Cerebral cortex最新文献_第2页

Neural correlates of the sense of agency in free and coerced moral decision-making among civilians and military personnel.

IF 2.9 2区医学

Cerebral cortex Pub Date : 2025-03-06 DOI: 10.1093/cercor/bhaf049

Emilie A Caspar, Antonin Rovai, Salvatore Lo Bue, Axel Cleeremans

{"title":"Neural correlates of the sense of agency in free and coerced moral decision-making among civilians and military personnel.","authors":"Emilie A Caspar, Antonin Rovai, Salvatore Lo Bue, Axel Cleeremans","doi":"10.1093/cercor/bhaf049","DOIUrl":"https://doi.org/10.1093/cercor/bhaf049","url":null,"abstract":"The sense of agency, the feeling of being the author of one's actions and outcomes, is critical for decision-making. While prior research has explored its neural correlates, most studies have focused on neutral tasks, overlooking moral decision-making. In addition, previous studies mainly used convenience samples, ignoring that some social environments may influence how authorship in moral decision-making is processed. This study investigated the neural correlates of sense of agency in civilians and military officer cadets, examining free and coerced choices in both agent and commander roles. Using a functional magnetic resonance imaging paradigm where participants could either freely choose or follow orders to inflict a mild shock on a victim, we assessed sense of agency through temporal binding-a temporal distortion between voluntary and less voluntary decisions. Our findings suggested that sense of agency is reduced when following orders compared to acting freely in both roles. Several brain regions correlated with temporal binding, notably the occipital lobe, superior/middle/inferior frontal gyrus, precuneus, and lateral occipital cortex. Importantly, no differences emerged between military and civilians at corrected thresholds, suggesting that daily environments have minimal influence on the neural basis of moral decision-making, enhancing the generalizability of the findings.","PeriodicalId":9715,"journal":{"name":"Cerebral cortex","volume":"35 3","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143603563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Structural pathways related to the subventricular zone are decreased in volume with altered microstructure in young adult males with autism spectrum disorder.

IF 2.9 2区医学

Cerebral cortex Pub Date : 2025-03-06 DOI: 10.1093/cercor/bhaf041

Keita Tsujimura, Alpen Ortug, José Luis Alatorre Warren, Tadashi Shiohama, Christopher J McDougle, Rachel E Marcus, Chieh-En Jane Tseng, Nicole R Zürcher, Nathaniel D Mercaldo, Susan Faja, Alika Maunakea, Jacob Hooker, Emi Takahashi

{"title":"Structural pathways related to the subventricular zone are decreased in volume with altered microstructure in young adult males with autism spectrum disorder.","authors":"Keita Tsujimura, Alpen Ortug, José Luis Alatorre Warren, Tadashi Shiohama, Christopher J McDougle, Rachel E Marcus, Chieh-En Jane Tseng, Nicole R Zürcher, Nathaniel D Mercaldo, Susan Faja, Alika Maunakea, Jacob Hooker, Emi Takahashi","doi":"10.1093/cercor/bhaf041","DOIUrl":"10.1093/cercor/bhaf041","url":null,"abstract":"Autism spectrum disorder is a neurodevelopmental condition characterized by reduced social communication and repetitive behaviors. Altered neurogenesis, including disturbed neuronal migration, has been implicated in autism spectrum disorder. Using diffusion MRI, we previously identified neuronal migration pathways in the human fetal brain and hypothesized that similar pathways persist into adulthood, with differences in volume and microstructural characteristics between individuals with autism spectrum disorder and controls. We analyzed diffusion MRI-based tractography of subventricular zone-related pathways in 15 young adult men with autism spectrum disorder and 18 controls at Massachusetts General Hospital, with validation through the Autism Imaging Data Exchange II dataset. Participants with autism spectrum disorder had reduced subventricular zone pathway volumes and fractional anisotropy compared to controls. Furthermore, subventricular zone pathway volume was positively correlated (r: 0.68; 95% CI: 0.25 to 0.88) with symptom severity, suggesting that individuals with more severe symptoms tended to have larger subventricular zone pathway volumes, normalized by brain size. Analysis of the Autism Imaging Data Exchange cohort confirmed these findings of reduced subventricular zone pathway volumes in autism spectrum disorder. While some of these pathways may potentially include inaccurately disconnected pathways that go through the subventricular zone, our results suggest that diffusion MRI-based tractography pathways anatomically linked to the periventricular region are associated with certain symptom types in adult males with autism spectrum disorder.","PeriodicalId":9715,"journal":{"name":"Cerebral cortex","volume":"35 3","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143584765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of spatial separation and background noise on brain functional connectivity during auditory selective spatial attention.

IF 2.9 2区医学

Cerebral cortex Pub Date : 2025-03-06 DOI: 10.1093/cercor/bhaf054

Hongxing Liu, Yanru Bai, Qi Zheng, Ran Zhao, Mingkun Guo, Jianing Zhu, Guangjian Ni

{"title":"Effects of spatial separation and background noise on brain functional connectivity during auditory selective spatial attention.","authors":"Hongxing Liu, Yanru Bai, Qi Zheng, Ran Zhao, Mingkun Guo, Jianing Zhu, Guangjian Ni","doi":"10.1093/cercor/bhaf054","DOIUrl":"https://doi.org/10.1093/cercor/bhaf054","url":null,"abstract":"Auditory selective spatial attention (ASSA) plays an important role in \"cocktail party\" scenes, but the effects of spatial separation between target and distractor sources and background noise on the associated brain responses have not been thoroughly investigated. This study utilized the multilayer time-varying brain network to reveal the effect patterns of different separation degrees and signal-to-noise ratio (SNR) levels on brain functional connectivity during ASSA. Specifically, a multilayer time-varying brain network with six time-windows equally divided by each epoch was constructed to investigate the segregation and integration of brain functional connectivity. The results showed that the inter-layer connectivity strength was consistently lower than the intra-layer connectivity strength for various separation degrees and SNR levels. Moreover, the connectivity strength of the multilayer time-varying brain network increased with decreasing separation degrees and initially increased and subsequently decreased with decreasing SNR levels. The second time-window of the network showed the most significant variation under some conditions and was determined as the core layer. The topology within the core layer was mainly reflected in the connectivity between the frontal and parietal-occipital cortices. In conclusion, these results suggest that spatial separation and background noise significantly modulate brain functional connectivity during ASSA.","PeriodicalId":9715,"journal":{"name":"Cerebral cortex","volume":"35 3","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143623740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Strategic mindset facilitates social feedback processing and self-concept adjustment.

IF 2.9 2区医学

Cerebral cortex Pub Date : 2025-03-06 DOI: 10.1093/cercor/bhaf061

Yi Huang, Yaqi Yang, Oi Ling Siu

{"title":"Strategic mindset facilitates social feedback processing and self-concept adjustment.","authors":"Yi Huang, Yaqi Yang, Oi Ling Siu","doi":"10.1093/cercor/bhaf061","DOIUrl":"10.1093/cercor/bhaf061","url":null,"abstract":"The mindsets related to individuals' abilities and personalities can explain why some people are more open to learning from others and improving themselves. A strategic mindset, which involves frequently asking oneself strategy-eliciting questions, has been linked to better academic performance among students. Yet the neuropsychological mechanisms underlying the strategic mindset in the domain of social interaction remain unclear. Here, we investigated the relationships among a strategic mindset, social feedback processing, and self-concept adjustment. Our event-related potential study (n = 41) showed a negative correlation between a strategic mindset and the neural indicator of social conflict (ie the N400 component). Moreover, a strategic mindset selectively responds to positive social feedback, supported by its positive correlations with the amplitude of the late positive potential in response to desirable feedback. Our behavioral study (n = 45) further demonstrated that individuals with a higher level of strategic mindset were more likely to update their self-concept based on conflicting opinions presented by others. We differentiated a strategic mindset from a growth mindset and showed that it explained unique variance in two studies. These findings may have practical implications for interventions aimed at encouraging individuals to ask strategy-eliciting questions and facilitating personal growth.","PeriodicalId":9715,"journal":{"name":"Cerebral cortex","volume":"35 3","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11934546/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143699746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Alexithymia shapes intersubject synchrony in brain activity during interoceptive sensation representations.

IF 2.9 2区医学

Cerebral cortex Pub Date : 2025-03-06 DOI: 10.1093/cercor/bhaf060

Xianrui Li, Xueyang Wang, Chuyao Peng, Zhiting Ren, Junlai Shan, Qian Luo, Dongtao Wei, Jiang Qiu

{"title":"Alexithymia shapes intersubject synchrony in brain activity during interoceptive sensation representations.","authors":"Xianrui Li, Xueyang Wang, Chuyao Peng, Zhiting Ren, Junlai Shan, Qian Luo, Dongtao Wei, Jiang Qiu","doi":"10.1093/cercor/bhaf060","DOIUrl":"https://doi.org/10.1093/cercor/bhaf060","url":null,"abstract":"Alexithymia is a subclinical condition that affects individuals' processing of emotions. Emerging evidence suggests that alexithymia results from a multidomain and multidimensional interoceptive failure. Although extensive research has examined the relationship between alexithymia and interoception, less is known about how alexithymia modulates the brain activity evoked by interoceptive sensations. In this study, we used task-based functional magnetic resonance imaging (fMRI) to assess intersubject correlations in response to interoceptive sensation words in individuals with high alexithymia and low alexithymia. Participants with high alexithymia (n = 29) and low alexithymia (n = 28) were instructed to view words during MRI scanning, each word corresponding to a specific emotional category related to interoceptive sensations. Intersubject correlation analysis identified several brain regions exhibiting increased synchronization in individuals with high alexithymia, including those involved in cognitive control. Follow-up analyses revealed that the left middle occipital gyrus and the right inferior frontal gyrus (orbital part) were more active during interoceptive sensation events in individuals with high alexithymia. Validation analyses revealed that the amygdala and insula are also crucial in representing interoceptive sensations. These findings shed light on the neural basis of interoceptive deficits in high alexithymia and have significant implications for the mechanisms regulating these differences.","PeriodicalId":9715,"journal":{"name":"Cerebral cortex","volume":"35 3","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143662443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Connectomics and neurotransmitter receptor profile explain regional tau pathology in Alzheimer's disease. 连接组学和神经递质受体特征解释了阿尔茨海默病的区域性tau病理学。

IF 2.9 2区医学

Cerebral cortex Pub Date : 2025-03-06 DOI: 10.1093/cercor/bhaf053

Fardin Nabizadeh

{"title":"Connectomics and neurotransmitter receptor profile explain regional tau pathology in Alzheimer's disease.","authors":"Fardin Nabizadeh","doi":"10.1093/cercor/bhaf053","DOIUrl":"https://doi.org/10.1093/cercor/bhaf053","url":null,"abstract":"Alzheimer's disease tau pathology spreads through neuronal pathways and synaptic connections. Alteration in synaptic activity facilitates tau spreading. Multiple neurotransmitter systems are shown to be implicated in Alzheimer's disease, but their influence on the trans-synaptic spread of tau is not well understood. I aimed to combine resting-state functional magnetic resonance imaging connectomics, neurotransmitter receptor profiles, and tau-PET data to explain the regional susceptibility to tau accumulation. The tau-PET imaging data of 161 amyloid-beta-negative cognitively unimpaired participants as control and 259 amyloid-beta-positive subjects were recruited from the Alzheimer's Disease Neuroimaging Initiative (ADNI). Linear regression analysis revealed that a higher tau-PET z-score is associated with a lower density of nine receptors in the serotonin, dopamine, gamma-aminobutyric acid (GABA), acetylcholine, and glutamate systems. Furthermore, adding four neurotransmitter receptor density z-scores significantly increased the proportion of explained variance by 3% to 7% compared to the epicenter-connectivity distance model in the group-level analysis. Also, adding nine neurotransmitter receptor density z-scores to the epicenter-connectivity distance model increased the explanatory power of variability in individual levels of tau-PET z-score by 3% to 8%. The current study demonstrated the additive value of atlas-based neurotransmitter receptor mapping and individual-level amyloid-beta-PET scans to enhance the connectivity-based explanation of tau accumulation.","PeriodicalId":9715,"journal":{"name":"Cerebral cortex","volume":"35 3","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143623728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Are resting-state network alterations in late-life depression related to synaptic density? Findings of a combined 11C-UCB-J PET and fMRI study.

IF 2.9 2区医学

Cerebral cortex Pub Date : 2025-03-06 DOI: 10.1093/cercor/bhaf028

Chih-Hao Lien, Thomas Vande Casteele, Maarten Laroy, Margot G A Van Cauwenberge, Ronald Peeters, Stefan Sunaert, Koen Van Laere, Patrick Dupont, Filip Bouckaert, Louise Emsell, Mathieu Vandenbulcke, Jan Van den Stock

{"title":"Are resting-state network alterations in late-life depression related to synaptic density? Findings of a combined 11C-UCB-J PET and fMRI study.","authors":"Chih-Hao Lien, Thomas Vande Casteele, Maarten Laroy, Margot G A Van Cauwenberge, Ronald Peeters, Stefan Sunaert, Koen Van Laere, Patrick Dupont, Filip Bouckaert, Louise Emsell, Mathieu Vandenbulcke, Jan Van den Stock","doi":"10.1093/cercor/bhaf028","DOIUrl":"https://doi.org/10.1093/cercor/bhaf028","url":null,"abstract":"This study investigates the relationship between resting-state functional magnetic resonance imaging (rs-fMRI) topological properties and synaptic vesicle glycoprotein 2A (SV2A) positron emission tomography (PET) synaptic density (SD) in late-life depression (LLD). 18 LLD patients and 33 healthy controls underwent rs-fMRI, 3D T1-weighted MRI, and 11C-UCB-J PET scans to assess SD. The rs-fMRI data were utilized to construct weighted networks for calculating four global topological metrics, including clustering coefficient, characteristic path length, global efficiency, and small-worldness, and six nodal metrics, including nodal clustering coefficient, nodal characteristic path length, nodal degree, nodal strength, local efficiency, and betweenness centrality. The 11C-UCB-J PET provided standardized uptake value ratios as SD measures. LLD patients exhibited preserved global topological organization, with reduced nodal properties in regions associated with LLD, such as the medial prefrontal cortex (mPFC), and increased nodal properties in the basal ganglia and cerebellar regions. Notably, a negative correlation was observed between betweenness centrality in the mPFC and depressive symptom severity. No significant alterations in SD or associations between rs-fMRI topological properties and SD were found, challenging the hypothesis that SD alterations are the molecular basis for rs-fMRI topological changes in LLD. Our findings suggest other molecular mechanisms may underlie the observed functional connectivity alterations in these patients.","PeriodicalId":9715,"journal":{"name":"Cerebral cortex","volume":"35 3","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143613664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Functional differentiation of the default and frontoparietal control networks predicts individual differences in creative achievement: evidence from macroscale cortical gradients.

IF 2.9 2区医学

Cerebral cortex Pub Date : 2025-03-06 DOI: 10.1093/cercor/bhaf046

Tyler A Sassenberg, Rex E Jung, Colin G DeYoung

{"title":"Functional differentiation of the default and frontoparietal control networks predicts individual differences in creative achievement: evidence from macroscale cortical gradients.","authors":"Tyler A Sassenberg, Rex E Jung, Colin G DeYoung","doi":"10.1093/cercor/bhaf046","DOIUrl":"10.1093/cercor/bhaf046","url":null,"abstract":"Much of the research on the neural correlates of creativity has emphasized creative cognition, and growing evidence suggests that creativity is related to functional properties of the default and frontoparietal control networks. The present work expands on this body of evidence by testing associations of creative achievement with connectivity profiles of brain networks assessed using macroscale cortical gradients. Using resting-state connectivity functional magnetic resonance imaging in 2 community samples (N's = 236 and 234), we found evidence that creative achievement is positively associated with greater functional dissimilarity between core regions of the default and frontoparietal control networks. These results suggest that creative achievement is supported by the ability of these 2 networks to carry out distinct cognitive roles. This research provides further evidence, using a cortical gradient approach, that individual differences in creative achievement can be predicted from functional properties of brain networks involved in higher-order cognition, and it aligns with past research on the functional connectivity correlates of creative task performance.","PeriodicalId":9715,"journal":{"name":"Cerebral cortex","volume":"35 3","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11890067/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143582208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hubs and interaction: the brain's meta-loop.

IF 2.9 2区医学

Cerebral cortex Pub Date : 2025-03-06 DOI: 10.1093/cercor/bhaf035

Cornelius Weiller, Marco Reisert, Pierre Levan, Jonas Hosp, Volker A Coenen, Michel Rijntjes

{"title":"Hubs and interaction: the brain's meta-loop.","authors":"Cornelius Weiller, Marco Reisert, Pierre Levan, Jonas Hosp, Volker A Coenen, Michel Rijntjes","doi":"10.1093/cercor/bhaf035","DOIUrl":"10.1093/cercor/bhaf035","url":null,"abstract":"We must reconcile the needs of the internal world and the demands of the external world to make decisions relevant to homeostasis, well-being, and flexible behavior. Engagement with the internal (eg interoceptive) world is linked to medial brain systems, whereas the extrapersonal space (eg exteroceptive) is associated with lateral brain systems. Using Human Connectome Project data, we found three association tracts connecting the action-related frontal lobe with perception-related posterior lobes. A lateral dorsal tract and a medial dorsal tract interact independently with a ventral tract at frontal and posterior hubs. The two frontal and the two posterior hubs are interconnected, forming a meta-loop that integrates lateral and medial brain systems. The four anatomical hubs correspond to the common nodes of the intrinsic cognitive brain networks such as the default mode network. These functional networks depend on the integration of both realms. Thus, the positioning of functional cognitive networks can be understood as the intersection of long anatomical association tracts. The strength of structural connectivity within lateral and medial brain systems correlates with performance on behavioral tests assessing theory of mind. The meta-loop provides an anatomical framework to associate neurological and psychiatric symptoms with functional and structural changes.","PeriodicalId":9715,"journal":{"name":"Cerebral cortex","volume":"35 3","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11903256/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143613666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lifespan trajectories of fornix volume and tractography: a 5.0 T MRI study.

IF 2.9 2区医学

Cerebral cortex Pub Date : 2025-03-06 DOI: 10.1093/cercor/bhaf057

Qiang Hu, Jia Xu, Sirui Li, Xiaohui Chen, Xiaoli Zhong, Xitong Liu, Jinxia Ren, Huan Wang, Chenhong Fan, Chunyu Li, Liang Wang, Jinfeng Lv, Xueying Xiong, Yaowen Xing, Yaqiong Xiao, Xiaopeng Song, Lei Gao, Haibo Xu

{"title":"Lifespan trajectories of fornix volume and tractography: a 5.0 T MRI study.","authors":"Qiang Hu, Jia Xu, Sirui Li, Xiaohui Chen, Xiaoli Zhong, Xitong Liu, Jinxia Ren, Huan Wang, Chenhong Fan, Chunyu Li, Liang Wang, Jinfeng Lv, Xueying Xiong, Yaowen Xing, Yaqiong Xiao, Xiaopeng Song, Lei Gao, Haibo Xu","doi":"10.1093/cercor/bhaf057","DOIUrl":"https://doi.org/10.1093/cercor/bhaf057","url":null,"abstract":"The fornix, playing a critical role in memory formation and maintenance, is recognized as an ultra-early biomarker for dementia. However, its trajectory during healthy aging remains incompletely understood. This study employed an ultra-high-field 5.0 T MRI to acquire high-resolution anatomical and multishell diffusion imaging data from 376 healthy adults aged 18 to 85. The aim was to correlate fornix characteristics with cognitive performance across multiple domains and map its lifespan trajectories. Using these data, we quantified fornix volume and tractography. Lifespan trajectories were identified by computing age-specific average patterns, which revealed distinct changes. Notably, nonlinear declines in fornix volume were observed, contrasting with fiber tract peaks between ages 18 to 40, which subsequently influenced volume-connectivity interactions. Additionally, a shift from predominant left-side to right-side fornix dominance was noted with aging. Regression analyses indicated that variations in fornix structure significantly moderated, rather than mediated, age-related differences in cognitive performance. These high-resolution imaging results provide novel insights into the role of the fornix's morphology and structural connectivity in individual cognitive differences and aging.","PeriodicalId":9715,"journal":{"name":"Cerebral cortex","volume":"35 3","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143656127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0