Cerebral cortexPub Date : 2025-04-01DOI: 10.1093/cercor/bhaf091
Marta Ghio, Karolin Haegert, Alexander Seidel, Boris Suchan, Patrizia Thoma, Christian Bellebaum
{"title":"The prediction of auditory consequences of own and observed actions: a brain decoding multivariate pattern study.","authors":"Marta Ghio, Karolin Haegert, Alexander Seidel, Boris Suchan, Patrizia Thoma, Christian Bellebaum","doi":"10.1093/cercor/bhaf091","DOIUrl":"https://doi.org/10.1093/cercor/bhaf091","url":null,"abstract":"<p><p>Evidence from the auditory domain suggests that sounds generated by self-performed as well as observed actions are processed differently compared to external sounds. This study aimed to investigate which brain regions are involved in the processing of auditory stimuli generated by actions, addressing the question of whether cerebellar forward models, which are supposed to predict the sensory consequences of self-performed actions, similarly underlie predictions for action observation. We measured brain activity with functional magnetic resonance imaging (fMRI) while participants elicited a sound via button press, observed another person performing this action, or listened to external sounds. By applying multivariate pattern analysis (MVPA), we found evidence for altered processing in the right auditory cortex for sounds following both self-performed and observed actions relative to external sounds. Evidence for the prediction of auditory action consequences was found in the bilateral cerebellum and the right supplementary motor area, but only for self-performed actions. Our results suggest that cerebellar forward models contribute to predictions of sensory consequences only for action performance. While predictions are also generated for action observation, the underlying mechanisms remain to be elucidated.</p>","PeriodicalId":9715,"journal":{"name":"Cerebral cortex","volume":"35 4","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12038811/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143981579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Cerebral cortexPub Date : 2025-04-01DOI: 10.1093/cercor/bhaf074
M Fiona Molloy, Aman Taxali, Mike Angstadt, Tristan Greathouse, Katherine Toda-Thorne, Katherine L McCurry, Alexander Weigard, Omid Kardan, Lily Burchell, Maria Dziubinski, Jason Choi, Melanie Vandersluis, Cleanthis Michael, Mary M Heitzeg, Chandra Sripada
{"title":"Regional, but not brain-wide, graph theoretic measures are robustly and reproducibly linked to general cognitive ability.","authors":"M Fiona Molloy, Aman Taxali, Mike Angstadt, Tristan Greathouse, Katherine Toda-Thorne, Katherine L McCurry, Alexander Weigard, Omid Kardan, Lily Burchell, Maria Dziubinski, Jason Choi, Melanie Vandersluis, Cleanthis Michael, Mary M Heitzeg, Chandra Sripada","doi":"10.1093/cercor/bhaf074","DOIUrl":"https://doi.org/10.1093/cercor/bhaf074","url":null,"abstract":"<p><p>General cognitive ability (GCA), also called \"general intelligence,\" is thought to depend on network properties of the brain, which can be quantified through graph theoretic measures such as small worldness and module degree. An extensive set of studies examined links between GCA and graphical properties of resting state connectomes. However, these studies often involved small samples, applied just a few graph theory measures in each study, and yielded inconsistent results, making it challenging to identify the architectural underpinnings of GCA. Here, we address these limitations by systematically investigating univariate and multivariate relationships between GCA and 17 whole-brain and node-level graph theory measures in individuals from the Adolescent Brain Cognitive Development Study (n = 5937). We demonstrate that whole-brain graph theory measures, including small worldness and global efficiency, fail to exhibit meaningful relationships with GCA. In contrast, multiple node-level graphical measures, especially module degree (within-network connectivity), exhibit strong associations with GCA. We establish the robustness of these results by replicating them in a second large sample, the Human Connectome Project (n = 847), and across a variety of modeling choices. This study provides the most comprehensive and definitive account to date of complex interrelationships between GCA and graphical properties of the brain's intrinsic functional architecture.</p>","PeriodicalId":9715,"journal":{"name":"Cerebral cortex","volume":"35 4","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143991191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Cerebral cortexPub Date : 2025-04-01DOI: 10.1093/cercor/bhaf065
Simone A Luchini, Xinbing Zhang, Ryan T White, Michael Lührs, Michal Ramot, Roger E Beaty
{"title":"Enhancing creativity with covert neurofeedback: causal evidence for default-executive network coupling in creative thinking.","authors":"Simone A Luchini, Xinbing Zhang, Ryan T White, Michael Lührs, Michal Ramot, Roger E Beaty","doi":"10.1093/cercor/bhaf065","DOIUrl":"10.1093/cercor/bhaf065","url":null,"abstract":"<p><p>Creativity neuroscience has consistently reported increased functional connectivity between the default mode network and the executive control network supports creative cognition, potentially reflecting coordination of generative and evaluative cognitive processes. However, evidence has been purely correlational-no causal demonstrations show that default mode network-executive control network interaction specifically drives creative performance. We sought causal evidence for default mode network-executive control network coupling in creative thinking using functional near-infrared spectroscopy-brain connectivity neurofeedback, which can endogenously modify functional connectivity through reinforcement learning. Importantly, we employed covert neurofeedback, where participants were unaware of the specific brain activity being trained, allowing for unbiased evaluation of cognitive and neural impacts. In a default-executive neurofeedback condition (n = 15), we entrained coupling between the medial prefrontal cortex and the dorsolateral prefrontal cortex, hubs of the default mode network and executive control network, respectively. We compared this with a default-motor condition (n = 15), entraining coupling between the medial prefrontal cortex and the supplementary motor area. Approximately 24 h later, default-executive neurofeedback led to increased coupling between the default mode network and the executive control network during a creative thinking task (generating creative object uses), extending to broader default mode network regions. Behaviorally, we observed a double dissociation: The default-executive condition increased idea originality, while the default-motor condition improved go/no-go reaction times. We thus provide the first evidence that default mode network-executive control network coupling causally enhances creative performance.</p>","PeriodicalId":9715,"journal":{"name":"Cerebral cortex","volume":"35 4","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143802611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Cerebral cortexPub Date : 2025-04-01DOI: 10.1093/cercor/bhaf095
{"title":"Correction to: Brain activation patterns reflecting differences in music training: listening by ear vs. reading sheet music for the recognition of contexts and structures in a composition.","authors":"","doi":"10.1093/cercor/bhaf095","DOIUrl":"10.1093/cercor/bhaf095","url":null,"abstract":"","PeriodicalId":9715,"journal":{"name":"Cerebral cortex","volume":"35 4","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11998910/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143978567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Exploring the neural mechanisms linking healthy aging and cognitive maintenance: insights from Mendelian randomization and mediation analyses.","authors":"Tianyuyi Feng, Weizhong Xiao, Yunfei Li, Xiaohu Zhao","doi":"10.1093/cercor/bhaf006","DOIUrl":"10.1093/cercor/bhaf006","url":null,"abstract":"<p><p>As global population ages, maintaining cognitive health in elderly is crucial. Previous studies suggest a positive link between healthy aging and cognition, but the neural mechanisms remain unclear. This study used genome-wide association studydata to investigate neural mechanisms between healthy aging and cognition. We employed 2-sample Mendelian randomization to evaluate causal relationship between healthy aging (indexed by a multivariate genetic predictor, mvAge) and 6 cognitive measurements. We then used a 2-step Mendelian randomization approach and mediation analysis to identify brain imaging-derived phenotypes potentially mediating this relationship. Mendelian randomization analysis indicated that healthy aging had a positive causal relationship with various cognitive functions (common executive function, intelligence, cognitive performance, and fluid intelligence score). Two-step Mendelian randomization analysis identified 27 brain imaging-derived phenotypes having robust causal relationships with healthy aging and various cognitive measurements. Mediation analysis suggested that volume of subcallosal cortex might mediate effects of healthy aging on all 4 cognitive functions. Volume of cerebellum's VIIb could mediate effects on common executive functions, while fractional anisotropy in the anterior thalamic radiation might mediate effects on intelligence and cognitive performance. These findings suggest that specific brain regions may play a potential mediating role in the relationship between healthy aging and cognitive maintenance.</p>","PeriodicalId":9715,"journal":{"name":"Cerebral cortex","volume":"35 3","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143633712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Normative modeling of brain morphometry in self-limited epilepsy with centrotemporal spikes.","authors":"Siqi Yang, Wei Liao, Yimin Zhou, Chengzong Peng, Juan Wang, Zhiqiang Zhang","doi":"10.1093/cercor/bhaf064","DOIUrl":"10.1093/cercor/bhaf064","url":null,"abstract":"<p><p>Self-limited epilepsy with centrotemporal spikes is the most common pediatric epilepsy, characterized by an age-dependent onset that typically arises during childhood brain development and is followed by remission at puberty. However, the heterogeneity in children's brain development at the individual level complicates the challenge of personalized treatment. Our goal is to quantify individual deviations from the normative range of brain morphometric variation in children with Self-limited epilepsy with centrotemporal spikes and to assess their associations with clinical manifestations and cognitive functions. We have developed sex-specific normative models on regional subcortical volume, cortical thickness, and surface area data from 457 healthy children sourced from two datasets. These models were then utilized to map the brain morphometric deviations of children with Self-limited epilepsy with centrotemporal spikes (n = 187) and sex- and age-matched healthy controls (n = 108) from another dataset. In the Self-limited epilepsy with centrotemporal spikes group, children exhibited a higher proportion of regions with infra-normal deviations in subcortical volumes, the number of regions with normative deviations correlated with disease duration, seizure frequency, and Raven's total score. Our findings suggest that a few extreme distributions of heterogeneous brain morphometric deviations are present in a minority of individuals, emphasizing the need to monitor brain abnormalities throughout the course of the disease.</p>","PeriodicalId":9715,"journal":{"name":"Cerebral cortex","volume":"35 3","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143699736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Cerebral cortexPub Date : 2025-03-06DOI: 10.1093/cercor/bhaf063
Liyu Zhou, Ting Xu, Tingyong Feng
{"title":"The hippocampus-IPL connectivity links to ADHD traits through sensory processing sensitivity.","authors":"Liyu Zhou, Ting Xu, Tingyong Feng","doi":"10.1093/cercor/bhaf063","DOIUrl":"10.1093/cercor/bhaf063","url":null,"abstract":"<p><p>Accumulating evidence suggests that individuals with high sensory processing sensitivity often experience sensory overload and have difficulty sustaining attention, which can particularly resemble attention deficit symptoms of attention-deficit/hyperactivity disorder. However, due to the lack of understanding about the potential neural pathways involved in those processes, a comprehensive view of how sensory processing sensitivity and attention deficit are related is generally limited. Here, we quantified the sensory processing sensitivity and attention deficit using the Highly Sensitive Person Scale and the Adult Attention-deficit/Hyperactivity Disorder Self-Report Scale, respectively, to investigate the association between sensory processing sensitivity and attention deficit and further identify the corresponding neural substrates via the use of resting-state functional Magnetic Resonance Imaging (fMRI) analyses. On the behavioral level, the results indicated a significantly positive correlation between sensory processing sensitivity and attention deficit traits, while on the neural level, the sensory processing sensitivity score was positively correlated with functional connectivity between the rostral hippocampus and inferior parietal lobule, which is the core regions of the attention network. Mediation analysis revealed that hippocampus-Inferior Parietal Lobule (IPL) connectivity can further influence attention deficit through a mediating role of sensory processing sensitivity. Overall, these findings suggest that enhanced functional coupling between the hippocampus and attention network regions may heighten sensitivity to environmental stimuli, leading to increased distractibility and potentially contributing to attention deficit.</p>","PeriodicalId":9715,"journal":{"name":"Cerebral cortex","volume":"35 3","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143656077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Decoding the impact of negative physical self-perception on inhibitory control ability from theta and beta rhythms.","authors":"Junwei Lian, Jiaqi Guo, Xu Dai, Xia Deng, Yong Liu, Jia Zhao, Xu Lei","doi":"10.1093/cercor/bhaf056","DOIUrl":"10.1093/cercor/bhaf056","url":null,"abstract":"<p><p>Previous studies have found inhibitory control differences between obese individuals and those of normal weight. However, some normal-weight individuals with high negative physical self-perception on the fatness subscale show restrictive eating behaviors and attentional bias toward high-calorie food, potentially influencing these differences. We collected behavioral and electroencephalography data using a novel inhibitory control task. Results showed that individuals with high negative physical self-perception on the fatness subscale exhibited significantly greater restraint eating behavior compared to controls. Both theta and beta power differed between groups, with higher theta power in the high negative physical self-perception on the fatness subscale group than in the obese group and more negative beta power in the high negative physical self-perception on the fatness subscale group compared to both other groups. Theta power was greater in no-go than go conditions, while beta power was more negative in response to high-calorie versus low-calorie food stimuli. Importantly, theta power successfully decoded go/no-go conditions across all groups using multivariate pattern analysis, while beta power distinguished these conditions only in the negative physical self-perception on the fatness subscale and control groups. These findings suggest that theta and beta power, along with multivariate pattern analysis, can reliably distinguish inhibitory control ability among the three groups, highlighting the importance of considering negative physical self-perception on the fatness subscale when assessing inhibitory control differences between normal-weight and obese individuals.</p>","PeriodicalId":9715,"journal":{"name":"Cerebral cortex","volume":"35 3","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143656022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Cerebral cortexPub Date : 2025-03-06DOI: 10.1093/cercor/bhaf062
Ping Jiang, Zhenxiang Xiao, Tao Geng, Jiayu Sun, Jiajun Xu, Xiaoqi Huang, Jing Li, Keith M Kendrick, Xi Jiang, Qiyong Gong
{"title":"A deep learning model for characterizing altered gyro-sulcal functional connectivity in abstinent males with methamphetamine use disorder and associated emotional symptoms.","authors":"Ping Jiang, Zhenxiang Xiao, Tao Geng, Jiayu Sun, Jiajun Xu, Xiaoqi Huang, Jing Li, Keith M Kendrick, Xi Jiang, Qiyong Gong","doi":"10.1093/cercor/bhaf062","DOIUrl":"10.1093/cercor/bhaf062","url":null,"abstract":"<p><p>Failure to manage emotional withdrawal symptoms can exacerbate relapse to methamphetamine use. Understanding the neuro-mechanisms underlying methamphetamine overuse and the associated emotional withdrawal symptoms is crucial for developing effective clinical strategies. This study aimed to investigate the distinct functional contributions of fine-scale gyro-sulcal signaling in the psychopathology of patients with methamphetamine use disorder and its associations with emotional symptoms. We recruited 48 male abstinent methamphetamine use disorders and 48 age- and gender-matched healthy controls, obtaining their resting-state functional magnetic resonance imaging data along with scores on anxiety and depressive symptoms. The proposed deep learning model, a spatio-temporal graph convolutional network utilizing gyro-sulcal subdivisions, achieved the highest average classification accuracy in distinguishing resting-state functional magnetic resonance imaging data of methamphetamine use disorders from healthy controls. Within this model, nodes in the lateral orbitofrontal cortex, and the habitual and executive control networks, contributed most significantly to the classification. Additionally, emotional symptom scores were negatively correlated with the sum of negative functional connectivity in the right caudal anterior cingulate sulcus and the functional connectivity between the left putamen and pallidum in methamphetamine use disorders. These findings provide novel insights into the differential functions of gyral and sulcal regions, enhancing our understanding of the neuro-mechanisms underlying methamphetamine use disorders.</p>","PeriodicalId":9715,"journal":{"name":"Cerebral cortex","volume":"35 3","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143691300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Cerebral cortexPub Date : 2025-03-06DOI: 10.1093/cercor/bhaf043
Paul W Czoty, Mohammad Kawas, Kedar Madi, Richard Barcus, Jeongchul Kim, Jeremy P Hudson, Lindsey K Galbo-Thomma, Hongyu Yuan, James B Daunais, Christopher T Whitlow
{"title":"A role for the insula in establishing social dominance: structural and functional MRI studies in nonhuman primates.","authors":"Paul W Czoty, Mohammad Kawas, Kedar Madi, Richard Barcus, Jeongchul Kim, Jeremy P Hudson, Lindsey K Galbo-Thomma, Hongyu Yuan, James B Daunais, Christopher T Whitlow","doi":"10.1093/cercor/bhaf043","DOIUrl":"10.1093/cercor/bhaf043","url":null,"abstract":"<p><p>Awareness of one's position in the social hierarchy is essential for survival. Conversely, poor social cognition is associated with several neuropsychiatric diseases. Although brain regions that mediate understanding of the social hierarchy are poorly understood, recent evidence implicates the insula. Magnetic resonance imaging (MRI) scans were acquired in twelve individually housed male cynomolgus monkeys to determine whether structural and functional characteristics of the insular cortex predicted the social rank that monkeys would attain once they formed stable social hierarchies. Structural MRI revealed that left insular volume was significantly larger in monkeys that would become dominant vs. subordinate. No differences were observed in other areas including amygdala, caudate nucleus, or prefrontal cortex. Volumetric differences were localized to dorsal anterior regions of both left and right insulae. Functional MRI revealed that global correlation, a measure of connectedness to the rest of the brain, was significantly lower in the left insula of monkeys who would become dominant vs. subordinate. Moreover, the fractional amplitude of low-frequency fluctuations, a reflection of spontaneous brain activity, trended lower in bilateral insula in the future dominant monkeys. This prospective study provides evidence for a role of the insula in the establishment and maintenance of social dominance relationships.</p>","PeriodicalId":9715,"journal":{"name":"Cerebral cortex","volume":"35 3","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11915092/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143655778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}