Cerebral cortex最新文献_第2页

Altered connectivity and network efficiency in preterm infants. 早产儿连通性和网络效率的改变。

IF 3 2区医学

Cerebral cortex Pub Date : 2026-10-05 DOI: 10.1093/cercor/bhag168

Karlo Stemberger, Domagoj Lasić, Nicolò Pecco, Matteo Canini, Ruža Grizelj, Tomislav Ćaleta, Miloš Judaš, Ivica Kostović, Marko Radoš, David Ozretić, Jelena Božek, Finn Lennartsson, Pasquale Anthony Della Rosa, Milan Radoš

{"title":"Altered connectivity and network efficiency in preterm infants.","authors":"Karlo Stemberger, Domagoj Lasić, Nicolò Pecco, Matteo Canini, Ruža Grizelj, Tomislav Ćaleta, Miloš Judaš, Ivica Kostović, Marko Radoš, David Ozretić, Jelena Božek, Finn Lennartsson, Pasquale Anthony Della Rosa, Milan Radoš","doi":"10.1093/cercor/bhag168","DOIUrl":"10.1093/cercor/bhag168","url":null,"abstract":"Preterm birth is associated with altered maturation of large-scale functional brain networks during the neonatal period. Acquisition and preprocessing variability across neonatal resting-state fMRI (rs-fMRI) studies limits cross-site comparability and may obscure prematurity-related alterations. We combined rs-fMRI data from 90 local preterm infants scanned at term-equivalent age (TEA) with data from 160 infants in the Developing Human Connectome Project (100 term-born and 60 preterm) to evaluate cross-site harmonization and characterize edge-wise functional connectivity and network efficiency. Data were preprocessed using an identical pipeline in SPM and CONN toolbox, harmonized with neuroCombat, and analyzed using per-edge analysis of covariance for connectivity and linear mixed-effects models for graph efficiency. Harmonization substantially reduced site-related variance and improved cross-site comparability. Relative to term-born controls, preterm infants showed widespread edge-wise hypoconnectivity, with only limited focal hyperconnectivity. Graph-theoretical analysis revealed reduced local alongside modestly increased global network efficiency in preterm infants, whereas regional connection-class composition did not interact with group. These findings support the feasibility of harmonizing multi-site neonatal rs-fMRI data and suggest that prematurity at TEA is characterized by widespread functional hypoconnectivity and a shift in the balance between local network segregation and large-scale functional integration.","PeriodicalId":9715,"journal":{"name":"Cerebral cortex","volume":"36 10","pages":""},"PeriodicalIF":3.0,"publicationDate":"2026-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13662217/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149179641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction to: Resolving competition in auditory cortex: effects of emotional content and misophonia sensitivity. 修正：解决听觉皮层的竞争：情绪内容和恐音症敏感性的影响。

IF 3 2区医学

Cerebral cortex Pub Date : 2026-09-01 DOI: 10.1093/cercor/bhag129

引用次数: 0

Correction to: Brain plasticity underlying sleep-dependent motor consolidation after motor imagery. 修正：运动意象后睡眠依赖运动巩固的大脑可塑性。

IF 3 2区医学

Cerebral cortex Pub Date : 2026-09-01 DOI: 10.1093/cercor/bhag153

引用次数: 0

Electrophysiological evidence that musical experience affects spatial auditory perception. 音乐体验影响空间听觉感知的电生理学证据。

IF 3 2区医学

Cerebral cortex Pub Date : 2026-09-01 DOI: 10.1093/cercor/bhag162

Hongxing Liu, Jianing Zhu, Kunyun Feng, Dong Yang, Guangjian Ni

{"title":"Electrophysiological evidence that musical experience affects spatial auditory perception.","authors":"Hongxing Liu, Jianing Zhu, Kunyun Feng, Dong Yang, Guangjian Ni","doi":"10.1093/cercor/bhag162","DOIUrl":"https://doi.org/10.1093/cercor/bhag162","url":null,"abstract":"Musical experience is associated with enhanced auditory abilities, but it remains unclear how these benefits are expressed across different stages of spatial auditory processing. Therefore, we examined participants with and without musical experience using a spatial auditory oddball paradigm with multiple spatial deviations under both unattended and attended conditions. Behavioral performance, event-related potentials, and phase-locking value (PLV)-based functional connectivity were jointly analyzed to characterize spatial auditory processing at behavioral, local neural, and network levels. Participants with musical experience showed higher localization accuracy and faster reaction times. During unattended listening, they exhibited larger mismatch negativity (MMN) amplitudes and stronger functional connectivity, particularly across frontal, temporal, and parietal-occipital regions, whereas during attended listening, they showed larger P300 amplitudes and enhanced large-scale neural synchronization, particularly between frontal and parietal-occipital regions. Moreover, MMN and P300 amplitudes were significantly associated with behavioral performance, linking these neural responses to spatial auditory ability. Together, these converging findings suggest that musical experience is associated with enhanced sensitivity to spatial auditory changes, more efficient attention-dependent processing, and stronger coordination across distributed brain networks. These findings provide an integrated view of how musical experience shapes spatial auditory processing across different attentional states.","PeriodicalId":9715,"journal":{"name":"Cerebral cortex","volume":"36 9","pages":""},"PeriodicalIF":3.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149079737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Targeted stimulation of face-selective visual cortex at retrieval boosts associative face memory in healthy young adults. 在检索时，有针对性地刺激面部选择视觉皮层可提高健康年轻人的联想面部记忆。

IF 3 2区医学

Cerebral cortex Pub Date : 2026-09-01 DOI: 10.1093/cercor/bhag135

Hendrik Heinbockel, Aidan J Horner, Lars Schwabe

{"title":"Targeted stimulation of face-selective visual cortex at retrieval boosts associative face memory in healthy young adults.","authors":"Hendrik Heinbockel, Aidan J Horner, Lars Schwabe","doi":"10.1093/cercor/bhag135","DOIUrl":"10.1093/cercor/bhag135","url":null,"abstract":"Episodic memory retrieval relies on encoding-pattern reinstatement (EPR), the reactivation of neural representations formed during encoding. Although EPR has been associated with successful remembering, it remains unclear whether this process can be proactively enhanced at retrieval. Specifically, it is unknown whether targeted brain stimulation immediately before retrieval can strengthen cortical reinstatement and improve memory in a content-specific manner. To address this question, we combined noninvasive brain stimulation with electroencephalography (EEG) in a 2-d associative memory paradigm. On day 1, participants encoded word-face and word-scene pairs. On day 2, immediately prior to retrieval, they received either intermittent theta burst stimulation (iTBS) or sham stimulation targeted to the right occipital face area, a region specialized for face processing. Pre-retrieval iTBS selectively enhanced associative memory for faces, but not scenes. While the behavioral findings demonstrate a category-specific enhancement of memory following stimulation, the exploratory multivariate pattern analysis on EEG data remained inconclusive as to whether EPR represents the mechanism underlying the observed memory benefit. Together, these findings show that targeted stimulation of face-selective visual cortex can selectively enhance associative face memory at retrieval, supporting a core tenet of the EPR framework and offering a potential pathway for targeted brain stimulation to alleviate content-specific memory deficits.","PeriodicalId":9715,"journal":{"name":"Cerebral cortex","volume":"36 9","pages":""},"PeriodicalIF":3.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148879370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Distinct neural routes for evaluative and informational social influence. 评估性和信息性社会影响的不同神经通路。

IF 3 2区医学

Cerebral cortex Pub Date : 2026-09-01 DOI: 10.1093/cercor/bhag107

Sriranjani Manivasagam, Thomas Schultze, Anne Schacht, Anna Fischer

{"title":"Distinct neural routes for evaluative and informational social influence.","authors":"Sriranjani Manivasagam, Thomas Schultze, Anne Schacht, Anna Fischer","doi":"10.1093/cercor/bhag107","DOIUrl":"10.1093/cercor/bhag107","url":null,"abstract":"Humans routinely revise their judgments based on input from others, but the brain mechanisms that distinguish evaluative from informational social influence remain unclear. We combined a preregistered electroencephalography (EEG) experiment (n = 87) with the Judge-Advisor System (JAS) to identify how two common forms of social information-feedback and advice-shape judgment and decision making. Participants made numerical estimates, received either feedback (\"good\"/\"bad\") or advice (a specific alternative estimate) that was either close to or far from their own, and then revised their response. Across behavioral and neural indices, both information types showed proximity-dependent effects, yet diverged in their temporal dynamics. Feedback elicited a feedback-related negativity (FRN) that decreased with confidence, indicating reflexive performance monitoring. Advice produced sustained late positive complex (LPC) activity whose onset slowed with higher confidence and lower proximity, reflecting deliberate integration of external information. For both, P300 amplitudes increased with proximity, consistent with the reward value of social validation. These findings reveal two complementary neurocognitive routes by which social information guides decisions: a rapid evaluative route engaged by feedback and a slower deliberative route engaged by advice. The results identify distinct temporal signatures of how the human brain incorporates others' input to refine its own judgments.","PeriodicalId":9715,"journal":{"name":"Cerebral cortex","volume":"36 9","pages":""},"PeriodicalIF":3.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148954957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multimodal white matter alterations in adolescent obsessive-compulsive disorder. 青少年强迫症的多模态白质改变。

IF 3 2区医学

Cerebral cortex Pub Date : 2026-09-01 DOI: 10.1093/cercor/bhag148

Kexu Zhang, Xiaochi Yuan, Chenchen Zhang, Rui Li, Runze Xu, Aixin Jia, Guanqiao Song, Kun Li

{"title":"Multimodal white matter alterations in adolescent obsessive-compulsive disorder.","authors":"Kexu Zhang, Xiaochi Yuan, Chenchen Zhang, Rui Li, Runze Xu, Aixin Jia, Guanqiao Song, Kun Li","doi":"10.1093/cercor/bhag148","DOIUrl":"10.1093/cercor/bhag148","url":null,"abstract":"Obsessive-compulsive disorder (OCD) emerging during adolescence coincides with a critical period of white matter maturation, yet the structural, functional, and molecular characteristics of white matter abnormalities remain incompletely understood. We acquired multimodal magnetic resonance imaging data from 40 adolescents with OCD and 40 healthy controls and quantified fractional anisotropy (FA) and fractional amplitude of low-frequency fluctuations (fALFF) along white matter tracts using Automated Fiber Quantification. Group comparisons, clinical correlation analyses, support vector machine classification, and molecular association analyses were performed. Adolescents with OCD exhibited increased FA in the bilateral anterior thalamic radiation (ATR) and left corticospinal tract, together with increased fALFF in the right ATR and right cingulum bundle (cingulate segment). Greater functional activity within the cingulum bundle was associated with lower symptom severity. A multimodal model integrating FA and fALFF achieved better classification performance than either modality alone. Molecular analyses linked white matter structural alterations to dopaminergic and cholinergic neurotransmitter systems, while transcriptomic analyses implicated neurodevelopmental and synaptic processes as well as excitatory and inhibitory neuronal cell types. These findings demonstrate convergent structural and functional alterations of white matter in adolescent OCD and suggest that their associated molecular signatures may provide insights into the biological context of these imaging abnormalities.","PeriodicalId":9715,"journal":{"name":"Cerebral cortex","volume":"36 9","pages":""},"PeriodicalIF":3.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148982308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Accent type modulates frequency-specific neural tracking of speech. 重音类型调节特定频率的语音神经跟踪。

IF 3 2区医学

Cerebral cortex Pub Date : 2026-09-01 DOI: 10.1093/cercor/bhag133

Anna M Czepiel, Holly Bradley, Christina M Vanden Bosch der Nederlanden, Elizabeth K Johnson

{"title":"Accent type modulates frequency-specific neural tracking of speech.","authors":"Anna M Czepiel, Holly Bradley, Christina M Vanden Bosch der Nederlanden, Elizabeth K Johnson","doi":"10.1093/cercor/bhag133","DOIUrl":"10.1093/cercor/bhag133","url":null,"abstract":"In the real world, listeners often find speech in a non-native (L2) accent harder to understand than speech in their own native (L1) accent. In ideal laboratory listening settings, these struggles can become smaller. For this reason, most research on L2 accent processing uses speech-in-noise paradigms to avoid ceiling effects. Here, we explore whether neural tracking provides a sensitive measure of L2-processing difficulties, even in ideal listening conditions. In our electroencephalography (EEG) study, Canadian English-speaking adults were presented with Canadian (L1) and Mandarin-accented (L2) English. We assessed neural tracking of speech by analyzing coherence between the speech envelope and EEG. We found significantly stronger tracking for L1-accented speech, in canonical delta-theta frequencies, as well as higher-frequency bands associated with fine-grained phonemic encoding. Exploratory analyses illustrated that transcription errors correlated with neural tracking and that neural tracking was greater for L1- than L2-accented speech at the word and phoneme rate. These findings indicate that accent type modulates neural tracking of speech at specific frequencies, even in passive, quiet settings. This study highlights the sensitivity of frequency-specific neural tracking methods for elucidating subtle accent-related variations in speech, offering a foundation for future work on accent processing across more diverse speaker and listener populations.","PeriodicalId":9715,"journal":{"name":"Cerebral cortex","volume":"36 9","pages":""},"PeriodicalIF":3.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13596737/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149023933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Parafascicular thalamus recruits motor and autonomic responses. 束旁丘脑调动运动和自主神经反应。

IF 3 2区医学

Cerebral cortex Pub Date : 2026-09-01 DOI: 10.1093/cercor/bhag155

Marina Roshchina, Henry H Yin

{"title":"Parafascicular thalamus recruits motor and autonomic responses.","authors":"Marina Roshchina, Henry H Yin","doi":"10.1093/cercor/bhag155","DOIUrl":"10.1093/cercor/bhag155","url":null,"abstract":"The parafascicular nucleus (Pf), part of the intralaminar thalamic nuclei, has been implicated in diverse functions such as attention, nociception, and behavioral flexibility, yet its precise contributions to behavior remain poorly defined. In this study, we used optogenetics to study the role of Pf projection neurons using high-resolution and continuous measures to quantify both skeletomotor and autonomic behavioral outputs, as well as motivational valence. Using optogenetic stimulation of Vglut2+ Pf neurons in male and female mice, combined with high-resolution tracking of movement kinematics, pupil diameter, and heart rate, we found that Pf stimulation elicits a stereotyped sequence of responses spanning multiple effector systems. Optogenetic activation produces rapid ipsiversive orienting, bilateral orofacial movements, followed by slower autonomic responses, including pupil constriction and bradycardia. These effects show distinct latencies. Finally, we found that Pf stimulation could be aversive, as mice avoided areas where stimulation was delivered. Together, our results indicate that Pf outputs can ultimately influence both skeletomotor outputs, like turning, and autonomic outputs, like pupil constriction. These findings broaden our understanding of Pf function and identify the Pf as a hub that links orienting behavior, parasympathetic regulation, and motivational valence.","PeriodicalId":9715,"journal":{"name":"Cerebral cortex","volume":"36 9","pages":""},"PeriodicalIF":3.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13617577/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149069226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Brain morphology network profiles in male and female youth with autism. 男女青少年自闭症患者的脑形态网络特征。

IF 3 2区医学

Cerebral cortex Pub Date : 2026-09-01 DOI: 10.1093/cercor/bhag156

Nooshin Safari, Isaac Levy, Aiying Zhang, Chirag Agarwal, Jesus M Cortes, Kevin A Pelphrey, John Darrell Van Horn, Javier Rasero

{"title":"Brain morphology network profiles in male and female youth with autism.","authors":"Nooshin Safari, Isaac Levy, Aiying Zhang, Chirag Agarwal, Jesus M Cortes, Kevin A Pelphrey, John Darrell Van Horn, Javier Rasero","doi":"10.1093/cercor/bhag156","DOIUrl":"10.1093/cercor/bhag156","url":null,"abstract":"Neuroimaging studies based on altered functional and structural connectivity have contributed to better characterizing males and females with Autism Spectrum Disorder (ASD), advancing our understanding of the male prevalence in diagnosis. However, much less is known about how brain networks are altered from a morphological perspective, and whether these alterations help explain sex-related characteristics in ASD. Here, we used structural MRI from a sex- and diagnosis-balanced sample of 337 young individuals (8 to 18 years) from the Autism Center of Excellence to elucidate sex-related alterations in morphology-based connectivity, calculated as the similarity between region-wise multivariate morphological signatures. Although no diagnosis-by-sex interaction network profile was found, within-sex analysis demonstrated that in males, ASD had significantly increased morphology-based connectivity involving the fusiform gyrus, medial orbitofrontal, entorhinal, and parahippocampal cortices. This network profile was linked to a core social-communication trait within the autistic group. Females with ASD exhibited a network profile notably comprising increased morphology-based connectivity in the entorhinal cortex, followed by the inferior parietal lobule and lateral occipital cortex; yet it lacked association with core autistic traits. These within-sex profiles had minimal overlap with networks from normative sex differences. Together, these findings offer new insights into the neurobiology of males and females with autism.","PeriodicalId":9715,"journal":{"name":"Cerebral cortex","volume":"36 9","pages":""},"PeriodicalIF":3.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13617571/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149069281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0