Cerebral cortex最新文献_第6页

Functional gradient characteristics analysis of preschool-aged children with autism spectrum disorder. 学龄前儿童自闭症谱系障碍的功能梯度特征分析。

IF 2.9 2区医学

Cerebral cortex Pub Date : 2025-04-01 DOI: 10.1093/cercor/bhaf098

Guangrong Wu, Linfeng Song, Yuanyuan Xu, Guomin Zhang, Jie Fang, Siyan Xiong, Wei Yang, Lin Jiang

{"title":"Functional gradient characteristics analysis of preschool-aged children with autism spectrum disorder.","authors":"Guangrong Wu, Linfeng Song, Yuanyuan Xu, Guomin Zhang, Jie Fang, Siyan Xiong, Wei Yang, Lin Jiang","doi":"10.1093/cercor/bhaf098","DOIUrl":"https://doi.org/10.1093/cercor/bhaf098","url":null,"abstract":"Autism spectrum disorder (ASD) is a neurodevelopmental condition marked by social and behavioral impairments, emerging in early childhood with unclear causes. The primary aim of this study is to investigate shifts in the functional gradients underlying hierarchical brain network organization in ASD and to assess their potential contribution to clinical symptom severity. Resting-state functional magnetic resonance imaging was used to examine changes in functional gradients across seven major brain networks in a cohort of 52 individuals with ASD and 40 healthy controls. In the somatomotor network, neither the first nor third gradient showed significant group differences; however, two regions-right paracentral lobule and right postcentral gyrus-exhibited significant differences in the second gradient. In the frontoparietal network, only the left middle frontal gyrus in the second gradient showed a significant group difference. For the ventral attention network, only the primary gradient exhibited significant differences in the left insula, the right insula, and the right median cingulate and paracingulate gyri. In the default mode network, all three gradients showed statistically significant differences. These results suggest potential neuroimaging biomarkers for assessing the severity of ASD in preschool-aged children.","PeriodicalId":9715,"journal":{"name":"Cerebral cortex","volume":"35 4","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143991188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cross-modal functional plasticity after cochlear implantation. 人工耳蜗植入后的跨模态功能可塑性。

IF 2.9 2区医学

Cerebral cortex Pub Date : 2025-04-01 DOI: 10.1093/cercor/bhaf084

Jamal Esmaelpoor, Tommy Peng, Beth Jelfs, Darren Mao, Maureen J Shader, Colette M McKay

{"title":"Cross-modal functional plasticity after cochlear implantation.","authors":"Jamal Esmaelpoor, Tommy Peng, Beth Jelfs, Darren Mao, Maureen J Shader, Colette M McKay","doi":"10.1093/cercor/bhaf084","DOIUrl":"https://doi.org/10.1093/cercor/bhaf084","url":null,"abstract":"Despite evidence that cross-modal effects after hearing loss and cochlear implantation are primarily driven by synaptic gain and efficacy, few studies have evaluated cross-modal functional connectivity (CMFC) to assess plasticity. This study, inspired by the psychophysiological interaction (PPI) method, addresses its limitations and provides a robust approach for assessing task-induced CMFC. Twenty-three postlingually deafened cochlear implant (CI) recipients and 17 normal-hearing (NH) participants took part in the study. Functional near-infrared spectroscopy was used to measure brain activity during audio-only and visual-only speech tasks, with resting-state FC as a baseline, at 1 month and 1 year postimplantation. CI users' speech understanding was assessed 1 year postimplantation. Significant negative correlations were observed between contralateral task-induced CMFC and speech outcomes, particularly in links from the angular gyrus (AG) to the visual cortex. One year after CI activation, higher task-induced CMFC was found in AG compared to the superior temporal gyrus, reflecting neural efficiency principles. Task-induced CMFC remained elevated in CI users compared to NH even after 1 year. These findings suggest task-induced CMFC as a significant marker of cross-modal plasticity and speech performance in CI recipients.","PeriodicalId":9715,"journal":{"name":"Cerebral cortex","volume":"35 4","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144062491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cognitive traits shape the brain activity associated with mental rotation. 认知特征塑造了与心理旋转相关的大脑活动。

IF 2.9 2区医学

Cerebral cortex Pub Date : 2025-04-01 DOI: 10.1093/cercor/bhaf069

Nadia M Bersier, Eleonora Fornari, Raffaella I Rumiati, Silvio Ionta

{"title":"Cognitive traits shape the brain activity associated with mental rotation.","authors":"Nadia M Bersier, Eleonora Fornari, Raffaella I Rumiati, Silvio Ionta","doi":"10.1093/cercor/bhaf069","DOIUrl":"https://doi.org/10.1093/cercor/bhaf069","url":null,"abstract":"Mental rotation is a spatial cognitive ability influenced by several factors, including cognitive traits. However, the relationship between mental rotation performance, cognitive traits, and brain activity is still uncertain. To fill this gap, we recorded functional magnetic resonance imaging data while 55 neurotypical participants performed mental rotation with images of geometric objects, human bodies, and real objects. Cognitive traits were evaluated through the Object-Spatial Imagery Questionnaire (visual cognitive style), a perspective-taking task, and the Cognitive Flexibility Scale. Analysis of accuracy and reaction time revealed that (i) mental rotation in spatial-visualizers was more accurate and faster than in object-visualizers, and (ii) visual cognitive style and perspective-taking positively correlated with mental rotation. Brain activity data indicated that (i) individuals with better mental rotation performance had smaller brain activation, particularly in sensorimotor regions, (ii) for the spatial-visual scale and perspective-taking, high scorers had smaller brain activity than low performers, (iii) for the object-visual scale, high scorers had greater brain activity than low scorers. Supporting a neural efficiency hypothesis, the present study highlights the influence of cognitive traits on mental rotation performance and brain efficiency, with spatial-visualizers showing more efficient neural processing. These findings contribute to our understanding of how cognitive styles shape spatial cognition.","PeriodicalId":9715,"journal":{"name":"Cerebral cortex","volume":"35 4","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12038815/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143968532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The functional connectivity between the right rostral anterior cingulate cortex and the right dorsolateral prefrontal cortex underlies the association between future self-continuity and self-control. 右吻侧前扣带皮层和右背外侧前额叶皮层之间的功能连接是未来自我连续性和自我控制之间联系的基础。

IF 2.9 2区医学

Cerebral cortex Pub Date : 2025-04-01 DOI: 10.1093/cercor/bhaf092

Jicheng Huang, Liang Chen, Hengyue Zhao, Ting Xu, Zixiao Xiong, Chenxu Yang, Tingyong Feng, Pan Feng

{"title":"The functional connectivity between the right rostral anterior cingulate cortex and the right dorsolateral prefrontal cortex underlies the association between future self-continuity and self-control.","authors":"Jicheng Huang, Liang Chen, Hengyue Zhao, Ting Xu, Zixiao Xiong, Chenxu Yang, Tingyong Feng, Pan Feng","doi":"10.1093/cercor/bhaf092","DOIUrl":"https://doi.org/10.1093/cercor/bhaf092","url":null,"abstract":"Future self-continuity refers to the perceived degree of similarity between one's present self and future self. Self-control refers to the ability to regulate and control inappropriate behaviors, enabling individuals to suppress immediate reactions that are inconsistent with long-term goals. Previous studies demonstrated a positive correlation between future self-continuity and self-control, yet the neural mechanisms underlying this relationship remain unclear. To address this question, we integrated behavioral assessments with resting-state functional magnetic resonance imaging (fMRI) and mediation modeling to investigate this relationship. Behavioral results confirmed a positive correlation between the two variables. Furthermore, neuroimaging results revealed that right rostral anterior cingulate cortex (R-rACC) to right dorsolateral prefrontal cortex (R-dlPFC) functional connectivity correlated with future self-continuity and mediated its relationship with self-control. These findings suggest that the functional connectivity between the R-rACC and the R-dlPFC may constitute the neural basis of the relationship between future self-continuity and self-control while offering a mechanistic framework to advance understanding of their interrelationship.","PeriodicalId":9715,"journal":{"name":"Cerebral cortex","volume":"35 4","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143987070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Microglial regulation of white matter development and its disruption in autism spectrum disorder. 自闭症谱系障碍中小胶质细胞对白质发育的调控及其中断。

IF 2.9 2区医学

Cerebral cortex Pub Date : 2025-04-01 DOI: 10.1093/cercor/bhaf109

Katherine Canada, Tanya M Evans, Kevin A Pelphrey

{"title":"Microglial regulation of white matter development and its disruption in autism spectrum disorder.","authors":"Katherine Canada, Tanya M Evans, Kevin A Pelphrey","doi":"10.1093/cercor/bhaf109","DOIUrl":"https://doi.org/10.1093/cercor/bhaf109","url":null,"abstract":"White matter, comprising approximately 50% of the human brain, is crucial for efficient neuronal signaling and a wide range of brain functions, including social cognition, sensation, memory, motor control, and information integration across cortical brain regions in the service of perception and cognition. White matter, composed of myelinated axons, results from complex interactions between different cell types, with oligodendrocytes (OLs) and microglia playing integral roles. Microglia, the brain's resident immune cells, regulate oligodendrogenesis through phagocytosis and molecular signaling, for example through cytokines, which promote and inhibit maturation stages of OL lineage cells. Maternal immune activation (MIA) is a recognized risk factor for neurodevelopmental disorders, especially autism spectrum disorder (ASD). The physiological presentation of ASD includes white matter abnormalities and immune dysregulation. Emerging evidence indicates that MIA may reduce microglial reactivity and alter cytokine release in offspring, potentially disrupting the delicate balance required for proper white matter development. Understanding the intricate interplay between oligodendrocytes, microglia, inflammation, and white matter development in the context of MIA provides valuable insights into the etiology of and core symptoms of ASD and possible therapeutic targets.","PeriodicalId":9715,"journal":{"name":"Cerebral cortex","volume":"35 4","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143976579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of gaming content from social media on individuals with internet gaming disorder: an fMRI study. 社交媒体游戏内容对网络游戏障碍患者的影响：一项功能磁共振成像研究。

IF 2.9 2区医学

Cerebral cortex Pub Date : 2025-04-01 DOI: 10.1093/cercor/bhaf096

Yuka Fujimoto, Junya Fujino, Daisuke Matsuyoshi, Daisuke Jitoku, Nanase Kobayashi, Chenyu Qian, Shoko Okuzumi, Shisei Tei, Takehiro Tamura, Takefumi Ueno, Makiko Yamada, Hidehiko Takahashi

{"title":"Effects of gaming content from social media on individuals with internet gaming disorder: an fMRI study.","authors":"Yuka Fujimoto, Junya Fujino, Daisuke Matsuyoshi, Daisuke Jitoku, Nanase Kobayashi, Chenyu Qian, Shoko Okuzumi, Shisei Tei, Takehiro Tamura, Takefumi Ueno, Makiko Yamada, Hidehiko Takahashi","doi":"10.1093/cercor/bhaf096","DOIUrl":"https://doi.org/10.1093/cercor/bhaf096","url":null,"abstract":"Internet gaming disorder is an increasing public health problem due to the widespread availability of online gaming. Social media platforms drive this trend by enabling gameplay sharing and increasing user engagement, potentially reinforcing addictive gaming behaviors. Understanding how gaming content exposure on social media affects brain activity in individuals with internet gaming disorder is crucial. This study aimed to investigate gaming content neural responses on social media in individuals with internet gaming disorder using functional magnetic resonance imaging. We aimed to determine differences in activation patterns that contribute to understanding the neurobiological underpinnings of internet gaming disorder by examining brain activity in these individuals and comparing it to healthy controls. Additionally, we investigated the association of brain activity with clinical characteristics (internet gaming disorder severity and illness duration). The participants with internet gaming disorder demonstrated increased bilateral orbitofrontal cortex, bilateral hippocampus, left precuneus, and right superior temporal gyrus activation in response to gaming-related cues on social media compared to healthy controls. Additionally, internet gaming disorder severity and illness duration correlated with left hippocampus activation levels. These results improve our understanding of how gaming-related content on social media affects individuals with internet gaming disorder. Our findings provide valuable information into the neurobiological features of internet gaming disorder and help develop effective treatment interventions.","PeriodicalId":9715,"journal":{"name":"Cerebral cortex","volume":"35 4","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143960445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Can microglia negatively impact myelin development in autism? 小胶质细胞会对自闭症患者的髓磷脂发育产生负面影响吗？

IF 2.9 2区医学

Cerebral cortex Pub Date : 2025-04-01 DOI: 10.1093/cercor/bhaf100

Gustavo Della-Flora Nunes

引用次数: 0

Impact of visual and auditory deprivation on speech perception: an EEG study. 视觉和听觉剥夺对言语感知的影响：一项脑电图研究。

IF 2.9 2区医学

Cerebral cortex Pub Date : 2025-04-01 DOI: 10.1093/cercor/bhaf086

Christine Turgeon, Vanessa Hadid, Paméla Trudeau-Fisette, Inga Knoth, Franco Lepore, Sarah Lippé, Lucie Ménard

{"title":"Impact of visual and auditory deprivation on speech perception: an EEG study.","authors":"Christine Turgeon, Vanessa Hadid, Paméla Trudeau-Fisette, Inga Knoth, Franco Lepore, Sarah Lippé, Lucie Ménard","doi":"10.1093/cercor/bhaf086","DOIUrl":"https://doi.org/10.1093/cercor/bhaf086","url":null,"abstract":"This study investigated the impact of auditory and visual deprivation on speech processing by analyzing auditory evoked potentials (MMN, P3a, P2, N2b) in congenitally blind individuals, cochlear implant (CI) users, and normal-hearing controls. Using a passive oddball paradigm with /u/ as the standard stimulus and /i/ and /y/ as deviants, we recorded and analyzed auditory evoked potentials in fronto-central and centro-parietal regions. Blind participants exhibited significantly faster MMN and N2b latencies than controls and CI users, reflecting enhanced auditory temporal resolution due to cross-modal plasticity. CI users showed reduced P2 and N2b amplitudes, indicating challenges in early sensory processing and conflict monitoring, particularly for the /i/-/u/ contrast. Notably, blind participants had larger P3a amplitudes, emphasizing superior attentional engagement in response to deviant stimuli. Postlingually deafened CI users exhibited greater P3a amplitudes than prelingually deafened users, underscoring the impact of early auditory experiences on cortical responses. These findings demonstrate distinct effects of sensory deprivation on speech processing, with blind individuals showing compensatory neural mechanisms and CI users experiencing sensory and cognitive challenges. The results underscore the need for personalized rehabilitation strategies to enhance outcomes for populations with sensory deprivation and highlight the potential of cross-modal plasticity in auditory rehabilitation.","PeriodicalId":9715,"journal":{"name":"Cerebral cortex","volume":"35 4","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12038810/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143983834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unraveling white matter alterations in autism: the role of oligodendrocytes, microglia, and neuroinflammation. 解开自闭症中的白质改变：少突胶质细胞、小胶质细胞和神经炎症的作用。

IF 2.9 2区医学

Cerebral cortex Pub Date : 2025-04-01 DOI: 10.1093/cercor/bhaf094

Yuri Bozzi

引用次数: 0

The laminar pattern of proprioceptive activation in human primary motor cortex. 人初级运动皮层本体感觉激活的层流模式。

IF 2.9 2区医学

Cerebral cortex Pub Date : 2025-04-01 DOI: 10.1093/cercor/bhaf076

Lasse Knudsen, Fanhua Guo, Daniel Sharoh, Jiepin Huang, Jakob U Blicher, Torben E Lund, Yan Zhou, Peng Zhang, Yan Yang

{"title":"The laminar pattern of proprioceptive activation in human primary motor cortex.","authors":"Lasse Knudsen, Fanhua Guo, Daniel Sharoh, Jiepin Huang, Jakob U Blicher, Torben E Lund, Yan Zhou, Peng Zhang, Yan Yang","doi":"10.1093/cercor/bhaf076","DOIUrl":"https://doi.org/10.1093/cercor/bhaf076","url":null,"abstract":"The primary motor cortex (M1) is increasingly being recognized for its vital role in proprioceptive somatosensation. However, our current understanding of proprioceptive processing at the laminar scale is limited. Empirical findings in primates and rodents suggest a pronounced role of superficial cortical layers, but the involvement of deep layers has yet to be examined in humans. Submillimeter resolution functional magnetic resonance imaging (fMRI) has emerged in recent years, paving the way for studying layer-dependent activity in humans (laminar fMRI). In the present study, laminar fMRI was employed to investigate the influence of proprioceptive somatosensation on M1 deep layer activation using passive finger movements. Significant M1 deep layer activation was observed in response to proprioceptive stimulation across 10 healthy subjects using a vascular space occupancy (VASO)-sequence at 7 T. For further validation, two additional datasets were included which were obtained using a balanced steady-state free precession sequence with ultrahigh (0.3 mm) in-plane resolution, yielding converging results. These results were interpreted in the light of previous laminar fMRI studies and the active inference account of motor control. We propose that a considerable proportion of M1 deep layer activation is due to proprioceptive influence and that deep layers of M1 constitute a key component in proprioceptive circuits.","PeriodicalId":9715,"journal":{"name":"Cerebral cortex","volume":"35 4","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11998912/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143978173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0