Cerebral cortex最新文献_第9页

Time to inhibit: P300 amplitude differences in individuals with high and low temporal efficiency.

IF 2.9 2区医学

Cerebral cortex Pub Date : 2025-02-05 DOI: 10.1093/cercor/bhae500

Klaudia Krystecka, Magdalena Stanczyk, Mateusz Choinski, Elzbieta Szelag, Aneta Szymaszek

{"title":"Time to inhibit: P300 amplitude differences in individuals with high and low temporal efficiency.","authors":"Klaudia Krystecka, Magdalena Stanczyk, Mateusz Choinski, Elzbieta Szelag, Aneta Szymaszek","doi":"10.1093/cercor/bhae500","DOIUrl":"10.1093/cercor/bhae500","url":null,"abstract":"Temporal processing and inhibitory control are closely interconnected. This study investigated whether individuals of high and low temporal efficiency display different behavioral and neural patterns while performing an electrophysiological Go/No-Go task. Individuals with lower temporal processing had significantly poorer behavioral performance of the task-slower reaction times to Go stimuli, greater number of omissions, and lower stimulus detectability (lower d-prime value)-than the high temporal efficiency group. Additionally, participants with low temporal efficiency had significantly lower P300 response to correct inhibitions (No-Go stimuli) compared to those with high temporal efficiency. Furthermore, the greater amplitude of the difference wave (No-Go vs Go) in the high temporal efficiency group may suggest superior efficacy of response inhibition and attention control processes in comparison to the low temporal efficiency group. These findings highlight significant differences in inhibitory control at both behavioral and neural levels in young adults differing in temporal processing efficiency.","PeriodicalId":9715,"journal":{"name":"Cerebral cortex","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11795308/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143073999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Enhancing retrieval capacity of the predictive brain through dorsolateral prefrontal cortex intervention. 通过干预背外侧前额叶皮层提高预测大脑的检索能力。

IF 2.9 2区医学

Cerebral cortex Pub Date : 2025-02-05 DOI: 10.1093/cercor/bhaf005

Laura Szücs-Bencze, Teodóra Vékony, Orsolya Pesthy, Krisztián Kocsis, Zsigmond Tamás Kincses, Nikoletta Szabó, Dezso Nemeth

{"title":"Enhancing retrieval capacity of the predictive brain through dorsolateral prefrontal cortex intervention.","authors":"Laura Szücs-Bencze, Teodóra Vékony, Orsolya Pesthy, Krisztián Kocsis, Zsigmond Tamás Kincses, Nikoletta Szabó, Dezso Nemeth","doi":"10.1093/cercor/bhaf005","DOIUrl":"10.1093/cercor/bhaf005","url":null,"abstract":"Extracting spatial or temporal patterns across experiences is essential for skill acquisition and predictive processes. The prefrontal cortex plays a central role in regulating competitive cognitive systems, with a particular influence on executive functions, often opposing statistical learning. This regulatory function may account for observed improvements in the acquisition and consolidation of statistical regularities following inhibition of the dorsolateral prefrontal cortex via repetitive transcranial magnetic stimulation. However, whether access to previously acquired statistical knowledge can similarly benefit from dorsolateral prefrontal cortex inhibition remains unclear. This preregistered study investigated the dorsolateral prefrontal cortex's role in retrieving pre-existing statistical knowledge of temporal regularities. Healthy human participants engaged in an implicit probabilistic sequence learning task followed by a 24-h consolidation period. Before retesting, they received either 1 Hz repetitive transcranial magnetic stimulation or sham stimulation over the left, right, or bilateral dorsolateral prefrontal cortex for 10 min. We observed that retrieval of statistical regularities was enhanced in the Bilateral dorsolateral prefrontal cortex group compared to the Sham group. Our findings suggest that dorsolateral prefrontal cortex inhibition may facilitate access to statistical knowledge, particularly when interhemispheric compensatory mechanisms are limited. These insights advance our understanding of the dynamic neural background of statistical learning and may inform strategies for cognitive enhancement.","PeriodicalId":9715,"journal":{"name":"Cerebral cortex","volume":"35 2","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11795508/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143188437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Altered spatiotemporal consistency and their genetic mechanisms in mild cognitive impairment: a combined neuroimaging and transcriptome study.

IF 2.9 2区医学

Cerebral cortex Pub Date : 2025-02-05 DOI: 10.1093/cercor/bhaf045

Yao Zhu, Anmo Wang, Yuyu Zhou, Shuya Yuan, Yang Ji, Wei Hu

{"title":"Altered spatiotemporal consistency and their genetic mechanisms in mild cognitive impairment: a combined neuroimaging and transcriptome study.","authors":"Yao Zhu, Anmo Wang, Yuyu Zhou, Shuya Yuan, Yang Ji, Wei Hu","doi":"10.1093/cercor/bhaf045","DOIUrl":"10.1093/cercor/bhaf045","url":null,"abstract":"The Four-dimensional (spatiotemporal) Consistency of local Neural Activities (FOCA) metric was utilized to assess spontaneous whole-brain activity. Despite its application, the genetic underpinnings of FOCA alterations in Alzheimer's Disease (AD)-related Mild Cognitive Impairment (MCI) remain largely unexplored. To elucidate these changes, we analyzed group FOCA differences in 41 MCI patients and 46 controls from the Alzheimer's Disease Neuroimaging Initiative database. Integrating the Allen Human Brain Atlas, we performed transcriptome-neuroimaging spatial association analyses to pinpoint genes correlating with MCI-related FOCA changes. We observed heightened FOCA in the frontal-parietal system and diminished FOCA in the temporal lobe and medium cingulate gyrus among MCI patients. These FOCA alterations were spatially linked to the expression of 384 genes, which were enriched in crucial molecular functions, biological processes, and cellular components of the cerebral cortex, as well as related pathways. These genes were specifically expressed in brain tissue and corticothalamic neurons, particularly during late cortical development. They also connected to various behavioral domains. Furthermore, these genes could form a protein-protein interaction network, supported by 34 hub genes. Our results suggest that local spatiotemporal consistency of spontaneous brain activity in MCI may stem from the complex interplay of a broad spectrum of genes with diverse functional features.","PeriodicalId":9715,"journal":{"name":"Cerebral cortex","volume":"35 2","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11879177/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143556003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Extending insights from LeDoux: using movies to study subjective, clinically meaningful experiences in neuroscience. 扩展勒杜的见解：利用电影研究神经科学中具有临床意义的主观体验。

IF 2.9 2区医学

Cerebral cortex Pub Date : 2025-01-08 DOI: 10.1093/cercor/bhae422

Peter A Kirk, Daniel S Pine, Katharina Kircanski

{"title":"Extending insights from LeDoux: using movies to study subjective, clinically meaningful experiences in neuroscience.","authors":"Peter A Kirk, Daniel S Pine, Katharina Kircanski","doi":"10.1093/cercor/bhae422","DOIUrl":"10.1093/cercor/bhae422","url":null,"abstract":"Neuroscience research with public health relevance to emotional disorders examines brain-behavior relations. Joe LeDoux's legacy advances these efforts in ways that remain truly unique. While recognized for his basic science research, he also inspires applied researchers, guiding an agenda for clinical scientists: understanding the pathophysiology of altered subjective experiences in emotional disorders. For brain imaging, movie-watching approaches help clinicians realize this agenda due to movies' relative strength in evoking rich, meaningful subjective experiences. Here, we describe methodological advances in movie-watching paradigms that might sustain LeDoux's impact by facilitating the discovery of neural mechanisms generating complex emotional responses. Of note, while linking subjective emotion to pathophysiology is a first step, innovations in movie-watching designs, especially involving therapeutic techniques for emotional disorders, can boost clinical application. Leveraging research on pathophysiology to generate novel therapy reflects the clinical legacy sustained through Joe LeDoux's rousing career.","PeriodicalId":9715,"journal":{"name":"Cerebral cortex","volume":" ","pages":"58-64"},"PeriodicalIF":2.9,"publicationDate":"2025-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11712263/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142459029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fear, learning, and the amygdala: a personal reflection in honor of Joseph LeDoux. 恐惧、学习和杏仁核：纪念约瑟夫-勒杜的个人思考。

IF 2.9 2区医学

Cerebral cortex Pub Date : 2025-01-08 DOI: 10.1093/cercor/bhae394

Kevin S LaBar

引用次数: 0

Honoring the legacy of Joseph E. LeDoux: introduction to the Special Issue. 纪念约瑟夫-E-勒杜的遗产：特刊导言。

IF 2.9 2区医学

Cerebral cortex Pub Date : 2025-01-08 DOI: 10.1093/cercor/bhae463

Daniela Schiller, Joshua Johansen, Linnaea Ostroff

引用次数: 0

When emotion and time meet from human and rodent perspectives: a central role for the amygdala? 从人类和啮齿动物的角度看情感与时间的交汇：杏仁核的核心作用？

IF 2.9 2区医学

Cerebral cortex Pub Date : 2025-01-08 DOI: 10.1093/cercor/bhae454

Valérie Doyère, Sylvie Droit-Volet

{"title":"When emotion and time meet from human and rodent perspectives: a central role for the amygdala?","authors":"Valérie Doyère, Sylvie Droit-Volet","doi":"10.1093/cercor/bhae454","DOIUrl":"10.1093/cercor/bhae454","url":null,"abstract":"Initiated by a long stay of Valérie Doyère in the laboratory of Joseph LeDoux, a Franco-American collaborative group was formed around the topic of emotion and time perception in a comparative perspective between humans and non-human animals. Here, we discuss results from our studies on the mechanisms underlying time distortion under 2 conditions, timing of a threatening stimulus and timing of a neutral stimulus in the context of fear, with insights from neurodevelopment. Although the type of temporal distortion depends on the experimental situations, in both humans and rodents a high-arousal emotion automatically triggers acceleration of an \"internal clock\" system, an effect that may rely on the early maturing amygdala. Our studies, particularly in humans, also point to the role of attention and self-awareness in regulating the effect of fear on timing, relying on the prefrontal cortex, a late maturing structure. Thus, in line with LeDoux, while the amygdala may process all characteristics of events (including time) necessary to quickly trigger appropriate survival behaviors, some type of time distortions may rely on higher-order processing, some specific to humans. The extent of the network underlying threat-related time distortions remains to be explored, with species comparisons being a promising means of investigation.","PeriodicalId":9715,"journal":{"name":"Cerebral cortex","volume":" ","pages":"34-41"},"PeriodicalIF":2.9,"publicationDate":"2025-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142692784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

How to interpret LeDoux's multistate hierarchical theory of consciousness. 如何解读勒杜的意识多态层次理论。

IF 2.9 2区医学

Cerebral cortex Pub Date : 2025-01-08 DOI: 10.1093/cercor/bhae389

Richard Brown

引用次数: 0

On role models and Joe LeDoux. 关于榜样和乔-勒杜。

IF 2.9 2区医学

Cerebral cortex Pub Date : 2025-01-08 DOI: 10.1093/cercor/bhae417

Sheena A Josselyn

{"title":"On role models and Joe LeDoux.","authors":"Sheena A Josselyn","doi":"10.1093/cercor/bhae417","DOIUrl":"10.1093/cercor/bhae417","url":null,"abstract":"Joseph LeDoux is a pioneering neuroscientist who has made profound discoveries that continue to impact our understanding of the neural basis of emotion and memory, particularly the role of the amygdala in threat conditioning. LeDoux's trailblazing and elegant studies were some of the first to examine the circuit basis of behavior. His work combined techniques to trace pathways into and out of the amygdala important for threat conditioning and related behaviors. Since that time, these types of circuit tracing studies have exploded in popularity across neuroscience, and I would argue, we all owe a debt to LeDoux for this. LeDoux has made numerous additional contributions to neuroscience and, by bringing emotion back to neuroscience, has helped unite neuroscience with psychology. A gifted writer with a knack for communicating complicated scientific ideas in an accessible manner, LeDoux has become an ambassador of science who uses his love of music to help educate and inspire. Perhaps more important than these laudable scientific achievements, LeDoux is also a true \"gentleman\" of science, showing that science need not be a contact sport. Here, I give a personal account on why Joseph LeDoux is one of my scientific role models.","PeriodicalId":9715,"journal":{"name":"Cerebral cortex","volume":" ","pages":"15-18"},"PeriodicalIF":2.9,"publicationDate":"2025-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11712266/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142459030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

My science and career with Joseph E. LeDoux. 我与约瑟夫-E-勒杜的科学和职业生涯

IF 2.9 2区医学

Cerebral cortex Pub Date : 2025-01-08 DOI: 10.1093/cercor/bhae466

Elizabeth A Phelps

引用次数: 0