Cognitive maps for hierarchical spaces in the human brain.

IF 2.9 2区 医学 Q2 NEUROSCIENCES
Michael Peer, Russell A Epstein
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引用次数: 0

Abstract

Many of the environments that we navigate through every day are hierarchically organized-they consist of spaces nested within other spaces. How do our mind/brains represent such environments? To address this question, we familiarized participants with a virtual environment consisting of a building within a courtyard, with objects distributed throughout the courtyard and building interior. We then scanned them with functional MRI (fMRI) while they performed a memory task that required them to think about spatial relationships within and across the subspaces. Behavioral responses were less accurate and response times were longer on trials requiring integration across the subspaces compared to trials not requiring integration. FMRI response differences between integration and non-integration trials were observed in scene-responsive and medial temporal lobe brain regions, which were correlated the behavioral integration effects in retrosplenial complex, occipital place area, and hippocampus. Multivoxel pattern analyses provided additional evidence for representations in these brain regions that reflected the hierarchical organization of the environment. These results indicate that people form cognitive maps of nested spaces by dividing them into subspaces and using an active cognitive process to integrate the subspaces. Similar mechanisms might be used to support hierarchical coding in memory more broadly.

人类大脑中层次空间的认知地图。
我们每天所经历的许多环境都是分层组织的——它们由嵌套在其他空间中的空间组成。我们的思想/大脑是如何表现这样的环境的?为了解决这个问题,我们让参与者熟悉了一个虚拟环境,这个环境由庭院内的建筑组成,物体分布在庭院和建筑内部。然后,我们用功能性磁共振成像(fMRI)对他们进行扫描,同时让他们执行一项记忆任务,要求他们思考子空间内部和子空间之间的空间关系。与不需要整合的实验相比,需要跨子空间整合的实验的行为反应更不准确,反应时间更长。在情景反应区和内侧颞叶脑区观察到整合与非整合试验的FMRI反应差异,这与脾后复合体、枕位区和海马的行为整合效应有关。多体素模式分析为这些大脑区域的表征提供了额外的证据,这些表征反映了环境的分层组织。这些结果表明,人们通过将嵌套空间划分为子空间并使用主动认知过程将子空间整合来形成嵌套空间的认知地图。类似的机制可以用于更广泛地支持内存中的分层编码。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Cerebral cortex
Cerebral cortex 医学-神经科学
CiteScore
6.30
自引率
8.10%
发文量
510
审稿时长
2 months
期刊介绍: Cerebral Cortex publishes papers on the development, organization, plasticity, and function of the cerebral cortex, including the hippocampus. Studies with clear relevance to the cerebral cortex, such as the thalamocortical relationship or cortico-subcortical interactions, are also included. The journal is multidisciplinary and covers the large variety of modern neurobiological and neuropsychological techniques, including anatomy, biochemistry, molecular neurobiology, electrophysiology, behavior, artificial intelligence, and theoretical modeling. In addition to research articles, special features such as brief reviews, book reviews, and commentaries are included.
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