Cerebral cortex最新文献_第6页

Voxel-based meta-analysis of gray matter abnormalities in idiopathic generalized epilepsy. 特发性全身性癫痫灰质异常的体素荟萃分析。

IF 2.9 2区医学

Cerebral cortex Pub Date : 2025-08-01 DOI: 10.1093/cercor/bhaf201

Xiang Huang, Limei Mao, Qiuxing Lin, Kailing Huang, Yuming Li, Peiwen Liu, Danyang Cao, Wenhao Li, Wei Li, Lili Zhao, Dong Zhou, Yingying Zhang, Dongmei An

{"title":"Voxel-based meta-analysis of gray matter abnormalities in idiopathic generalized epilepsy.","authors":"Xiang Huang, Limei Mao, Qiuxing Lin, Kailing Huang, Yuming Li, Peiwen Liu, Danyang Cao, Wenhao Li, Wei Li, Lili Zhao, Dong Zhou, Yingying Zhang, Dongmei An","doi":"10.1093/cercor/bhaf201","DOIUrl":"10.1093/cercor/bhaf201","url":null,"abstract":"This meta-analysis aims to investigate the convergent gray matter alterations observed in idiopathic generalized epilepsy through voxel-based morphometry studies. Voxel-based morphometry studies investigating the whole-brain gray matter alterations between patients with idiopathic generalized epilepsy and healthy controls were systematically searched. A coordinate-based meta-analysis of gray matter alterations was performed utilizing the anisotropic effect size-based signed differential mapping. Subgroup analyses were also conducted to further validate these findings and identify specificities. Twenty-two studies including 913 idiopathic generalized epilepsy patients and 887 healthy controls were enrolled. Patients with idiopathic generalized epilepsy exhibited increased gray matter in the right cuneus cortex, precuneus, superior frontal gyrus, middle frontal gyrus, parahippocampal gyrus, and fusiform gyrus, while exhibiting decreased gray matter in the bilateral thalami, left caudate nucleus, and right insula. Subgroup analyses revealed overlapping gray matter alterations in the bilateral thalami, with specific involvement of frontal lobe and insula in juvenile myoclonic epilepsy, right superior temporal gyrus in generalized tonic-clonic seizures alone, and bilateral paracentral lobules in absence epilepsy. This meta-analysis identified that both cortical and subcortical structural abnormalities especially thalamo-cortical circuit was involved in patients with idiopathic generalized epilepsy, while overlapped and disassociated gray matter alterations were identified across different idiopathic generalized epilepsy subsyndromes.","PeriodicalId":9715,"journal":{"name":"Cerebral cortex","volume":"35 8","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144774743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Amygdala and cortical substrates of subjective well-being: pathways to reduced aggression in emotional processing contexts. 主观幸福感的杏仁核和皮层底物：情绪加工情境下攻击性降低的途径。

IF 2.9 2区医学

Cerebral cortex Pub Date : 2025-08-01 DOI: 10.1093/cercor/bhaf204

Yanxia Ge, Jinlian Wang, Chang Liu, Xiang Li, Hohjin Im, Pinchun Wang, Weipeng Jin, Wenwei Zhu, Qianyi Shangguan, Guang Zhao, Xin Niu, Zong Zhang, Zixi Li, Qiang Wang

{"title":"Amygdala and cortical substrates of subjective well-being: pathways to reduced aggression in emotional processing contexts.","authors":"Yanxia Ge, Jinlian Wang, Chang Liu, Xiang Li, Hohjin Im, Pinchun Wang, Weipeng Jin, Wenwei Zhu, Qianyi Shangguan, Guang Zhao, Xin Niu, Zong Zhang, Zixi Li, Qiang Wang","doi":"10.1093/cercor/bhaf204","DOIUrl":"https://doi.org/10.1093/cercor/bhaf204","url":null,"abstract":"Subjective well-being has been implicated in the regulation of aggressive behavior, potentially through its influence on mood and neural processing. However, the underlying neuropsychological mechanisms remain insufficiently understood. This study aimed to elucidate the neural correlates of subjective well-being and examine its potential association with aggression using a two-part investigation. The first involved a functional MRI study (n = 111), focusing on amygdala responses to emotional face processing and broader cortical activation related to subjective well-being. The second involved a larger behavioral sample (n = 627) to assess the relationship between subjective well-being and aggression, as well as the mediating role of emotional variables. Behaviorally, subjective well-being was inversely associated with anger, hostility, and overall aggression, and with negative affect, anxiety, and depression. Mediation analyses demonstrated significant effects of mood (negative affect, depression, and anxiety) in linking subjective well-being to aggression. Neuroimaging results revealed that individuals with higher subjective well-being displayed attenuated amygdala reactivity to fearful faces. Additionally, intersubject representational similarity analyses demonstrated that individuals with similar subjective well-being levels shared more convergent neural activation patterns in visual (e.g., occipital pole, lateral occipital cortex, middle temporal gyrus, and fusiform) and the emotional network (e.g., insula), but not within the amygdala. These findings provide novel insights into the neuropsychological mechanisms linking well-being to emotional regulation and aggression.","PeriodicalId":9715,"journal":{"name":"Cerebral cortex","volume":"35 8","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144774741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The phase of slow wave oscillations couples with high gamma power in human electrocorticography during performed and imagined repetitive movements. 在执行和想象的重复运动中，人体皮质电图中的慢波振荡相位与高伽马功率耦合。

IF 2.9 2区医学

Cerebral cortex Pub Date : 2025-08-01 DOI: 10.1093/cercor/bhaf226

Eva Calvo Merino, Qiang Sun, Marc M Van Hulle

{"title":"The phase of slow wave oscillations couples with high gamma power in human electrocorticography during performed and imagined repetitive movements.","authors":"Eva Calvo Merino, Qiang Sun, Marc M Van Hulle","doi":"10.1093/cercor/bhaf226","DOIUrl":"https://doi.org/10.1093/cercor/bhaf226","url":null,"abstract":"High Gamma Band (HGB) and Slow Wave Oscillations (SWOs) have been identified as significant features in movement neurophysiology. HGB reflects local neuronal activity, while SWOs inform on the temporal characteristics of movement, especially during repetitive tasks. However, to date, they have mostly been studied separately, leaving details on their interaction largely unknown. Here, we looked at Phase Amplitude Coupling (PAC) to assess interactions between SWO phase and HGB power. We use a publicly-available electrocorticography (ECoG) dataset recorded during repetitive motor execution (ME) and motor imagery (MI) of hand and tongue movements. We found channels with significant SWO-HGB PAC for all subjects and tasks, distributed across multiple brain regions. In the sensorimotor cortex PAC occurred at specific coupling phases and was primarily observed during ME, while frontal and temporal regions exhibited similar PAC levels across ME and MI but lacked distinct preferred coupling phases. When training decoders for movement detection, PAC underperformed compared to SWOs or HGB; however, it showed a strong correlation with accuracy when single-channel SWOs were used as decoding feature, highlighting its potential for channel selection. Weaker correlations were found when PAC was compared to task-related HGB power increases, suggesting that these represent distinct neural features.","PeriodicalId":9715,"journal":{"name":"Cerebral cortex","volume":"35 8","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144944191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Empathy responses to others' physical pain in the deaf college students: evidence from an event-related potential study. 聋人大学生对他人身体疼痛的共情反应：来自事件相关电位研究的证据。

IF 2.9 2区医学

Cerebral cortex Pub Date : 2025-08-01 DOI: 10.1093/cercor/bhaf198

Xue Du, Chenxi Li, Jian Liang, Jianjun Mou, Qinqin Zheng

引用次数: 0

Lateralised modulation of posterior alpha oscillations by closed loop auditory stimulation during memory retention. 记忆保持过程中闭环听觉刺激对后α振荡的横向调节。

IF 2.9 2区医学

Cerebral cortex Pub Date : 2025-08-01 DOI: 10.1093/cercor/bhaf250

Henry Hebron, Radost Dimitrova, Valeria Jaramillo, Derk-Jan Dijk, Ines R Violante

{"title":"Lateralised modulation of posterior alpha oscillations by closed loop auditory stimulation during memory retention.","authors":"Henry Hebron, Radost Dimitrova, Valeria Jaramillo, Derk-Jan Dijk, Ines R Violante","doi":"10.1093/cercor/bhaf250","DOIUrl":"https://doi.org/10.1093/cercor/bhaf250","url":null,"abstract":"Alpha oscillations have been implicated in the maintenance of working memory representations. Notably, when memorised content is spatially lateralised, the power of posterior alpha activity exhibits corresponding lateralisation during the retention interval, consistent with the retinotopic organisation of the visual cortex. Beyond power, alpha frequency has also been linked to memory performan ce, with faster alpha rhythms associated with enhanced retention. These findings position alpha oscillations as a promising target for neuromodulation. In this study, we demonstrate that although alpha frequency is not typically lateralised in a retinotopic manner during working memory retention, such lateralisation can be externally induced. Using alpha closed-loop auditory stimulation targeted to opposite alpha phases on opposite cortices and leveraging the previously demonstrated phase-dependent modulation of alpha oscillations' frequency by sound, we successfully modulated alpha frequency asymmetrically between the visual cortices. The extent of induced frequency lateralisation was associated with the behavioural asymmetry in task performance.","PeriodicalId":9715,"journal":{"name":"Cerebral cortex","volume":"35 8","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145029001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neural mechanisms of physical and social pain empathy: an activation likelihood estimation meta-analysis of fMRI studies. 生理和社会疼痛共情的神经机制：fMRI研究的激活似然估计meta分析。

IF 2.9 2区医学

Cerebral cortex Pub Date : 2025-08-01 DOI: 10.1093/cercor/bhaf227

Peng Zhang, Lin Ding, Mingliang Wang, Shuyi Qiu

{"title":"Neural mechanisms of physical and social pain empathy: an activation likelihood estimation meta-analysis of fMRI studies.","authors":"Peng Zhang, Lin Ding, Mingliang Wang, Shuyi Qiu","doi":"10.1093/cercor/bhaf227","DOIUrl":"https://doi.org/10.1093/cercor/bhaf227","url":null,"abstract":"This study employed a systematic meta-analysis to elucidate neural representation differences between empathy for physical and social pain. Addressing the critical unresolved question of neurofunctional similarities and distinctions between these two empathy types, we performed an activation likelihood estimation coordinate-based meta-analysis, quantitatively synthesizing 35 functional MRI studies. Key findings revealed the following: (i) Physical pain empathy demonstrated significant left-lateralized activation patterns involving core regions of the mirror neuron system-including emotional resonance (anterior cingulate cortex, prefrontal cortex), affective-cognitive integration (anterior insula), and action comprehension (inferior frontal gyrus, inferior parietal lobule); (ii) social pain empathy selectively activated the mentalizing network (dorsomedial prefrontal cortex/medial prefrontal cortex); (iii) differential analyses identified the inferior parietal lobule, anterior cingulate cortex, and superior frontal gyrus as core discriminative regions, with no shared activated brain areas detected. These findings provide large-scale evidence supporting functional segregation in neural substrates between empathy subtypes, offering critical neuroimaging evidence for multidimensional models of empathy.","PeriodicalId":9715,"journal":{"name":"Cerebral cortex","volume":"35 8","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144944578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Temporal interference stimulation modulates verbal working memory: an EEG study on hemispheric lateralization and neural dynamics. 时间干扰刺激调节言语工作记忆：脑电研究半球侧化和神经动力学。

IF 2.9 2区医学

Cerebral cortex Pub Date : 2025-08-01 DOI: 10.1093/cercor/bhaf102

Jiahe Sun, Huixian Wu, Yishu Chen, Meng Zhang, Zhenyu Qian, Jiaojiao Lü, Yu Liu, Hongfei Ji, Jie Li, Jie Zhuang

{"title":"Temporal interference stimulation modulates verbal working memory: an EEG study on hemispheric lateralization and neural dynamics.","authors":"Jiahe Sun, Huixian Wu, Yishu Chen, Meng Zhang, Zhenyu Qian, Jiaojiao Lü, Yu Liu, Hongfei Ji, Jie Li, Jie Zhuang","doi":"10.1093/cercor/bhaf102","DOIUrl":"https://doi.org/10.1093/cercor/bhaf102","url":null,"abstract":"Temporal interference stimulation (TIS) is a novel technique for neural modulation; however, its precise effects on verbal working memory (WM) and underlying neural mechanisms remain underexplored. This study employed electroencephalogram (EEG) to investigate the temporal dynamics of TIS-induced modulation, with a particular focus on hemispheric lateralization, an aspect often overlooked. Using a delayed recognition task, we categorized WM into high-load and low-load conditions and applied TIS to the left and right hemispheres with sham stimulation as a control. The results revealed a robust right-lateralized effect of TIS under high-load conditions, characterized by increased N200 amplitude and decreased P300 amplitude at the right parietal site post-stimulation, whereas no significant effects emerged under low-load conditions. This pattern of results contrasts sharply with the null effects in low-load conditions, highlighting the influence of TIS on verbal WM under high-load conditions. Furthermore, our study uncovered distinct activation patterns between the 2 hemispheres, suggesting a complex interplay between hemispheric lateralization and TIS-induced neural modulation. Supporting the attention-memory model, our results indicated that the right parietal TIS facilitates cognitive resource redistribution through attentional modulation. This study fills a critical gap in understanding the impact of TIS on verbal WM and provides novel insights into its cognitive enhancement potential.","PeriodicalId":9715,"journal":{"name":"Cerebral cortex","volume":"35 8","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144768452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neurophysiological correlates of modifiable dementia risk factors in cognitively unimpaired older adults. 认知功能未受损老年人可改变的痴呆危险因素的神经生理学相关性

IF 2.9 2区医学

Cerebral cortex Pub Date : 2025-08-01 DOI: 10.1093/cercor/bhaf179

Jacob M Levenstein, Ciara Treacy, Sophie C Andrews

{"title":"Neurophysiological correlates of modifiable dementia risk factors in cognitively unimpaired older adults.","authors":"Jacob M Levenstein, Ciara Treacy, Sophie C Andrews","doi":"10.1093/cercor/bhaf179","DOIUrl":"10.1093/cercor/bhaf179","url":null,"abstract":"The 2024 Lancet Commission on Dementia estimates that up to 45% of dementia cases could be prevented by addressing modifiable risk factors, emphasizing both prevention opportunities and the need to understand the biological mechanisms. This study investigated neurophysiological mechanisms underlying modifiable dementia risk factors in cognitively unimpaired older adults. Seventy-nine cognitively unimpaired older adults underwent magnetic resonance imaging brain scans, with spectroscopy measurements taken from the sensorimotor cortex (SMC) and prefrontal cortex (PFC), using a Hadamard Encoding and Reconstruction of MEGA-Edited Spectroscopy sequence, optimized for measuring GABA+. Modifiable dementia risk scores were calculated using the Assessment for Cognitive Health and Dementia Risk (CogDrisk). Hierarchical linear regression analyses revealed a significant negative relationship within the SMC, with lower GABA+ (β = -0.249, P = 0.009) associated with higher risk scores. In the PFC, lower tNAA and tCho concentrations significantly predicted higher risk scores (β = -0.168 and -0.170, respectively). These findings suggest that GABAergic system alterations may underlie the pathophysiology of modifiable dementia risk in healthy aging, while changes in tNAA and tCho may reflect early alterations in neuronal integrity. These region-specific neurochemical findings may help identify potential early biomarkers for dementia risk and suggest new therapeutic pathways for preventive interventions.","PeriodicalId":9715,"journal":{"name":"Cerebral cortex","volume":"35 8","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12341911/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144834136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Thirty years of SPM-BrainMap synergy: making and mining coordinate-based literature. 三十年的SPM-BrainMap协同：制作和挖掘基于坐标的文献。

IF 2.9 2区医学

Cerebral cortex Pub Date : 2025-08-01 DOI: 10.1093/cercor/bhaf240

Peter T Fox

引用次数: 0

The emergence of genetic variants linked to brain and cognitive traits in human evolution. 人类进化中与大脑和认知特征相关的基因变异的出现。

IF 2.9 2区医学

Cerebral cortex Pub Date : 2025-08-01 DOI: 10.1093/cercor/bhaf127

Ilan Libedinsky, Yongbin Wei, Christiaan de Leeuw, James K Rilling, Danielle Posthuma, Martijn P van den Heuvel

{"title":"The emergence of genetic variants linked to brain and cognitive traits in human evolution.","authors":"Ilan Libedinsky, Yongbin Wei, Christiaan de Leeuw, James K Rilling, Danielle Posthuma, Martijn P van den Heuvel","doi":"10.1093/cercor/bhaf127","DOIUrl":"10.1093/cercor/bhaf127","url":null,"abstract":"Human evolution involved major anatomical transformations, including a rapid increase in brain volume over the last 2 million years. Examination of fossil records provides insight into these physical changes but offers limited information on the evolution of brain function and cognition. A complementary approach integrates genome dating from the Human Genome Dating Project with genome-wide association studies to trace the emergence of genetic variants linked to human traits over 5 million years. We find that genetic variants underlying cortical morphology (~300,000 years, P = 4 × 10-28), fluid intelligence (~500,000 years, P = 1.4 × 10-4), and psychiatric disorders (~475,000 years, P = 5.9 × 10-33) emerged relatively recently in hominin evolution. Among psychiatric phenotypes, variants associated with depression (~24,000 years, P = 1.6 × 10-4) and alcoholism-related traits (~40,000 years, P = 5.2 × 10-12) are the youngest. Genes with recent evolutionary modifications are involved in intelligence (P = 1.7 × 10-6) and cortical area (P = 3.5 × 10-4) and exhibit elevated expression in language-related areas (P = 7.1 × 10-4), a hallmark of human cognition. Our findings suggest that recently evolved genetic variants shaped the human brain, cognition, and psychiatric traits.","PeriodicalId":9715,"journal":{"name":"Cerebral cortex","volume":"35 8","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12345208/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144834139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0