Cerebral cortex最新文献_第3页

Differential neurogenic patterns underlie the formation of primary and secondary areas in the developing somatosensory cortex.

IF 2.9 2区医学

Cerebral cortex Pub Date : 2025-01-05 DOI: 10.1093/cercor/bhae491

Naoto Ohte, Takayuki Kimura, Rintaro Sekine, Shoko Yoshizawa, Yuta Furusho, Daisuke Sato, Chihiro Nishiyama, Carina Hanashima

{"title":"Differential neurogenic patterns underlie the formation of primary and secondary areas in the developing somatosensory cortex.","authors":"Naoto Ohte, Takayuki Kimura, Rintaro Sekine, Shoko Yoshizawa, Yuta Furusho, Daisuke Sato, Chihiro Nishiyama, Carina Hanashima","doi":"10.1093/cercor/bhae491","DOIUrl":"https://doi.org/10.1093/cercor/bhae491","url":null,"abstract":"The cerebral cortex consists of hierarchically organized areas interconnected by reciprocal axonal projections. However, the coordination of neurogenesis to optimize neuronal production and wiring between distinct cortical areas remains largely unexplored. The somatosensory cortex plays a crucial role in processing tactile information, with inputs from peripheral sensory receptors relayed through the thalamus to the primary and secondary somatosensory areas. To investigate the dynamics of neurogenesis in cortical circuit formation, we employed temporal genetic fate mapping of glutamatergic neuron cohorts across the somatosensory cortices. Our analysis revealed that neuronal production in the secondary somatosensory cortex (S2) precedes that of the primary somatosensory cortex (S1) from the deep-layer neuron production period and terminates earlier. We further revealed a progressive decline in upper-layer neuron output in S2, attributed to the attenuation of the apical ventricular surface, resulting in a reduced number of upper-layer neurons within S2. These findings support the existence of a protomap mechanism governing the area-specific assembly of primary and secondary areas in the developing neocortex.","PeriodicalId":9715,"journal":{"name":"Cerebral cortex","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142930790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Identifying causal neural oscillations underlying working memory.

IF 2.9 2区医学

Cerebral cortex Pub Date : 2025-01-05 DOI: 10.1093/cercor/bhae492

Mina Mirjalili, Reza Zomorrodi, Zafiris J Daskalakis, Daniel M Blumberger, Sean L Hill, Tarek K Rajji

{"title":"Identifying causal neural oscillations underlying working memory.","authors":"Mina Mirjalili, Reza Zomorrodi, Zafiris J Daskalakis, Daniel M Blumberger, Sean L Hill, Tarek K Rajji","doi":"10.1093/cercor/bhae492","DOIUrl":"https://doi.org/10.1093/cercor/bhae492","url":null,"abstract":"Electroencephalography is instrumental in understanding neurophysiological mechanisms underlying working memory. While numerous studies have associated electroencephalography features to working memory, understanding causal relationships leads to better characterization of the neurophysiological mechanisms that are directly linked to working memory. Personalized causal modeling is a tool to discover these direct links between brain features and working memory performance. Therefore, we applied this approach to electroencephalography data from 66 adult healthy participants collected while performing a 3-back working memory task. Using graphical causal modeling, we discovered causal neural oscillations of working memory performance and compared the causal features between two groups: high and low performers. Total number of causal features in high performers was higher than low performers. Among the causal features, right temporal gamma oscillation was ~5 times (z-score = 3.87, P = 0.0001) more frequently a causal feature among high performers than low performers. However, the power of causal temporal gamma oscillation was not different between the two groups. Our findings suggest that one potential approach to improve working memory performance is to induce more causal gamma oscillations. This can be achieved by generating more local gamma entrainment over the right temporal cortex, rather than simply increasing gamma power.","PeriodicalId":9715,"journal":{"name":"Cerebral cortex","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142930791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neural correlates of reciprocity bias: social debts modulate unfairness perception of violation during third-party observation.

IF 2.9 2区医学

Cerebral cortex Pub Date : 2025-01-04 DOI: 10.1093/cercor/bhae497

Yinling Zhang, Rongrong Chen, Siqi Liu, Peiqi Chen, Xiaoqin Mai

{"title":"Neural correlates of reciprocity bias: social debts modulate unfairness perception of violation during third-party observation.","authors":"Yinling Zhang, Rongrong Chen, Siqi Liu, Peiqi Chen, Xiaoqin Mai","doi":"10.1093/cercor/bhae497","DOIUrl":"https://doi.org/10.1093/cercor/bhae497","url":null,"abstract":"The phenomenon of beneficiaries ignoring benefactors' violations, ranging from everyday favors to bribes, is widespread yet lacks targeted theoretical and empirical attention. We propose a conceptual framework that includes \"social debt\" and \"reciprocity bias,\" where \"social debt\" is defined as information about benefits bestowed by benefactors and \"reciprocity bias\" as the influence of social debt on beneficiaries' perceptions and decisions in situations involving the benefactor. To investigate this bias in moral perception and its cognitive-neural mechanisms, we manipulated three levels of social debt (none, less, more) by varying the amount of unasked benefits that benefactors bestowed upon participants. Participants then observed the distributor's fair or unfair allocation of resources to another person, while their electroencephalography (EEG) was recorded. Results indicate that more (vs. none/less) social debt reduces perceptions of unfairness toward benefactors' violations and enhances fairness perceptions of their norm adherence. This was, accompanied by the diminished fairness effect on fronto-centered P2 and a reversal fairness effect on the power of theta oscillations (4 to 7 Hz). These findings support a multilevel reciprocity bias in fairness perception, suggesting that strong social debt may heighten concern for benefactor's interests and increase the adaptive value of their violations at the cognitive-neural level.","PeriodicalId":9715,"journal":{"name":"Cerebral cortex","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-01-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142930792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The microgravity environment affects sensorimotor adaptation and its neural correlates.

IF 2.9 2区医学

Cerebral cortex Pub Date : 2025-01-04 DOI: 10.1093/cercor/bhae502

G D Tays, K E Hupfeld, H R McGregor, L A Banker, Y E De Dios, J J Bloomberg, P A Reuter-Lorenz, A P Mulavara, S J Wood, R D Seidler

{"title":"The microgravity environment affects sensorimotor adaptation and its neural correlates.","authors":"G D Tays, K E Hupfeld, H R McGregor, L A Banker, Y E De Dios, J J Bloomberg, P A Reuter-Lorenz, A P Mulavara, S J Wood, R D Seidler","doi":"10.1093/cercor/bhae502","DOIUrl":"https://doi.org/10.1093/cercor/bhae502","url":null,"abstract":"The microgravity environment results in transient changes in sensorimotor behavior upon astronauts' return to Earth; the effects on behavior inflight are less understood. We examined whether adaptation to sensory conflict is disrupted in microgravity, suggesting competition for adaptive resources. We evaluated sensorimotor adaptation pre-, in-, and post-flight, as well as functional brain changes at pre- and post-flight, in astronauts participating in International Space Station missions. Astronauts (n = 13) performed this task pre- and four times post-flight within an MRI scanner and performed the task three times in microgravity during a 6-mo mission. We collected behavioral data from Earth-bound controls (n = 13) along the same timeline. Astronauts displayed no change in adaptation from pre- to inflight or following their return to Earth. They showed greater aftereffects of adaptation inflight; controls did not. Astronauts also displayed increased brain activity from pre- to post-flight. These increases did not return to baseline levels until 90 d post-flight. This pattern of brain activity may reflect compensation, allowing astronauts to maintain pre-flight performance levels. These findings indicate that microgravity does not alter short-term visuomotor adaptation; however, it does affect de-adaptation, and post-flight sensorimotor neural activation can take up to 90 d to return to pre-flight levels.","PeriodicalId":9715,"journal":{"name":"Cerebral cortex","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-01-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142930796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diagnosis of Alzheimer's disease using FusionNet with improved secretary bird optimization algorithm for optimal MK-SVM based on imaging genetic data.

IF 2.9 2区医学

Cerebral cortex Pub Date : 2025-01-04 DOI: 10.1093/cercor/bhae498

Luyun Wang, Jinhua Sheng, Qiao Zhang, Yan Song, Qian Zhang, Binbing Wang, Rong Zhang

{"title":"Diagnosis of Alzheimer's disease using FusionNet with improved secretary bird optimization algorithm for optimal MK-SVM based on imaging genetic data.","authors":"Luyun Wang, Jinhua Sheng, Qiao Zhang, Yan Song, Qian Zhang, Binbing Wang, Rong Zhang","doi":"10.1093/cercor/bhae498","DOIUrl":"https://doi.org/10.1093/cercor/bhae498","url":null,"abstract":"Alzheimer's disease is an irreversible central neurodegenerative disease, and early diagnosis of Alzheimer's disease is beneficial for its prevention and early intervention treatment. In this study, we propose a novel framework, FusionNet-ISBOA-MK-SVM, which integrates a fusion network (FusionNet) and improved secretary bird optimization algorithm to optimize multikernel support vector machine for Alzheimer's disease diagnosis. The model leverages multimodality data, including functional magnetic resonance imaging and genetic information (single-nucleotide polymorphisms). Specifically, FusionNet employs U-shaped hierarchical graph convolutional networks and sparse graph attention networks to select feature effectively. Extensive validation using the Alzheimer's Disease Neuroimaging Initiative dataset demonstrates the model's superior interpretability and classification performance. Compared to other state-of-the-art machine learning methods, FusionNet-ISBOA-MK-SVM achieves classification accuracies of 98.6%, 95.7%, 93.0%, 91.8%, 93.1%, and 95.4% for HC vs. AD, EMCI vs. AD, LMCI vs. AD, EMCI vs. AD, HC vs. EMCI, and HC vs. LMCI, respectively. Moreover, the proposed model identifies affected brain regions and pathogenic genes, offering deeper insights into the mechanisms and progression of Alzheimer's disease. These findings provide valuable scientific evidence to support early diagnosis and preventive strategies for Alzheimer's disease.","PeriodicalId":9715,"journal":{"name":"Cerebral cortex","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-01-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142930778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The early-onset Alzheimer's disease MRI signature: a replication and extension analysis in early-stage AD.

IF 2.9 2区医学

Cerebral cortex Pub Date : 2024-12-03 DOI: 10.1093/cercor/bhae475

Rashi I Mehta, Cierra M Keith, Camila Vieira Ligo Teixeira, Patrick D Worhunsky, Holly E Phelps, Melanie Ward, Mark Miller, R Osvaldo Navia, Stephanie Pockl, Nafiisah Rajabalee, Michelle M Coleman, Pierre-François D'Haese, Ali R Rezai, Kirk C Wilhelmsen, Marc W Haut

{"title":"The early-onset Alzheimer's disease MRI signature: a replication and extension analysis in early-stage AD.","authors":"Rashi I Mehta, Cierra M Keith, Camila Vieira Ligo Teixeira, Patrick D Worhunsky, Holly E Phelps, Melanie Ward, Mark Miller, R Osvaldo Navia, Stephanie Pockl, Nafiisah Rajabalee, Michelle M Coleman, Pierre-François D'Haese, Ali R Rezai, Kirk C Wilhelmsen, Marc W Haut","doi":"10.1093/cercor/bhae475","DOIUrl":"10.1093/cercor/bhae475","url":null,"abstract":"Early-onset Alzheimer's disease (EOAD) is less investigated than the more common late-onset Alzheimer's disease (LOAD) despite its more aggressive course. A cortical signature of EOAD was recently proposed and may facilitate EOAD investigation. Here, we aimed to validate this proposed MRI biomarker of EOAD neurodegeneration in an Appalachian clinical cohort. We also compared differences in EOAD signature atrophy in participants with biomarker-positive EOAD, LOAD, early-onset non-AD pathologies, and cognitively normal individuals. Cortical thinning was reliably detected in eight of nine signature areas of persons with EOAD relative to cognitively normal individuals despite very early disease stage. Additionally, individuals with EOAD showed thinner cortex in most signature regions relative to those with early-onset non-AD pathologies. EOAD and LOAD showed similar cortical atrophy within most EOAD signature regions. Whole-brain vertex-wise cortical analyses supported these findings. Furthermore, signature cortical atrophy showed expected relationships with measures of global and specific cognitive and functional status. This investigation further validates and expands upon the recently defined EOAD signature and suggests its robustness within a rural population, even at early disease stage. Larger scale and longitudinal studies employing this marker of EOAD neurodegeneration are needed to further understand clinical effects and appropriate management of persons with EOAD.","PeriodicalId":9715,"journal":{"name":"Cerebral cortex","volume":"34 12","pages":""},"PeriodicalIF":2.9,"publicationDate":"2024-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11664631/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142876265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Acknowledgement. 致谢。

IF 2.9 2区医学

Cerebral cortex Pub Date : 2024-12-03 DOI: 10.1093/cercor/bhae467

引用次数: 0

Dissociating goal from outcome during action observation.

IF 2.9 2区医学

Cerebral cortex Pub Date : 2024-12-03 DOI: 10.1093/cercor/bhae487

Shuchen Liu, Moritz F Wurm, Alfonso Caramazza

{"title":"Dissociating goal from outcome during action observation.","authors":"Shuchen Liu, Moritz F Wurm, Alfonso Caramazza","doi":"10.1093/cercor/bhae487","DOIUrl":"10.1093/cercor/bhae487","url":null,"abstract":"Understanding the goal of an observed action requires computing representations that are invariant to specific instantiations of the action. For example, we can accurately infer the goal of an action even when the agent's desired outcome is not achieved. Observing actions consistently recruits a set of frontoparietal and posterior temporal regions, often labeled the \"action observation network.\" While progress has been made in charting which regions of the action observation network are involved in understanding goals of observed actions, it is not clear where goals are represented independently of outcomes. We used functional magnetic resonance-based multivariate pattern analysis to identify such regions. Human participants (20 females, 12 males) watched videos of successful and failed attempts of actions with different goals involving two different object types. We found that the bilateral anterior inferior parietal lobe and the right ventral premotor cortex distinguished between object-specific action goals regardless of outcomes. The left anterior inferior parietal lobe encodes action goals regardless of both outcomes and object types. Our results provide insights into the neural basis of representing action goals and the different roles of frontoparietal and posterior temporal regions in action understanding.","PeriodicalId":9715,"journal":{"name":"Cerebral cortex","volume":"34 12","pages":""},"PeriodicalIF":2.9,"publicationDate":"2024-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11666468/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142881288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Arousal effects on oscillatory dynamics in the non-human primate brain. 唤醒对非人灵长类大脑振荡动态的影响。

IF 2.9 2区医学

Cerebral cortex Pub Date : 2024-12-03 DOI: 10.1093/cercor/bhae473

Shashank A Anand, Fatih Sogukpinar, Ilya E Monosov

{"title":"Arousal effects on oscillatory dynamics in the non-human primate brain.","authors":"Shashank A Anand, Fatih Sogukpinar, Ilya E Monosov","doi":"10.1093/cercor/bhae473","DOIUrl":"10.1093/cercor/bhae473","url":null,"abstract":"Arousal states are thought to influence many aspects of cognition and behavior by broadly modulating neural activity. Many studies have observed arousal-related modulations of alpha (~8 to 15 Hz) and gamma (~30 to 50 Hz) power and coherence in local field potentials across relatively small groups of brain regions. However, the global pattern of arousal-related oscillatory modulation in local field potentials is yet to be fully elucidated. We simultaneously recorded local field potentials in numerous cortical and subcortical regions in the primate brain and assessed oscillatory activity and inter-regional coherence associated with arousal state. In high arousal states, we found a uniquely strong and coherent gamma oscillation between the amygdala and basal forebrain. In low arousal rest-like states, a relative increase in coherence at alpha frequencies was present across sampled brain regions, with the notable exception of the medial temporal lobe. We consider how these patterns of activity may index arousal-related brain states that support the processing of incoming sensory stimuli during high arousal states and memory-related functions during rest.","PeriodicalId":9715,"journal":{"name":"Cerebral cortex","volume":"34 12","pages":""},"PeriodicalIF":2.9,"publicationDate":"2024-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11659775/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142863060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Identification of Pappa and Sall3 as Gli3 direct target genes acting downstream of cilia signaling in corticogenesis.

IF 2.9 2区医学

Cerebral cortex Pub Date : 2024-12-03 DOI: 10.1093/cercor/bhae480

Shinjini Basu, Lena Mautner, Kae Whiting, Kerstin Hasenpusch-Theil, Malgorzata Borkowska, Thomas Theil

{"title":"Identification of Pappa and Sall3 as Gli3 direct target genes acting downstream of cilia signaling in corticogenesis.","authors":"Shinjini Basu, Lena Mautner, Kae Whiting, Kerstin Hasenpusch-Theil, Malgorzata Borkowska, Thomas Theil","doi":"10.1093/cercor/bhae480","DOIUrl":"10.1093/cercor/bhae480","url":null,"abstract":"The cerebral cortex is critical for advanced cognitive functions and relies on a vast network of neurons to carry out its highly intricate neural tasks. Generating cortical neurons in accurate numbers hinges on cell signaling orchestrated by primary cilia to coordinate the proliferation and differentiation of cortical stem cells. While recent research has shed light on multiple ciliary roles in corticogenesis, specific mechanisms downstream of cilia signaling remain largely unexplored. We previously showed that an excess of early-born cortical neurons in mice mutant for the ciliary gene Inpp5e was rescued by re-introducing Gli3 repressor. By comparing expression profiles between Inpp5e and Gli3 mutants, we here identified novel Gli3 target genes. This approach highlighted the transcription factor gene Sall3 and Pappalysin1 (Pappa), a metalloproteinase involved in IGF signaling, as upregulated genes in both mutants. Further examination revealed that Gli3 directly binds to Sall3 and Pappa enhancers and suppresses their activity in the dorsal telencephalon. Collectively, our analyses provide important mechanistic insights into how primary cilia govern the behavior of neural stem cells, ultimately ensuring the production of adequate numbers of neurons during corticogenesis.","PeriodicalId":9715,"journal":{"name":"Cerebral cortex","volume":"34 12","pages":""},"PeriodicalIF":2.9,"publicationDate":"2024-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11666469/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142881292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0