Cerebral cortex最新文献_第7页

Visual dominance over tactile and auditory processing in human medial pulvinar. 人类内侧枕侧的视觉优势优于触觉和听觉加工。

IF 3 2区医学

Cerebral cortex Pub Date : 2026-08-01 DOI: 10.1093/cercor/bhag116

Maxime Gaudet-Trafit, Mathilda Froesel, Souhir Dali, Franck Lamberton, Suliann Ben Hamed

{"title":"Visual dominance over tactile and auditory processing in human medial pulvinar.","authors":"Maxime Gaudet-Trafit, Mathilda Froesel, Souhir Dali, Franck Lamberton, Suliann Ben Hamed","doi":"10.1093/cercor/bhag116","DOIUrl":"10.1093/cercor/bhag116","url":null,"abstract":"Optimal processing of our environment relies on the integration of information across sensory modalities. The pulvinar is known to play a key role in visual and face processing, but its involvement in auditory and tactile domains remains poorly understood. Here, we used fMRI localizer tasks to characterize pulvinar functional organization and connectivity during face, voice, and tactile processing. We reproduce the activation of the ventro-medial pulvinar during face perception and describe condition-dependent changes in pulvinar connectivity with face-processing areas, together with reduced connectivity with early visual and default mode network regions. Small clusters overlapping the medial pulvinar were also observed during air-puff stimulation of the face, hand, and foot, accompanied by condition-dependent changes in pulvino-cortical connectivity as a function of the stimulated body part, although these effects were detected at exploratory statistical thresholds. No reliable positive pulvinar activation was detected during voice or non-voice stimulation within the sensitivity limits of the present paradigm. Overall, these results highlight robust visual pulvinar responses and suggest a possible, but preliminary, involvement of the medial pulvinar in tactile processing, together with context-dependent patterns of functional connectivity with cortical areas.","PeriodicalId":9715,"journal":{"name":"Cerebral cortex","volume":"36 8","pages":""},"PeriodicalIF":3.0,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148788723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Alternative splicing in layer 3 pyramidal neurons differs across regions of the human cortical hierarchy. 第三层锥体神经元的选择性剪接在人类皮层层次的不同区域是不同的。

IF 3 2区医学

Cerebral cortex Pub Date : 2026-08-01 DOI: 10.1093/cercor/bhag115

Kevin F Dowling, John F Enwright Iii, Dominique Arion, David A Lewis

{"title":"Alternative splicing in layer 3 pyramidal neurons differs across regions of the human cortical hierarchy.","authors":"Kevin F Dowling, John F Enwright Iii, Dominique Arion, David A Lewis","doi":"10.1093/cercor/bhag115","DOIUrl":"10.1093/cercor/bhag115","url":null,"abstract":"The primate neocortex is organized as hierarchical networks of functionally distinct regions. In the dorsal visual stream network, information is conveyed from primary visual (V1) to posterior parietal (PPC) and dorsolateral prefrontal (DLPFC) cortices. This information transfer is mediated primarily by layer 3 pyramidal neurons (L3PNs), which differ across these regions in morphology, excitability, and intracellular Ca2+ regulation. These region-specific L3PN properties may be influenced by alternative splicing (AS) of pre-mRNA, which occurs extensively in the human brain. To explore the potential impact of AS of region-specific L3PN properties, we analyzed RNA-seq data from pools of L3PNs dissected from human V1, PPC, and DLPFC. We found that <6% of genes with regional differences in expression also differed in AS. This finding indicates that the absence of transcriptional differences is insufficient to conclude that a gene does not contribute functional differences between regions. Additionally, there were numerous regional differences in AS, particularly between V1 and DLPFC or PPC L3PNs, which involved genes associated with neuron morphology and Ca2+ regulation; > 90% of these AS differences involved functionally relevant sequences (eg phosphorylation sites, etc.). These findings suggest AS contributes to region-specific L3PN properties relevant to the function of the dorsal visual stream.","PeriodicalId":9715,"journal":{"name":"Cerebral cortex","volume":"36 8","pages":""},"PeriodicalIF":3.0,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13490750/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148788668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Vibrotactile beat sensitivity in deaf individuals: behavioral and neural evidence. 失聪个体的振动触觉灵敏度：行为和神经证据。

IF 3 2区医学

Cerebral cortex Pub Date : 2026-07-14 DOI: 10.1093/cercor/bhag111

Sean A Gilmore, Phuong-Nghi Pham, Frank A Russo

{"title":"Vibrotactile beat sensitivity in deaf individuals: behavioral and neural evidence.","authors":"Sean A Gilmore, Phuong-Nghi Pham, Frank A Russo","doi":"10.1093/cercor/bhag111","DOIUrl":"10.1093/cercor/bhag111","url":null,"abstract":"Beat sensitivity is typically studied in the auditory modality, yet the temporal prediction mechanisms that support beat processing are thought to be supramodal and may be accessible through other sensory channels. Deafness provides a powerful model for examining whether these mechanisms can be recruited through somatosensory input. We compared vibrotactile beat sensitivity in deaf (n = 17) and hearing (n = 16) adults using frequency-tagging EEG and sensorimotor synchronization (SMS) during exposure to isochronous and temporally complex vibrotactile rhythms. Neural entrainment was quantified as spectral power at beat-related frequencies, while SMS variability indexed behavioral precision. Deaf participants exhibited significantly stronger neural entrainment to vibrotactile rhythms than hearing controls. Behaviorally, deaf individuals showed reduced tapping variability, an effect that was selectively enhanced for temporally complex rhythms, suggesting more efficient extraction of higher-order temporal structure. These neural and behavioral enhancements occurred despite comparable within-group entrainment across rhythm types. Together, these findings demonstrate that beat-based temporal prediction can be robustly achieved through vibrotactile input in the absence of auditory experience. This work provides combined behavioral and neural evidence for vibrotactile beat sensitivity in deaf individuals and indicates that somatosensory pathways can support predictive timing mechanisms typically associated with audition.","PeriodicalId":9715,"journal":{"name":"Cerebral cortex","volume":"36 7","pages":""},"PeriodicalIF":3.0,"publicationDate":"2026-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13421781/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148629476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Long-term reliability and stability of parameterized resting state EEG: evidence from a five-year follow-up. 参数化静息状态脑电图的长期可靠性和稳定性：来自五年随访的证据。

IF 3 2区医学

Cerebral cortex Pub Date : 2026-07-14 DOI: 10.1093/cercor/bhag113

Polina Politanskaia, Jacinta Bywater, Anna J Finley, Hannah A D Keage, Nicholas J Kelley, Daniel J McKeown, Victor R Schinazi, Douglas J Angus

{"title":"Long-term reliability and stability of parameterized resting state EEG: evidence from a five-year follow-up.","authors":"Polina Politanskaia, Jacinta Bywater, Anna J Finley, Hannah A D Keage, Nicholas J Kelley, Daniel J McKeown, Victor R Schinazi, Douglas J Angus","doi":"10.1093/cercor/bhag113","DOIUrl":"10.1093/cercor/bhag113","url":null,"abstract":"Several aspects of parameterized neural activity, including the aperiodic exponent and individual peak alpha frequency, have emerged as promising biomarkers for ageing, pathology, and cognitive decline. Their potential clinical application is tempered by a lack of evidence on long-term temporal stability. Existing investigations have largely relied on cross-sectional designs or considered stability for up to 90 days. Here, we examined five-year reliability, stability, and age-associated changes in periodic and aperiodic neural activity using electroencephalography in adults aged 20-70 years. Resting-state EEG was recorded in two sessions, approximately five years apart. We extracted the aperiodic exponent, aperiodic offset, peak alpha power, and individual alpha peak frequency and examined test-retest reliability at both the channel and cluster levels. All parameters demonstrated fair to excellent test-retest reliability (intraclass correlations = 0.51-0.88). Linear mixed models revealed that individual peak alpha frequency decreased, the aperiodic exponent flattened, and parameterized alpha power remained unchanged. There were no interactions between time and age. Our findings suggest that parameterized activity is reliable over long timeframes, and demonstrates changes consistent with ageing-related processes. Spectral parameterization may provide a means of characterizing within-person neurophysiological changes across adulthood. Future research should explore the utility of identifying deviations that may indicate pathology.","PeriodicalId":9715,"journal":{"name":"Cerebral cortex","volume":"36 7","pages":""},"PeriodicalIF":3.0,"publicationDate":"2026-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13456336/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148705401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Relationship of glymphatic dysfunction and frontothalamic structure with cognitive impairment in attention deficit hyperactivity disorder. 注意缺陷多动障碍中淋巴功能障碍和额丘脑结构与认知障碍的关系。

IF 3 2区医学

Cerebral cortex Pub Date : 2026-07-14 DOI: 10.1093/cercor/bhag099

Manxue Zhang, Bohua Li, Sixun Li, Shengnan Zhao, Lei Li, Yuchu Jiang, Mingjing Situ, Yi Huang

{"title":"Relationship of glymphatic dysfunction and frontothalamic structure with cognitive impairment in attention deficit hyperactivity disorder.","authors":"Manxue Zhang, Bohua Li, Sixun Li, Shengnan Zhao, Lei Li, Yuchu Jiang, Mingjing Situ, Yi Huang","doi":"10.1093/cercor/bhag099","DOIUrl":"https://doi.org/10.1093/cercor/bhag099","url":null,"abstract":"Cognitive deficits constitute a core feature of attention deficit hyperactivity disorder (ADHD), yet their underlying neurobiological mechanisms remain incompletely understood. This study investigates the tripartite relationship among glymphatic function, gray matter volume (GMV), and cognitive deficits in pediatric ADHD. We enrolled 159 children with ADHD and 163 typically developing controls. All participants underwent cognitive assessments and multimodal magnetic resonance imaging (MRI). We analyzed group differences in cognitive performance, GMV, and glymphatic function. Exploratory mediation analyses using a regression-based approach (PROCESS) were used to examine the relationships between these variables. Children with ADHD showed significant impairment in sustained attention and emotional regulation (P < 0.001). The ADHD group exhibited reduced glymphatic function, as indicated by a lower along the Perivascular Space (ALPS) index (P < 0.001). GMV abnormalities in ADHD spatially overlapped with ALPS-anchored regions in the parahippocampal-thalamo-frontal circuits. Critically, exploratory mediation analysis provided preliminary, hypothesis-generating evidence that the association between reduced GMV in prefrontal regions (left medial prefrontal cortex and medial superior frontal gyrus) and cognitive deficits may be mediated by glymphatic dysfunction (P < 0.05). Our findings establish glymphatic dysfunction as a feature of pediatric ADHD that co-occurs with fronto-thalamic abnormalities, nominating the glymphatic system as a potential therapeutic target for cognitive comorbidities in ADHD.","PeriodicalId":9715,"journal":{"name":"Cerebral cortex","volume":"36 7","pages":""},"PeriodicalIF":3.0,"publicationDate":"2026-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148705485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Aging shifts hippocampal reactivation from selective reinstatement to category-level misbinding during episodic memory. 在情景记忆中，衰老将海马的再激活从选择性恢复转移到类别水平的错误结合。

IF 3 2区医学

Cerebral cortex Pub Date : 2026-07-14 DOI: 10.1093/cercor/bhag114

Destaw B Mekbib, Ian M McDonough

{"title":"Aging shifts hippocampal reactivation from selective reinstatement to category-level misbinding during episodic memory.","authors":"Destaw B Mekbib, Ian M McDonough","doi":"10.1093/cercor/bhag114","DOIUrl":"10.1093/cercor/bhag114","url":null,"abstract":"Episodic memory is the ability to bind elements of an experience into coherent associations. This ability declines with age, often producing errors that can interfere with daily life. Memory distortions might arise from unstable hippocampal representations that cannot be maintained across encoding, storage, and later retrieval. However, whether aging disrupts the temporal continuity of these representations across memory phases has not been directly tested. Here, adults aged 20-74 completed functional magnetic resonance imaging (fMRI) scanning during an associative memory task involving face-object and face-scene pairings, followed by post-encoding rest and a cued retrieval test. Using multivoxel correlation structure analyses, we quantified hippocampal pattern similarity across each memory stage. Increasing age was associated with increased category errors and reduced representational similarity across all transitions. Higher encoding-retrieval similarity predicted better associative accuracy in younger adults and was less predictive in middle-aged and diminished in older adults. Uniquely among older adults, greater cross-phase similarity predicted elevated category-level binding errors, suggesting a shift from selective reactivation to misbinding with age. Baseline hippocampal organization and encoding-specific connectivity supported accurate reinstatement only in younger adults. Aging disrupts hippocampal stability, possibly representing a core mechanism of age-related decline in associative memory across the adult lifespan.","PeriodicalId":9715,"journal":{"name":"Cerebral cortex","volume":"36 7","pages":""},"PeriodicalIF":3.0,"publicationDate":"2026-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13456335/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148705421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Combined effects of motor imagery and tendon vibration on corticospinal excitability. 运动意象和肌腱振动对皮质脊髓兴奋性的联合影响。

IF 3 2区医学

Cerebral cortex Pub Date : 2026-07-14 DOI: 10.1093/cercor/bhag106

Vincent Malejac, Vianney Rozand, Aymeric Guillot, Thomas Lapole

{"title":"Combined effects of motor imagery and tendon vibration on corticospinal excitability.","authors":"Vincent Malejac, Vianney Rozand, Aymeric Guillot, Thomas Lapole","doi":"10.1093/cercor/bhag106","DOIUrl":"https://doi.org/10.1093/cercor/bhag106","url":null,"abstract":"Motor imagery (MI) engages neural networks involved in movement execution and modulates corticospinal excitability (CSE). Proprioceptive inputs associated with movement may further influence corticospinal engagement during MI. Tendon vibration (TV) provides proprioceptive stimulation without requiring actual movement and has also been shown to increase CSE. This study investigated whether combining MI with TV enhances corticospinal excitability and whether these effects are reproducible across sessions. Sixteen healthy participants (11 males; 24.9 ± 6.3 years) completed two similar sessions. Transcranial magnetic stimulation was used to elicit motor-evoked potentials from the wrist muscle under four conditions: rest (REST), MI of maximal wrist flexion, TV applied to the wrist, and the combination of both MI and TV (MITV). CSE was quantified during each condition as the area under the recruitment curve, obtained by progressively increasing TMS intensity. The MITV condition led to a significantly greater increase compared to REST, MI, and TV (P < 0.001). Specifically, MITV showed a 80% greater increase in CSE compared with MI. In addition, the TV and MI conditions both exhibited greater CSE than REST. Reproducibility analysis revealed poor to good reliability across sessions. Results suggest that combining MI with TV may enhance corticospinal engagement compared with MI alone.","PeriodicalId":9715,"journal":{"name":"Cerebral cortex","volume":"36 7","pages":""},"PeriodicalIF":3.0,"publicationDate":"2026-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148629390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Language-based labeling modulates oscillatory neural dynamics of social pain processing. 基于语言的标记调节社会疼痛加工的振荡神经动力学。

IF 3 2区医学

Cerebral cortex Pub Date : 2026-07-14 DOI: 10.1093/cercor/bhag103

Jiahe Sun, Liyue Lin, Jiayi Zhao, Min Li, Ruyan Jiao, Jie Li, Hongfei Ji, Jie Zhuang

{"title":"Language-based labeling modulates oscillatory neural dynamics of social pain processing.","authors":"Jiahe Sun, Liyue Lin, Jiayi Zhao, Min Li, Ruyan Jiao, Jie Li, Hongfei Ji, Jie Zhuang","doi":"10.1093/cercor/bhag103","DOIUrl":"https://doi.org/10.1093/cercor/bhag103","url":null,"abstract":"The neurocognitive mechanisms underlying language-based implicit modulation of social pain remain poorly understood. To examine the neural dynamics associated with this process, we recorded electroencephalography (EEG) from 39 healthy adults completing a three-condition labeling task: social exclusion labeling, affect labeling, and gender labeling. Results showed that social exclusion labeling produced stronger modulation of social pain-related neural responses than affect labeling, as reflected in reduced N400 and P300 amplitudes, suggesting a more efficient allocation of cognitive resources during social pain processing. Time-frequency analyses revealed suppressed left-hemisphere theta oscillations, especially in prefrontal regions implicated in cognitive-affective control. Multivariate pattern analysis (MVPA) further demonstrated distinct neural activation patterns across conditions, particularly within theta and beta bands during early and late processing stages. In addition, the exploratory theta-beta phase-amplitude coupling analysis suggested reduced cross-frequency coordination under social exclusion labeling, consistent with lower cognitive demand and altered neural encoding of socially painful stimuli. Together, these findings identify social exclusion labeling as a distinct language-based route for the implicit modulation of social pain, extending affect-labeling accounts and underscoring the importance of social-contextual semantic processing. This evidence may inform future research on language-based strategies for regulating socially painful experiences.","PeriodicalId":9715,"journal":{"name":"Cerebral cortex","volume":"36 7","pages":""},"PeriodicalIF":3.0,"publicationDate":"2026-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148705407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A neuroanatomical basis for co-occurring low attention and low reading ability. 低注意力和低阅读能力同时发生的神经解剖学基础。

IF 3 2区医学

Cerebral cortex Pub Date : 2026-07-14 DOI: 10.1093/cercor/bhag100

Michael F Romano, Pierre Nedelec, Maria Luisa Mandelli, Jason D Yeatman, Luke W Bonham, Pedro Pinheiro-Chagas, Leo P Sugrue, Marilu Gorno-Tempini, Andreas M Rauschecker

{"title":"A neuroanatomical basis for co-occurring low attention and low reading ability.","authors":"Michael F Romano, Pierre Nedelec, Maria Luisa Mandelli, Jason D Yeatman, Luke W Bonham, Pedro Pinheiro-Chagas, Leo P Sugrue, Marilu Gorno-Tempini, Andreas M Rauschecker","doi":"10.1093/cercor/bhag100","DOIUrl":"10.1093/cercor/bhag100","url":null,"abstract":"Attention deficit hyperactivity disorder (ADHD) and dyslexia are two common disorders that can have devastating impacts on child development and occur together more often than one would expect by chance. Identifying imaging markers characteristic of a combined ADHD and dyslexia phenotype could improve our ability to diagnose these entities early and inform our understanding of the underlying disease processes. In this study, we set out to determine whether there are unique cortical, white matter, or subcortical characteristics in adolescents with combined low attention (LA) and low reading ability (LR), which we utilized as behavioral surrogate markers of ADHD and dyslexia. We conducted a retrospective, cross-sectional analysis using imaging, demographic, genetic, and neuropsychiatric data from 8779 individuals in the Adolescent Behavioral Cognitive Development study. We modeled cortical area, subcortical volume, and white matter integrity (fractional anisotropy) across brain regions and white matter tracts as functions of LA and LR. Cortical area was reduced in both LA and LR separately, with overlapping reductions in orbitofrontal cortex that persist in vertex-wise maps after adjustment for total cortical area. Global white matter integrity uniquely differed in individuals with combined LA/LR. These findings are most supportive of a shared underlying susceptibility for ADHD and dyslexia.","PeriodicalId":9715,"journal":{"name":"Cerebral cortex","volume":"36 7","pages":""},"PeriodicalIF":3.0,"publicationDate":"2026-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13425234/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148629439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Action fluency and conscious intention: being aware of what we are about to do. 动作流畅性和有意识的意图：意识到我们将要做什么。

IF 3 2区医学

Cerebral cortex Pub Date : 2026-07-14 DOI: 10.1093/cercor/bhag108

Zheng Huang, Silvia Seghezzi, Patrick Haggard

{"title":"Action fluency and conscious intention: being aware of what we are about to do.","authors":"Zheng Huang, Silvia Seghezzi, Patrick Haggard","doi":"10.1093/cercor/bhag108","DOIUrl":"10.1093/cercor/bhag108","url":null,"abstract":"Voluntary actions are often accompanied by a clear, preceding conscious experience of intention. However, the nature of this experience, and the neural mechanisms underlying it, have proved difficult to study scientifically. Many previous studies instructed participants to make simple manual actions, and then report their preceding intention only retrospectively. We combined a typing-based verbal fluency paradigm with pseudorandom probes of conscious experience to address these issues, and used electroencephalography (EEG) to explore neural correlates of prospective intention. Across one behavioral and one EEG experiment, involving 51 participants, we found conscious intention emerged over 1 s before estimated action onset. Further, we found an EEG readiness-potential-like activity that was stronger prior to probes that participants reported as interrupting a conscious intention, compared to other probes. In addition, probes that interrupted conscious intention were found to occur after lateralization of the readiness-potential-like activity to the hemisphere contralateral to the hand that participants reported would type the first letter. Our results provide novel evidence for a prospective experience of conscious intention associated with neural processes that precede voluntary actions. Significance Statement Many models of voluntary action assume that an experience of conscious intention precedes movement onset, but the mechanisms underlying this experience are highly controversial. By randomly probing experiences of intention during an action generation task involving typing-based verbal fluency, we developed a new method for estimating time of conscious intention, and its neural mechanisms. The method estimates that experiences of prospective intention occur over 1 s before action. Concurrent EEG recordings suggested that the EEG signals classically used as precursor indices of voluntary action are also associated with the experience of prospective intention.","PeriodicalId":9715,"journal":{"name":"Cerebral cortex","volume":"36 7","pages":""},"PeriodicalIF":3.0,"publicationDate":"2026-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13456334/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148705461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0