Cerebral cortex最新文献_第4页

It's all connected! Multivariate pattern analysis of inter-network connectivity distinguishes between reappraisal and passive viewing of emotional scenes. 这一切都是相连的！网络间连通性的多变量模式分析区分了情感场景的重新评价和被动观看。

IF 2.9 2区医学

Cerebral cortex Pub Date : 2025-06-04 DOI: 10.1093/cercor/bhaf161

Scarlett Horner, Thomas Rawliuk, Ryan M Ferstl, Andrew L Lyons, Janeen Martin, Diana J Gorbet, W Dale Stevens, Steven G Greening

{"title":"It's all connected! Multivariate pattern analysis of inter-network connectivity distinguishes between reappraisal and passive viewing of emotional scenes.","authors":"Scarlett Horner, Thomas Rawliuk, Ryan M Ferstl, Andrew L Lyons, Janeen Martin, Diana J Gorbet, W Dale Stevens, Steven G Greening","doi":"10.1093/cercor/bhaf161","DOIUrl":"10.1093/cercor/bhaf161","url":null,"abstract":"Down-regulation using reappraisal is often associated with negative connectivity between prefrontal areas such as the dorsolateral prefrontal cortex (dlPFC) and areas associated with emotion such as the insula and amygdala, though a network perspective is often lacking in emotion regulation research. Whereas the dlPFC is associated with the attentional control network (ACN), the insula and amygdala are associated with the salience and limbic networks, respectively. The default mode network (DMN), including the ventromedial PFC, also contributes to emotion regulation. The present study sought to determine if inter-network functional connectivity can dissociate reappraising from passively viewing a negative image using multivariate pattern analysis (MVPA). Thirty-one participants completed a functional magnetic resonance imaging task in which they reappraised and viewed negative images. Behavioral and skin conductance response results indicated that reappraisal was associated with reductions in negative affect compared to viewing. The univariate connectivity analysis revealed that connections between aspects of the DMN and ACN differed between reappraising versus viewing negative images. Notably, the inter-network connectivity MVPA results demonstrated that whether one was reappraising versus viewing an image could be predicted better than chance, with several connections reliably contributing to the model, including those between ACN and DMN.","PeriodicalId":9715,"journal":{"name":"Cerebral cortex","volume":"35 6","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12192433/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144494897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neural responses to shared positive and negative experiences: unveiling the social feedback processing dynamics. 分享积极和消极经验的神经反应：揭示社会反馈加工动态。

IF 2.9 2区医学

Cerebral cortex Pub Date : 2025-06-04 DOI: 10.1093/cercor/bhaf121

Wenxian Ruan, Jieying Chen, Yanhong Wu

{"title":"Neural responses to shared positive and negative experiences: unveiling the social feedback processing dynamics.","authors":"Wenxian Ruan, Jieying Chen, Yanhong Wu","doi":"10.1093/cercor/bhaf121","DOIUrl":"https://doi.org/10.1093/cercor/bhaf121","url":null,"abstract":"This study examined the impacts of shared experience valence on the dynamic processing of social feedback. Electroencephalography (EEG) was recorded when participants performed an adapted social judgment paradigm with three stages: social feedback expectation, social feedback evaluation, and expectation updating. Behavioral analysis revealed higher acceptance expectation and lower rejection expectation in the shared positive experience (SPE) condition than in the shared negative experience (SNE) condition; receiving acceptance feedback increased acceptance expectation in the subsequent trial. EEG results revealed that at the social feedback expectation stage, rejection evoked a larger stimulus-preceding negativity magnitude than acceptance in the SNE but not SPE condition. At the social feedback evaluation stage, rejection feedback evoked a smaller early frontal theta than acceptance feedback in the SNE but not SPE condition; unexpected acceptance evoked a larger P300 than unexpected rejection in the SPE but not SNE condition. At the expectation updating stage, unexpected acceptance elicited larger late posterior theta than expected acceptance in the SNE but not SPE condition. These results suggest that shared positive experiences reduce vigilance toward impending rejection and increase sensitivity to pleasantness, whereas shared negative experiences blunt reactivity to rejection feedback and foster social learning from unexpected acceptance to enhance positive expectation.","PeriodicalId":9715,"journal":{"name":"Cerebral cortex","volume":"35 6","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144233310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The induction of a specific mental set for problem solving is accompanied by increased neural representational similarities. 解决问题的特定心理集合的归纳伴随着神经表征相似性的增加。

IF 2.9 2区医学

Cerebral cortex Pub Date : 2025-06-04 DOI: 10.1093/cercor/bhaf128

Ze Zhang, Tengteng Tan, Furong Huang, Xingxu Xie, Lei Han, Jing Luo

{"title":"The induction of a specific mental set for problem solving is accompanied by increased neural representational similarities.","authors":"Ze Zhang, Tengteng Tan, Furong Huang, Xingxu Xie, Lei Han, Jing Luo","doi":"10.1093/cercor/bhaf128","DOIUrl":"https://doi.org/10.1093/cercor/bhaf128","url":null,"abstract":"A mental set is a cognitive bias that results from repeatedly applying a stereotypical problem-solving strategy, which can hinder new and creative ideas. However, the neural mechanisms underlying mental set induction remain unclear. We hypothesized that repeated use of a strategy increases neural representation similarity, thus producing a mental set. To test this, we conducted representational similarity analysis across continuously presented mindset-induction trials using the same loose chunk decomposition problem-solving strategy. This induction was expected to impair the solving of subsequent probe trials requiring a more insightful tight chunk decomposition strategy. Results showed that neural representational similarity increased across loose chunk decomposition induction stages, particularly in regions related to cognitive control, mental operations, and the default mode network. These increases predicted activation in the anterior cingulate cortex and medial frontal lobe during tight chunk decomposition trials. Furthermore, the medial frontal lobe moderated the impact of increased similarity during mental set induction, affecting representational changes from loose chunk decomposition to tight chunk decomposition in perceptual, operative, and executive processing regions. In summary, our findings suggest that increased neural representational similarity in goal-directed mental manipulation networks and the default mode network supports mental set induction, enhancing conflict resolution and representational change during creative problem-solving with different strategies.","PeriodicalId":9715,"journal":{"name":"Cerebral cortex","volume":"35 6","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144233312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Trends and global productivity in artificial intelligence research in clinical neurology and neuroimaging: a bibliometric analysis from 1980 to 2024. 临床神经病学和神经影像学人工智能研究的趋势和全球生产力：1980年至2024年的文献计量学分析。

IF 2.9 2区医学

Cerebral cortex Pub Date : 2025-06-04 DOI: 10.1093/cercor/bhaf148

Sadettin Ersoy, Elif Hazal Ersoy, Aysegul Danis, Sule Aydın Turkoglu

{"title":"Trends and global productivity in artificial intelligence research in clinical neurology and neuroimaging: a bibliometric analysis from 1980 to 2024.","authors":"Sadettin Ersoy, Elif Hazal Ersoy, Aysegul Danis, Sule Aydın Turkoglu","doi":"10.1093/cercor/bhaf148","DOIUrl":"10.1093/cercor/bhaf148","url":null,"abstract":"This bibliometric study examines the trends and global productivity of artificial intelligence (AI) research in clinical neurology and neuroimaging from 1980 to 2024. Data were retrieved from the Web of Science database, encompassing 5,020 publications focusing on AI in clinical neurology and neuroimaging. Among these, 2,687 were original research articles, predominantly published in English, with an average of 19.44 citations per article and an H-index of 90. Our analysis reveals a significant increase in publication activity, particularly after 2019, with the annual count peaking at 607 articles in 2024. The United States and China emerged as the leading contributors, and a strong positive correlation was found between publication productivity and both gross domestic product (GDP) and GDP purchasing power parity. However, no significant relationship was observed with the Human Development Index. Key research areas include radiology, psychiatry, and surgery, with machine learning and deep learning dominating the field. Regression models predict continued growth in AI-related research, underscoring its expanding role in advancing diagnostic and therapeutic strategies for neurological disorders. This study highlights the importance of interdisciplinary collaboration and high-impact journals in shaping the future of AI applications in clinical neurology and neuroimaging.","PeriodicalId":9715,"journal":{"name":"Cerebral cortex","volume":"35 6","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144339937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Developmental trajectory deviation for hierarchical function system in attention-deficit/hyperactivity disorder. 注意缺陷/多动障碍中等级功能系统的发展轨迹偏差。

IF 2.9 2区医学

Cerebral cortex Pub Date : 2025-06-04 DOI: 10.1093/cercor/bhaf119

Qin Tang, Qingquan Cao, Lin Liu, Pan Wang, Huafu Chen, Bharat B Biswal

{"title":"Developmental trajectory deviation for hierarchical function system in attention-deficit/hyperactivity disorder.","authors":"Qin Tang, Qingquan Cao, Lin Liu, Pan Wang, Huafu Chen, Bharat B Biswal","doi":"10.1093/cercor/bhaf119","DOIUrl":"https://doi.org/10.1093/cercor/bhaf119","url":null,"abstract":"Attention-deficit/hyperactivity disorder is a typically neurodevelopmental disorder with intra-/inter-network dysconnectivity, indicating that characterizing its age-dependent hierarchical function system changes is crucial to understanding the disease's course. Combining hierarchical spatial gradient and partial least squares regression analysis methods, we investigated the cortical abnormalities of functional gradient in individuals with attention-deficit/hyperactivity disorder and its relationships with genic transcriptomic information. Additionally, we described the hierarchical function system development during childhood using developmental curve fitting analysis. We observed increased functional gradients in the regions within visual and dorsal attention networks, and decreased gradients distributing in the regions with limbic and default mode networks. Compared with the typical developmental age-gradient track curve, individuals with attention-deficit/hyperactivity disorder exhibited earlier turning points and smaller curve's variation ranges. Gene expression analysis showed a significantly overlapped enrichment pathways associated with nervous system development between the genes we identified and those previously reported. Above-abnormal functional gradients and network-level averaged gradient values exhibited significant correlations with clinical inattention scores in attention-deficit/hyperactivity disorder. Overall, our findings characterized changes in hierarchical functional systems and their age-dependent relationships from both macro-neuroimaging and micro-genetic dimensions, advancing understanding of the underlying neural mechanisms behind neurodevelopmental disorders.","PeriodicalId":9715,"journal":{"name":"Cerebral cortex","volume":"35 6","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144246647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Learning to combine top-down context and feed-forward representations under ambiguity with apical and basal dendrites. 学习结合自上而下的上下文和顶端和基部树突模糊情况下的前馈表征。

IF 2.9 2区医学

Cerebral cortex Pub Date : 2025-06-04 DOI: 10.1093/cercor/bhaf134

Nizar Islah, Guillaume Etter, Mashbayar Tugsbayar, Busra Tugce Gurbuz, Blake Richards, Eilif B Muller

{"title":"Learning to combine top-down context and feed-forward representations under ambiguity with apical and basal dendrites.","authors":"Nizar Islah, Guillaume Etter, Mashbayar Tugsbayar, Busra Tugce Gurbuz, Blake Richards, Eilif B Muller","doi":"10.1093/cercor/bhaf134","DOIUrl":"10.1093/cercor/bhaf134","url":null,"abstract":"One of the hallmark features of neocortical anatomy is the presence of extensive top-down projections into primary sensory areas. It is hypothesized that one of the roles of these top-down projections is to carry contextual information that helps animals to resolve ambiguities in sensory data. One proposed mechanism of contextual integration is a combination of input streams at distinct apical and basal dendrites of pyramidal neurons. Computationally, however, it is yet to be demonstrated how such an architecture could leverage distinct compartments for flexible contextual integration and sensory processing. Here, we implement a deep neural network with distinct apical and basal compartments that integrates (a) contextual information from top-down projections to apical compartments and (b) sensory representations driven by bottom-up projections to basal compartments. In addition, we develop a new contextual integration task using generative modeling. The performance of deep neural networks augmented with our \"apical prior\" exceeds that of single-compartment networks. We find that a sparse subset of neurons of the context-relevant categories receive the largest top-down signals. We further show that this sparse gain modulation is necessary. Altogether, this suggests that the \"apical prior\" could be key for handling the ambiguities that animals encounter in the real world.","PeriodicalId":9715,"journal":{"name":"Cerebral cortex","volume":"35 6","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12205961/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144474074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multiscale cortical morphometry reveals pronounced regional and scale-dependent variations across the lifespan. 多尺度皮层形态测量揭示了明显的区域和尺度依赖性的变化在整个生命周期。

IF 2.9 2区医学

Cerebral cortex Pub Date : 2025-06-04 DOI: 10.1093/cercor/bhaf154

Karoline Leiberg, Timo Blattner, Bethany Little, Victor B B Mello, Fernanda H P de Moraes, Christian Rummel, Peter N Taylor, Bruno Mota, Yujiang Wang

{"title":"Multiscale cortical morphometry reveals pronounced regional and scale-dependent variations across the lifespan.","authors":"Karoline Leiberg, Timo Blattner, Bethany Little, Victor B B Mello, Fernanda H P de Moraes, Christian Rummel, Peter N Taylor, Bruno Mota, Yujiang Wang","doi":"10.1093/cercor/bhaf154","DOIUrl":"10.1093/cercor/bhaf154","url":null,"abstract":"Characterizing changes in cortical morphology across the lifespan is fundamental for both research and clinical applications. Most studies report a monotonic decrease in commonly used morphometrics, such as cortical thickness and volume, with only subtle regional variations in the rate of decline. However, these findings are limited to a single length scale. Here, we delineate changes across the lifespan in multiscale morphometrics. We applied multiscale morphometric analysis to structural MRI from subjects aged 6 to 88 years from Nathan Kline Institute Rockland Sample (n = 833) and Cambridge Centre for Ageing and Neuroscience (n = 641), and derived population-level lifespan trajectories at multiple length scales. Lifespan trajectories show diverging and even opposing trends at different spatial scales. Larger scales (1.86 mm) displayed the strongest changes across the lifespan (up to 60%) when considering entire cortical hemispheres. Lobal variations also became more pronounced in scales over 0.7 mm. In a proof-of-principle brain age prediction context, multiscale morphometrics provided additional predictive value, boosting the adjusted $R^{2}$ of the model from 0.35 to 0.7. Our study provides a comprehensive multiscale description of cortical morphology across the lifespan, forming foundations for normative models to identify multiscale morphological abnormalities. Our results reveal the complementary information contained in different spatial scales, suggesting that morphometrics should be considered at multiple length scales.","PeriodicalId":9715,"journal":{"name":"Cerebral cortex","volume":"35 6","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12205997/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144474075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Frequency- and layer-specific effects of high-frequency STN stimulation on mouse motor cortical areas in vivo. 高频STN刺激对小鼠体内运动皮质区的频率和层特异性影响。

IF 2.9 2区医学

Cerebral cortex Pub Date : 2025-06-04 DOI: 10.1093/cercor/bhaf137

Svenja L Kreis, Gabriel Gonzalez-Escamilla, Daniela Mirzac, Muthuraman Muthuraman, Heiko J Luhmann, Sergiu Groppa

{"title":"Frequency- and layer-specific effects of high-frequency STN stimulation on mouse motor cortical areas in vivo.","authors":"Svenja L Kreis, Gabriel Gonzalez-Escamilla, Daniela Mirzac, Muthuraman Muthuraman, Heiko J Luhmann, Sergiu Groppa","doi":"10.1093/cercor/bhaf137","DOIUrl":"https://doi.org/10.1093/cercor/bhaf137","url":null,"abstract":"High-frequency deep brain stimulation (DBS) of the subthalamic nucleus (STN) is an effective evidence-based therapy for Parkinson's disease; however, its effects on the motor network are unclear. In anesthetized mice we studied the layer (L)- and frequency-specific effects of DBS on the connectivity between STN and rostral and caudal forelimb area (RFA and CFA) layers, the respective homologs to human premotor and motor cortex. Multi-site extracellular recordings served to quantify local field potential-driven activity at rest and during burst STN stimulation at multiple stimulation-frequencies for 10 min. The combination of frequency-specific coherence and information flow dynamics from effective connectivity (EC) demonstrated that 160 Hz STN stimulation increases the high-γ power in RFA and CFA. Additionally, 160 Hz STN stimulation reduced the β- and high γ-frequency coherence between RFA, CFA, and STN, as well as the EC from STN towards RFA and CFA, but no change in the connectivity from cortex towards STN was attested, demonstrating hyperdirect pathway activation. Our work provides empirical insights into the mechanisms of action of DBS, which represent an important basis for the further development of this therapy.","PeriodicalId":9715,"journal":{"name":"Cerebral cortex","volume":"35 6","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144246648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Genetic and environmental contributions to ReHo and fALFF in early adolescence vary across brain regions. 基因和环境对青春期早期ReHo和fALFF的影响在不同的大脑区域有所不同。

IF 2.9 2区医学

Cerebral cortex Pub Date : 2025-06-04 DOI: 10.1093/cercor/bhaf143

Lachlan T Strike, Katie L McMahon, Sarah E Medland, Greig I de Zubicaray

{"title":"Genetic and environmental contributions to ReHo and fALFF in early adolescence vary across brain regions.","authors":"Lachlan T Strike, Katie L McMahon, Sarah E Medland, Greig I de Zubicaray","doi":"10.1093/cercor/bhaf143","DOIUrl":"10.1093/cercor/bhaf143","url":null,"abstract":"Research on genetic and environmental influences on brain function generally focuses on connections between brain areas. A different yet unexplored approach is to examine activity within local brain regions. We investigated the influence of genes and environmental effects on two specific measures of local brain function: regional homogeneity and fractional amplitude of low-frequency fluctuations. Participants were drawn from a sample of adolescent twins on two occasions (mean ages 11.5 and 13.2 yr, n = 278 and 248). Results showed that genetic and environmental factors influenced brain function in almost all 210 cortical regions examined. Moreover, genetic and common environmental factors influencing regional homogeneity and fractional amplitude of low-frequency fluctuation values at wave 1 (9 to 14 yr) also influenced values at wave 2 (10 to 16 yr) for many regions. However, the influence of genetic and common environmental factors varied across the cortex, exhibiting different patterns in different regions. Furthermore, we found new (ie independent) genetic and environmental influences on brain activity at wave 2, again with regional patterns. Exploratory analyses found weak associations between anxiety and depressive symptoms and local brain function in several regions of the temporal lobe. These findings are consistent with similar studies of other resting-state functional MRI metrics (ie functional connectivity).","PeriodicalId":9715,"journal":{"name":"Cerebral cortex","volume":"35 6","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12205945/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144339924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring the neural mechanisms of ADHD in children: a multifeature cross-task fNIRS analysis. 探讨儿童ADHD的神经机制：多特征跨任务fNIRS分析。

IF 2.9 2区医学

Cerebral cortex Pub Date : 2025-06-04 DOI: 10.1093/cercor/bhaf155

Mengxiang Chu, Jiaojiao Ren, Lijuan Yang, Yunxiang Ma, Zhengyu Zhong, Xiaowei He, Hongbo Guo, Xiao Li, Jingjing Yu, Zhaohui Wang

{"title":"Exploring the neural mechanisms of ADHD in children: a multifeature cross-task fNIRS analysis.","authors":"Mengxiang Chu, Jiaojiao Ren, Lijuan Yang, Yunxiang Ma, Zhengyu Zhong, Xiaowei He, Hongbo Guo, Xiao Li, Jingjing Yu, Zhaohui Wang","doi":"10.1093/cercor/bhaf155","DOIUrl":"https://doi.org/10.1093/cercor/bhaf155","url":null,"abstract":"Children with attention-deficit hyperactivity disorder exhibit multidimensional abnormalities of brain function, and the identification of key brain regions is often inconsistent across studies due to the influence of specific cognitive demands and feature selection. We conducted multifeature cross-task analysis and correlation analysis of functional near-infrared spectroscopy-based functional activity and connectivity under both resting state and verbal fluency task. Results reveal that more pronounced brain activation differences were observed in the right hemisphere of attention-deficit hyperactivity disorder group compared with healthy controls, particularly in channels 7 and 13, with cross-task consistent activation patterns. The strongest connectivity appeared between the right dorsolateral prefrontal cortex and the right frontopolar cortex in both resting state and verbal fluency task. Meanwhile, the task-related significant differences were mainly found in the left hemisphere, with fewer connectivity differences between tasks than between groups. Furthermore, a complex nonlinear relationship was identified between brain activation intensity and functional connectivity in attention-deficit hyperactivity disorder, a negative correlation in resting state, and a positive correlation in half of the brain regions (including bilateral dorsolateral prefrontal cortex) during verbal fluency task. These findings support the existing attention-deficit hyperactivity disorder mechanisms and supplement the complexity of cross-task brain functional reorganization and fixed functional abnormalities, thereby advancing research on the neurobiological basis of attention-deficit hyperactivity disorder.","PeriodicalId":9715,"journal":{"name":"Cerebral cortex","volume":"35 6","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144494895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0