Cerebral cortex最新文献_第9页

Selective removal of visual working memory items at test. 在测试中选择性地去除视觉工作记忆项目。

IF 3 2区医学

Cerebral cortex Pub Date : 2026-06-02 DOI: 10.1093/cercor/bhag066

Chong Zhao, Temilade Adekoya, Sintra Horwitz, Edward Awh, Edward K Vogel

引用次数: 0

Ephaptic coupling can explain variability in neural activity. 触觉耦合可以解释神经活动的变异性。

IF 3 2区医学

Cerebral cortex Pub Date : 2026-06-02 DOI: 10.1093/cercor/bhag098

Dimitris A Pinotsis, Earl K Miller

引用次数: 0

The longitudinal development of intrinsic timescales in infancy and their relation to alpha brain rhythm. 婴儿期内在时间尺度的纵向发展及其与α脑节律的关系。

IF 3 2区医学

Cerebral cortex Pub Date : 2026-06-02 DOI: 10.1093/cercor/bhag077

Anna Truzzi, Josué Rico-Picó, Maria Rosario Rueda, Rhodri Cusack

{"title":"The longitudinal development of intrinsic timescales in infancy and their relation to alpha brain rhythm.","authors":"Anna Truzzi, Josué Rico-Picó, Maria Rosario Rueda, Rhodri Cusack","doi":"10.1093/cercor/bhag077","DOIUrl":"10.1093/cercor/bhag077","url":null,"abstract":"Adult brain regions differ in the intrinsic timescales (INT) over which they integrate information. This spatial organization appears to emerge gradually: infants' brain activity recorded during sleep with functional magnetic resonance imaging (fMRI) shows overall longer INT and a different spatial structure. However, since fMRI is sensitive to hemodynamic confounds and is affected by arousal state, these factors may have accounted for observed age-related differences. Here, we used electroencephalography (EEG) to investigate for the first time how INT develop in infancy in a longitudinal sample from 6 to 16-months-old (exploratory cohort, n = 45; validation cohort, n = 45) and adults (n = 10). Infants were awake and engaged in baseline visual protocol, and adults were recorded under comparable (and distinct) conditions. Infant intrinsic timescales shortened from 6 to 16-months but remained longer than those of adults at all ages. Finally, INT correlated with alpha lagged coherence, a metric of self-predictability and, to lesser extent, with alpha peak frequency, suggesting that alpha oscillatory activity may contribute to the emergence of INT. Identifying the mechanisms underlying longer INT early in infancy-a finding replicated across fMRI and EEG-is a crucial step toward understanding the neural computations that allow infants to extract and learn patterns from their environment.","PeriodicalId":9715,"journal":{"name":"Cerebral cortex","volume":"36 6","pages":""},"PeriodicalIF":3.0,"publicationDate":"2026-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13293257/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148315904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Language laterality and cognitive skills: does anatomy matter? 语言偏侧性和认知技能：解剖学重要吗？

IF 3 2区医学

Cerebral cortex Pub Date : 2026-06-02 DOI: 10.1093/cercor/bhag067

Ieva Andrulyte, Laure Zago, Gael Jobard, Herve Lemaitre, Francesca M Branzi, Francois Rheault, Laurent Petit, Simon S Keller

{"title":"Language laterality and cognitive skills: does anatomy matter?","authors":"Ieva Andrulyte, Laure Zago, Gael Jobard, Herve Lemaitre, Francesca M Branzi, Francois Rheault, Laurent Petit, Simon S Keller","doi":"10.1093/cercor/bhag067","DOIUrl":"10.1093/cercor/bhag067","url":null,"abstract":"Brain anatomy, particularly white matter microstructure, is thought to play a critical role in the relationships between cognitive function and language lateralisation. This study investigates whether white matter microstructural parameters of the arcuate fasciculus and corpus callosum is associated with cognitive performance across distinct language lateralisation groups. Neuroimaging and cognitive data from 279 healthy adults were sourced from the BIL&GIN database. Participants completed a sentence production functional magnetic resonance imaging (fMRI) task, diffusion MRI, and cognitive tasks assessing verbal, visuospatial, and arithmetic skills. Significant positive associations were observed in strongly atypical individuals between fractional anisotropy in the splenium and working memory (R2 = 0.96, pFDR = 0.042) and between fractional anisotropy (FA) in the genu and visuospatial attention (R2 = 0.92, pFDR = 0.042). ANCOVA revealed that cross-dominant individuals had significantly lower visuospatial attention scores compared to consistently lateralized individuals (pFDR = 0.02). These findings challenge the notion that atypical lateralisation is inherently maladaptive and suggest that white matter pathways may serve as an alternative mechanism for supporting cognitive function in individuals with rightward language dominance. Furthermore, the results highlight the cognitive disadvantages of crossed dominance, implicating disrupted interhemispheric communication as a potential underlying mechanism.","PeriodicalId":9715,"journal":{"name":"Cerebral cortex","volume":"36 6","pages":""},"PeriodicalIF":3.0,"publicationDate":"2026-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13298645/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148327165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An expanded cortical map of von Economo neurons in the human medial prefrontal cortex. 人类内侧前额叶皮层中von Economo神经元的扩展皮层图。

IF 3 2区医学

Cerebral cortex Pub Date : 2026-06-02 DOI: 10.1093/cercor/bhag074

Daniela Ortiz-Muñoz, Carlos Arturo González-Acosta, Oscar Alonso Plaza-Patiño, Efraín Buriticá-Ramírez, Lina Vanessa Becerra-Hernández

{"title":"An expanded cortical map of von Economo neurons in the human medial prefrontal cortex.","authors":"Daniela Ortiz-Muñoz, Carlos Arturo González-Acosta, Oscar Alonso Plaza-Patiño, Efraín Buriticá-Ramírez, Lina Vanessa Becerra-Hernández","doi":"10.1093/cercor/bhag074","DOIUrl":"10.1093/cercor/bhag074","url":null,"abstract":"Von Economo neurons (VENs) are large bipolar projection cells, confined to the anterior cingulate and frontoinsular cortices, yet their broader cortical distribution remains unresolved. Previously, we reported these neurons in the dorsomedial portion of cortical area 9 and polar-medial area 10. Here, we describe the presence, density, and morphological features of VENs across seven cytoarchitectonic areas of the human medial prefrontal cortex (mPFC) (25, 32p, 32s, 10m, 14r, 11m, and 10r). Using immunohistochemistry and quantitative morphometry in postmortem tissue, we identified VENs and established consistent distribution patterns, with VENs significantly more abundant in dysgranular (32p, 32s, 25) than granular areas (10m, 10r, 11m, 14r), showing higher densities and larger somata preferentially located on cortical crests and in the right hemisphere. On average, VENs were 55% larger than neighboring pyramidal neurons, and their density covaried with soma size, revealing a regional efficiency gradient. These findings extend the known VEN map beyond previously described regions, indicating that their organization reflects cytoarchitectonic specialization and hemispheric asymmetry. By demonstrating that VENs populate a broader mPFC network implicated in interoception, motivation, and social cognition, these results support a proposed role for VENs as integrative nodes within prefrontal limbic circuits, with potential relevance for neuropsychiatric disorders.","PeriodicalId":9715,"journal":{"name":"Cerebral cortex","volume":"36 6","pages":""},"PeriodicalIF":3.0,"publicationDate":"2026-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13327109/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148374646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The neural mechanisms of aligning spatial perspectives. 对齐空间视角的神经机制。

IF 3 2区医学

Cerebral cortex Pub Date : 2026-06-02 DOI: 10.1093/cercor/bhag090

Scott O Murray, Bridget Leonard, Kristin Woodard, John A Pyles

{"title":"The neural mechanisms of aligning spatial perspectives.","authors":"Scott O Murray, Bridget Leonard, Kristin Woodard, John A Pyles","doi":"10.1093/cercor/bhag090","DOIUrl":"10.1093/cercor/bhag090","url":null,"abstract":"Visual perspective-taking requires mentally adopting another spatial viewpoint by aligning one's own perspective with that of a reference, such as another person or object. This alignment process is thought to rely on embodied spatial transformations engaging both spatial computation and motor-related systems. Using functional magnetic resonance imaging (fMRI), we tested whether neural responses scale with angular disparity between observer and reference viewpoints. Participants judged the relative position of objects from the perspective of either an avatar or an empty chair across alignment conditions and rotation angles. Unaligned conditions elicited stronger activation than aligned conditions in a distributed network encompassing medial frontal, premotor, opercular, posterior parietal, ventral temporal, and cerebellar regions. Both reaction time and Blood-Oxygen-Level-Dependent signal (BOLD) magnitude increased linearly with angular disparity, and individual differences in response time correlated with activation magnitude, linking behavioral effort to neural computation. Comparable results were obtained when the reference was a chair, indicating that these mechanisms generalize beyond social contexts. Together, these findings reveal a cerebello-frontoparietal network that supports perspective alignment through embodied simulation, spatial transformation, and predictive modeling, providing a unified account of the neural computations underlying VPT.","PeriodicalId":9715,"journal":{"name":"Cerebral cortex","volume":"36 6","pages":""},"PeriodicalIF":3.0,"publicationDate":"2026-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13313315/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148350942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

From regions to networks: reframing the role of the extrastriate body area. 从区域到网络：重构域外身体区域的角色。

IF 3 2区医学

Cerebral cortex Pub Date : 2026-06-02 DOI: 10.1093/cercor/bhag080

Angelika Lingnau

引用次数: 0

The multifaceted involvement of subregions of the rat prefrontal cortex in the formation of enduring associative olfactory memory. 大鼠前额叶皮层亚区在持久联想嗅觉记忆形成中的多面参与。

IF 2.9 2区医学

Cerebral cortex Pub Date : 2026-06-02 DOI: 10.1093/cercor/bhag048

Céline Duffau, Bruno Bontempi, Olivier Nicole

{"title":"The multifaceted involvement of subregions of the rat prefrontal cortex in the formation of enduring associative olfactory memory.","authors":"Céline Duffau, Bruno Bontempi, Olivier Nicole","doi":"10.1093/cercor/bhag048","DOIUrl":"10.1093/cercor/bhag048","url":null,"abstract":"Enduring memory engrams initially depend on the hippocampus but progressively shift toward cortical networks during systems consolidation. How these extrahippocampal regions cooperate to establish remote, corticalized memories remains poorly understood. Using a socially transmitted food preference paradigm combined with c-fos activity mapping, we identified distinct contributions of rat prefrontal subregions-including the orbitofrontal (OFC), medial prefrontal (mPFC), anterior cingulate (ACC), and posterior cingulate (PCC) cortices-to recent and remote olfactory associative memory retrieval. Activity patterns revealed a time-dependent reorganization of cortical circuits: the OFC and ACC were preferentially recruited during remote memory retrieval, whereas the PCC was more active for recent memory. Fos imaging and chemogenetic manipulations further demonstrated that the mPFC supports both encoding and retrieval of recent and remote memory, indicating a dual role compared with other prefrontal areas. Despite widespread neuronal activation, cortical engram formation follows a rostral-caudal functional gradient, where discrete prefrontal subregions exhibit distinct activation kinetics. These findings reveal that enduring memory consolidation involves coordinated, region-specific reorganization within the prefrontal cortex, with the mPFC acting as a central hub ensuring the integration and persistence of olfactory associative memories across time.","PeriodicalId":9715,"journal":{"name":"Cerebral cortex","volume":"36 6","pages":""},"PeriodicalIF":2.9,"publicationDate":"2026-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148161939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The mystery of a single brain region. 单一大脑区域的奥秘。

IF 3 2区医学

Cerebral cortex Pub Date : 2026-06-02 DOI: 10.1093/cercor/bhag093

Marina A Pavlova

引用次数: 0

Laminar architecture of visual and auditory responses in the supplementary eye field of macaques. 猕猴辅助视场中视觉和听觉反应的层流结构。

IF 3 2区医学

Cerebral cortex Pub Date : 2026-06-02 DOI: 10.1093/cercor/bhag064

Pranavan Thirunavukkarasu, Steven P Errington, Amirsaman Sajad, Benjamin W Corrigan, Jeffrey D Schall

{"title":"Laminar architecture of visual and auditory responses in the supplementary eye field of macaques.","authors":"Pranavan Thirunavukkarasu, Steven P Errington, Amirsaman Sajad, Benjamin W Corrigan, Jeffrey D Schall","doi":"10.1093/cercor/bhag064","DOIUrl":"10.1093/cercor/bhag064","url":null,"abstract":"We describe properties and laminar organization of visual and auditory responses sampled with linear electrode arrays in and around the supplementary eye field of four macaque monkeys performing a visually guided task with a tone secondary reinforcer. Of pyramidal neurons in all layers and interneurons in L3 and L5/6, one-quarter were visually responsive, one-quarter, auditory, with 30% bimodal. Visual neurons were less common rostral, lateral, and medial to the supplementary eye field. Facilitated visual and auditory responses were much more common than suppressed. Pyramidal and interneurons responded to the stimulus in either hemifield with a weak bias for contralateral targets. Visual response latencies were comparable to values previously reported and later than auditory responses. Facilitated visual responses of interneurons preceded those of pyramidal neurons. Transient visual responses preceded sustained. Current-source density revealed visually evoked current sinks after auditory sinks that were transient for bright flashes and prolonged for the discrete task target. The earliest sink appeared at the L3 to L5 border and spread superficially and deeper with idiosyncratic variability across monkeys. These findings reveal new details about sensory processing in medial frontal cortex and complement our previous descriptions of the functional properties and laminar organization of neurons supporting cognitive control.","PeriodicalId":9715,"journal":{"name":"Cerebral cortex","volume":"36 6","pages":""},"PeriodicalIF":3.0,"publicationDate":"2026-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13280951/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148276159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0