Cerebral cortex最新文献_第9页

Differential links in 16p11.2 deletion carriers reveal aberrant connections between large-scale networks.

IF 2.9 2区医学

Cerebral cortex Pub Date : 2025-02-05 DOI: 10.1093/cercor/bhae474

Abid Y Qureshi, Jared A Nielsen, Jorge Sepulcre

{"title":"Differential links in 16p11.2 deletion carriers reveal aberrant connections between large-scale networks.","authors":"Abid Y Qureshi, Jared A Nielsen, Jorge Sepulcre","doi":"10.1093/cercor/bhae474","DOIUrl":"10.1093/cercor/bhae474","url":null,"abstract":"Qualitatively different topographical patterns of connections are thought to underlie individual differences in thought and behavior, particularly at heteromodal association areas. As such, we hypothesized that connections unique to 16p11.2 deletion carriers compared to controls, rather than hyper- or hypo-connectivity, would serve as a better model to explain the cognitive and behavioral changes observed in individuals carrying this autism-risk copy number variation. Using a spatially-unbiased, data-driven approach we found that differential links clustered non-uniformly across the cortex-particularly at the superior temporal gyrus and sulcus, posterior insula, cingulate sulcus, and inferior parietal lobule bilaterally. At these hotspots, altered local connectivity that spanned across the borders of cortical large-scale networks coincided with aberrant distant interconnectivity between large-scale networks. This was most evident between the auditory and the dorsomedial default (DNb) networks-such that greater between-network interconnectivity was associated with greater communication and social impairment. Entangled connectivity between large-scale networks may preclude each network from having the necessary fidelity to operate properly, particularly when the 2 networks have opposing organization principles-namely, local specialization (segregation) versus global coherency (integration).","PeriodicalId":9715,"journal":{"name":"Cerebral cortex","volume":"35 2","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11859958/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143499002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Relationship between increased binding potential of possible 5-HT2A receptors in the ventral hippocampus by subchronic phencyclidine and disturbed social interaction in rats: a PET study using 18F-altanserin.

IF 2.9 2区医学

Cerebral cortex Pub Date : 2025-02-05 DOI: 10.1093/cercor/bhaf037

Eiichi Jodo, Tomoaki Nakazono, Kazumi Takahashi, Yoshiaki Suzuki, Ken-Yo Hoshino, Naoyuki Ukon, Songji Zhao, Taiki Joho, Kazuhiro Takahashi, Hiroshi Ito, Satoshi Eifuku

{"title":"Relationship between increased binding potential of possible 5-HT2A receptors in the ventral hippocampus by subchronic phencyclidine and disturbed social interaction in rats: a PET study using 18F-altanserin.","authors":"Eiichi Jodo, Tomoaki Nakazono, Kazumi Takahashi, Yoshiaki Suzuki, Ken-Yo Hoshino, Naoyuki Ukon, Songji Zhao, Taiki Joho, Kazuhiro Takahashi, Hiroshi Ito, Satoshi Eifuku","doi":"10.1093/cercor/bhaf037","DOIUrl":"https://doi.org/10.1093/cercor/bhaf037","url":null,"abstract":"Subchronic administration of the psychotomimetic drug phencyclidine is known to exacerbate serotonin 5-HT2A receptor-relevant behavioral abnormalities. However, the effects of subchronic phencyclidine on 5-HT2A receptors remain unclear. Here, we investigated the effects of subchronic phencyclidine on the binding potential (BPND) of 5-HT2A receptors in the rat brain using positron emission tomography. Adult male Sprague-Dawley rats received intraperitoneal injection of either phencyclidine (10 mg/kg) or physiological saline once daily, a total of 15 times. positron emission tomography scans were performed twice, before and after drug administration, using 18F-altanserin, a selective 5-HT2A receptor radioactive marker. Two behavioral tests, the sociability test and the social interaction test, were performed before each positron emission tomography scan. The social interaction time was significantly shortened by subchronic phencyclidine. The BPND of the 5-HT2A receptors was significantly increased after subchronic phencyclidine administration in the medial prefrontal cortex, ventral hippocampus, motor cortex, and somatosensory cortex. The BPND change between the pre- and postdrug periods in the ventral hippocampus showed a significant negative correlation (r = 0.73) with that of the social interaction time change. Our results suggest that upregulation of 5-HT2A receptors in the ventral hippocampus may play a role in disturbed social ability and the development of negative symptoms.","PeriodicalId":9715,"journal":{"name":"Cerebral cortex","volume":"35 2","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143555882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diagnosis of Alzheimer's disease using FusionNet with improved secretary bird optimization algorithm for optimal MK-SVM based on imaging genetic data. 利用FusionNet结合改进的秘书鸟优化算法对基于影像遗传数据的最优MK-SVM进行阿尔茨海默病诊断。

IF 2.9 2区医学

Cerebral cortex Pub Date : 2025-02-05 DOI: 10.1093/cercor/bhae498

Luyun Wang, Jinhua Sheng, Qiao Zhang, Yan Song, Qian Zhang, Binbing Wang, Rong Zhang

{"title":"Diagnosis of Alzheimer's disease using FusionNet with improved secretary bird optimization algorithm for optimal MK-SVM based on imaging genetic data.","authors":"Luyun Wang, Jinhua Sheng, Qiao Zhang, Yan Song, Qian Zhang, Binbing Wang, Rong Zhang","doi":"10.1093/cercor/bhae498","DOIUrl":"10.1093/cercor/bhae498","url":null,"abstract":"Alzheimer's disease is an irreversible central neurodegenerative disease, and early diagnosis of Alzheimer's disease is beneficial for its prevention and early intervention treatment. In this study, we propose a novel framework, FusionNet-ISBOA-MK-SVM, which integrates a fusion network (FusionNet) and improved secretary bird optimization algorithm to optimize multikernel support vector machine for Alzheimer's disease diagnosis. The model leverages multimodality data, including functional magnetic resonance imaging and genetic information (single-nucleotide polymorphisms). Specifically, FusionNet employs U-shaped hierarchical graph convolutional networks and sparse graph attention networks to select feature effectively. Extensive validation using the Alzheimer's Disease Neuroimaging Initiative dataset demonstrates the model's superior interpretability and classification performance. Compared to other state-of-the-art machine learning methods, FusionNet-ISBOA-MK-SVM achieves classification accuracies of 98.6%, 95.7%, 93.0%, 91.8%, 93.1%, and 95.4% for HC vs. AD, EMCI vs. AD, LMCI vs. AD, EMCI vs. AD, HC vs. EMCI, and HC vs. LMCI, respectively. Moreover, the proposed model identifies affected brain regions and pathogenic genes, offering deeper insights into the mechanisms and progression of Alzheimer's disease. These findings provide valuable scientific evidence to support early diagnosis and preventive strategies for Alzheimer's disease.","PeriodicalId":9715,"journal":{"name":"Cerebral cortex","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142930778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

MDD-SSTNet: detecting major depressive disorder by exploring spectral-spatial-temporal information on resting-state electroencephalography data based on deep neural network. MDD-SSTNet：基于深度神经网络的静息状态脑电图数据的频谱-时空信息挖掘检测重度抑郁症。

IF 2.9 2区医学

Cerebral cortex Pub Date : 2025-02-05 DOI: 10.1093/cercor/bhae505

Qiurong Chen, Min Xia, Jinfei Li, Yiqian Luo, Xiuzhu Wang, Fali Li, Yi Liang, Yangsong Zhang

{"title":"MDD-SSTNet: detecting major depressive disorder by exploring spectral-spatial-temporal information on resting-state electroencephalography data based on deep neural network.","authors":"Qiurong Chen, Min Xia, Jinfei Li, Yiqian Luo, Xiuzhu Wang, Fali Li, Yi Liang, Yangsong Zhang","doi":"10.1093/cercor/bhae505","DOIUrl":"10.1093/cercor/bhae505","url":null,"abstract":"Major depressive disorder (MDD) is a psychiatric disorder characterized by persistent lethargy that can lead to suicide in severe cases. Hence, timely and accurate diagnosis and treatment are crucial. Previous neuroscience studies have demonstrated that major depressive disorder subjects exhibit topological brain network changes and different temporal electroencephalography (EEG) characteristics compared to healthy controls. Based on these phenomena, we proposed a novel model, termed as MDD-SSTNet, for detecting major depressive disorder by exploring spectral-spatial-temporal information from resting-state EEG with deep convolutional neural network. Firstly, MDD-SSTNet used the Sinc filter to obtain specific frequency band features from pre-processed EEG data. Secondly, two parallel branches were used to extract temporal and spatial features through convolution and other operations. Finally, the model was trained with a combined loss function of center loss and Binary Cross-Entropy Loss. Using leave-one-subject-out cross-validation on the HUSM dataset and MODMA dataset, the MDD-SSTNet model outperformed six baseline models, achieving average classification accuracies of 93.85% and 65.08%, respectively. These results indicate that MDD-SSTNet could effectively mine spatial-temporal difference information between major depressive disorder subjects and healthy control subjects, and it holds promise to provide an efficient approach for MDD detection with EEG data.","PeriodicalId":9715,"journal":{"name":"Cerebral cortex","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143001071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hemispheric asymmetry of the white matter microstructure in schizophrenia patients with persistent auditory verbal hallucinations.

IF 2.9 2区医学

Cerebral cortex Pub Date : 2025-02-05 DOI: 10.1093/cercor/bhaf030

Jinguang Li, Jingqi He, Honghong Ren, Chunwang Li, Zongchang Li, Xiaogang Chen, Ying He, Jinsong Tang

{"title":"Hemispheric asymmetry of the white matter microstructure in schizophrenia patients with persistent auditory verbal hallucinations.","authors":"Jinguang Li, Jingqi He, Honghong Ren, Chunwang Li, Zongchang Li, Xiaogang Chen, Ying He, Jinsong Tang","doi":"10.1093/cercor/bhaf030","DOIUrl":"https://doi.org/10.1093/cercor/bhaf030","url":null,"abstract":"The link between hemispheric asymmetry and auditory verbal hallucinations in schizophrenia is underexplored with neuroimaging evidence. This study examined white matter asymmetries in schizophrenia patients. Diffusion tensor imaging data from 52 patients with persistent auditory verbal hallucinations, 33 who never experienced auditory verbal hallucinations, and 40 healthy controls were analyzed. Asymmetry indices for fractional anisotropy, axial diffusivity, radial diffusivity, and mean diffusivity were calculated for the whole-brain white matter skeleton and 22 pairs of regions of interest. The persistent auditory verbal hallucination group showed reduced fractional anisotropy asymmetry index in the whole-brain white matter skeleton compared to healthy control and never experienced auditory verbal hallucination groups, indicating altered asymmetry. Region of interest analysis revealed decreased fractional anisotropy asymmetry index in nine pairs and increased mean diffusivity AI in two pairs in the persistent auditory verbal hallucination group. Greater rightward asymmetry in the superior longitudinal fasciculus correlated with more severe auditory verbal hallucinations in persistent auditory verbal hallucination patients. No significant asymmetry differences were found between never experienced auditory verbal hallucinations and healthy control groups. Ridge regression analysis demonstrated that including the fractional anisotropy asymmetry index of the superior longitudinal fasciculus increased the explained variance in auditory verbal hallucination severity. These findings highlight distinct white matter asymmetry patterns in persistent auditory verbal hallucination patients, suggesting that hemispheric asymmetry plays a key role in the pathology of auditory verbal hallucinations in schizophrenia.Highlights: ","PeriodicalId":9715,"journal":{"name":"Cerebral cortex","volume":"35 2","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143425164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Innate numerosity perception and its roots in early vision.

IF 2.9 2区医学

Cerebral cortex Pub Date : 2025-02-05 DOI: 10.1093/cercor/bhaf016

Ben Harvey

引用次数: 0

Time to inhibit: P300 amplitude differences in individuals with high and low temporal efficiency.

IF 2.9 2区医学

Cerebral cortex Pub Date : 2025-02-05 DOI: 10.1093/cercor/bhae500

Klaudia Krystecka, Magdalena Stanczyk, Mateusz Choinski, Elzbieta Szelag, Aneta Szymaszek

{"title":"Time to inhibit: P300 amplitude differences in individuals with high and low temporal efficiency.","authors":"Klaudia Krystecka, Magdalena Stanczyk, Mateusz Choinski, Elzbieta Szelag, Aneta Szymaszek","doi":"10.1093/cercor/bhae500","DOIUrl":"10.1093/cercor/bhae500","url":null,"abstract":"Temporal processing and inhibitory control are closely interconnected. This study investigated whether individuals of high and low temporal efficiency display different behavioral and neural patterns while performing an electrophysiological Go/No-Go task. Individuals with lower temporal processing had significantly poorer behavioral performance of the task-slower reaction times to Go stimuli, greater number of omissions, and lower stimulus detectability (lower d-prime value)-than the high temporal efficiency group. Additionally, participants with low temporal efficiency had significantly lower P300 response to correct inhibitions (No-Go stimuli) compared to those with high temporal efficiency. Furthermore, the greater amplitude of the difference wave (No-Go vs Go) in the high temporal efficiency group may suggest superior efficacy of response inhibition and attention control processes in comparison to the low temporal efficiency group. These findings highlight significant differences in inhibitory control at both behavioral and neural levels in young adults differing in temporal processing efficiency.","PeriodicalId":9715,"journal":{"name":"Cerebral cortex","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11795308/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143073999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Enhancing retrieval capacity of the predictive brain through dorsolateral prefrontal cortex intervention. 通过干预背外侧前额叶皮层提高预测大脑的检索能力。

IF 2.9 2区医学

Cerebral cortex Pub Date : 2025-02-05 DOI: 10.1093/cercor/bhaf005

Laura Szücs-Bencze, Teodóra Vékony, Orsolya Pesthy, Krisztián Kocsis, Zsigmond Tamás Kincses, Nikoletta Szabó, Dezso Nemeth

{"title":"Enhancing retrieval capacity of the predictive brain through dorsolateral prefrontal cortex intervention.","authors":"Laura Szücs-Bencze, Teodóra Vékony, Orsolya Pesthy, Krisztián Kocsis, Zsigmond Tamás Kincses, Nikoletta Szabó, Dezso Nemeth","doi":"10.1093/cercor/bhaf005","DOIUrl":"10.1093/cercor/bhaf005","url":null,"abstract":"Extracting spatial or temporal patterns across experiences is essential for skill acquisition and predictive processes. The prefrontal cortex plays a central role in regulating competitive cognitive systems, with a particular influence on executive functions, often opposing statistical learning. This regulatory function may account for observed improvements in the acquisition and consolidation of statistical regularities following inhibition of the dorsolateral prefrontal cortex via repetitive transcranial magnetic stimulation. However, whether access to previously acquired statistical knowledge can similarly benefit from dorsolateral prefrontal cortex inhibition remains unclear. This preregistered study investigated the dorsolateral prefrontal cortex's role in retrieving pre-existing statistical knowledge of temporal regularities. Healthy human participants engaged in an implicit probabilistic sequence learning task followed by a 24-h consolidation period. Before retesting, they received either 1 Hz repetitive transcranial magnetic stimulation or sham stimulation over the left, right, or bilateral dorsolateral prefrontal cortex for 10 min. We observed that retrieval of statistical regularities was enhanced in the Bilateral dorsolateral prefrontal cortex group compared to the Sham group. Our findings suggest that dorsolateral prefrontal cortex inhibition may facilitate access to statistical knowledge, particularly when interhemispheric compensatory mechanisms are limited. These insights advance our understanding of the dynamic neural background of statistical learning and may inform strategies for cognitive enhancement.","PeriodicalId":9715,"journal":{"name":"Cerebral cortex","volume":"35 2","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11795508/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143188437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Altered spatiotemporal consistency and their genetic mechanisms in mild cognitive impairment: a combined neuroimaging and transcriptome study.

IF 2.9 2区医学

Cerebral cortex Pub Date : 2025-02-05 DOI: 10.1093/cercor/bhaf045

Yao Zhu, Anmo Wang, Yuyu Zhou, Shuya Yuan, Yang Ji, Wei Hu

{"title":"Altered spatiotemporal consistency and their genetic mechanisms in mild cognitive impairment: a combined neuroimaging and transcriptome study.","authors":"Yao Zhu, Anmo Wang, Yuyu Zhou, Shuya Yuan, Yang Ji, Wei Hu","doi":"10.1093/cercor/bhaf045","DOIUrl":"10.1093/cercor/bhaf045","url":null,"abstract":"The Four-dimensional (spatiotemporal) Consistency of local Neural Activities (FOCA) metric was utilized to assess spontaneous whole-brain activity. Despite its application, the genetic underpinnings of FOCA alterations in Alzheimer's Disease (AD)-related Mild Cognitive Impairment (MCI) remain largely unexplored. To elucidate these changes, we analyzed group FOCA differences in 41 MCI patients and 46 controls from the Alzheimer's Disease Neuroimaging Initiative database. Integrating the Allen Human Brain Atlas, we performed transcriptome-neuroimaging spatial association analyses to pinpoint genes correlating with MCI-related FOCA changes. We observed heightened FOCA in the frontal-parietal system and diminished FOCA in the temporal lobe and medium cingulate gyrus among MCI patients. These FOCA alterations were spatially linked to the expression of 384 genes, which were enriched in crucial molecular functions, biological processes, and cellular components of the cerebral cortex, as well as related pathways. These genes were specifically expressed in brain tissue and corticothalamic neurons, particularly during late cortical development. They also connected to various behavioral domains. Furthermore, these genes could form a protein-protein interaction network, supported by 34 hub genes. Our results suggest that local spatiotemporal consistency of spontaneous brain activity in MCI may stem from the complex interplay of a broad spectrum of genes with diverse functional features.","PeriodicalId":9715,"journal":{"name":"Cerebral cortex","volume":"35 2","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11879177/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143556003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Extending insights from LeDoux: using movies to study subjective, clinically meaningful experiences in neuroscience. 扩展勒杜的见解：利用电影研究神经科学中具有临床意义的主观体验。

IF 2.9 2区医学

Cerebral cortex Pub Date : 2025-01-08 DOI: 10.1093/cercor/bhae422

Peter A Kirk, Daniel S Pine, Katharina Kircanski

{"title":"Extending insights from LeDoux: using movies to study subjective, clinically meaningful experiences in neuroscience.","authors":"Peter A Kirk, Daniel S Pine, Katharina Kircanski","doi":"10.1093/cercor/bhae422","DOIUrl":"10.1093/cercor/bhae422","url":null,"abstract":"Neuroscience research with public health relevance to emotional disorders examines brain-behavior relations. Joe LeDoux's legacy advances these efforts in ways that remain truly unique. While recognized for his basic science research, he also inspires applied researchers, guiding an agenda for clinical scientists: understanding the pathophysiology of altered subjective experiences in emotional disorders. For brain imaging, movie-watching approaches help clinicians realize this agenda due to movies' relative strength in evoking rich, meaningful subjective experiences. Here, we describe methodological advances in movie-watching paradigms that might sustain LeDoux's impact by facilitating the discovery of neural mechanisms generating complex emotional responses. Of note, while linking subjective emotion to pathophysiology is a first step, innovations in movie-watching designs, especially involving therapeutic techniques for emotional disorders, can boost clinical application. Leveraging research on pathophysiology to generate novel therapy reflects the clinical legacy sustained through Joe LeDoux's rousing career.","PeriodicalId":9715,"journal":{"name":"Cerebral cortex","volume":" ","pages":"58-64"},"PeriodicalIF":2.9,"publicationDate":"2025-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11712263/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142459029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0