Cerebral cortex最新文献_第5页

One cell to rule them all: Immune regulation of the brain in autism spectrum disorder. 一个细胞可以统治所有细胞：自闭症谱系障碍中大脑的免疫调节。

IF 2.9 2区医学

Cerebral cortex Pub Date : 2025-04-01 DOI: 10.1093/cercor/bhaf099

Paul Ashwood

引用次数: 0

Enhanced reciprocal connections of the prefrontoparietal-thalamo-hippocampal circuit in older adults. 老年人前额叶-顶叶-丘脑-海马回路的相互连接增强。

IF 2.9 2区医学

Cerebral cortex Pub Date : 2025-04-01 DOI: 10.1093/cercor/bhaf080

Zhen Ouyang, Haixia Jiang, Feng Zhang, Xue Wang, Chuqiao Geng, Mingjuan Zhao, Dong Cui, Zihao Zheng, Li Dong, Qing Jiao, Weifang Cao

{"title":"Enhanced reciprocal connections of the prefrontoparietal-thalamo-hippocampal circuit in older adults.","authors":"Zhen Ouyang, Haixia Jiang, Feng Zhang, Xue Wang, Chuqiao Geng, Mingjuan Zhao, Dong Cui, Zihao Zheng, Li Dong, Qing Jiao, Weifang Cao","doi":"10.1093/cercor/bhaf080","DOIUrl":"https://doi.org/10.1093/cercor/bhaf080","url":null,"abstract":"Cognitive functions rely on specific brain circuits involving cortical and subcortical regions. However, how age-related changes in effective connectivity within the prefrontoparietal-thalamo-hippocampal circuit affect cognition remains unclear. This study included 143 healthy older adults (60 to 88 yrs) and 124 young adults (18 to 44 yrs), using regression dynamic causal modeling to analyze resting-state functional magnetic resonance imaging data. Compared to young adults, older adults showed increased reciprocal effective connectivity within the ventromedial prefrontal cortex-lateral thalamic nuclei-right caudal hippocampus circuit. Enhanced bidirectional connectivity was also observed within the frontoparietal network, between the pregenual cingulate gyrus and superior frontal gyrus, and between lateral thalamic nuclei (LTN) and frontal pole. Additionally, heightened connectivity between thalamus and hippocampus negatively correlated with cognitive performance. Our findings reveal significant age-related increases in effective connectivity within the prefrontoparietal-thalamo-hippocampal circuit, linked to cognitive performance levels. Increased connectivity may indicate compensatory mechanisms helping preserve cognitive function in healthy aging. These results advance our understanding of neural dynamics underlying cognitive aging and potential adaptive mechanisms in older adults.","PeriodicalId":9715,"journal":{"name":"Cerebral cortex","volume":"35 4","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143974212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluating the evolution and inter-individual variability of infant functional module development from 0 to 5 yr old. 评价0 ~ 5岁婴儿功能模块发育的演化和个体间变异。

IF 2.9 2区医学

Cerebral cortex Pub Date : 2025-04-01 DOI: 10.1093/cercor/bhaf071

Lingbin Bian, Nizhuan Wang, Yuanning Li, Adeel Razi, Qian Wang, Han Zhang, Dinggang Shen

引用次数: 0

Genetic mechanisms underlying gray matter atrophy in Parkinson's disease: a combined transcriptome and neuroimaging study. 帕金森病灰质萎缩的遗传机制：转录组和神经影像学的联合研究。

IF 2.9 2区医学

Cerebral cortex Pub Date : 2025-04-01 DOI: 10.1093/cercor/bhaf097

Yi Ji, Min Xu, Han Zhao, Huanhuan Cai, Kaidong Chen, Li Zhang, Haixia Mao, Feng Wang, Jiajia Zhu, Xiangming Fang

{"title":"Genetic mechanisms underlying gray matter atrophy in Parkinson's disease: a combined transcriptome and neuroimaging study.","authors":"Yi Ji, Min Xu, Han Zhao, Huanhuan Cai, Kaidong Chen, Li Zhang, Haixia Mao, Feng Wang, Jiajia Zhu, Xiangming Fang","doi":"10.1093/cercor/bhaf097","DOIUrl":"https://doi.org/10.1093/cercor/bhaf097","url":null,"abstract":"Extensive studies have demonstrated significant gray matter atrophy in patients with Parkinson's disease (PD); however, the underlying gene expression mechanisms remain largely unknown. To comprehensively characterize the gray matter volume alterations in PD patients, we conducted a neuroimaging meta-analysis and validated the observed atrophic phenotypes in an independent dataset. Leveraging the Allen Human Brain Atlas (AHBA), we linked brain transcriptomic data to neuroimaging phenotypes to identify genes associated with PD-related gray matter atrophy. Further enrichment analyses and functional characterization explored the potential roles of these correlated genes in disease pathology. Both the neuroimaging meta-analysis and independent dataset analysis consistently revealed significant gray matter atrophy in PD, particularly in the superior temporal gyrus, highly associated with sensory and motor functions. Spatial transcriptome-neuroimaging correlation analysis identified 1,952 overlapping genes whose expression levels were significantly correlated with the spatial distribution of gray matter atrophy in PD patients. These genes were enriched in several key biological processes and molecular pathways, exhibiting region- and cell type-specific expression, particularly in dopaminergic receptor neurons of brain tissue. This study delineates the spatial distribution of gray matter atrophy in PD and suggests that this neurodegenerative phenotype may result from complex interactions among multiple functionally relevant genes.","PeriodicalId":9715,"journal":{"name":"Cerebral cortex","volume":"35 4","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143987068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Information transfer and recovery for the sense of touch. 触觉的信息传递和恢复。

IF 2.9 2区医学

Cerebral cortex Pub Date : 2025-04-01 DOI: 10.1093/cercor/bhaf073

Chao Huang, Bernhard Englitz, Andrey Reznik, Fleur Zeldenrust, Tansu Celikel

{"title":"Information transfer and recovery for the sense of touch.","authors":"Chao Huang, Bernhard Englitz, Andrey Reznik, Fleur Zeldenrust, Tansu Celikel","doi":"10.1093/cercor/bhaf073","DOIUrl":"10.1093/cercor/bhaf073","url":null,"abstract":"Transformation of postsynaptic potentials into action potentials is the rate-limiting step of communication in neural networks. The efficiency of this intracellular information transfer also powerfully shapes stimulus representations in sensory cortices. Using whole-cell recordings and information-theoretic measures, we show herein that somatic postsynaptic potentials accurately represent stimulus location on a trial-by-trial basis in single neurons, even 4 synapses away from the sensory periphery in the whisker system. This information is largely lost during action potential generation but can be rapidly (<20 ms) recovered using complementary information in local populations in a cell-type-specific manner. These results show that as sensory information is transferred from one neural locus to another, the circuits reconstruct the stimulus with high fidelity so that sensory representations of single neurons faithfully represent the stimulus in the periphery, but only in their postsynaptic potentials, resulting in lossless information processing for the sense of touch in the primary somatosensory cortex.","PeriodicalId":9715,"journal":{"name":"Cerebral cortex","volume":"35 4","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11976729/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143802613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neural correlates of how egoistic, altruistic, and mixed motivations modulate the influence of self-deception on deceptive behavior. 利己主义、利他主义和混合动机如何调节自我欺骗对欺骗行为的影响的神经关联。

IF 2.9 2区医学

Cerebral cortex Pub Date : 2025-04-01 DOI: 10.1093/cercor/bhaf077

Zijun Huang, Bowei Zhong, Tengji Yang, Wei Fan

{"title":"Neural correlates of how egoistic, altruistic, and mixed motivations modulate the influence of self-deception on deceptive behavior.","authors":"Zijun Huang, Bowei Zhong, Tengji Yang, Wei Fan","doi":"10.1093/cercor/bhaf077","DOIUrl":"10.1093/cercor/bhaf077","url":null,"abstract":"Using event-related potentials, this study investigated the interplay between self-deception and varying motivations in influencing deceptive behavior. Participants in either the self-deception or nonself-deception condition were instructed to make deceptive decisions under different motivational contexts. Behavioral responses and neural activity were recorded throughout the decision-making process. Behaviorally, there were no significant differences in deception proportions between the self-deception and nonself-deception conditions under egoistic or mixed motivations. However, under altruistic motivation, participants in the self-deception condition engaged in more deceptive behavior compared to those in the nonself-deception condition. Event-related potential results revealed no significant differences in P2 and N2 amplitudes between the self-deception and nonself-deception conditions under egoistic or mixed motivations. However, under altruistic motivation, the self-deception condition was associated with reduced P2 amplitudes and more negative N2 amplitudes relative to the nonself-deception condition. Additionally, no significant interaction in P3 amplitudes was found between self-deception and different motivations. These findings suggest that the effect of self-deception on deceptive behavior is modulated by different motivations. Specifically, egoistic or mixed motivations might be associated with a self-serving tendency in deceptive behavior, while altruistic motivation appeared to enhance deceptive behavior in the self-deception condition, potentially to foster a prosocial image.","PeriodicalId":9715,"journal":{"name":"Cerebral cortex","volume":"35 4","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143802615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Framing major depressive disorder as a condition of network imbalance at the compartment level: a proof-of-concept study. 将重度抑郁障碍作为隔室水平的网络不平衡状况：一项概念验证研究。

IF 2.9 2区医学

Cerebral cortex Pub Date : 2025-04-01 DOI: 10.1093/cercor/bhaf089

Tien-Wen Lee

{"title":"Framing major depressive disorder as a condition of network imbalance at the compartment level: a proof-of-concept study.","authors":"Tien-Wen Lee","doi":"10.1093/cercor/bhaf089","DOIUrl":"https://doi.org/10.1093/cercor/bhaf089","url":null,"abstract":"Major depressive disorder (MDD) is associated with hypoactivity in the frontoparietal (FP) system and hyperactivity in the limbic (LM) system. The widely accepted limbic-cortical dysregulation model has recently been extended by the concept of imbalanced reciprocal suppression between these 2 systems. This study investigates the refined theoretical framework. Neuroimaging datasets from 60 MDD and 60 healthy controls were obtained from the Canadian Biomarker Integration Network in Depression database, including structural magnetic resonance imaging (MRI) and resting-state functional MRI (rsfMRI). The cerebral cortex was parcellated using the modular analysis and similarity measurements (MOSI) technique. For each node, the average amplitude of low-frequency fluctuation (avgALFF) and nodal strength were calculated. Correlation analyses were conducted to establish an adjacency matrix and assess the relationship between nodal power and strength. The results indicated that the LM system in MDD displayed higher partition numbers and avgALFF (P < 0.005). A significant negative correlation between nodal strength and power was replicated (P < 1E-10), suggesting that greater functional input enhances regional neural suppression. Notably, MDD participants exhibited a higher negative correlation between FP nodal power and LM-FP connectivity (stronger suppression) but a lower negative correlation between LM nodal power and FP-LM connectivity (weaker suppression). These findings support the theory of abnormal cortical signal organization and reciprocal suppression in MDD.","PeriodicalId":9715,"journal":{"name":"Cerebral cortex","volume":"35 4","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143976258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Brain connectivity changes in response to cortical electrical stimulation in blind neuroprosthesis users. 盲人神经假体使用者在皮质电刺激下的脑连通性改变。

IF 2.9 2区医学

Cerebral cortex Pub Date : 2025-04-01 DOI: 10.1093/cercor/bhaf075

Fernando Daniel Farfán, Leili Soo, Fabrizio Grani, María Dolores Grima-Murcia, Eduardo Fernández

{"title":"Brain connectivity changes in response to cortical electrical stimulation in blind neuroprosthesis users.","authors":"Fernando Daniel Farfán, Leili Soo, Fabrizio Grani, María Dolores Grima-Murcia, Eduardo Fernández","doi":"10.1093/cercor/bhaf075","DOIUrl":"10.1093/cercor/bhaf075","url":null,"abstract":"The success of visual neuroprostheses in long-term blind individuals depends not only on the prosthetic technology but also on the brain's ability to readjust its multimodal sensory processing circuits. This study investigates longitudinal changes in resting-state cortical connectivity in two blind subjects implanted with an intracortical microelectrode array (10 × 10 Utah Electrode Array) in the visual cortex for 6 months. During this period, daily microstimulation sessions elicited phosphene perception, and periodic electroencephalographic recordings in the resting state were conducted. Cortical connectivity was quantified using spectral coherence across 64 electroencephalographic channels. Results revealed significant changes in connectivity patterns pre- and post-implantation, with linear trends observed during the implantation period. These trends varied between subjects: User 1 exhibited changes in the 7 to 13 Hz band, while user 2 showed changes in the 15 to 30 Hz band. This study highlights the brain's adaptive capacity in response to sensory restoration and provides insights into optimizing neuroplasticity for improved outcomes in neuroprosthetic interventions.","PeriodicalId":9715,"journal":{"name":"Cerebral cortex","volume":"35 4","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143771513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A scene-selective region in the superior parietal lobule for visually guided navigation. 顶叶上小叶中用于视觉导航的场景选择区域。

IF 2.9 2区医学

Cerebral cortex Pub Date : 2025-04-01 DOI: 10.1093/cercor/bhaf082

Hee Kyung Yoon, Yaelan Jung, Andrew S Persichetti, Daniel D Dilks

{"title":"A scene-selective region in the superior parietal lobule for visually guided navigation.","authors":"Hee Kyung Yoon, Yaelan Jung, Andrew S Persichetti, Daniel D Dilks","doi":"10.1093/cercor/bhaf082","DOIUrl":"https://doi.org/10.1093/cercor/bhaf082","url":null,"abstract":"Growing evidence indicates that the occipital place area (OPA) is involved in \"visually guided navigation.\" Here, we propose that a recently uncovered scene-selective region in the superior parietal lobule is also involved in visually guided navigation. First, using functional magnetic resonance imaging (fMRI), we found that the superior parietal lobule (SPL) responds significantly more to scene stimuli than to face and object stimuli across two sets of stimuli (i.e. dynamic and static), confirming its scene selectivity. Second, we found that the SPL, like the OPA, processes two kinds of information necessary for visually guided navigation: first-person perspective motion and sense (left/right) information in scenes. Third, resting-state fMRI data revealed that SPL is preferentially connected to OPA, compared to other scene-selective regions, indicating that SPL and OPA are part of the same system. Fourth, analysis of previously published fMRI data showed that SPL, like OPA, responds significantly more while participants perform a visually guided navigation task compared to both a scene categorization task and a baseline task, further supporting our hypothesis in an independent dataset. Taken together, these findings indicate the existence of a new scene-selective region for visually guided navigation and raise interesting questions about the precise role that SPL, compared to OPA, may play within visually guided navigation.","PeriodicalId":9715,"journal":{"name":"Cerebral cortex","volume":"35 4","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12014905/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143981870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Co-occurring positive and negative prediction error signals are independent of stimulus repetition effects. 同时出现的正负预测误差信号不受刺激重复效应的影响。

IF 2.9 2区医学

Cerebral cortex Pub Date : 2025-04-01 DOI: 10.1093/cercor/bhaf078

Sophie Siestrup, Lena Maria Leeners, Jennifer Pomp, Marlen A Roehe, Anoushiravan Zahedi, Ricarda I Schubotz

{"title":"Co-occurring positive and negative prediction error signals are independent of stimulus repetition effects.","authors":"Sophie Siestrup, Lena Maria Leeners, Jennifer Pomp, Marlen A Roehe, Anoushiravan Zahedi, Ricarda I Schubotz","doi":"10.1093/cercor/bhaf078","DOIUrl":"https://doi.org/10.1093/cercor/bhaf078","url":null,"abstract":"Both the absence of a predicted stimulus and the unexpected presentation of another stimulus result in increased activation in the areas processing the stimuli. These signals are termed negative and positive prediction errors, respectively. Here, we showed that both types of prediction errors can occur simultaneously and independently of stimulus repetition effects. Participants performed a reaction time task in a magnetic resonance scanner while being exposed to face and place stimuli with a distinct probabilistic distribution resulting in unexpected omissions and unexpected presentations of those stimuli. Participants' responses were significantly faster for expected as compared to neutral or unexpected trials, showing that they learned the statistical regularities inherent to the task. Moreover, the region of interest analysis of beta estimates extracted from the fusiform face area and the parahippocampal place area revealed co-occurring negative and positive prediction error signals. This was evidenced by increases in brain activation for unexpected omissions and unexpected presentations of visual stimuli when compared to expected stimuli. Our results also underlined that these effects occur independently of stimulus repetition effects. Altogether, these findings support a predictive coding model of cognition, highlighting the importance of considering the potential dual nature of expectation violations.","PeriodicalId":9715,"journal":{"name":"Cerebral cortex","volume":"35 4","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143981873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0