xu, Piia Astikainen","doi":"10.1093/cercor/bhaf181","DOIUrl":"10.1093/cercor/bhaf181","url":null,"abstract":"Previous brain research on phonetic learning of foreign speech sounds has focused on learning outcomes, mostly neglecting the dynamical neural changes during learning. In the present study, Finnish-speaking participants listened passively to a repeated presentation of vowel /a/ with infrequent changes in Mandarin tone for 2 h per day for 4 consecutive days while their brain activity was recorded using electroencephalography. While our previous study has reported the brain activity changes from test recordings conducted before and after the sound exposure, we here analyzed the data recorded during the exposure. We investigated learning dynamics across daily exposure sessions using event-related potentials and multivariate pattern analysis and within sessions using a sliding average across trials. Both mismatch negativity and P3a-markers of change detection and preattentive attention shifts-exhibited learning-related changes in both the event-related potential analysis and multivariate pattern analysis. Changes in multivariate pattern analysis were evident after the first 2-h training session, while event-related potential-based effects emerged later. During the daily exposure sessions, the mismatch negativity amplitude gradually decreased over the first 3 d, whereas the P3a amplitude exhibited an opposite trend, showing a significant increase, and only on day 1. These findings demonstrate dynamic neural changes driven by passive exposure and pave the way for investigating learning processes across multiple levels of analysis, including event-related potential, single-trial dynamics, and machine learning-based methods.","PeriodicalId":9715,"journal":{"name":"Cerebral cortex","volume":"35 7","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12262118/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144641909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0